JP2012523569A5 - - Google Patents
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- Publication number
- JP2012523569A5 JP2012523569A5 JP2012504866A JP2012504866A JP2012523569A5 JP 2012523569 A5 JP2012523569 A5 JP 2012523569A5 JP 2012504866 A JP2012504866 A JP 2012504866A JP 2012504866 A JP2012504866 A JP 2012504866A JP 2012523569 A5 JP2012523569 A5 JP 2012523569A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- nucleic acid
- acid moiety
- composition
- functional group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical group 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 12
- 125000000524 functional group Chemical group 0.000 claims 9
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 5
- 239000004472 Lysine Substances 0.000 claims 5
- 235000018977 lysine Nutrition 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 210000004962 mammalian cell Anatomy 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 2
- 108020004414 DNA Proteins 0.000 claims 2
- 210000002421 cell wall Anatomy 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101001007348 Arachis hypogaea Galactose-binding lectin Proteins 0.000 claims 1
- 102000053602 DNA Human genes 0.000 claims 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000013922 glutamic acid Nutrition 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 235000004400 serine Nutrition 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 235000008521 threonine Nutrition 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 235000002374 tyrosine Nutrition 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16774809P | 2009-04-08 | 2009-04-08 | |
| US61/167,748 | 2009-04-08 | ||
| US24312309P | 2009-09-16 | 2009-09-16 | |
| US61/243,123 | 2009-09-16 | ||
| PCT/US2010/030397 WO2010118235A1 (en) | 2009-04-08 | 2010-04-08 | Dna-cell conjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016130419A Division JP2016168062A (ja) | 2009-04-08 | 2016-06-30 | Ｄｎａ−細胞コンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012523569A JP2012523569A (ja) | 2012-10-04 |
| JP2012523569A5 true JP2012523569A5 (enExample) | 2013-05-30 |
| JP5964746B2 JP5964746B2 (ja) | 2016-08-03 |
Family
ID=42936579
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504866A Active JP5964746B2 (ja) | 2009-04-08 | 2010-04-08 | Ｄｎａ−細胞コンジュゲート |
| JP2016130419A Pending JP2016168062A (ja) | 2009-04-08 | 2016-06-30 | Ｄｎａ−細胞コンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016130419A Pending JP2016168062A (ja) | 2009-04-08 | 2016-06-30 | Ｄｎａ−細胞コンジュゲート |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9327036B2 (enExample) |
| EP (1) | EP2417249B1 (enExample) |
| JP (2) | JP5964746B2 (enExample) |
| CN (3) | CN102575228A (enExample) |
| CA (1) | CA2757884C (enExample) |
| ES (1) | ES2924287T3 (enExample) |
| WO (1) | WO2010118235A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013019714A1 (en) | 2011-07-29 | 2013-02-07 | The Trustees Of Columbia University In The City Of New York | Mems affinity sensor for continuous monitoring of analytes |
| US9671364B2 (en) | 2011-12-22 | 2017-06-06 | Becton, Dickinson And Company | Methods and apparatus for rapid detection of infectious microorganisms |
| US9160024B1 (en) * | 2012-06-22 | 2015-10-13 | The United States Of America, As Represented By The Secretary Of The Navy | Grafting of biomolecules onto microbial fuel cells |
| WO2014160363A1 (en) * | 2013-03-14 | 2014-10-02 | Baylor Research Institute | Surface modification of porcine islets |
| CN105102627B (zh) * | 2013-03-15 | 2018-10-19 | 纽约哥伦比亚大学理事会 | 用于检测样品中多种预定化合物的方法 |
| EP2799872B1 (en) * | 2013-05-01 | 2017-10-18 | F. Hoffmann-La Roche AG | Selective release of sub-group of biological units |
| CN104212758A (zh) * | 2013-05-31 | 2014-12-17 | 复旦大学 | 一种构建遗传性状嵌合多细胞结构方法 |
| US11952622B2 (en) | 2013-07-18 | 2024-04-09 | The Johns Hopkins University | Analysis of DNA-containing samples and resolution of mixed contributor DNA samples |
| WO2015042539A1 (en) * | 2013-09-20 | 2015-03-26 | Board Of Regents, The University Of Texas System | Fabrication of iridium oxide ph sensors and sensor arrays |
| WO2015168656A2 (en) * | 2014-05-02 | 2015-11-05 | Adheren Incorporated | Biological complexes and methods for using same |
| WO2016022696A1 (en) | 2014-08-05 | 2016-02-11 | The Trustees Of Columbia University In The City Of New York | Method of isolating aptamers for minimal residual disease detection |
| CA2993401C (en) * | 2014-10-28 | 2018-09-18 | The Governing Council Of The University Of Toronto | Electrochemical metabolic activity detecting device |
| US9926524B2 (en) | 2014-12-22 | 2018-03-27 | Saint-Gobain Performance Plastics Corporation | Gas permeable material |
| US10655097B2 (en) | 2014-12-22 | 2020-05-19 | Saint-Gobain Performance Plastics Corporation | T-cell culture double bag assembly |
| US10280390B2 (en) | 2014-12-22 | 2019-05-07 | Saint-Gobain Performance Plastics Corporation | System for culture of cells in a controlled environment |
| US11427861B2 (en) | 2016-03-17 | 2022-08-30 | Massachusetts Institute Of Technology | Methods for identifying and modulating co-occurant cellular phenotypes |
| US11874268B2 (en) * | 2016-06-12 | 2024-01-16 | Nanohesgarsazan Salamat Arya Ncubation Center For Equipment And Devices | Method and system for metastasis diagnosis and prognosis |
| WO2018170515A1 (en) * | 2017-03-17 | 2018-09-20 | The Broad Institute, Inc. | Methods for identifying and modulating co-occurant cellular phenotypes |
| CN107037218B (zh) * | 2017-05-04 | 2019-02-15 | 中南大学 | 一种膜蛋白检测制剂、非标记肿瘤纳米探针及使用方法 |
| WO2020010366A1 (en) * | 2018-07-06 | 2020-01-09 | The Regents Of The University Of California | Lipid-modified oligonucleotides and methods of using the same |
| US11208648B2 (en) * | 2018-11-16 | 2021-12-28 | International Business Machines Corporation | Determining position and transcriptomes of biological cells |
| CA3113841A1 (en) * | 2019-03-01 | 2020-09-10 | Illumina, Inc. | High-throughput single-nuclei and single-cell libraries and methods of making and of using |
| BR102019006678A2 (pt) * | 2019-04-02 | 2020-10-06 | Universidade Federal de Uberlândia | Processo de modificação da superfície de eletrodos para construção de biossensores eletroquímicos |
| CN110205291A (zh) * | 2019-04-28 | 2019-09-06 | 蚌埠医学院第一附属医院 | 一种膜表面工程化nk细胞的制备方法及药物组合物与应用 |
| CN112014361B (zh) * | 2019-05-30 | 2023-09-15 | 华东理工大学 | 一种基于多氨基荧光纳米簇的细胞膜唾液酸快速成像标记方法 |
| US12091313B2 (en) | 2019-08-26 | 2024-09-17 | The Research Foundation For The State University Of New York | Electrodynamically levitated actuator |
| US20210129134A1 (en) * | 2019-11-04 | 2021-05-06 | Rarecyte, Inc. | Reference slide |
| CN114630906A (zh) * | 2019-11-04 | 2022-06-14 | 生物辐射实验室股份有限公司 | 用于单细胞测序的细胞条码化 |
| US20240125764A1 (en) * | 2019-11-08 | 2024-04-18 | The Regents Of The University Of California | Compositions and methods for temporal control of cell modulation |
| CN111534475B (zh) * | 2019-11-28 | 2022-03-15 | 厦门诺康得生物科技有限公司 | 一种细胞表面偶联抗体的方法及其应用 |
| CN112280829B (zh) * | 2020-04-07 | 2023-12-26 | 南方科技大学 | 一种试剂盒、样本标记方法、单细胞测序方法 |
| US20230294097A1 (en) * | 2020-05-04 | 2023-09-21 | The Regents Of The University Of California | Electrochemical cellular circuits |
| WO2022099058A1 (en) * | 2020-11-09 | 2022-05-12 | The General Hospital Corporation | Methods of determining surface glycan density |
| CN114574496B (zh) * | 2020-12-01 | 2024-04-09 | 上海交通大学医学院附属仁济医院 | 核苷类衍生物改性的核酸适体sgc8 |
| WO2022190733A1 (ja) * | 2021-03-10 | 2022-09-15 | ソニーグループ株式会社 | 生体粒子分析方法及び生体粒子分析用試薬キット |
| CN113083383B (zh) * | 2021-03-18 | 2022-10-25 | 华中农业大学 | 微流控芯片装置、制备方法及土壤微生物群落培养方法 |
| CN113092425B (zh) * | 2021-03-29 | 2022-09-27 | 上海交通大学 | 一种基于pH响应的DNA纳米机器建立可编程细胞间通讯的方法 |
| JP7697656B2 (ja) * | 2021-05-10 | 2025-06-24 | 国立大学法人鳥取大学 | 人工ウイルスキャプシド |
| US20220364160A1 (en) | 2021-05-14 | 2022-11-17 | Akoya Biosciences, Inc. | Amplification of RNA Detection Signals in Biological Samples |
| WO2023014825A1 (en) | 2021-08-03 | 2023-02-09 | Akoya Biosciences, Inc. | Rna detection by selective labeling and amplification |
| EP4272764A1 (en) * | 2022-05-03 | 2023-11-08 | Scipio Bioscience | Method of complexing biological units with particles |
| CN116712556B (zh) * | 2023-07-20 | 2025-03-28 | 南通大学附属医院 | 一种靶向中枢神经系统的药物递送载体复合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067308B1 (en) * | 2000-03-28 | 2006-06-27 | Bioagri Corporation | Vector for genetically modifying non-human animals |
| DE10019154A1 (de) * | 2000-04-18 | 2001-10-31 | Univ Eberhard Karls | Zellbindende Nukleinsäuremoleküle (Aptamere) |
| CN1764721A (zh) * | 2003-01-31 | 2006-04-26 | 普罗美加公司 | 官能团与蛋白质的共价束缚 |
| US20060263336A1 (en) | 2003-03-24 | 2006-11-23 | Caplan Arnold I | Cell targeting methods and compositions |
| US20070087400A1 (en) * | 2004-07-30 | 2007-04-19 | Aldis Darzins | Covalent tethering of functional groups to proteins and substrates therefor |
| DE102006026191A1 (de) * | 2006-05-26 | 2007-11-29 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Vorrichtung und Substanz zur Isolierung von mesenchymalen Stammzellen (MSC) |
| JP2007319153A (ja) * | 2006-06-02 | 2007-12-13 | Takashi Otsu | 核酸リガンドと中和剤との組み合わせ製剤 |
| CA2659745A1 (en) * | 2006-08-02 | 2008-02-07 | California Institute Of Technology | Methods and systems for detecting and/or sorting targets |
-
2010
- 2010-04-08 EP EP10762440.5A patent/EP2417249B1/en active Active
- 2010-04-08 CN CN2010800213506A patent/CN102575228A/zh active Pending
- 2010-04-08 JP JP2012504866A patent/JP5964746B2/ja active Active
- 2010-04-08 CN CN201710671296.3A patent/CN107326002A/zh active Pending
- 2010-04-08 ES ES10762440T patent/ES2924287T3/es active Active
- 2010-04-08 US US13/263,129 patent/US9327036B2/en active Active
- 2010-04-08 CN CN202110460486.7A patent/CN113186149A/zh active Pending
- 2010-04-08 WO PCT/US2010/030397 patent/WO2010118235A1/en not_active Ceased
- 2010-04-08 CA CA2757884A patent/CA2757884C/en active Active
-
2016
- 2016-03-01 US US15/057,604 patent/US9969970B2/en active Active
- 2016-06-30 JP JP2016130419A patent/JP2016168062A/ja active Pending
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