JP2012523432A5 - - Google Patents
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- Publication number
- JP2012523432A5 JP2012523432A5 JP2012504890A JP2012504890A JP2012523432A5 JP 2012523432 A5 JP2012523432 A5 JP 2012523432A5 JP 2012504890 A JP2012504890 A JP 2012504890A JP 2012504890 A JP2012504890 A JP 2012504890A JP 2012523432 A5 JP2012523432 A5 JP 2012523432A5
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- compound
- oxygen atom
- transplant
- organ
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000001519 tissue Anatomy 0.000 claims 38
- 238000000034 method Methods 0.000 claims 37
- 150000001875 compounds Chemical class 0.000 claims 27
- 125000004430 oxygen atom Chemical group O* 0.000 claims 20
- 210000000056 organ Anatomy 0.000 claims 18
- 208000028867 ischemia Diseases 0.000 claims 16
- 108010060804 Toll-Like Receptor 4 Proteins 0.000 claims 12
- 102000008228 Toll-like receptor 2 Human genes 0.000 claims 12
- 108010060888 Toll-like receptor 2 Proteins 0.000 claims 12
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 12
- 125000002252 acyl group Chemical group 0.000 claims 12
- 230000010410 reperfusion Effects 0.000 claims 11
- 210000004072 lung Anatomy 0.000 claims 10
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 239000005557 antagonist Substances 0.000 claims 8
- 239000003761 preservation solution Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 125000004434 sulfur atom Chemical group 0.000 claims 8
- 206010030113 Oedema Diseases 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
- 210000002027 skeletal muscle Anatomy 0.000 claims 5
- 210000004872 soft tissue Anatomy 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 238000000338 in vitro Methods 0.000 claims 3
- 230000000302 ischemic effect Effects 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 208000010496 Heart Arrest Diseases 0.000 claims 2
- 206010033799 Paralysis Diseases 0.000 claims 2
- 230000000747 cardiac effect Effects 0.000 claims 2
- 238000007675 cardiac surgery Methods 0.000 claims 2
- 210000002216 heart Anatomy 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 210000002429 large intestine Anatomy 0.000 claims 2
- 210000004185 liver Anatomy 0.000 claims 2
- 210000003205 muscle Anatomy 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000000399 orthopedic effect Effects 0.000 claims 2
- 210000004923 pancreatic tissue Anatomy 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 210000001147 pulmonary artery Anatomy 0.000 claims 2
- 210000000813 small intestine Anatomy 0.000 claims 2
- 239000000243 solution Substances 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 125000006539 C12 alkyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 229910019142 PO4 Inorganic materials 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 210000005013 brain tissue Anatomy 0.000 claims 1
- 150000008271 glucosaminides Chemical class 0.000 claims 1
- 210000005003 heart tissue Anatomy 0.000 claims 1
- 210000005228 liver tissue Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 230000010412 perfusion Effects 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 239000010452 phosphate Substances 0.000 claims 1
- 210000003492 pulmonary vein Anatomy 0.000 claims 1
- 210000005084 renal tissue Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16808909P | 2009-04-09 | 2009-04-09 | |
| US61/168,089 | 2009-04-09 | ||
| PCT/US2010/030556 WO2010118334A1 (en) | 2009-04-09 | 2010-04-09 | Methods of treating edema related to ischemia-reperfusion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523432A JP2012523432A (ja) | 2012-10-04 |
| JP2012523432A5 true JP2012523432A5 (enExample) | 2013-05-16 |
Family
ID=42936599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012504890A Pending JP2012523432A (ja) | 2009-04-09 | 2010-04-09 | 虚血再灌流に関係する浮腫を治療する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120064044A1 (enExample) |
| EP (1) | EP2416651A4 (enExample) |
| JP (1) | JP2012523432A (enExample) |
| KR (1) | KR20120005025A (enExample) |
| CN (1) | CN102458113A (enExample) |
| AU (1) | AU2010233151A1 (enExample) |
| BR (1) | BRPI1010516A2 (enExample) |
| CA (1) | CA2757998A1 (enExample) |
| EA (1) | EA201101349A1 (enExample) |
| IL (1) | IL215604A0 (enExample) |
| MX (1) | MX2011010616A (enExample) |
| SG (1) | SG175133A1 (enExample) |
| WO (1) | WO2010118334A1 (enExample) |
| ZA (1) | ZA201107815B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2268286B1 (en) | 2008-04-09 | 2016-04-06 | The University of North Carolina At Chapel Hill | Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation |
| KR101937498B1 (ko) * | 2011-03-03 | 2019-04-10 | 쿠아크 파마수티칼스 인코퍼레이티드 | 폐 질환 및 손상을 치료하기 위한 조성물 및 방법 |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CN110446511B (zh) | 2017-03-10 | 2024-04-02 | 北卡罗来纳大学查珀尔希尔分校 | 短效的基于肝素的抗凝血剂化合物和方法 |
| WO2019010216A1 (en) | 2017-07-03 | 2019-01-10 | The University Of North Carolina At Chapel Hill | ENZYMATIC SYNTHESIS OF HOMOGENEOUS CHONDROITIN SULFATE OLIGOSACCHARIDES |
| CN111601603A (zh) | 2017-11-03 | 2020-08-28 | 北卡罗来纳大学查珀尔希尔分校 | 具有抗炎活性的硫酸化寡糖 |
| US11458151B2 (en) | 2018-02-12 | 2022-10-04 | Inimmune Corporation | Toll-like receptor ligands |
| CN112437667B (zh) | 2018-06-20 | 2024-05-28 | 北卡罗来纳大学查珀尔希尔分校 | 细胞保护方法和组合物 |
| JP2023501568A (ja) * | 2019-11-13 | 2023-01-18 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05139992A (ja) * | 1991-11-13 | 1993-06-08 | Ajinomoto Co Inc | ヒトａｄｆを含有する臓器保護剤 |
| US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| US7960522B2 (en) * | 2003-01-06 | 2011-06-14 | Corixa Corporation | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| JPWO2004085396A1 (ja) * | 2003-03-26 | 2006-06-29 | 三菱ウェルファーマ株式会社 | 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法 |
| US7928132B2 (en) * | 2004-08-06 | 2011-04-19 | Ohio University | Methods for the amelioration of episodes of acute or chronic ulcerative colitis |
| US20060211752A1 (en) * | 2004-03-16 | 2006-09-21 | Kohn Leonard D | Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression |
| EP2170366B1 (en) * | 2007-08-03 | 2013-11-06 | Opsona Therapeutics Limited | Use of tlr-2 antagonists for treatment of reperfusion injury and tissue damage |
| EP2268286B1 (en) * | 2008-04-09 | 2016-04-06 | The University of North Carolina At Chapel Hill | Methods of regulating actin cytoskeletal rearrangement and intercellular gap formation |
-
2010
- 2010-04-09 US US13/263,435 patent/US20120064044A1/en not_active Abandoned
- 2010-04-09 MX MX2011010616A patent/MX2011010616A/es not_active Application Discontinuation
- 2010-04-09 BR BRPI1010516-6A patent/BRPI1010516A2/pt not_active IP Right Cessation
- 2010-04-09 WO PCT/US2010/030556 patent/WO2010118334A1/en not_active Ceased
- 2010-04-09 AU AU2010233151A patent/AU2010233151A1/en not_active Abandoned
- 2010-04-09 CN CN2010800259139A patent/CN102458113A/zh active Pending
- 2010-04-09 SG SG2011073475A patent/SG175133A1/en unknown
- 2010-04-09 KR KR1020117026569A patent/KR20120005025A/ko not_active Withdrawn
- 2010-04-09 JP JP2012504890A patent/JP2012523432A/ja active Pending
- 2010-04-09 EP EP10762505.5A patent/EP2416651A4/en not_active Withdrawn
- 2010-04-09 EA EA201101349A patent/EA201101349A1/ru unknown
- 2010-04-09 CA CA2757998A patent/CA2757998A1/en not_active Abandoned
-
2011
- 2011-10-06 IL IL215604A patent/IL215604A0/en unknown
- 2011-10-25 ZA ZA2011/07815A patent/ZA201107815B/en unknown
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