JP2012523432A - 虚血再灌流に関係する浮腫を治療する方法 - Google Patents

虚血再灌流に関係する浮腫を治療する方法 Download PDF

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Publication number
JP2012523432A
JP2012523432A JP2012504890A JP2012504890A JP2012523432A JP 2012523432 A JP2012523432 A JP 2012523432A JP 2012504890 A JP2012504890 A JP 2012504890A JP 2012504890 A JP2012504890 A JP 2012504890A JP 2012523432 A JP2012523432 A JP 2012523432A
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Prior art keywords
tissue
compound
group
organ
lung
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JP2012504890A
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English (en)
Japanese (ja)
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JP2012523432A5 (enExample
Inventor
マイケル イーガン トーマス
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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Publication of JP2012523432A publication Critical patent/JP2012523432A/ja
Publication of JP2012523432A5 publication Critical patent/JP2012523432A5/ja
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2012504890A 2009-04-09 2010-04-09 虚血再灌流に関係する浮腫を治療する方法 Pending JP2012523432A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16808909P 2009-04-09 2009-04-09
US61/168,089 2009-04-09
PCT/US2010/030556 WO2010118334A1 (en) 2009-04-09 2010-04-09 Methods of treating edema related to ischemia-reperfusion

Publications (2)

Publication Number Publication Date
JP2012523432A true JP2012523432A (ja) 2012-10-04
JP2012523432A5 JP2012523432A5 (enExample) 2013-05-16

Family

ID=42936599

Family Applications (1)

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JP2012504890A Pending JP2012523432A (ja) 2009-04-09 2010-04-09 虚血再灌流に関係する浮腫を治療する方法

Country Status (14)

Country Link
US (1) US20120064044A1 (enExample)
EP (1) EP2416651A4 (enExample)
JP (1) JP2012523432A (enExample)
KR (1) KR20120005025A (enExample)
CN (1) CN102458113A (enExample)
AU (1) AU2010233151A1 (enExample)
BR (1) BRPI1010516A2 (enExample)
CA (1) CA2757998A1 (enExample)
EA (1) EA201101349A1 (enExample)
IL (1) IL215604A0 (enExample)
MX (1) MX2011010616A (enExample)
SG (1) SG175133A1 (enExample)
WO (1) WO2010118334A1 (enExample)
ZA (1) ZA201107815B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5562939B2 (ja) * 2008-04-09 2014-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル アクチン細胞骨格再編成及び細胞間ギャップ形成調節の方法
CN103492572A (zh) * 2011-03-03 2014-01-01 夸克医药公司 用于治疗肺疾病和损伤的组合物和方法
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
JP7330893B2 (ja) 2017-03-10 2023-08-22 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 短時間作用型ヘパリンベースの抗凝集剤化合物及び方法
US11993627B2 (en) 2017-07-03 2024-05-28 The University Of North Carolina At Chapel Hill Enzymatic synthesis of homogeneous chondroitin sulfate oligosaccharides
WO2019090203A1 (en) 2017-11-03 2019-05-09 The University Of North Carolina At Chapel Hill Sulfated oligosaccharides having anti-inflammatory activity
EP3752182B1 (en) 2018-02-12 2024-05-15 Inimmune Corporation Toll-like receptor ligands
WO2019246264A1 (en) 2018-06-20 2019-12-26 The University Of North Carolina At Chapel Hill Cell protective methods and compositions
JP2023501568A (ja) * 2019-11-13 2023-01-18 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 肝虚血再灌流障害におけるヘパラン硫酸（ｈｓ）オリゴ糖の効果

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05139992A (ja) * 1991-11-13 1993-06-08 Ajinomoto Co Inc ヒトａｄｆを含有する臓器保護剤
WO2004085396A1 (ja) * 2003-03-26 2004-10-07 Mitsubishi Pharma Corporation 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6113918A (en) * 1997-05-08 2000-09-05 Ribi Immunochem Research, Inc. Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors
US7960522B2 (en) * 2003-01-06 2011-06-14 Corixa Corporation Certain aminoalkyl glucosaminide phosphate compounds and their use
US7928132B2 (en) * 2004-08-06 2011-04-19 Ohio University Methods for the amelioration of episodes of acute or chronic ulcerative colitis
US20060211752A1 (en) * 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
EP2170366B1 (en) * 2007-08-03 2013-11-06 Opsona Therapeutics Limited Use of tlr-2 antagonists for treatment of reperfusion injury and tissue damage
JP5562939B2 (ja) * 2008-04-09 2014-07-30 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル アクチン細胞骨格再編成及び細胞間ギャップ形成調節の方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05139992A (ja) * 1991-11-13 1993-06-08 Ajinomoto Co Inc ヒトａｄｆを含有する臓器保護剤
WO2004085396A1 (ja) * 2003-03-26 2004-10-07 Mitsubishi Pharma Corporation 虚血再灌流障害の予防または治療剤、臓器保存剤およびスクリーニング方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6014021492; ＢＡＺＩＮ，　Ｈ．Ｇ．　ｅｔ　ａｌ．: Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．１８, 2008, ｐ．５３５０-５３５４ *
JPN6014021493; ＣＡＳＩＲＡＧＨＩ，　Ｍ．　ｅｔ　ａｌ．: Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｈｅａｒｔ　ａｎｄ　Ｌｕｎｇ　Ｔｒａｎｓｐｌａｎｔａｔｉｏｎ Ｖｏｌ．２７，　Ｎｏ．２Ｓ, 2008, Ｓ２１４-２１５ *

Also Published As

Publication number Publication date
SG175133A1 (en) 2011-12-29
EP2416651A1 (en) 2012-02-15
US20120064044A1 (en) 2012-03-15
WO2010118334A1 (en) 2010-10-14
MX2011010616A (es) 2012-03-14
CN102458113A (zh) 2012-05-16
KR20120005025A (ko) 2012-01-13
ZA201107815B (en) 2013-04-24
CA2757998A1 (en) 2010-10-14
EP2416651A4 (en) 2014-03-26
EA201101349A1 (ru) 2012-05-30
BRPI1010516A2 (pt) 2015-08-25
IL215604A0 (en) 2011-12-29
AU2010233151A1 (en) 2011-11-17

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