JP2012521997A - 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 - Google Patents

眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 Download PDF

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Publication number
JP2012521997A
JP2012521997A JP2012502224A JP2012502224A JP2012521997A JP 2012521997 A JP2012521997 A JP 2012521997A JP 2012502224 A JP2012502224 A JP 2012502224A JP 2012502224 A JP2012502224 A JP 2012502224A JP 2012521997 A JP2012521997 A JP 2012521997A
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Prior art keywords
compound
weight percent
microspheres
implant
latanoprost
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Pending
Application number
JP2012502224A
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English (en)
Japanese (ja)
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JP2012521997A5 (enExample
Inventor
マイケル アール ロビンソン
ジェイムズ エイ バーク
フイ リウ
ワーナー シー オリーラ
ロン ティー スパーダ
スコット ウィットカップ
アラザル エヌ ゲブレメスケル
パトリック エム ヒューズ
クン シュー
マリアン エム ドゥー
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Allergan Inc
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Allergan Inc
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Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2012521997A publication Critical patent/JP2012521997A/ja
Publication of JP2012521997A5 publication Critical patent/JP2012521997A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012502224A 2009-03-25 2010-03-25 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 Pending JP2012521997A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/411,250 2009-03-25
US12/411,250 US20100247606A1 (en) 2009-03-25 2009-03-25 Intraocular sustained release drug delivery systems and methods for treating ocular conditions
PCT/US2010/028584 WO2010111449A1 (en) 2009-03-25 2010-03-25 Intraocular sustained release drug delivery systems and methods for treating ocular conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014183177A Division JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Publications (2)

Publication Number Publication Date
JP2012521997A true JP2012521997A (ja) 2012-09-20
JP2012521997A5 JP2012521997A5 (enExample) 2013-05-16

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012502224A Pending JP2012521997A (ja) 2009-03-25 2010-03-25 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法
JP2014183177A Pending JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Family Applications After (1)

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JP2014183177A Pending JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Country Status (13)

Country Link
US (1) US20100247606A1 (enExample)
EP (1) EP2411013B1 (enExample)
JP (2) JP2012521997A (enExample)
KR (4) KR20170064556A (enExample)
CN (1) CN102497865A (enExample)
AU (3) AU2010229891A1 (enExample)
BR (1) BRPI1012324A2 (enExample)
CA (1) CA2756065A1 (enExample)
IL (1) IL215205A0 (enExample)
MX (1) MX2011009901A (enExample)
NZ (1) NZ595294A (enExample)
RU (2) RU2532333C2 (enExample)
WO (1) WO2010111449A1 (enExample)

Cited By (4)

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JP2014530177A (ja) * 2011-09-16 2014-11-17 フオベア・フアルマシユテイカル アニリン誘導体、それらの調製およびそれらの治療適用
JP2016515618A (ja) * 2013-04-01 2016-05-30 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 持続的眼内放出のためのマイクロスフェア薬剤送達システム
JP2016520561A (ja) * 2013-04-12 2016-07-14 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 脂肪減少のためのビマトプロスト、ビマトプロスト類似体、プロスタミド及びプロスタグランジンの持続放出
JP2018528169A (ja) * 2015-08-19 2018-09-27 ジェニヴィジョン インク． 眼科用薬物の定量的な眼窩周囲への適用

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US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
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US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US7947732B2 (en) * 2007-07-13 2011-05-24 Allergan, Inc. Therapeutic substituted chlorocyclopentanols
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US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
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WO2010111449A1 (en) 2010-09-30
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CA2756065A1 (en) 2010-09-30
CN102497865A (zh) 2012-06-13
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JP2015007117A (ja) 2015-01-15
IL215205A0 (en) 2011-12-29
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RU2014133501A (ru) 2016-03-10
RU2011140433A (ru) 2013-04-27

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