JP2012521997A - 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 - Google Patents

眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 Download PDF

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Publication number
JP2012521997A
JP2012521997A JP2012502224A JP2012502224A JP2012521997A JP 2012521997 A JP2012521997 A JP 2012521997A JP 2012502224 A JP2012502224 A JP 2012502224A JP 2012502224 A JP2012502224 A JP 2012502224A JP 2012521997 A JP2012521997 A JP 2012521997A
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Prior art keywords
compound
weight percent
microspheres
implant
latanoprost
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Pending
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JP2012502224A
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English (en)
Japanese (ja)
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JP2012521997A5 (enExample
Inventor
マイケル アール ロビンソン
ジェイムズ エイ バーク
フイ リウ
ワーナー シー オリーラ
ロン ティー スパーダ
スコット ウィットカップ
アラザル エヌ ゲブレメスケル
パトリック エム ヒューズ
クン シュー
マリアン エム ドゥー
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Allergan Inc
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Allergan Inc
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Application filed by Allergan Inc filed Critical Allergan Inc
Publication of JP2012521997A publication Critical patent/JP2012521997A/ja
Publication of JP2012521997A5 publication Critical patent/JP2012521997A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/557Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2012502224A 2009-03-25 2010-03-25 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法 Pending JP2012521997A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12/411,250 2009-03-25
US12/411,250 US20100247606A1 (en) 2009-03-25 2009-03-25 Intraocular sustained release drug delivery systems and methods for treating ocular conditions
PCT/US2010/028584 WO2010111449A1 (en) 2009-03-25 2010-03-25 Intraocular sustained release drug delivery systems and methods for treating ocular conditions

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014183177A Division JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Publications (2)

Publication Number Publication Date
JP2012521997A true JP2012521997A (ja) 2012-09-20
JP2012521997A5 JP2012521997A5 (enExample) 2013-05-16

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012502224A Pending JP2012521997A (ja) 2009-03-25 2010-03-25 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法
JP2014183177A Pending JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Family Applications After (1)

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JP2014183177A Pending JP2015007117A (ja) 2009-03-25 2014-09-09 眼内徐放型ドラッグ送達システムおよび眼症状を処置する方法

Country Status (13)

Country Link
US (1) US20100247606A1 (enExample)
EP (1) EP2411013B1 (enExample)
JP (2) JP2012521997A (enExample)
KR (4) KR20120006998A (enExample)
CN (1) CN102497865A (enExample)
AU (3) AU2010229891A1 (enExample)
BR (1) BRPI1012324A2 (enExample)
CA (1) CA2756065A1 (enExample)
IL (1) IL215205A0 (enExample)
MX (1) MX2011009901A (enExample)
NZ (1) NZ595294A (enExample)
RU (2) RU2532333C2 (enExample)
WO (1) WO2010111449A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
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JP2014530177A (ja) * 2011-09-16 2014-11-17 フオベア・フアルマシユテイカル アニリン誘導体、それらの調製およびそれらの治療適用
JP2016515618A (ja) * 2013-04-01 2016-05-30 アラーガン、インコーポレイテッドAllergan,Incorporated 持続的眼内放出のためのマイクロスフェア薬剤送達システム
JP2016520561A (ja) * 2013-04-12 2016-07-14 アラーガン、インコーポレイテッドAllergan,Incorporated 脂肪減少のためのビマトプロスト、ビマトプロスト類似体、プロスタミド及びプロスタグランジンの持続放出
JP2018528169A (ja) * 2015-08-19 2018-09-27 ジェニヴィジョン インク. 眼科用薬物の定量的な眼窩周囲への適用

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US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7947732B2 (en) * 2007-07-13 2011-05-24 Allergan, Inc. Therapeutic substituted chlorocyclopentanols
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US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US20100104654A1 (en) 2008-10-27 2010-04-29 Allergan, Inc. Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
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US10413506B2 (en) 2010-04-03 2019-09-17 Praful Doshi Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia
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RU2011140433A (ru) 2013-04-27
NZ595294A (en) 2013-11-29
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RU2014133501A (ru) 2016-03-10
BRPI1012324A2 (pt) 2016-03-15
KR20170064556A (ko) 2017-06-09
IL215205A0 (en) 2011-12-29
AU2016231616A1 (en) 2016-10-20
CN102497865A (zh) 2012-06-13
KR20160120800A (ko) 2016-10-18
EP2411013A1 (en) 2012-02-01
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CA2756065A1 (en) 2010-09-30
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RU2532333C2 (ru) 2014-11-10

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