RU2532333C2 - Внутриглазные системы доставки лекарственного средства с замедленным высвобождением и способы лечения глазных заболеваний - Google Patents
Внутриглазные системы доставки лекарственного средства с замедленным высвобождением и способы лечения глазных заболеваний Download PDFInfo
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- RU2532333C2 RU2532333C2 RU2011140433/15A RU2011140433A RU2532333C2 RU 2532333 C2 RU2532333 C2 RU 2532333C2 RU 2011140433/15 A RU2011140433/15 A RU 2011140433/15A RU 2011140433 A RU2011140433 A RU 2011140433A RU 2532333 C2 RU2532333 C2 RU 2532333C2
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- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
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| US20090148527A1 (en) * | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
| US9498457B2 (en) | 2004-04-30 | 2016-11-22 | Allergan, Inc. | Hypotensive prostamide-containing biodegradable intraocular implants and related implants |
| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US8722097B2 (en) | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7799336B2 (en) | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| US7993634B2 (en) | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US7947732B2 (en) * | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| US9095404B2 (en) | 2008-05-12 | 2015-08-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US9877973B2 (en) | 2008-05-12 | 2018-01-30 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| EP2276439A4 (en) | 2008-05-12 | 2013-11-27 | Univ Utah Res Found | DEVICE AND CORRESPONDING METHODS FOR INTRAOCULAR MEDICAMENT ADMINISTRATION |
| US10064819B2 (en) | 2008-05-12 | 2018-09-04 | University Of Utah Research Foundation | Intraocular drug delivery device and associated methods |
| US20100104654A1 (en) | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 薬剤溶出眼内インプラント |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (en) | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| KR102337046B1 (ko) * | 2010-01-22 | 2021-12-08 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
| ES2634551T3 (es) | 2010-04-03 | 2017-09-28 | Praful Doshi | Métodos para revestir una lente de contacto |
| US10413506B2 (en) | 2010-04-03 | 2019-09-17 | Praful Doshi | Medical devices including medicaments and methods of making and using same including enhancing comfort, enhancing drug penetration, and treatment of myopia |
| US20120022137A1 (en) * | 2010-07-21 | 2012-01-26 | Rivers Hongwen M | METHOD OF CONTROLLING INITIAL DRUG RELEASE OF siRNA FROM SUSTAINED-RELEASE IMPLANTS |
| SG187770A1 (en) | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A liposomal formulation for ocular drug delivery |
| MX2013001866A (es) * | 2010-08-17 | 2013-05-22 | Allergan Inc | Agonistas de receptor de prostaglandina suptipo-2(ep2) o receptor de prostaglandina suptipo-4(ep4) para tratar la opacidad de la cornea |
| WO2012149278A1 (en) | 2011-04-29 | 2012-11-01 | Allergan, Inc. | Sustained release latanoprost implant |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| US20130035338A1 (en) * | 2011-08-05 | 2013-02-07 | Gordon Tang | Eyelid treatment |
| EP2567689A1 (en) * | 2011-09-12 | 2013-03-13 | Visiotact Pharma | Ophthtalmic compositions comprising prostaglandin F2 alpha derivatives and hyaluronic acid |
| EP2570402A1 (en) * | 2011-09-16 | 2013-03-20 | Fovea Pharmaceuticals | Bi-aryl derivatives, their preparation and their therapeutic application |
| JP2014530177A (ja) | 2011-09-16 | 2014-11-17 | フオベア・フアルマシユテイカル | アニリン誘導体、それらの調製およびそれらの治療適用 |
| EP2623490A1 (en) * | 2012-02-03 | 2013-08-07 | Fovea Pharmaceuticals | 2-(3-aminophenoxy)-acetic acid derivatives as EP2 receptor agonists for use in treatment of glaucoma |
| TWI560172B (en) * | 2011-11-02 | 2016-12-01 | Theravance Biopharma R&D Ip Llc | Neprilysin inhibitors |
| US9283231B2 (en) * | 2013-01-31 | 2016-03-15 | Icon Bioscience, Inc. | Sustained release formulations for the treatment of intraocular pressure of glaucoma |
| CN104055695B (zh) * | 2013-03-22 | 2016-12-28 | 深圳市绿蛙生物科技有限公司 | 中药型快干消毒护手霜及其制备方法 |
| CN105188666A (zh) * | 2013-04-01 | 2015-12-23 | 阿勒根公司 | 用于持续的眼内释放的微球药物递送系统 |
| CA2908731A1 (en) * | 2013-04-12 | 2014-10-16 | Allergan, Inc. | Sustained release of bimatoprost, bimatoprost analogs, prostamides and prostaglandins for fat reduction |
| TR201802759T4 (tr) | 2013-10-31 | 2018-03-21 | Allergan Inc | Prostamid içeren intraoküler implantlar ve kullanım yöntemleri. |
| CN106132397A (zh) * | 2013-12-06 | 2016-11-16 | 恩维希亚治疗股份有限公司 | 用于治疗眼部疾病的前房内植入物 |
| US9956195B2 (en) | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
| WO2015175544A1 (en) * | 2014-05-12 | 2015-11-19 | Allergan, Inc. | Quaternary ammonium alkyl esters of prostanoid derivatives as stable prodrugs |
| EP3148491B1 (en) | 2014-05-29 | 2020-07-01 | Glaukos Corporation | Implants with controlled drug delivery features and manufacturing method for said implants |
| CN105266952A (zh) * | 2014-07-09 | 2016-01-27 | 首都医科大学附属北京同仁医院 | 一种抗青光眼手术中所用防术后结膜粘连的器材 |
| ES2900025T3 (es) * | 2014-09-06 | 2022-03-15 | Integral Biosystems Llc | Procedimientos y composiciones biocompatibles para lograr la liberación mantenida de fármaco en el ojo |
| EP3233067B1 (en) | 2014-12-18 | 2019-11-06 | DSM IP Assets B.V. | Drug delivery system for delivery of acid sensitive drugs |
| WO2016187426A1 (en) * | 2015-05-19 | 2016-11-24 | Amorphex Therapeutics Llc | A device that delivers a sustained low-dose of a myopia-suppressing drug |
| WO2016200688A1 (en) * | 2015-06-06 | 2016-12-15 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium |
| WO2017015604A1 (en) * | 2015-07-23 | 2017-01-26 | Envisia Therapeutics, Inc. | Intravitreal drug delivery systems for the treatment of ocular conditions |
| US9820954B2 (en) * | 2015-08-19 | 2017-11-21 | Jenivision Inc. | Quantitative peri-orbital application of ophthalmology drugs |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11458041B2 (en) | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| GB201522441D0 (en) | 2015-12-18 | 2016-02-03 | Midatech Pharma Wales Ltd | Sustained release cyclosporine-loaded microparticles |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| KR102408596B1 (ko) | 2016-06-02 | 2022-06-13 | 에이디에스 테라퓨틱스 엘엘씨 | 비정상적 신생혈관이 있는 안구 질환 치료를 위한, 닌테다닙을 사용하는 조성물 및 방법 |
| JP7430529B2 (ja) * | 2016-09-23 | 2024-02-13 | インセプト・リミテッド・ライアビリティ・カンパニー | 前房内薬物送達デポ |
| US20200206137A1 (en) * | 2017-07-17 | 2020-07-02 | Wolfcreek Biotech Pte Ltd | Microparticle formulations for delivery of active agents |
| RU2685499C1 (ru) * | 2018-07-19 | 2019-04-18 | федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Способ лечения прогрессирующей миопии у детей с выявленным привычно-избыточным напряжением аккомодации |
| WO2020047141A1 (en) * | 2018-08-30 | 2020-03-05 | Liu Yunxiang | Ophthalmic injectable formulation preparing and oculopathy treating and preventing |
| PL427837A1 (pl) * | 2018-11-22 | 2020-06-01 | Gbj Pharma Spółka Z Ograniczoną Odpowiedzialnością | Systemy do ciągłego obwodowego podawania latanoprostu dla obniżania ciśnienia śródgałkowego |
| CN113646014A (zh) * | 2019-02-08 | 2021-11-12 | 俄亥俄州创新基金会 | 释放抗氧化剂的玻璃体替代物以及其用途 |
| CA3166738A1 (en) | 2020-02-06 | 2021-08-12 | Charles D. Blizzard | Travoprost compositions and methods for treating ocular diseases |
| FI3884929T3 (fi) | 2020-03-25 | 2023-08-07 | Ocular Therapeutix Inc | Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti |
| CA3177005A1 (en) | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| CA3177759A1 (en) * | 2020-05-15 | 2021-11-18 | Je Min CHAE | Methods and compositions for reducing intraocular pressure |
| JP7689144B2 (ja) * | 2020-06-03 | 2025-06-05 | グラウコス コーポレイション | Ｒｈｏキナーゼ阻害剤放出インプラントおよび関連する使用方法 |
| JP2024506872A (ja) * | 2021-02-05 | 2024-02-15 | ジェニヴィジョン インク． | Ｅｐ２受容体アゴニストの眼窩周囲投与のための組成物および方法 |
| CN113133431A (zh) * | 2021-02-25 | 2021-07-20 | 中南大学 | 慢性高眼压合并长眼轴动物模型的建立方法、模型及应用 |
| CN120897764A (zh) | 2023-04-11 | 2025-11-04 | 视尔普斯眼科公司 | 包含阿西替尼多晶型物iv的眼部植入物 |
| WO2024243081A1 (en) * | 2023-05-19 | 2024-11-28 | The Trustees Of Columbia University In The City Of New York | Treating elevated intraocular pressure with nicotinamide |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT252264B (de) * | 1965-03-17 | 1967-02-10 | Etapharm Chem Pharm Lab Ges M | Verfahren zur Herstellung eines reinen hochviskosen Hyaluronsäurepräparates |
| US3749776A (en) * | 1970-08-28 | 1973-07-31 | Allergan Pharma | Method for blocking prostaglandin activity |
| US4403353A (en) * | 1981-06-25 | 1983-09-13 | Tennant Jerald L | Anterior chamber implant lens |
| US4599353A (en) * | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
| US5166331A (en) * | 1983-10-10 | 1992-11-24 | Fidia, S.P.A. | Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same |
| US6309669B1 (en) * | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US5585401A (en) * | 1994-12-09 | 1996-12-17 | The Reents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
| US5612027A (en) * | 1995-04-18 | 1997-03-18 | Galin; Miles A. | Controlled release of miotic and mydriatic drugs in the anterior chamber |
| US5972326A (en) * | 1995-04-18 | 1999-10-26 | Galin; Miles A. | Controlled release of pharmaceuticals in the anterior chamber of the eye |
| US7867186B2 (en) * | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| AU2003217531A1 (en) * | 2002-05-02 | 2003-11-17 | Massachusetts Eye And Ear Infirmary | Ocular drug delivery systems and use thereof |
| BR0315304A (pt) * | 2002-11-06 | 2005-08-16 | Alza Corp | Formulações com depósito para liberação controlada |
| US20040193095A1 (en) * | 2003-03-29 | 2004-09-30 | Shadduck John H. | Implants for treating ocular hypertension, methods of use and methods of fabrication |
| WO2005072701A1 (en) * | 2004-01-20 | 2005-08-11 | Allergan, Inc. | Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid |
| WO2005072703A2 (en) * | 2004-01-26 | 2005-08-11 | Control Delivery Systems, Inc. | Controlled and sustained delivery of nucleic acid-based therapeutic agents |
| US8147865B2 (en) * | 2004-04-30 | 2012-04-03 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
| US20060182781A1 (en) * | 2004-04-30 | 2006-08-17 | Allergan, Inc. | Methods for treating ocular conditions with cyclic lipid contraining microparticles |
| US8722097B2 (en) * | 2004-04-30 | 2014-05-13 | Allergan, Inc. | Oil-in-water method for making polymeric implants containing a hypotensive lipid |
| US7993634B2 (en) * | 2004-04-30 | 2011-08-09 | Allergan, Inc. | Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods |
| US20050244471A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Estradiol derivative and estratopone containing sustained release intraocular implants and related methods |
| US8673341B2 (en) * | 2004-04-30 | 2014-03-18 | Allergan, Inc. | Intraocular pressure reduction with intracameral bimatoprost implants |
| US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| US7799336B2 (en) * | 2004-04-30 | 2010-09-21 | Allergan, Inc. | Hypotensive lipid-containing biodegradable intraocular implants and related methods |
| BRPI0609021A2 (pt) * | 2005-03-10 | 2010-01-12 | Allergan Inc | gama lactamas substituìdas, composição e uso das mesmas |
| MX339797B (es) * | 2005-10-18 | 2016-06-10 | Allergan Inc | Terapia ocular que usa derivados glucocorticoides que penetran selectivamente los tejidos del segmento posterior. |
| US7427685B2 (en) * | 2005-12-06 | 2008-09-23 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| US7585895B2 (en) * | 2005-12-06 | 2009-09-08 | Allergan, Inc. | Therapeutic substituted cyclopentanes |
| KR20080082618A (ko) * | 2005-12-16 | 2008-09-11 | 알콘, 인코퍼레이티드 | Ａｌｋ5 조절제를 사용한 안압의 조절 |
| EP3338743A1 (en) * | 2006-01-17 | 2018-06-27 | Novartis Ag | Drug delivery treatment device |
| US7592364B2 (en) * | 2006-02-28 | 2009-09-22 | Allergan, Inc. | Substituted gamma lactams as therapeutic agents |
| US20080097335A1 (en) * | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
| EP2364707B1 (en) * | 2006-08-07 | 2013-04-03 | Bausch & Lomb Incorporated | Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof |
| US8969415B2 (en) * | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| US8846073B2 (en) * | 2006-12-19 | 2014-09-30 | Allergan, Inc. | Low temperature processes for making cyclic lipid implants for intraocular use |
| US8722726B2 (en) * | 2007-01-25 | 2014-05-13 | Allergan, Inc. | Substituted arylcyclopentenes as therapeutic agents |
| US7589213B2 (en) * | 2007-04-27 | 2009-09-15 | Old David W | Therapeutic substituted lactams |
| US11078262B2 (en) * | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| US7947732B2 (en) * | 2007-07-13 | 2011-05-24 | Allergan, Inc. | Therapeutic substituted chlorocyclopentanols |
| IL186598A0 (en) * | 2007-10-11 | 2008-11-03 | Mohammad Abdulrazik | Composition and method for the treatment or prevention of glaucoma and ocular hypertension |
| CN101952261B (zh) * | 2007-11-09 | 2013-06-12 | 阿勒根公司 | 具有前列腺素活性的取代环戊烷 |
| EP2288385A2 (en) * | 2008-04-16 | 2011-03-02 | Allergan, Inc. | Combination therapy for glaucoma |
| EP2296621A1 (en) * | 2008-05-20 | 2011-03-23 | Yale University | Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use |
| US20100104654A1 (en) * | 2008-10-27 | 2010-04-29 | Allergan, Inc. | Prostaglandin and prostamide drug delivery systems and intraocular therapeutic uses thereof |
| KR102337046B1 (ko) * | 2010-01-22 | 2021-12-08 | 알러간, 인코포레이티드 | 전방내 서방성 치료제 이식물 |
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2009
- 2009-03-25 US US12/411,250 patent/US20100247606A1/en not_active Abandoned
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2010
- 2010-03-25 AU AU2010229891A patent/AU2010229891A1/en not_active Abandoned
- 2010-03-25 RU RU2011140433/15A patent/RU2532333C2/ru active
- 2010-03-25 KR KR1020117023983A patent/KR20120006998A/ko not_active Withdrawn
- 2010-03-25 KR KR1020187027407A patent/KR20180108883A/ko not_active Ceased
- 2010-03-25 NZ NZ595294A patent/NZ595294A/xx not_active IP Right Cessation
- 2010-03-25 CA CA2756065A patent/CA2756065A1/en not_active Abandoned
- 2010-03-25 CN CN2010800229237A patent/CN102497865A/zh active Pending
- 2010-03-25 BR BRPI1012324A patent/BRPI1012324A2/pt not_active Application Discontinuation
- 2010-03-25 JP JP2012502224A patent/JP2012521997A/ja active Pending
- 2010-03-25 WO PCT/US2010/028584 patent/WO2010111449A1/en not_active Ceased
- 2010-03-25 KR KR1020167027799A patent/KR20160120800A/ko not_active Withdrawn
- 2010-03-25 MX MX2011009901A patent/MX2011009901A/es not_active Application Discontinuation
- 2010-03-25 EP EP10723400.7A patent/EP2411013B1/en active Active
- 2010-03-25 KR KR1020177014845A patent/KR20170064556A/ko not_active Ceased
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2011
- 2011-09-18 IL IL215205A patent/IL215205A0/en unknown
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2014
- 2014-08-15 RU RU2014133501A patent/RU2664686C2/ru active
- 2014-09-09 JP JP2014183177A patent/JP2015007117A/ja active Pending
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2016
- 2016-09-23 AU AU2016231616A patent/AU2016231616A1/en not_active Abandoned
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2018
- 2018-08-03 AU AU2018211329A patent/AU2018211329A1/en not_active Abandoned
Non-Patent Citations (1)
| Title |
|---|
| WOODWARD DF et al, Molecular characterization and ocular hypotensive properties of the prostanoid EP2 receptor. J Ocul Pharmacol Ther. 1995 Fall;11(3):447-54. онлайн [найдено 07.04.2014], найдено из Интернет PMID 8590276. MARTINEZ A et al, A comparison of the safety and intraocular pressure lowering of bimatoprost/timolol fixed combination versus latanoprost/timolol fixed combination in patients with open-angle glaucoma, Curr Med Res Opin. 2007 May;23(5):1025-32. онлайн [найдено 07.04.2014], найдено из Интернет http://www.ncbi.nlm.nih.gov/pubmed/17519068 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120006998A (ko) | 2012-01-19 |
| MX2011009901A (es) | 2011-11-18 |
| US20100247606A1 (en) | 2010-09-30 |
| WO2010111449A1 (en) | 2010-09-30 |
| RU2011140433A (ru) | 2013-04-27 |
| NZ595294A (en) | 2013-11-29 |
| EP2411013B1 (en) | 2020-08-19 |
| JP2012521997A (ja) | 2012-09-20 |
| RU2014133501A (ru) | 2016-03-10 |
| BRPI1012324A2 (pt) | 2016-03-15 |
| KR20170064556A (ko) | 2017-06-09 |
| IL215205A0 (en) | 2011-12-29 |
| AU2016231616A1 (en) | 2016-10-20 |
| CN102497865A (zh) | 2012-06-13 |
| KR20160120800A (ko) | 2016-10-18 |
| EP2411013A1 (en) | 2012-02-01 |
| RU2664686C2 (ru) | 2018-08-21 |
| KR20180108883A (ko) | 2018-10-04 |
| CA2756065A1 (en) | 2010-09-30 |
| JP2015007117A (ja) | 2015-01-15 |
| AU2010229891A1 (en) | 2011-10-20 |
| AU2018211329A1 (en) | 2018-08-23 |
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