JP2012521768A - 抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 - Google Patents
抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 Download PDFInfo
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Life Sciences & Earth Sciences (AREA)
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
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- Immunology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Physics & Mathematics (AREA)
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- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
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- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16402309P | 2009-03-27 | 2009-03-27 | |
| US61/164,023 | 2009-03-27 | ||
| PCT/US2010/028877 WO2010111625A1 (en) | 2009-03-27 | 2010-03-26 | Compositions and methods for using multispecific-binding proteins comprising an antibody-receptor combination |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012521768A true JP2012521768A (ja) | 2012-09-20 |
| JP2012521768A5 JP2012521768A5 (OSRAM) | 2013-05-09 |
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| JP2012502294A Pending JP2012521768A (ja) | 2009-03-27 | 2010-03-26 | 抗体−受容体の組み合わせを含む多特異的結合性タンパク質を用いるための組成物および方法 |
Country Status (8)
| Country | Link |
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| US (1) | US20120134993A1 (OSRAM) |
| EP (1) | EP2411407A1 (OSRAM) |
| JP (1) | JP2012521768A (OSRAM) |
| KR (1) | KR20110134494A (OSRAM) |
| CN (1) | CN102448984A (OSRAM) |
| AU (1) | AU2010229705A1 (OSRAM) |
| MX (1) | MX2011009810A (OSRAM) |
| WO (1) | WO2010111625A1 (OSRAM) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017522052A (ja) * | 2014-07-21 | 2017-08-10 | 曁南大学 | ヒトFGFR2c細胞外ドメイン146−356とそれをコードする遺伝子及びそれらの応用 |
| JP2017526635A (ja) * | 2014-06-28 | 2017-09-14 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | デュアルpdgf/vegfアンタゴニスト |
| US11066465B2 (en) | 2015-12-30 | 2021-07-20 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| US11071771B2 (en) | 2014-10-17 | 2021-07-27 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
| US11155610B2 (en) | 2014-06-28 | 2021-10-26 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011075185A1 (en) | 2009-12-18 | 2011-06-23 | Oligasis | Targeted drug phosphorylcholine polymer conjugates |
| MX2015012778A (es) * | 2013-03-15 | 2016-01-20 | Intermune Inc | Marcadores proteomicos de fibrosis pulmonar idiopatica (fpi). |
| EP3013851A4 (en) * | 2013-06-25 | 2016-12-28 | Sépia Pesquisa E Desenvolvimento | MODULATORS OF BRADYKININ RECEPTORS AND THEIR USE |
| US9879081B2 (en) | 2013-06-25 | 2018-01-30 | Samsung Electronics Co., Ltd. | Protein complex, bispecific antibody including the protein complex, and method of preparation thereof |
| KR102060187B1 (ko) | 2013-07-19 | 2019-12-27 | 삼성전자주식회사 | Vegf-c, vegf-d 및/또는 안지오포이에틴-2를 동시에 저해하는 융합 폴리펩타이드 및 이의 용도 |
| PL3041513T3 (pl) | 2013-09-08 | 2021-01-25 | Kodiak Sciences Inc. | Obojnaczojonowe polimerowe koniugaty czynnika viii |
| CN113957146A (zh) | 2014-09-26 | 2022-01-21 | 詹森药业有限公司 | 使用fgfr突变基因组鉴定将对用fgfr抑制剂进行治疗有反应的癌症患者 |
| US12428483B2 (en) | 2014-12-22 | 2025-09-30 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of making and using thereof |
| WO2016106158A1 (en) | 2014-12-22 | 2016-06-30 | Systimmune, Inc. | Bispecific tetravalent antibodies and methods of making and using thereof |
| UA128057C2 (uk) | 2015-07-15 | 2024-03-27 | Ґенмаб А/С | Гуманізоване або химерне антитіло, яке зв'язує cd3 людини |
| WO2017091850A1 (en) * | 2015-11-30 | 2017-06-08 | Pieris Australia Pty Ltd. | Novel anti-angiogenic fusion polypeptides |
| WO2018011421A1 (en) | 2016-07-14 | 2018-01-18 | Genmab A/S | Multispecific antibodies against cd40 and cd137 |
| PT3592769T (pt) | 2017-03-09 | 2024-07-31 | Genmab As | Anticorpos contra pd-l1 |
| UA127586C2 (uk) | 2017-03-31 | 2023-10-25 | Ґенмаб Холдінґ Б.В. | Біспецифічні анти-cd37-антитіла, моноклональні анти-cd37-антитіла та способи їх застосування |
| CN111406067B (zh) | 2017-08-04 | 2022-11-08 | 健玛保 | 与pd-l1和cd137结合的结合剂及其用途 |
| US12077586B2 (en) | 2018-09-19 | 2024-09-03 | LAVA Therapeutics N.V. | Bispecific antibodies for use in the treatment of hematological malignancies |
| MA53812A (fr) | 2018-10-04 | 2021-08-11 | Genmab Holding B V | Compositions pharmaceutiques comprenant des anticorps anti-cd37 bispécifiques |
| KR20210124959A (ko) | 2018-11-06 | 2021-10-15 | 젠맵 에이/에스 | 항체 제제 |
| NL2022494B1 (en) | 2019-02-01 | 2020-08-19 | Lava Therapeutics B V | Novel CD40-binding antibodies |
| EP3917960A1 (en) | 2019-02-01 | 2021-12-08 | LAVA Therapeutics N.V. | Novel cd40-binding antibodies |
| JPWO2021010326A1 (OSRAM) * | 2019-07-12 | 2021-01-21 | ||
| EP3792283A1 (en) | 2019-09-16 | 2021-03-17 | Lava Therapeutics B.V. | Treatment of cancer comprising administration of vgamma9vdelta2 t cell receptor binding antibodies |
| WO2021155916A1 (en) | 2020-02-04 | 2021-08-12 | BioNTech SE | Treatment involving antigen vaccination and binding agents binding to pd-l1 and cd137 |
| MY210125A (en) | 2020-03-18 | 2025-08-28 | Genmab As | Antibodies binding to b7h4 |
| JP2023524149A (ja) | 2020-05-08 | 2023-06-08 | ジェンマブ エー/エス | Cd3およびcd20に対する二重特異性抗体 |
| US20230272110A1 (en) | 2020-07-08 | 2023-08-31 | LAVA Therapeutics N.V. | Antibodies that bind psma and gamma-delta t cell receptors |
| JP2023536340A (ja) | 2020-08-06 | 2023-08-24 | ビオンテック・ソシエタス・エウロパエア | コロナウイルスsタンパク質のための結合剤 |
| BR112023004327A2 (pt) | 2020-09-10 | 2023-04-04 | Genmab As | Método para tratar leucemia linfocítica crônica em um sujeito humano |
| MX2023002545A (es) | 2020-09-10 | 2023-03-14 | Genmab As | Anticuerpo biespecifico contra cumulo de diferenciacion 3 (cd3) y cumulo de diferenciacion 20 (cd20) en terapia de combinacion para el tratamiento de linfoma difuso de celulas b grandes. |
| JP2024501403A (ja) | 2020-12-10 | 2024-01-12 | ラヴァ・セラピューティクス・エヌ・ヴイ | ガンマ-デルタt細胞受容体に結合する抗体 |
| US20240141071A1 (en) | 2021-02-26 | 2024-05-02 | LAVA Therapeutics N.V. | Antibodies that bind cd123 and gamma-delta t cell receptors |
| US20240383982A1 (en) | 2021-05-07 | 2024-11-21 | Genmab A/S | Pharmaceutical compositions comprising bispecific antibodies binding to b7h4 and cd3 |
| IL309319A (en) | 2021-06-21 | 2024-02-01 | Genmab As | Combined dosage regimen CD137 and PD-L1 binding agents |
| TW202328193A (zh) | 2021-09-13 | 2023-07-16 | 美商健生生物科技公司 | 用於治療癌症的CD33 x Vδ2多特異性抗體 |
| AU2022361691A1 (en) | 2021-10-08 | 2024-03-28 | Genmab A/S | Antibodies binding to cd30 and cd3 |
| EP4419109A1 (en) | 2021-10-21 | 2024-08-28 | LAVA Therapeutics N.V. | Uses of gamma delta t cell activating antibodies |
| WO2023174521A1 (en) | 2022-03-15 | 2023-09-21 | Genmab A/S | Binding agents binding to epcam and cd137 |
| EP4285926A1 (en) | 2022-05-30 | 2023-12-06 | LAVA Therapeutics N.V. | Combination treatment for chronic lymphocytic leukemia |
| EP4292609A1 (en) | 2022-06-15 | 2023-12-20 | LAVA Therapeutics N.V. | Compositions comprising antibodies that bind gamma-delta t cell receptors |
| EP4292610A1 (en) | 2022-06-15 | 2023-12-20 | LAVA Therapeutics N.V. | Variant antibodies that bind gamma-delta t cell receptors |
| NL2032398B1 (en) | 2022-07-06 | 2024-01-23 | Academisch Ziekenhuis Leiden | Bispecific antibody and uses thereof |
| CN118420715B (zh) * | 2023-03-23 | 2025-01-24 | 湖南中晟全肽生物科技股份有限公司 | 一种结合fgfr2受体的多肽及其用途 |
| EP4438624A1 (en) | 2023-03-27 | 2024-10-02 | LAVA Therapeutics N.V. | Antibodies that bind nectin-4 and gamma-delta t cell receptors |
| WO2024200573A1 (en) | 2023-03-27 | 2024-10-03 | LAVA Therapeutics N.V. | Nectin-4 binding agents and methods of use |
| AR132290A1 (es) | 2023-04-05 | 2025-06-11 | Genmab As | Composiciones farmacéuticas que comprenden anticuerpos que se unen a cd30 y cd3 |
| WO2025003280A1 (en) | 2023-06-30 | 2025-01-02 | Genmab A/S | Antibodies binding to fibroblast activation protein alpha and death receptor 4 |
| WO2025012118A2 (en) | 2023-07-07 | 2025-01-16 | LAVA Therapeutics N.V. | 5t4 binding agents and methods of use |
| WO2025024780A1 (en) | 2023-07-27 | 2025-01-30 | LAVA Therapeutics N.V. | Antibodies that bind gamma-delta t cell receptors for the treatment of cancer |
| WO2025056180A1 (en) | 2023-09-15 | 2025-03-20 | BioNTech SE | Methods of treatment using agents binding to epcam and cd137 in combination with pd-1 axis binding antagonists |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2004536579A (ja) * | 2001-04-13 | 2004-12-09 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
| JP2008222711A (ja) * | 2005-07-22 | 2008-09-25 | Five Prime Therapeutics Inc | Fgfr融合タンパク質によって疾患を治療するための組成物および方法 |
| WO2009025846A2 (en) * | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003020906A2 (en) * | 2001-08-31 | 2003-03-13 | Abmaxis, Inc. | Multivalent protein conjugate with multiple ligand-binding domains of receptors |
| WO2005087812A1 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for vegf/pdgf family of growth factors |
| CN1997382A (zh) * | 2004-05-05 | 2007-07-11 | 梅里麦克制药股份有限公司 | 调节生物活性的双特异性结合剂 |
| PL2274008T3 (pl) * | 2008-03-27 | 2014-07-31 | Zymogenetics Inc | Kompozycje i sposoby hamowania PDGFRbeta i VEGF-A |
-
2010
- 2010-03-26 KR KR1020117025299A patent/KR20110134494A/ko not_active Ceased
- 2010-03-26 CN CN2010800230893A patent/CN102448984A/zh active Pending
- 2010-03-26 AU AU2010229705A patent/AU2010229705A1/en not_active Abandoned
- 2010-03-26 EP EP10722828A patent/EP2411407A1/en not_active Ceased
- 2010-03-26 US US13/260,408 patent/US20120134993A1/en not_active Abandoned
- 2010-03-26 JP JP2012502294A patent/JP2012521768A/ja active Pending
- 2010-03-26 WO PCT/US2010/028877 patent/WO2010111625A1/en not_active Ceased
- 2010-03-26 MX MX2011009810A patent/MX2011009810A/es not_active Application Discontinuation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004536579A (ja) * | 2001-04-13 | 2004-12-09 | ヒューマン ジノーム サイエンシーズ, インコーポレイテッド | 血管内皮増殖因子2 |
| JP2008222711A (ja) * | 2005-07-22 | 2008-09-25 | Five Prime Therapeutics Inc | Fgfr融合タンパク質によって疾患を治療するための組成物および方法 |
| WO2009025846A2 (en) * | 2007-08-22 | 2009-02-26 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
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| JPN6015015102; Cancer Cell Vol.8, 2005, p299-309 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017526635A (ja) * | 2014-06-28 | 2017-09-14 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | デュアルpdgf/vegfアンタゴニスト |
| JP2021091700A (ja) * | 2014-06-28 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | デュアルvegf/pdgfアンタゴニスト |
| US11155610B2 (en) | 2014-06-28 | 2021-10-26 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| JP7100425B2 (ja) | 2014-06-28 | 2022-07-13 | コディアック サイエンシーズ インコーポレイテッド | デュアルpdgf/vegfアンタゴニスト |
| JP7373514B2 (ja) | 2014-06-28 | 2023-11-02 | コディアック サイエンシーズ インコーポレイテッド | デュアルvegf/pdgfアンタゴニスト |
| JP2017522052A (ja) * | 2014-07-21 | 2017-08-10 | 曁南大学 | ヒトFGFR2c細胞外ドメイン146−356とそれをコードする遺伝子及びそれらの応用 |
| US11071771B2 (en) | 2014-10-17 | 2021-07-27 | Kodiak Sciences Inc. | Butyrylcholinesterase zwitterionic polymer conjugates |
| US11066465B2 (en) | 2015-12-30 | 2021-07-20 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
| US12071476B2 (en) | 2018-03-02 | 2024-08-27 | Kodiak Sciences Inc. | IL-6 antibodies and fusion constructs and conjugates thereof |
| US11912784B2 (en) | 2019-10-10 | 2024-02-27 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010111625A1 (en) | 2010-09-30 |
| CN102448984A (zh) | 2012-05-09 |
| EP2411407A1 (en) | 2012-02-01 |
| US20120134993A1 (en) | 2012-05-31 |
| KR20110134494A (ko) | 2011-12-14 |
| MX2011009810A (es) | 2011-09-30 |
| AU2010229705A1 (en) | 2011-10-20 |
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