JP2012520663A5 - - Google Patents
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- Publication number
- JP2012520663A5 JP2012520663A5 JP2012500143A JP2012500143A JP2012520663A5 JP 2012520663 A5 JP2012520663 A5 JP 2012520663A5 JP 2012500143 A JP2012500143 A JP 2012500143A JP 2012500143 A JP2012500143 A JP 2012500143A JP 2012520663 A5 JP2012520663 A5 JP 2012520663A5
- Authority
- JP
- Japan
- Prior art keywords
- ctag1b
- prame
- ctag2
- primer
- maga3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091058556 CTAG1B Proteins 0.000 claims 29
- 102100025570 Cancer/testis antigen 1 Human genes 0.000 claims 29
- 102100039510 Cancer/testis antigen 2 Human genes 0.000 claims 25
- 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 claims 25
- 239000002773 nucleotide Substances 0.000 claims 22
- 125000003729 nucleotide group Chemical group 0.000 claims 22
- 108060006580 PRAME Proteins 0.000 claims 19
- 239000000523 sample Substances 0.000 claims 17
- 102000036673 PRAME Human genes 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 108091034117 Oligonucleotide Proteins 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 230000011987 methylation Effects 0.000 claims 9
- 238000007069 methylation reaction Methods 0.000 claims 9
- 101150066024 PRAME gene Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 230000004927 fusion Effects 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 108091027568 Single-stranded nucleotide Proteins 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical group NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000001024 immunotherapeutic effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000013610 patient sample Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 102000025850 HLA-A2 Antigen Human genes 0.000 claims 1
- 108010074032 HLA-A2 Antigen Proteins 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 1
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000003308 immunostimulating effect Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims 1
- 238000013188 needle biopsy Methods 0.000 claims 1
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims 1
- 229930182490 saponin Natural products 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 229960001295 tocopherol Drugs 0.000 claims 1
- 229930003799 tocopherol Natural products 0.000 claims 1
- 235000010384 tocopherol Nutrition 0.000 claims 1
- 239000011732 tocopherol Substances 0.000 claims 1
- 229940044655 toll-like receptor 9 agonist Drugs 0.000 claims 1
- 239000007762 w/o emulsion Substances 0.000 claims 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16093509P | 2009-03-17 | 2009-03-17 | |
| US61/160,935 | 2009-03-17 | ||
| PCT/EP2010/001674 WO2010105815A2 (en) | 2009-03-17 | 2010-03-17 | Improved detection of gene expression |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012520663A JP2012520663A (ja) | 2012-09-10 |
| JP2012520663A5 true JP2012520663A5 (enExample) | 2013-05-02 |
Family
ID=42224406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012500143A Pending JP2012520663A (ja) | 2009-03-17 | 2010-03-17 | 遺伝子発現の改良された検出 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20120039993A1 (enExample) |
| EP (1) | EP2408933A2 (enExample) |
| JP (1) | JP2012520663A (enExample) |
| KR (1) | KR20120002534A (enExample) |
| CN (1) | CN102575284A (enExample) |
| AU (1) | AU2010225125A1 (enExample) |
| BR (1) | BRPI1009873A2 (enExample) |
| CA (1) | CA2755734A1 (enExample) |
| EA (1) | EA021100B1 (enExample) |
| IL (1) | IL215182A0 (enExample) |
| MX (1) | MX2011009597A (enExample) |
| SG (1) | SG174877A1 (enExample) |
| WO (1) | WO2010105815A2 (enExample) |
| ZA (1) | ZA201107175B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2481813A1 (en) * | 2011-02-01 | 2012-08-01 | Centro di Riferimento Oncologico - Istituto Nazionale Tumori - Aviano | Markers of cutaneous melanoma and uses thereof |
| KR20130081515A (ko) | 2012-01-09 | 2013-07-17 | 삼성전자주식회사 | Ｌｅｄ 패키지용 기판 및 ｌｅｄ 패키지 제조방법 |
| US9096905B2 (en) * | 2012-02-23 | 2015-08-04 | Medical Diagnostic Laboratories, Llc | Detecting DNA methylation of BCL2, CDKN2A and NID2 genes to predict bladder cancer in humans |
| US11021752B2 (en) | 2013-03-15 | 2021-06-01 | Myriad Genetics, Inc. | Genes and gene signatures for diagnosis and treatment of melanoma |
| US20180187267A1 (en) * | 2017-01-05 | 2018-07-05 | Michael J. Powell | Method for conducting early detection of colon cancer and/or of colon cancer precursor cells and for monitoring colon cancer recurrence |
| EP3164508B1 (en) | 2014-07-02 | 2023-06-07 | Myriad myPath, LLC | Genes and gene signatures for diagnosis and treatment of melanoma |
| CN104611453B (zh) * | 2015-02-28 | 2016-08-24 | 基因科技（上海）有限公司 | 诊断基因甲基化的探针组及其应用 |
| WO2016208466A1 (ja) * | 2015-06-22 | 2016-12-29 | ウシオ電機株式会社 | 検出対象物質の検出方法 |
| US11685955B2 (en) | 2016-05-16 | 2023-06-27 | Dimo Dietrich | Method for predicting response of patients with malignant diseases to immunotherapy |
| DE102016005947B3 (de) | 2016-05-16 | 2017-06-08 | Dimo Dietrich | Verfahren zur Abschätzung der Prognose und zur Prädiktion des Ansprechens auf eine Immuntherapie von Patienten mit malignen Erkrankungen |
| CN109400697B (zh) * | 2017-08-17 | 2021-04-23 | 香雪生命科学技术（广东）有限公司 | 一种识别prame抗原短肽的tcr及其相关组合物 |
| US11441182B2 (en) * | 2018-08-08 | 2022-09-13 | Virginia Commonwealth University | Multiplexed and recyclable single-molecule sensors for quantitative analysis of nucleic-acid biomarkers |
| JP7216995B2 (ja) * | 2018-12-05 | 2023-02-02 | 学校法人関西医科大学 | 胸腺癌バイオマーカー及び胸腺腫瘍の予後予測マーカー |
| CN110387421A (zh) * | 2019-08-28 | 2019-10-29 | 深圳市新合生物医疗科技有限公司 | 用于肺癌检测的DNA甲基化qPCR试剂盒及使用方法 |
| RU2760573C1 (ru) * | 2021-01-20 | 2021-11-29 | Общество с ограниченной ответственностью "Эс Джи" | Набор олигонуклеотидных праймеров и флуоресцентно-меченых зондов для выявления эпигенетических маркеров рака шейки матки |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4437975A (en) | 1977-07-20 | 1984-03-20 | Mobil Oil Corporation | Manufacture of lube base stock oil |
| IE72468B1 (en) | 1987-07-31 | 1997-04-09 | Univ Leland Stanford Junior | Selective amplification of target polynucleotide sequences |
| US5804381A (en) | 1996-10-03 | 1998-09-08 | Cornell Research Foundation | Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof |
| US6252052B1 (en) | 1996-10-03 | 2001-06-26 | Cornell Research Foundation, Inc | Antibodies which bind to NY-ESO-1 cancer associated proteins, and hybridomas which produce these antibodies |
| US6417165B1 (en) | 1988-03-27 | 2002-07-09 | Ludwig Institute For Cancer Research | NY-ESO-1-peptide derivatives, and uses thereof |
| US6723832B1 (en) | 1996-10-03 | 2004-04-20 | Ludwig Institute For Cancer Research | Isolated peptides corresponding to amino acid sequences of NY-ESO-1, which bind to MHC Class I and MHC Class II molecules, and uses thereof |
| ZA899593B (en) | 1988-12-16 | 1990-09-26 | Siska Diagnostics Inc | Self-sustained,sequence replication system |
| SE466259B (sv) | 1990-05-31 | 1992-01-20 | Arne Forsgren | Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal |
| US5342774A (en) | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
| DE69313134T2 (de) | 1992-06-25 | 1998-02-26 | Smithkline Beecham Biolog | Adjuvantien enthaltende impfstoffzusammensetzung |
| GB9326253D0 (en) | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| AU713040B2 (en) | 1994-07-15 | 1999-11-18 | University Of Iowa Research Foundation, The | Immunomodulatory oligonucleotides |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5698396A (en) | 1995-06-07 | 1997-12-16 | Ludwig Institute For Cancer Research | Method for identifying auto-immunoreactive substances from a subject |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6117635A (en) | 1996-07-16 | 2000-09-12 | Intergen Company | Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon |
| US6083716A (en) | 1996-09-06 | 2000-07-04 | The Trustees Of The University Of Pennsylvania | Chimpanzee adenovirus vectors |
| US6251603B1 (en) | 1996-10-03 | 2001-06-26 | Ludwig Institute For Cancer Research | Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample |
| US6303347B1 (en) | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
| US6113918A (en) | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| DE19752759A1 (de) | 1997-11-28 | 1999-07-01 | Basf Coatings Ag | Triboelektrisch aufladbare Pulverlacke |
| BR9907691B1 (pt) | 1998-02-05 | 2011-05-31 | derivado de antìgeno e antìgeno da famìlia mage associado a tumor, seqüência de ácido nucléico, codificando os mesmos, seus usos na preparação de vacina, processo para produção de vacina e vacina. | |
| US6140050A (en) | 1998-06-26 | 2000-10-31 | Ludwig Institute For Cancer Research | Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith |
| ATE315405T1 (de) | 1998-08-10 | 2006-02-15 | Antigenics Inc | Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung |
| US6800730B1 (en) | 1998-10-02 | 2004-10-05 | Ludwig Institute For Cancer Research | Isolated peptides which bind to MHC class II molecules, and uses thereof |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| US6605711B1 (en) | 1999-11-15 | 2003-08-12 | Ludwig Institute For Cancer Research | NY-ESO-1 peptide derivatives, and uses thereof |
| US6689742B1 (en) | 2000-02-25 | 2004-02-10 | Chancellors, Masters And Scholars Of The University Of Oxford | NY-ESO-1 peptide derivatives, and uses thereof |
| US6756044B1 (en) | 2000-02-09 | 2004-06-29 | Genvec, Inc. | Antigenic complexes and methods |
| MXPA04004876A (es) | 2001-11-21 | 2004-07-30 | Univ Pennsylvania | Secuencias de acido nucleico y de aminoacido de adenovirus de simio, vectores que contienen los mismos y metodos de uso. |
| US20030134404A1 (en) | 2001-11-26 | 2003-07-17 | Lochrie Michael A. | Methods for producing stocks of recombinant AAV virions |
| WO2003065806A1 (en) | 2002-02-04 | 2003-08-14 | Corixa Corporation | New immunoeffector compounds |
| WO2004067726A2 (en) | 2003-01-29 | 2004-08-12 | Keck Graduate Institute | Isothermal reactions for the amplification of oligonucleotides |
| WO2004110246A2 (en) * | 2003-05-15 | 2004-12-23 | Illumina, Inc. | Methods and compositions for diagnosing conditions associated with specific dna methylation patterns |
| DE10329240A1 (de) * | 2003-06-24 | 2005-01-20 | Epigenomics Ag | Verfahren zur Analyse des Cytosin-Methylierungsstatus von Cancer-Testis-Antigenen für eine individualisierte Immuntherapie |
| GB0409940D0 (en) | 2004-05-04 | 2004-06-09 | Glaxosmithkline Biolog Sa | Vaccine |
| US20090005268A1 (en) * | 2005-07-18 | 2009-01-01 | Epigenomics Ag | Compositions and Methods for Cancer Diagnostics Comprising Pan-Cancer Markers |
| EP2118128B1 (en) * | 2007-01-15 | 2012-11-07 | GlaxoSmithKline Biologicals SA | Fusion proteins comprising the tumor rejection antigens ny-eso-1 and lage-1 |
| US20080187535A1 (en) | 2007-01-15 | 2008-08-07 | Normand Blais | Vaccine |
| WO2009076478A2 (en) * | 2007-12-10 | 2009-06-18 | The Johns Hopkins University | Hypomethylated genes in cancer |
| WO2009108917A2 (en) * | 2008-02-29 | 2009-09-03 | Oncomethylome Sciences, S.A. | Markers for improved detection of breast cancer |
-
2010
- 2010-03-17 BR BRPI1009873A patent/BRPI1009873A2/pt not_active IP Right Cessation
- 2010-03-17 CN CN2010800214975A patent/CN102575284A/zh active Pending
- 2010-03-17 KR KR1020117024214A patent/KR20120002534A/ko not_active Withdrawn
- 2010-03-17 US US13/256,865 patent/US20120039993A1/en not_active Abandoned
- 2010-03-17 CA CA2755734A patent/CA2755734A1/en not_active Abandoned
- 2010-03-17 EP EP10711334A patent/EP2408933A2/en not_active Withdrawn
- 2010-03-17 AU AU2010225125A patent/AU2010225125A1/en not_active Abandoned
- 2010-03-17 EA EA201171131A patent/EA021100B1/ru not_active IP Right Cessation
- 2010-03-17 JP JP2012500143A patent/JP2012520663A/ja active Pending
- 2010-03-17 SG SG2011067386A patent/SG174877A1/en unknown
- 2010-03-17 WO PCT/EP2010/001674 patent/WO2010105815A2/en not_active Ceased
- 2010-03-17 MX MX2011009597A patent/MX2011009597A/es not_active Application Discontinuation
-
2011
- 2011-09-15 IL IL215182A patent/IL215182A0/en unknown
- 2011-09-30 ZA ZA2011/07175A patent/ZA201107175B/en unknown
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