JP2012519728A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012519728A5 JP2012519728A5 JP2011553553A JP2011553553A JP2012519728A5 JP 2012519728 A5 JP2012519728 A5 JP 2012519728A5 JP 2011553553 A JP2011553553 A JP 2011553553A JP 2011553553 A JP2011553553 A JP 2011553553A JP 2012519728 A5 JP2012519728 A5 JP 2012519728A5
- Authority
- JP
- Japan
- Prior art keywords
- fatty acid
- preconcentrate
- mixtures
- acid
- dha
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 120
- 239000003921 oil Substances 0.000 claims 86
- 235000019198 oils Nutrition 0.000 claims 86
- 235000014113 dietary fatty acids Nutrition 0.000 claims 75
- 239000000194 fatty acid Substances 0.000 claims 75
- 229930195729 fatty acid Natural products 0.000 claims 75
- 150000004665 fatty acids Chemical class 0.000 claims 70
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims 68
- -1 sulfate ethers Chemical class 0.000 claims 63
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 56
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 56
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 56
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 56
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 48
- 235000020669 docosahexaenoic acid Nutrition 0.000 claims 46
- 239000004094 surface-active agent Substances 0.000 claims 36
- 229940090949 docosahexaenoic acid Drugs 0.000 claims 34
- 229960003511 macrogol Drugs 0.000 claims 28
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 15
- 239000004359 castor oil Substances 0.000 claims 15
- 235000019438 castor oil Nutrition 0.000 claims 15
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims 15
- DVSZKTAMJJTWFG-SKCDLICFSA-N (2e,4e,6e,8e,10e,12e)-docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCC\C=C\C=C\C=C\C=C\C=C\C=C\C(O)=O DVSZKTAMJJTWFG-SKCDLICFSA-N 0.000 claims 12
- GZJLLYHBALOKEX-UHFFFAOYSA-N 6-Ketone, O18-Me-Ussuriedine Natural products CC=CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O GZJLLYHBALOKEX-UHFFFAOYSA-N 0.000 claims 12
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 12
- 239000012141 concentrate Substances 0.000 claims 12
- KAUVQQXNCKESLC-UHFFFAOYSA-N docosahexaenoic acid (DHA) Natural products COC(=O)C(C)NOCC1=CC=CC=C1 KAUVQQXNCKESLC-UHFFFAOYSA-N 0.000 claims 12
- 238000012377 drug delivery Methods 0.000 claims 12
- 125000004494 ethyl ester group Chemical group 0.000 claims 11
- 238000000034 method Methods 0.000 claims 11
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 10
- IZHVBANLECCAGF-UHFFFAOYSA-N 2-hydroxy-3-(octadecanoyloxy)propyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCCCC IZHVBANLECCAGF-UHFFFAOYSA-N 0.000 claims 10
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 10
- 239000004698 Polyethylene Substances 0.000 claims 10
- 229920002675 Polyoxyl Polymers 0.000 claims 10
- 229920001213 Polysorbate 20 Polymers 0.000 claims 10
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 claims 10
- 239000002736 nonionic surfactant Substances 0.000 claims 10
- 150000003904 phospholipids Chemical group 0.000 claims 10
- 229920000573 polyethylene Polymers 0.000 claims 10
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 10
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 10
- 229920001451 polypropylene glycol Polymers 0.000 claims 10
- 229940068977 polysorbate 20 Drugs 0.000 claims 10
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 9
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 9
- 229920000053 polysorbate 80 Polymers 0.000 claims 9
- 229940068968 polysorbate 80 Drugs 0.000 claims 9
- 239000003963 antioxidant agent Substances 0.000 claims 8
- 230000003078 antioxidant effect Effects 0.000 claims 8
- 235000006708 antioxidants Nutrition 0.000 claims 8
- 150000001298 alcohols Chemical class 0.000 claims 7
- 150000003626 triacylglycerols Chemical class 0.000 claims 7
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 claims 6
- OQOCQFSPEWCSDO-JLNKQSITSA-N 6Z,9Z,12Z,15Z,18Z-Heneicosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCC(O)=O OQOCQFSPEWCSDO-JLNKQSITSA-N 0.000 claims 6
- 235000021294 Docosapentaenoic acid Nutrition 0.000 claims 6
- OPGOLNDOMSBSCW-CLNHMMGSSA-N Fursultiamine hydrochloride Chemical compound Cl.C1CCOC1CSSC(\CCO)=C(/C)N(C=O)CC1=CN=C(C)N=C1N OPGOLNDOMSBSCW-CLNHMMGSSA-N 0.000 claims 6
- AHANXAKGNAKFSK-PDBXOOCHSA-N all-cis-icosa-11,14,17-trienoic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCCCC(O)=O AHANXAKGNAKFSK-PDBXOOCHSA-N 0.000 claims 6
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims 6
- 235000021342 arachidonic acid Nutrition 0.000 claims 6
- 229940114079 arachidonic acid Drugs 0.000 claims 6
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical group COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims 6
- IQLUYYHUNSSHIY-HZUMYPAESA-N eicosatetraenoic acid Chemical compound CCCCCCCCCCC\C=C\C=C\C=C\C=C\C(O)=O IQLUYYHUNSSHIY-HZUMYPAESA-N 0.000 claims 6
- PRHHYVQTPBEDFE-UHFFFAOYSA-N eicosatrienoic acid Natural products CCCCCC=CCC=CCCCCC=CCCCC(O)=O PRHHYVQTPBEDFE-UHFFFAOYSA-N 0.000 claims 6
- OQOCQFSPEWCSDO-UHFFFAOYSA-N heneicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCCC(O)=O OQOCQFSPEWCSDO-UHFFFAOYSA-N 0.000 claims 6
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 6
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 6
- 239000006014 omega-3 oil Substances 0.000 claims 6
- JIWBIWFOSCKQMA-UHFFFAOYSA-N stearidonic acid Natural products CCC=CCC=CCC=CCC=CCCCCC(O)=O JIWBIWFOSCKQMA-UHFFFAOYSA-N 0.000 claims 6
- FFJCNSLCJOQHKM-CLFAGFIQSA-N (z)-1-[(z)-octadec-9-enoxy]octadec-9-ene Chemical compound CCCCCCCC\C=C/CCCCCCCCOCCCCCCCC\C=C/CCCCCCCC FFJCNSLCJOQHKM-CLFAGFIQSA-N 0.000 claims 5
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 5
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 5
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 claims 5
- WECGLUPZRHILCT-GSNKCQISSA-N 1-linoleoyl-sn-glycerol Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@@H](O)CO WECGLUPZRHILCT-GSNKCQISSA-N 0.000 claims 5
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims 5
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims 5
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims 5
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 5
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 5
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 5
- SHBUUTHKGIVMJT-UHFFFAOYSA-N Hydroxystearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OO SHBUUTHKGIVMJT-UHFFFAOYSA-N 0.000 claims 5
- 229920001219 Polysorbate 40 Polymers 0.000 claims 5
- 229930006000 Sucrose Natural products 0.000 claims 5
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 150000008051 alkyl sulfates Chemical class 0.000 claims 5
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 5
- 239000003945 anionic surfactant Substances 0.000 claims 5
- 229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 claims 5
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims 5
- 229960001950 benzethonium chloride Drugs 0.000 claims 5
- 239000003833 bile salt Substances 0.000 claims 5
- 229940093761 bile salts Drugs 0.000 claims 5
- ABDBNWQRPYOPDF-UHFFFAOYSA-N carbonofluoridic acid Chemical compound OC(F)=O ABDBNWQRPYOPDF-UHFFFAOYSA-N 0.000 claims 5
- 239000003093 cationic surfactant Substances 0.000 claims 5
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims 5
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims 5
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims 5
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims 5
- 229920001577 copolymer Polymers 0.000 claims 5
- UYAAVKFHBMJOJZ-UHFFFAOYSA-N diimidazo[1,3-b:1',3'-e]pyrazine-5,10-dione Chemical compound O=C1C2=CN=CN2C(=O)C2=CN=CN12 UYAAVKFHBMJOJZ-UHFFFAOYSA-N 0.000 claims 5
- LLRANSBEYQZKFY-UHFFFAOYSA-N dodecanoic acid;propane-1,2-diol Chemical compound CC(O)CO.CCCCCCCCCCCC(O)=O LLRANSBEYQZKFY-UHFFFAOYSA-N 0.000 claims 5
- UQSQSQZYBQSBJZ-UHFFFAOYSA-N fluorosulfonic acid Chemical class OS(F)(=O)=O UQSQSQZYBQSBJZ-UHFFFAOYSA-N 0.000 claims 5
- 229940049654 glyceryl behenate Drugs 0.000 claims 5
- 229940074045 glyceryl distearate Drugs 0.000 claims 5
- 229940075507 glyceryl monostearate Drugs 0.000 claims 5
- 229920001477 hydrophilic polymer Polymers 0.000 claims 5
- 229920001600 hydrophobic polymer Polymers 0.000 claims 5
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 5
- 229940072106 hydroxystearate Drugs 0.000 claims 5
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims 5
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 claims 5
- 229940066429 octoxynol Drugs 0.000 claims 5
- 229920002113 octoxynol Polymers 0.000 claims 5
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 5
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 5
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 5
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 5
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 5
- 229940101027 polysorbate 40 Drugs 0.000 claims 5
- 229940116423 propylene glycol diacetate Drugs 0.000 claims 5
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 5
- 150000003235 pyrrolidines Chemical class 0.000 claims 5
- 150000003856 quaternary ammonium compounds Chemical class 0.000 claims 5
- 239000005720 sucrose Substances 0.000 claims 5
- 239000002888 zwitterionic surfactant Substances 0.000 claims 5
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 4
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 4
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 4
- 241000195493 Cryptophyta Species 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000005642 Oleic acid Substances 0.000 claims 4
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 4
- 239000002775 capsule Substances 0.000 claims 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 235000021323 fish oil Nutrition 0.000 claims 4
- 239000007903 gelatin capsule Substances 0.000 claims 4
- 230000005802 health problem Effects 0.000 claims 4
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 4
- 230000000813 microbial effect Effects 0.000 claims 4
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 4
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 4
- PWVUXRBUUYZMKM-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCO PWVUXRBUUYZMKM-UHFFFAOYSA-N 0.000 claims 3
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 claims 3
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 claims 3
- 229920001214 Polysorbate 60 Polymers 0.000 claims 3
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 claims 3
- 235000020664 gamma-linolenic acid Nutrition 0.000 claims 3
- 229960004488 linolenic acid Drugs 0.000 claims 3
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims 3
- 229920000847 nonoxynol Polymers 0.000 claims 3
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 3
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 3
- 229940113124 polysorbate 60 Drugs 0.000 claims 3
- WBHHMMIMDMUBKC-XLNAKTSKSA-N ricinelaidic acid Chemical compound CCCCCC[C@@H](O)C\C=C\CCCCCCCC(O)=O WBHHMMIMDMUBKC-XLNAKTSKSA-N 0.000 claims 3
- 229960003656 ricinoleic acid Drugs 0.000 claims 3
- FEUQNCSVHBHROZ-UHFFFAOYSA-N ricinoleic acid Natural products CCCCCCC(O[Si](C)(C)C)CC=CCCCCCCCC(=O)OC FEUQNCSVHBHROZ-UHFFFAOYSA-N 0.000 claims 3
- WSWCOQWTEOXDQX-MQQKCMAXSA-M (E,E)-sorbate Chemical compound C\C=C\C=C\C([O-])=O WSWCOQWTEOXDQX-MQQKCMAXSA-M 0.000 claims 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
- 208000032928 Dyslipidaemia Diseases 0.000 claims 2
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
- 150000004996 alkyl benzenes Chemical class 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 229920005862 polyol Polymers 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- 229920000136 polysorbate Polymers 0.000 claims 2
- 229950008882 polysorbate Drugs 0.000 claims 2
- 238000004094 preconcentration Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 229940075554 sorbate Drugs 0.000 claims 2
- 229940114926 stearate Drugs 0.000 claims 2
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 206010014486 Elevated triglycerides Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 238000008214 LDL Cholesterol Methods 0.000 claims 1
- 108010069201 VLDL Cholesterol Proteins 0.000 claims 1
- 230000009084 cardiovascular function Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 239000004064 cosurfactant Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- 208000006575 hypertriglyceridemia Diseases 0.000 claims 1
- 230000036737 immune function Effects 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 238000002156 mixing Methods 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000030363 nerve development Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000004382 visual function Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15861309P | 2009-03-09 | 2009-03-09 | |
| US61/158,613 | 2009-03-09 | ||
| US24263009P | 2009-09-15 | 2009-09-15 | |
| US61/242,630 | 2009-09-15 | ||
| US25429309P | 2009-10-23 | 2009-10-23 | |
| US25429109P | 2009-10-23 | 2009-10-23 | |
| US61/254,293 | 2009-10-23 | ||
| US61/254,291 | 2009-10-23 | ||
| PCT/IB2010/000824 WO2010103404A1 (en) | 2009-03-09 | 2010-03-09 | Compositions comprising a fatty acid oil mixture and a surfactant, and methods and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253166A Division JP6723009B2 (ja) | 2009-03-09 | 2015-12-25 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012519728A JP2012519728A (ja) | 2012-08-30 |
| JP2012519728A5 true JP2012519728A5 (https=) | 2013-07-25 |
| JP6176894B2 JP6176894B2 (ja) | 2017-08-09 |
Family
ID=42727856
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553553A Active JP6176894B2 (ja) | 2009-03-09 | 2010-03-09 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
| JP2015253166A Active JP6723009B2 (ja) | 2009-03-09 | 2015-12-25 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
| JP2018018093A Pending JP2018090600A (ja) | 2009-03-09 | 2018-02-05 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
| JP2020018504A Active JP7199389B2 (ja) | 2009-03-09 | 2020-02-06 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015253166A Active JP6723009B2 (ja) | 2009-03-09 | 2015-12-25 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
| JP2018018093A Pending JP2018090600A (ja) | 2009-03-09 | 2018-02-05 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
| JP2020018504A Active JP7199389B2 (ja) | 2009-03-09 | 2020-02-06 | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (6) | US11612579B2 (https=) |
| EP (4) | EP3915554A1 (https=) |
| JP (4) | JP6176894B2 (https=) |
| KR (3) | KR101966874B1 (https=) |
| CN (3) | CN110538148A (https=) |
| AU (1) | AU2010222648B2 (https=) |
| BR (1) | BRPI1009431A2 (https=) |
| CA (2) | CA3065860A1 (https=) |
| CO (1) | CO6501136A2 (https=) |
| EA (1) | EA022028B1 (https=) |
| ES (3) | ES2894340T3 (https=) |
| IL (1) | IL215043A (https=) |
| MX (1) | MX2011009503A (https=) |
| NZ (1) | NZ595204A (https=) |
| PH (1) | PH12019500030A1 (https=) |
| SG (1) | SG174314A1 (https=) |
| WO (3) | WO2010103402A1 (https=) |
Families Citing this family (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2894340T3 (es) * | 2009-03-09 | 2022-02-14 | Basf As | Composiciones que comprenden una mezcla de aceites de ácidos grasos y un tensioactivo, y métodos y usos de las mismas |
| US8207363B2 (en) | 2009-03-19 | 2012-06-26 | Martek Biosciences Corporation | Thraustochytrids, fatty acid compositions, and methods of making and uses thereof |
| PT3278665T (pt) | 2009-04-29 | 2020-11-19 | Amarin Pharmaceuticals Ie Ltd | Composição farmacêutica estável e métodos de utilização das mesmas |
| SG175390A1 (en) | 2009-04-29 | 2011-12-29 | Amarin Corp Plc | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| CN106074486A (zh) | 2009-06-15 | 2016-11-09 | 阿马里纳药物爱尔兰有限公司 | 在相伴他汀类疗法的对象中降低甘油三酯、没有增加ldl‑c水平的组合物和方法 |
| US20110071176A1 (en) | 2009-09-23 | 2011-03-24 | Amarin Pharma, Inc. | Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same |
| US9717703B2 (en) | 2009-10-16 | 2017-08-01 | Glaxosmithkline Llc | Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed |
| US9370493B2 (en) * | 2009-10-23 | 2016-06-21 | Pronova Biopharma Norge As | Coated capsules and tablets of a fatty acid oil mixture |
| WO2011050474A1 (en) | 2009-10-29 | 2011-05-05 | Acasti Pharma, Inc. | Concentrated therapeutic phospholipid compositions |
| PE20130491A1 (es) | 2009-12-30 | 2013-05-02 | Basf Pharma Callanish Ltd | Proceso simulado de separacion cromatografica de lecho movil para la purificacion de acidos grasos poliinsaturados |
| WO2011090493A1 (en) | 2010-01-19 | 2011-07-28 | Martek Biosciences Corporation | Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof |
| US11236351B2 (en) | 2010-05-17 | 2022-02-01 | Dow Agrosciences Llc | Production of DHA and other LC PUFAs in plants |
| US20140004186A1 (en) * | 2010-09-08 | 2014-01-02 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture comprising epa and dha in free acid form, a surfactant, and a statin |
| WO2012032414A2 (en) * | 2010-09-08 | 2012-03-15 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture, a surfactant, and a statin |
| US20140017308A1 (en) * | 2010-09-08 | 2014-01-16 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture, a free fatty acid, and a statin |
| ES2618604T3 (es) * | 2010-11-05 | 2017-06-21 | Pronova Biopharma Norge As | Métodos de tratamiento usando compuestos lipídicos |
| US11712429B2 (en) | 2010-11-29 | 2023-08-01 | Amarin Pharmaceuticals Ireland Limited | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| NZ778131A (en) | 2010-11-29 | 2023-03-31 | Amarin Pharmaceuticals Ie Ltd | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US8952000B2 (en) * | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events |
| US20120302639A1 (en) * | 2011-02-16 | 2012-11-29 | Pivotal Therapeutics Inc. | Omega 3 formulations for treatment of risk factors for cardiovascular disease and protection against sudden death |
| EP2675446A1 (en) * | 2011-02-16 | 2013-12-25 | Pivotal Therapeutics, Inc. | Omega 3 formulations comprising epa, dha and dpa for treatment of risk factors for cardiovascular disease |
| US9119826B2 (en) | 2011-02-16 | 2015-09-01 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagniostic assay for the dietary management of cardiovascular patients with cardiovascular disease (CVD) who are deficient in blood EPA and DHA levels |
| US8951514B2 (en) * | 2011-02-16 | 2015-02-10 | Pivotal Therapeutics Inc. | Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels |
| JP2014505729A (ja) * | 2011-02-16 | 2014-03-06 | ピヴォタル セラピューティクス インコーポレイテッド | コレステロールの低減および心血管事象の低減のための、コレステロール吸収阻害剤（アゼチジノン）およびω３脂肪酸（ＥＰＡ、ＤＨＡ、ＤＰＡ） |
| CA2827561A1 (en) * | 2011-02-16 | 2012-08-23 | Pivotal Therapeutics, Inc. | Omega 3 fatty acid diagniostic assay for the dietary management of patients with cardiovascular disease (cvd) |
| US8715648B2 (en) | 2011-02-16 | 2014-05-06 | Pivotal Therapeutics Inc. | Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics |
| WO2012112531A1 (en) * | 2011-02-16 | 2012-08-23 | Pivotal Therapeutics, Inc. | Statin and omega 3 fatty acids (epa, dha and dpa) for use in cardiovascular diseases |
| US8697676B2 (en) * | 2011-06-15 | 2014-04-15 | Ronald E Rosedale | Omega-3 fatty acid nutriceutical composition and optimization method |
| US8865685B2 (en) * | 2011-06-30 | 2014-10-21 | Johnson & Johnson Vision Care, Inc. | Esters for treatment of ocular inflammatory conditions |
| GB201111594D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New improved process |
| GB201111591D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Further new process |
| GB201111601D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New process |
| GB201111595D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | Improved process |
| GB201111589D0 (en) | 2011-07-06 | 2011-08-24 | Equateq Ltd | New modified process |
| HK1198515A1 (en) | 2011-07-21 | 2015-05-15 | Dsm Ip Assets B.V. | Fatty acid compositions |
| US20140323569A1 (en) * | 2011-07-21 | 2014-10-30 | Krishna Raman | Microbial oils enriched in polyunsaturated fatty acids |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸（ｄｈａ）及其他長鏈多元不飽和脂肪酸（ｌｃ－ｐｕｆａ）之技術 |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| WO2013072767A1 (en) * | 2011-11-18 | 2013-05-23 | Pronova Biopharma Norge As | Compositions and preconcentrates comprising at least one salicylate and omega-3 fatty acid oil mixture |
| RS57777B1 (sr) | 2012-01-06 | 2018-12-31 | Omthera Pharmaceuticals Inc | Dpa-obogaćene kompozicije omega-3 polinezasićenih masnih kiselina u obliku slobodne kiseline |
| EP2827839B1 (en) | 2012-03-20 | 2019-02-27 | Particle Dynamics International, LLC | Gelling agent-based dosage form |
| US20150132389A1 (en) * | 2012-03-30 | 2015-05-14 | Sancilio & Company, Inc. | Omega-3 Fatty Acid Ester Compositions |
| US10898458B2 (en) | 2012-03-30 | 2021-01-26 | Micelle Biopharma, Inc. | Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states |
| US20150125529A1 (en) * | 2012-03-30 | 2015-05-07 | Sancilio & Company, Inc. | Omega-3 Fatty Acid Ester Compositions |
| US9480651B2 (en) * | 2012-03-30 | 2016-11-01 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions unitary pharmaceutical dosage forms |
| JP6359517B2 (ja) * | 2012-03-30 | 2018-07-18 | サンシリオ アンド カンパニー, インコーポレイテッドSancilio & Company, Inc. | ω−３脂肪酸エステル組成物 |
| US20160228397A1 (en) * | 2012-03-30 | 2016-08-11 | Sancilio & Company, Inc. | Omega-3 fatty acid ester compositions |
| EP2846779A4 (en) | 2012-05-07 | 2015-12-16 | Omthera Pharmaceuticals Inc | STATIN AND OMEGA-3 FATTY ACID COMPOSITIONS |
| KR20240096704A (ko) | 2012-05-14 | 2024-06-26 | 가부시키가이샤 닛스이 | 환경 오염 물질을 저감시킨 고도 불포화 지방산 또는 고도 불포화 지방산 에틸에스테르 및 그 제조 방법 |
| US20140194512A1 (en) * | 2012-06-17 | 2014-07-10 | Matinas Biopharma, Inc. | Compositions comprising docosapentaenoic acid and methods of use |
| EP2861227A4 (en) | 2012-06-17 | 2016-01-27 | Matinas Biopharma Inc | OMEGA-3 PENTAIC ACID COMPOSITIONS AND METHODS OF USE |
| WO2014074552A2 (en) | 2012-11-06 | 2014-05-15 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy |
| CN103015230B (zh) * | 2012-11-27 | 2015-04-01 | 广州嘉德乐生化科技有限公司 | 一种单硬脂酸甘油酯和聚氧乙烯醚脂肪酸皂的组合物 |
| CA2894183A1 (en) * | 2012-12-06 | 2014-06-12 | Matinas Biopharma, Inc. | Omega-3 pentaenoic acid compositions and methods of use |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| GB201300354D0 (en) | 2013-01-09 | 2013-02-20 | Basf Pharma Callanish Ltd | Multi-step separation process |
| US9452151B2 (en) | 2013-02-06 | 2016-09-27 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing apolipoprotein C-III |
| MX377728B (es) | 2013-02-28 | 2025-03-11 | Pronova Biopharma Norge As | Composición que comprende un compuesto lípido, un triglicerido y un tensioactivo, y métodos de uso de la misma. |
| CA2905671A1 (en) * | 2013-03-13 | 2014-09-18 | Matinas Biopharma Inc. | Omega-3 pentaenoic acid compositions and methods of use |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US20140322314A1 (en) * | 2013-04-29 | 2014-10-30 | Matinas Biopharma, Inc. | Omega-3 Fatty Acid Formulations for Use as Pharmaceutical Treatment |
| US9428711B2 (en) | 2013-05-07 | 2016-08-30 | Groupe Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| US8802880B1 (en) | 2013-05-07 | 2014-08-12 | Group Novasep | Chromatographic process for the production of highly purified polyunsaturated fatty acids |
| WO2015008848A1 (ja) | 2013-07-18 | 2015-01-22 | 持田製薬株式会社 | ω３脂肪酸の自己乳化組成物 |
| US9801843B2 (en) * | 2013-07-18 | 2017-10-31 | Mochida Pharmaceutical Co., Ltd. | Self-emulsifying composition of ω3 fatty acid |
| WO2015011724A2 (en) * | 2013-07-22 | 2015-01-29 | Kms Health Center Pvt Ltd | A novel omega -3 fatty acid composition with a plant extract |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| EP2883860B1 (fr) | 2013-12-11 | 2016-08-24 | Novasep Process | Procédé chromatographique de production d'acides gras polyinsaturés |
| KR102416853B1 (ko) | 2013-12-20 | 2022-07-05 | 마라 리뉴어블즈 코퍼레이션 | 미생물로부터 오일을 회수하는 방법 |
| JP6303017B2 (ja) | 2014-01-07 | 2018-03-28 | ノヴァセプ プロセスＮｏｖａｓｅｐ Ｐｒｏｃｅｓｓ | 芳香族アミノ酸を精製する方法 |
| WO2015113987A1 (en) * | 2014-01-28 | 2015-08-06 | Fresenius Kabi Deutschland Gmbh | Composition comprising epa and dha triglycerides for parenteral administration |
| US11458096B2 (en) | 2014-04-09 | 2022-10-04 | Pulse Pharmaceuticals Pvt. Ltd. | Composition and method of producing nanoformulation of water insoluble bioactives in aqueous base |
| TWI725937B (zh) * | 2014-06-06 | 2021-05-01 | 美商海洋原料公司 | ω-３組成物、劑型及使用方法 |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| WO2016071434A1 (en) * | 2014-11-05 | 2016-05-12 | Abbott Laboratories Gmbh | Processes for producing compositions with improved safety profile comprising pancreatin and compositions suitable for pharmaceutical use |
| CN105614638A (zh) * | 2014-11-28 | 2016-06-01 | 深圳市前海安测信息技术有限公司 | Dha纳米乳及其制备方法和其在健康保健饮品中的应用 |
| US11007161B1 (en) * | 2014-12-31 | 2021-05-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermatic surfactant films |
| US10561627B2 (en) * | 2014-12-31 | 2020-02-18 | Eric Morrison | Ibuprofen nanoparticle carriers encapsulated with hermetic surfactant films |
| MY185428A (en) | 2015-01-21 | 2021-05-19 | Mochida Pharm Co Ltd | Self-emulsifying composition of ?-3 fatty acid |
| CN107922308B (zh) * | 2015-06-02 | 2024-11-12 | 内斯托尔株式会社 | 新型甘油三酯及其用途 |
| RU2655803C2 (ru) * | 2016-03-10 | 2018-05-29 | АД Смарт, СИА | Фармацевтическая композиция для профилактики и лечения атеросклероза |
| WO2017158439A1 (en) * | 2016-03-16 | 2017-09-21 | Omegatri As | Powders and tablets comprising omega-3 fatty acid derivatives and methods for their production |
| US10851395B2 (en) | 2016-06-10 | 2020-12-01 | MARA Renewables Corporation | Method of making lipids with improved cold flow properties |
| CN106072611A (zh) * | 2016-06-20 | 2016-11-09 | 威海百合生物技术股份有限公司 | 一种含不饱和脂肪酸的多相稀释组合物 |
| GB201611920D0 (en) * | 2016-07-08 | 2016-08-24 | Astrazeneca Ab | Pharmaceutical compositions |
| AU2017301077B2 (en) * | 2016-08-12 | 2022-07-07 | Pharmako Biotechnologies Pty Limited | Omega-3 compositions and methods relating thereto |
| WO2018054265A1 (zh) * | 2016-09-20 | 2018-03-29 | 张碧婷 | 亲水性脂类组合物的包装组合物，其制备及调配方法和应用 |
| EP3559206B1 (en) | 2016-12-22 | 2025-12-03 | Mara Renewables Corporation | Methods for producing biomass rich in dha, palmitic acid and protein using a eukaryotic microorganism |
| CN107048405A (zh) * | 2017-03-03 | 2017-08-18 | 武汉锶博睿医药技术有限公司 | 脂肪酸组件微胶囊及其制备方法 |
| GR1009542B (el) | 2018-04-25 | 2019-06-07 | Φαρματεν Α.Β.Ε.Ε. | Καψουλα μαλακης γελης που περιλαμβανει εναν εκλεκτικο ρυθμιστη οιστρογονικων υποδοχεων |
| EP3586643A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586640A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586641A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Dha enriched polyunsaturated fatty acid compositions |
| EP3586642A1 (en) | 2018-06-21 | 2020-01-01 | Nuseed Pty Ltd | Ala enriched polyunsaturated fatty acid compositions |
| KR20210110890A (ko) | 2018-09-24 | 2021-09-09 | 애머린 파마슈티칼스 아일랜드 리미티드 | 대상체에서 심혈관 사건의 위험도를 감소시키는 방법 |
| HUE072655T2 (hu) | 2018-11-30 | 2025-12-28 | Evonik Operations Gmbh | Foszfolipidek és zsírsav-sók diszperzióját tartalmazó készítmény |
| EP3955906A1 (en) | 2019-04-18 | 2022-02-23 | Akershus Universitetssykehus HF | Combination therapy comprising an ffar4 agonist and an alpha-7 nachr agonist or positive modulator |
| KR102096391B1 (ko) * | 2019-10-11 | 2020-04-06 | (주)아이엠디팜 | 액상결정 구조체를 형성하는 오메가-3-지방산 조성물 |
| CN110584084A (zh) * | 2019-10-17 | 2019-12-20 | 广州白云山汉方现代药业有限公司 | 一种乳化稳定剂及含该乳化稳定剂的营养乳液 |
| US12427134B2 (en) | 2019-11-12 | 2025-09-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter |
| KR20220163979A (ko) | 2020-04-03 | 2022-12-12 | 마라 리뉴어블즈 코퍼레이션 | 높은 수준의 오메가-3 지방산을 갖는 미생물 오일 |
| CN113827547A (zh) * | 2020-06-23 | 2021-12-24 | 南京清普生物科技有限公司 | 一种缓释制剂组合物 |
| CN111729125B (zh) * | 2020-07-31 | 2022-10-04 | 陕西佰傲再生医学有限公司 | 骨止血材料 |
| JP2021008518A (ja) * | 2020-10-21 | 2021-01-28 | 持田製薬株式会社 | ω３脂肪酸の自己乳化組成物 |
| EP4271414A4 (en) | 2020-12-31 | 2024-11-27 | The Governing Council of the University of Toronto | FULLY DILUABLE SELF-MICROEMULSIFYING DELIVERY SYSTEMS (SMEDDS) FOR POORLY WATER-SOLUBLE POLAR SOLUTES |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
| CN116407543B (zh) * | 2021-12-29 | 2025-12-12 | 中国科学院上海药物研究所 | Epa-ee纳米脂质组合物、及其制剂、制备方法和应用 |
| KR20230161551A (ko) * | 2022-05-18 | 2023-11-28 | 부광약품 주식회사 | 제제학적으로 안정성이 향상된 연질 캡슐 |
| KR102895710B1 (ko) * | 2022-11-24 | 2025-12-05 | 주식회사 노바웰스 | 자가유화전달시스템을 이용한 지용성 생리활성성분의 흡수력 증대를 위한 조성물 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5312473B1 (https=) | 1971-05-24 | 1978-05-01 | ||
| GB2033745B (en) * | 1978-05-26 | 1983-08-17 | Wellcome Found | Fatty acid and derivatives thereof for use in treatment or prophylaxis of thromboembolic conditions |
| PH19942A (en) | 1980-11-18 | 1986-08-14 | Sintex Inc | Microencapsulation of water soluble polypeptides |
| AU552068B2 (en) | 1981-09-21 | 1986-05-22 | Asama Chemical Co. Ltd. | Preservation of edible oils |
| DE3381777D1 (de) | 1982-12-09 | 1990-09-06 | Advanced Drug Tech | Einfach absorbierbare fettsaeureemulsionen. |
| JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4843095A (en) * | 1987-08-07 | 1989-06-27 | Century Laboratories, Inc. | Free fatty acids for treatment or propyhlaxis of rheumatoid arthritis arthritis |
| GB2209937B (en) | 1987-09-21 | 1991-07-03 | Depiopharm S A | Water insoluble polypeptides |
| US5035896A (en) | 1988-06-15 | 1991-07-30 | Warner-Lambert Company | Water insoluble drugs coated by coacervated fish gelatin |
| GB8819110D0 (en) | 1988-08-11 | 1988-09-14 | Norsk Hydro As | Antihypertensive drug & method for production |
| US5532002A (en) * | 1989-08-17 | 1996-07-02 | Cortecs Limited | Gelatin pharmaceutical formulations |
| FI920646A0 (fi) | 1989-08-17 | 1992-02-14 | Cortecs Ltd | Farmaceutiska preparat. |
| CH683149A5 (fr) | 1991-07-22 | 1994-01-31 | Debio Rech Pharma Sa | Procédé pour la préparation de microsphères en matériau polymère biodégradable. |
| GB9405304D0 (en) | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| US5501077A (en) * | 1994-05-27 | 1996-03-26 | Springwell Dispensers, Inc. | Thermoelectric water chiller |
| JPH0889167A (ja) | 1994-09-27 | 1996-04-09 | Nippon Oil & Fats Co Ltd | 多価不飽和脂肪酸含有醗酵乳の製造方法 |
| MY118354A (en) | 1995-05-01 | 2004-10-30 | Scarista Ltd | 1,3-propane diol derivatives as bioactive compounds |
| GB9509764D0 (en) | 1995-05-15 | 1995-07-05 | Tillotts Pharma Ag | Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids |
| DE19608137A1 (de) * | 1996-03-02 | 1997-09-04 | Meyer Lucas Gmbh & Co | Lipid-Zubereitungen für diätetische Zwecke |
| WO1999029335A1 (en) | 1997-12-05 | 1999-06-17 | Chong Kun Dang Corp. | Pharmaceutical composition containing cyclosporin |
| WO1999029316A1 (en) * | 1997-12-10 | 1999-06-17 | Severson, Mary, L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
| WO1999029300A1 (en) | 1997-12-10 | 1999-06-17 | Rtp Pharma Inc. | Self-emulsifying fenofibrate formulations |
| CA2331640A1 (en) * | 1998-05-07 | 1999-11-11 | Elan Corporation Plc | Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems |
| GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
| US20050037065A1 (en) | 1999-05-27 | 2005-02-17 | Drugtech Corporation | Nutritional formulations |
| DK1157692T3 (da) | 2000-05-22 | 2006-02-06 | Pro Aparts Investimentos E Con | Sammensætning af fedtsyrer indeholdende mindst 80 vægt-% EPA og DHA, derivater deraf og farmaceutisk anvendelse deraf |
| EP1279400A1 (en) * | 2001-07-25 | 2003-01-29 | Target Hit sa | Modifying the fatty acid composition of cell membranes of organs and tissues |
| KR100441167B1 (ko) * | 2001-12-27 | 2004-07-21 | 씨제이 주식회사 | 마이크로에멀젼 예비 농축액 조성물 |
| ITMI20020269A1 (it) * | 2002-02-12 | 2003-08-12 | Victorix Assets Ltd | Uso di steri etilici di acidi poliinsaturi omega-3 in pazienti con insufficienza cardiaca |
| GB0210212D0 (en) | 2002-05-03 | 2002-06-12 | Univ Southampton | Effects of dietary N-3 and N-6 pufa intake on atheromatous plaque stability |
| ITMI20022511A1 (it) | 2002-11-26 | 2004-05-27 | Victorix Assets Ltd | Uso di composizioni farmaceutiche contenenti esteri etilici di acidi poliinsaturi omega-3 nella orevenzione della fibrillazione atriale. |
| US20040254357A1 (en) | 2002-12-19 | 2004-12-16 | Zaloga Gary P. | Fatty acid phenolic conjugates |
| AU2003288606A1 (en) * | 2002-12-20 | 2004-07-14 | Pronova Biocare As | Use of a fatty acid composition for treatment of male infertility |
| SE0303513D0 (sv) * | 2003-12-19 | 2003-12-19 | Pronova Biocare As | Use of a fatty acid composition comprising at least one of epa and dha or any combinations thereof |
| GB0403247D0 (en) * | 2004-02-13 | 2004-03-17 | Tillotts Pharma Ag | A pharmaceutical composition |
| GB0413729D0 (en) | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| GB0413730D0 (en) * | 2004-06-18 | 2004-07-21 | Tillotts Pharma Ag | A pharmaceutical composition and its use |
| US20090030077A1 (en) * | 2004-08-06 | 2009-01-29 | Transform Pharmaceuticals Inc. | Novel Fenofibrate Formulations and Related Methods of Treatment |
| NZ552390A (en) * | 2004-08-06 | 2010-01-29 | Transform Pharmaceuticals Inc | Novel fenofibrate formulations and related methods of treatment |
| JP2008509154A (ja) * | 2004-08-06 | 2008-03-27 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なスタチン薬剤組成物および関連治療方法 |
| AU2005274574B2 (en) * | 2004-08-18 | 2011-03-17 | Ace Aps | Cosmetic and pharmaceutical compositions comprising ACE inhibitors and/or angiotensin II receptor antagonists |
| US20060051462A1 (en) | 2004-09-03 | 2006-03-09 | Wang Jimmy X | Self emulsifying compositions for delivering lipophilic coenzyme Q10 and other dietary ingredients |
| CN101098690A (zh) * | 2004-12-06 | 2008-01-02 | 瑞莱恩特医药品有限公司 | 用于血脂治疗的ω-3脂肪酸和脂血异常剂 |
| GB0428384D0 (en) * | 2004-12-24 | 2005-02-02 | Sla Pharma Ag | Eicosapentaenoic acid |
| US20090054523A1 (en) * | 2005-01-24 | 2009-02-26 | Morten Bryhn | Use of a Fatty Acid Composition Containing DHA for the Production of a Medical Product or a Food Stuff for the Treatment of Amyloidos-Related Diseases |
| KR20070108945A (ko) | 2005-03-08 | 2007-11-13 | 릴라이언트 파마슈티컬스 인코퍼레이티드 | 스타틴과 오메가-3 지방산 및 그 조합물을 이용한 치료 |
| BRPI0613704A2 (pt) | 2005-07-08 | 2011-02-01 | Mochida Pharm Co Ltd | composição para impedir o inìcio e/ou a recorrência de eventos cardiovasculares |
| ITMI20051560A1 (it) * | 2005-08-10 | 2007-02-11 | Tiberio Bruzzese | Composizione di acidi grassi n-3 con elevata concentrazione di epa e-o dha e contenente acidi grassi n-6 |
| NZ569068A (en) | 2005-12-20 | 2011-11-25 | Cenestra Llc | Omega 3 fatty acid formulations of EPA and DHA |
| EP1991208A2 (en) | 2006-02-10 | 2008-11-19 | SportsCom Danmark ApS | Coated tablets, their methods of preparation, and related uses |
| MY153288A (en) * | 2006-06-28 | 2015-01-29 | Hovid Berhad | An effective pharmaceutical carrier for poorly bioavailable drugs |
| EP2049098A2 (en) | 2006-07-21 | 2009-04-22 | Reliant Pharmaceuticals, Inc. | Omega-3 fatty acids for use in treating resistant hypertension |
| WO2008011178A2 (en) * | 2006-07-21 | 2008-01-24 | Reliant Pharmaceuticals, Inc. | Compositions comprising omega-3 fatty acids, and their use in treating peripheral artery disease and intermittent claudication |
| US7676518B2 (en) | 2006-08-16 | 2010-03-09 | Sap Ag | Clustering for structured data |
| JP2010506920A (ja) * | 2006-10-18 | 2010-03-04 | リライアント・ファーマシューティカルズ・インコーポレイテッド | Ｌｐ−ｐｌａ２濃度を減少させるためのオメガ−３脂肪酸 |
| CA2677670C (en) * | 2007-03-20 | 2010-08-03 | Centre De Recherche Sur Les Biotechnologies Marines | Compositions comprising polyunsaturated fatty acid monoglycerides or derivatives thereof and uses thereof |
| RU2009139002A (ru) * | 2007-03-23 | 2011-04-27 | Новартис АГ (CH) | Применение замаскированной или с нанесенным на нее покрытием соли меди для лечения дегенерации желтого пятна |
| US20080261896A1 (en) * | 2007-04-11 | 2008-10-23 | Sinphar Pharmaceutical Co., Ltd. | Testosterone generating and metabolizing enhancer |
| WO2009009040A2 (en) | 2007-07-06 | 2009-01-15 | Baum Seth J | Fatty acid compositions and methods of use |
| US8370627B2 (en) | 2008-01-04 | 2013-02-05 | University Of Yamanashi | Confidential communication method |
| MX2010007609A (es) | 2008-01-10 | 2010-08-04 | Takeda Pharmaceutical | Formulacion de capsula. |
| US20100062057A1 (en) | 2008-09-10 | 2010-03-11 | Pronova BioPharma Norge AS. | Formulation |
| US20100130608A1 (en) | 2008-10-01 | 2010-05-27 | Martek Biosciences Corporation | Compositions and methods for reducing triglyceride levels |
| ES2894340T3 (es) * | 2009-03-09 | 2022-02-14 | Basf As | Composiciones que comprenden una mezcla de aceites de ácidos grasos y un tensioactivo, y métodos y usos de las mismas |
| US9717703B2 (en) | 2009-10-16 | 2017-08-01 | Glaxosmithkline Llc | Emulsion and emulsion preconcentrate compositions comprising omega-3 fatty acids and uses thereof are disclosed |
| US9370493B2 (en) | 2009-10-23 | 2016-06-21 | Pronova Biopharma Norge As | Coated capsules and tablets of a fatty acid oil mixture |
-
2010
- 2010-03-09 ES ES10750438T patent/ES2894340T3/es active Active
- 2010-03-09 KR KR1020187007824A patent/KR101966874B1/ko active Active
- 2010-03-09 KR KR1020117023450A patent/KR101841756B1/ko active Active
- 2010-03-09 EP EP21186673.6A patent/EP3915554A1/en active Pending
- 2010-03-09 MX MX2011009503A patent/MX2011009503A/es unknown
- 2010-03-09 WO PCT/IB2010/000791 patent/WO2010103402A1/en not_active Ceased
- 2010-03-09 ES ES10750436T patent/ES2881885T3/es active Active
- 2010-03-09 CA CA3065860A patent/CA3065860A1/en not_active Abandoned
- 2010-03-09 EP EP10764152.4A patent/EP2405903B1/en active Active
- 2010-03-09 EA EA201171113A patent/EA022028B1/ru not_active IP Right Cessation
- 2010-03-09 ES ES10764152T patent/ES2979118T3/es active Active
- 2010-03-09 WO PCT/IB2010/000788 patent/WO2010119319A1/en not_active Ceased
- 2010-03-09 US US13/255,595 patent/US11612579B2/en active Active
- 2010-03-09 WO PCT/IB2010/000824 patent/WO2010103404A1/en not_active Ceased
- 2010-03-09 US US13/255,602 patent/US9532963B2/en active Active
- 2010-03-09 SG SG2011065075A patent/SG174314A1/en unknown
- 2010-03-09 CN CN201910497672.0A patent/CN110538148A/zh active Pending
- 2010-03-09 KR KR1020197009512A patent/KR102118478B1/ko active Active
- 2010-03-09 CN CN201410322762.3A patent/CN104146955A/zh active Pending
- 2010-03-09 NZ NZ595204A patent/NZ595204A/en unknown
- 2010-03-09 EP EP10750436.7A patent/EP2405895B1/en active Active
- 2010-03-09 EP EP10750438.3A patent/EP2405902B1/en active Active
- 2010-03-09 US US13/255,587 patent/US11395811B2/en active Active
- 2010-03-09 AU AU2010222648A patent/AU2010222648B2/en active Active
- 2010-03-09 BR BRPI1009431A patent/BRPI1009431A2/pt not_active Application Discontinuation
- 2010-03-09 CN CN2010800203059A patent/CN102421422A/zh active Pending
- 2010-03-09 CA CA2754860A patent/CA2754860C/en active Active
- 2010-03-09 PH PH12019500030A patent/PH12019500030A1/en unknown
- 2010-03-09 JP JP2011553553A patent/JP6176894B2/ja active Active
-
2011
- 2011-09-08 IL IL215043A patent/IL215043A/en not_active IP Right Cessation
- 2011-10-03 CO CO11130069A patent/CO6501136A2/es not_active Application Discontinuation
-
2015
- 2015-12-25 JP JP2015253166A patent/JP6723009B2/ja active Active
-
2016
- 2016-11-14 US US15/350,522 patent/US10028928B2/en active Active
-
2018
- 2018-02-05 JP JP2018018093A patent/JP2018090600A/ja active Pending
- 2018-07-23 US US16/043,097 patent/US10596142B2/en active Active
-
2020
- 2020-02-06 JP JP2020018504A patent/JP7199389B2/ja active Active
- 2020-03-24 US US16/828,062 patent/US11523999B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012519728A5 (https=) | ||
| JP7199389B2 (ja) | 脂肪酸油混合物及び界面活性剤を含む組成物、並びにその方法及び使用 | |
| JP6835664B2 (ja) | 脂肪酸油混合物の被覆型カプセル剤および錠剤 | |
| JP2013508348A5 (https=) | ||
| JP2013537186A (ja) | 脂肪酸油混合物と遊離脂肪酸とスタチンとを含む組成物 | |
| US20230218560A1 (en) | Compositions comprising a fatty acid oil mixture and a surfactant, and methods and uses thereof | |
| TW201311294A (zh) | 含脂肪酸油混合物、界面活性劑與司它汀（ｓｔａｔｉｎ）的組成物 |