JP2012517239A5 - - Google Patents
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- Publication number
- JP2012517239A5 JP2012517239A5 JP2011550155A JP2011550155A JP2012517239A5 JP 2012517239 A5 JP2012517239 A5 JP 2012517239A5 JP 2011550155 A JP2011550155 A JP 2011550155A JP 2011550155 A JP2011550155 A JP 2011550155A JP 2012517239 A5 JP2012517239 A5 JP 2012517239A5
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- virus
- reassortant influenza
- donor viruses
- reassortant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000700605 Viruses Species 0.000 claims 14
- 241000712461 unidentified influenza virus Species 0.000 claims 14
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 229920001184 polypeptide Polymers 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 230000006978 adaptation Effects 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 229960001226 live attenuated influenza Drugs 0.000 claims 1
- 102000040430 polynucleotide Human genes 0.000 claims 1
- 108091033319 polynucleotide Proteins 0.000 claims 1
- 239000002157 polynucleotide Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000029812 viral genome replication Effects 0.000 claims 1
- 210000000605 viral structure Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15209409P | 2009-02-12 | 2009-02-12 | |
| US61/152,094 | 2009-02-12 | ||
| PCT/US2010/022970 WO2010093537A2 (en) | 2009-02-12 | 2010-02-03 | Influenza hemagglutinin and neuraminidase variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012517239A JP2012517239A (ja) | 2012-08-02 |
| JP2012517239A5 true JP2012517239A5 (https=) | 2013-03-14 |
| JP5818693B2 JP5818693B2 (ja) | 2015-11-18 |
Family
ID=42562246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011550155A Expired - Fee Related JP5818693B2 (ja) | 2009-02-12 | 2010-02-03 | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US8613935B2 (https=) |
| EP (1) | EP2396033B1 (https=) |
| JP (1) | JP5818693B2 (https=) |
| CN (1) | CN102361649A (https=) |
| AU (1) | AU2010213966B2 (https=) |
| BR (1) | BRPI1008549A2 (https=) |
| CA (1) | CA2752205A1 (https=) |
| MX (2) | MX2011008497A (https=) |
| RU (2) | RU2535970C2 (https=) |
| SG (2) | SG173642A1 (https=) |
| WO (1) | WO2010093537A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0610525Y2 (ja) | 1986-02-06 | 1994-03-16 | 三洋電機株式会社 | キヤプスタンモ−タ制御回路 |
| JP4980895B2 (ja) | 2004-05-25 | 2012-07-18 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| CN104140958A (zh) | 2006-08-09 | 2014-11-12 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
| SG173642A1 (en) | 2009-02-12 | 2011-09-29 | Medimmune Llc | Influenza hemagglutinin and neuraminidase variants |
| JP2013541528A (ja) | 2010-09-21 | 2013-11-14 | マサチューセッツ インスティテュート オブ テクノロジー | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
| CN108103084B (zh) * | 2017-11-21 | 2020-06-26 | 浙江迪福润丝生物科技有限公司 | 区分免疫和感染动物h5亚型禽流感疫苗株及其制备方法和应用 |
Family Cites Families (51)
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| US3992522A (en) | 1973-01-24 | 1976-11-16 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Temperature-sensitive recombinant mutant viruses and a process for producing same |
| US4071618A (en) | 1974-09-03 | 1978-01-31 | Research Foundation For Microbial Diseases Of Osaka University | Process for preparing virus disease live vaccines |
| JPS57136528A (en) | 1981-02-09 | 1982-08-23 | Hayashibara Biochem Lab Inc | Preparation of viral vaccine |
| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US4634666A (en) | 1984-01-06 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Human-murine hybridoma fusion partner |
| US4752473A (en) * | 1984-10-12 | 1988-06-21 | The Regents Of The University Of California | Expression of glycosylated human influenza hemagglutinin proteins |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5166057A (en) | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US5665362A (en) | 1990-09-25 | 1997-09-09 | Cantab Pharmaceuticals Research Limited | Viral vaccines |
| EP1473361A3 (en) | 1992-04-14 | 2004-11-17 | The Mount Sinai School Of Medicine, Of The City University Of New York | Genetically engineered attenuated viruses |
| IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
| ATE257175T1 (de) | 1994-07-18 | 2004-01-15 | Conzelmann Karl Klaus Prof Dr | Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus |
| US5789229A (en) | 1994-09-30 | 1998-08-04 | Uab Research Foundation | Stranded RNA virus particles |
| US5716821A (en) | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
| US6146873A (en) | 1994-11-10 | 2000-11-14 | Baxter Aktiengesellschaft | Production of orthomyxoviruses in monkey kidney cells using protein-free media |
| US5756341A (en) | 1994-11-10 | 1998-05-26 | Immuno Ag | Method for controlling the infectivity of viruses |
| US7153510B1 (en) | 1995-05-04 | 2006-12-26 | Yale University | Recombinant vesiculoviruses and their uses |
| US5690937A (en) | 1995-06-05 | 1997-11-25 | Aviron | Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene |
| ATE181112T1 (de) | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| US6264957B1 (en) | 1995-09-27 | 2001-07-24 | The United States Of America As Represented By The Department Of Health And Human Services | Product of infectious respiratory syncytial virus from cloned nucleotide sequences |
| DK0864645T3 (da) | 1995-10-31 | 2005-10-24 | Dnavec Research Inc | Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet |
| DK0863202T3 (da) | 1995-11-01 | 2010-09-27 | Dnavec Research Inc | Rekombinant Sendai-virus |
| US6090391A (en) | 1996-02-23 | 2000-07-18 | Aviron | Recombinant tryptophan mutants of influenza |
| WO1998002530A1 (en) | 1996-07-15 | 1998-01-22 | The Government Of The United States Of America, As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences |
| CA2265554A1 (en) | 1996-09-27 | 1998-04-02 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales |
| BR9809456B1 (pt) | 1997-05-23 | 2011-06-28 | molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica. | |
| DE69837764T2 (de) | 1997-07-11 | 2008-01-31 | Yale University, New Haven | Rhabdovirus mit gentechnisch veränderter hülle |
| KR20010030630A (ko) | 1997-09-19 | 2001-04-16 | 윌리암 에이취 캘넌, 에곤 이 버그 | 약독화 호흡 신시티아 바이러스 |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| EP1035209A1 (en) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stable recombinant influenza viruses free of helper viruses |
| US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
| DE122008000035I1 (de) | 1999-04-06 | 2009-05-20 | Wisconsin Alumni Res Found | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
| WO2001064860A2 (en) | 2000-03-02 | 2001-09-07 | Polymun Scientific Immunbiologische Forschung Gmbh | Recombinant influenza a viruses |
| ES2319864T3 (es) | 2000-04-28 | 2009-05-14 | St. Jude Children's Research Hospital | Sistema de transfeccion de adn para la generacion de virus infecciosos de arn de cadena negativa. |
| JP5063852B2 (ja) | 2000-09-25 | 2012-10-31 | ポリマン サイエンティフィック イミューンバイオロジッシュ フォーシュング ゲゼルシャフト ミット ベシュレンクテル ファフツング | 生ワクチン及び製造方法 |
| USPP15035P3 (en) * | 2001-06-27 | 2004-07-27 | Marko Zaninovich, Inc. | Grapevine ‘12-76-71’ |
| KR100600988B1 (ko) * | 2002-03-13 | 2006-07-13 | 주식회사 엘지생명과학 | Ｄｎａ 면역화에서 인플루엔자 ｎｐ 유전자 ｄｎａ를 함께투여하여 면역반응을 증가시키는 방법 |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| DK1499348T3 (en) * | 2002-04-26 | 2015-01-05 | Medimmune Llc | PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| US7037707B2 (en) | 2003-09-04 | 2006-05-02 | St. Jude Children's Research Hospital | Method for generating influenza viruses and vaccines |
| JP4980895B2 (ja) | 2004-05-25 | 2012-07-18 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| EP2388340B1 (en) | 2004-11-01 | 2013-04-03 | Eiken Kagaku Kabushiki Kaisha | Method of detecting H7 avian influenza virus |
| EP2471552B1 (en) | 2005-03-08 | 2015-05-06 | MedImmune, LLC | Reassortant influenza viruses |
| RU2315101C2 (ru) * | 2006-01-10 | 2008-01-20 | ГУ "Научно-исследовательский институт экспериментальной медицины "Российской Академии медицинских наук (ГУ НИИЭМ РАМН) | Вакцинный штамм вируса гриппа а/17/калифорния/ 04/6 (н3n2) и донор аттенуации а/ленинград/134/17/к7/57 (н2n2) для его получения |
| CN104140958A (zh) | 2006-08-09 | 2014-11-12 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
| WO2009014919A2 (en) * | 2007-07-13 | 2009-01-29 | Iowa State University Research Foundation, Inc. | H2n3 influenza a viruses and methods of use |
| SG173642A1 (en) | 2009-02-12 | 2011-09-29 | Medimmune Llc | Influenza hemagglutinin and neuraminidase variants |
-
2010
- 2010-02-03 SG SG2011057791A patent/SG173642A1/en unknown
- 2010-02-03 EP EP10741567.1A patent/EP2396033B1/en not_active Not-in-force
- 2010-02-03 WO PCT/US2010/022970 patent/WO2010093537A2/en not_active Ceased
- 2010-02-03 JP JP2011550155A patent/JP5818693B2/ja not_active Expired - Fee Related
- 2010-02-03 SG SG2014010185A patent/SG2014010185A/en unknown
- 2010-02-03 US US12/699,108 patent/US8613935B2/en not_active Expired - Fee Related
- 2010-02-03 CA CA 2752205 patent/CA2752205A1/en not_active Abandoned
- 2010-02-03 MX MX2011008497A patent/MX2011008497A/es active IP Right Grant
- 2010-02-03 CN CN2010800138806A patent/CN102361649A/zh active Pending
- 2010-02-03 BR BRPI1008549A patent/BRPI1008549A2/pt not_active IP Right Cessation
- 2010-02-03 RU RU2011137404/10A patent/RU2535970C2/ru not_active IP Right Cessation
- 2010-02-03 AU AU2010213966A patent/AU2010213966B2/en not_active Ceased
-
2011
- 2011-08-11 MX MX2013015094A patent/MX343411B/es unknown
-
2013
- 2013-11-21 US US14/086,902 patent/US9119812B2/en not_active Expired - Fee Related
-
2014
- 2014-10-08 RU RU2014140731A patent/RU2014140731A/ru not_active Application Discontinuation
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