JP2012516682A5 - - Google Patents
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- Publication number
- JP2012516682A5 JP2012516682A5 JP2011547047A JP2011547047A JP2012516682A5 JP 2012516682 A5 JP2012516682 A5 JP 2012516682A5 JP 2011547047 A JP2011547047 A JP 2011547047A JP 2011547047 A JP2011547047 A JP 2011547047A JP 2012516682 A5 JP2012516682 A5 JP 2012516682A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- vector according
- human adenovirus
- adenovirus vector
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 206010028980 Neoplasm Diseases 0.000 claims description 24
- 201000011510 cancer Diseases 0.000 claims description 16
- 206010009944 Colon cancer Diseases 0.000 claims description 6
- 208000003445 Mouth Neoplasms Diseases 0.000 claims description 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 6
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 6
- 201000002528 pancreatic cancer Diseases 0.000 claims description 6
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 6
- 206010005949 Bone cancer Diseases 0.000 claims description 4
- 208000018084 Bone neoplasm Diseases 0.000 claims description 4
- 208000003174 Brain Neoplasms Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 208000008839 Kidney Neoplasms Diseases 0.000 claims description 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 4
- 208000005890 Neuroma Diseases 0.000 claims description 4
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 4
- 206010038389 Renal cancer Diseases 0.000 claims description 4
- 206010039491 Sarcoma Diseases 0.000 claims description 4
- 201000000052 gastrinoma Diseases 0.000 claims description 4
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 4
- 201000010982 kidney cancer Diseases 0.000 claims description 4
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims description 4
- 201000007270 liver cancer Diseases 0.000 claims description 4
- 208000014018 liver neoplasm Diseases 0.000 claims description 4
- 201000005202 lung cancer Diseases 0.000 claims description 4
- 208000020816 lung neoplasm Diseases 0.000 claims description 4
- 206010038038 rectal cancer Diseases 0.000 claims description 4
- 201000001275 rectum cancer Diseases 0.000 claims description 4
- 206010061424 Anal cancer Diseases 0.000 claims description 2
- 208000007860 Anus Neoplasms Diseases 0.000 claims description 2
- 206010004272 Benign hydatidiform mole Diseases 0.000 claims description 2
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 206010006187 Breast cancer Diseases 0.000 claims description 2
- 208000026310 Breast neoplasm Diseases 0.000 claims description 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 2
- 208000005243 Chondrosarcoma Diseases 0.000 claims description 2
- 208000006332 Choriocarcinoma Diseases 0.000 claims description 2
- 206010014733 Endometrial cancer Diseases 0.000 claims description 2
- 206010014759 Endometrial neoplasm Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 208000006168 Ewing Sarcoma Diseases 0.000 claims description 2
- 201000008808 Fibrosarcoma Diseases 0.000 claims description 2
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims description 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims description 2
- 206010067807 Gingival cancer Diseases 0.000 claims description 2
- 206010018404 Glucagonoma Diseases 0.000 claims description 2
- 208000017604 Hodgkin disease Diseases 0.000 claims description 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims description 2
- 208000006937 Hydatidiform mole Diseases 0.000 claims description 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims description 2
- 206010061523 Lip and/or oral cavity cancer Diseases 0.000 claims description 2
- 206010062038 Lip neoplasm Diseases 0.000 claims description 2
- 206010073059 Malignant neoplasm of unknown primary site Diseases 0.000 claims description 2
- 208000032271 Malignant tumor of penis Diseases 0.000 claims description 2
- 208000015021 Meningeal Neoplasms Diseases 0.000 claims description 2
- 206010027406 Mesothelioma Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims description 2
- 206010029260 Neuroblastoma Diseases 0.000 claims description 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 208000010191 Osteitis Deformans Diseases 0.000 claims description 2
- 208000000035 Osteochondroma Diseases 0.000 claims description 2
- 206010033128 Ovarian cancer Diseases 0.000 claims description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 2
- 208000027868 Paget disease Diseases 0.000 claims description 2
- 208000000821 Parathyroid Neoplasms Diseases 0.000 claims description 2
- 208000002471 Penile Neoplasms Diseases 0.000 claims description 2
- 206010034299 Penile cancer Diseases 0.000 claims description 2
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims description 2
- 206010034811 Pharyngeal cancer Diseases 0.000 claims description 2
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims description 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 2
- 206010036832 Prolactinoma Diseases 0.000 claims description 2
- 206010060862 Prostate cancer Diseases 0.000 claims description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 2
- 201000000582 Retinoblastoma Diseases 0.000 claims description 2
- 208000004337 Salivary Gland Neoplasms Diseases 0.000 claims description 2
- 206010061934 Salivary gland cancer Diseases 0.000 claims description 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims description 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims description 2
- 206010041329 Somatostatinoma Diseases 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000000389 T-cell leukemia Diseases 0.000 claims description 2
- 208000028530 T-cell lymphoblastic leukemia/lymphoma Diseases 0.000 claims description 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims description 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims description 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims description 2
- 206010057644 Testis cancer Diseases 0.000 claims description 2
- 206010043515 Throat cancer Diseases 0.000 claims description 2
- 208000000728 Thymus Neoplasms Diseases 0.000 claims description 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims description 2
- 206010062129 Tongue neoplasm Diseases 0.000 claims description 2
- 208000006842 Tonsillar Neoplasms Diseases 0.000 claims description 2
- 208000023915 Ureteral Neoplasms Diseases 0.000 claims description 2
- 206010046392 Ureteric cancer Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims description 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims description 2
- 208000008383 Wilms tumor Diseases 0.000 claims description 2
- 201000008629 Zollinger-Ellison syndrome Diseases 0.000 claims description 2
- 201000005188 adrenal gland cancer Diseases 0.000 claims description 2
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims description 2
- 201000011165 anus cancer Diseases 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 201000010881 cervical cancer Diseases 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 208000029742 colonic neoplasm Diseases 0.000 claims description 2
- 210000000750 endocrine system Anatomy 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 208000024519 eye neoplasm Diseases 0.000 claims description 2
- 201000010175 gallbladder cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 208000015419 gastrin-producing neuroendocrine tumor Diseases 0.000 claims description 2
- 201000007116 gestational trophoblastic neoplasm Diseases 0.000 claims description 2
- 201000010235 heart cancer Diseases 0.000 claims description 2
- 208000024348 heart neoplasm Diseases 0.000 claims description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 2
- 206010022498 insulinoma Diseases 0.000 claims description 2
- 201000002313 intestinal cancer Diseases 0.000 claims description 2
- 201000006721 lip cancer Diseases 0.000 claims description 2
- 208000022006 malignant tumor of meninges Diseases 0.000 claims description 2
- 208000026037 malignant tumor of neck Diseases 0.000 claims description 2
- 208000026045 malignant tumor of parathyroid gland Diseases 0.000 claims description 2
- 208000027202 mammary Paget disease Diseases 0.000 claims description 2
- 201000001441 melanoma Diseases 0.000 claims description 2
- 206010027191 meningioma Diseases 0.000 claims description 2
- 201000005962 mycosis fungoides Diseases 0.000 claims description 2
- 201000008026 nephroblastoma Diseases 0.000 claims description 2
- 210000005036 nerve Anatomy 0.000 claims description 2
- 201000008106 ocular cancer Diseases 0.000 claims description 2
- 208000021255 pancreatic insulinoma Diseases 0.000 claims description 2
- 201000001219 parotid gland cancer Diseases 0.000 claims description 2
- 201000002628 peritoneum cancer Diseases 0.000 claims description 2
- 208000028591 pheochromocytoma Diseases 0.000 claims description 2
- 201000002511 pituitary cancer Diseases 0.000 claims description 2
- 201000003437 pleural cancer Diseases 0.000 claims description 2
- 208000030153 prolactin-producing pituitary gland adenoma Diseases 0.000 claims description 2
- 201000000849 skin cancer Diseases 0.000 claims description 2
- 201000002314 small intestine cancer Diseases 0.000 claims description 2
- 206010062261 spinal cord neoplasm Diseases 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 201000003120 testicular cancer Diseases 0.000 claims description 2
- 201000002510 thyroid cancer Diseases 0.000 claims description 2
- 201000006134 tongue cancer Diseases 0.000 claims description 2
- 208000029387 trophoblastic neoplasm Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 206010046766 uterine cancer Diseases 0.000 claims description 2
- 206010046885 vaginal cancer Diseases 0.000 claims description 2
- 208000013139 vaginal neoplasm Diseases 0.000 claims description 2
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims description 2
- 201000005102 vulva cancer Diseases 0.000 claims description 2
- 239000013598 vector Substances 0.000 claims 17
- 230000000174 oncolytic effect Effects 0.000 claims 11
- 241000598171 Human adenovirus sp. Species 0.000 claims 10
- 108700019146 Transgenes Proteins 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 4
- 108020004684 Internal Ribosome Entry Sites Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 108020004414 DNA Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 101000716693 Homo sapiens Sodium/iodide cotransporter Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 108010029697 CD40 Ligand Proteins 0.000 claims 1
- 102100032937 CD40 ligand Human genes 0.000 claims 1
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 206010047741 Vulval cancer Diseases 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 210000002808 connective tissue Anatomy 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 229960001388 interferon-beta Drugs 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000007918 intramuscular administration Methods 0.000 claims 1
- 239000007928 intraperitoneal injection Substances 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 102000003390 tumor necrosis factor Human genes 0.000 claims 1
- 241000701161 unidentified adenovirus Species 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 description 1
- 208000001894 Nasopharyngeal Neoplasms Diseases 0.000 description 1
- 206010044002 Tonsil cancer Diseases 0.000 description 1
- 201000010918 connective tissue cancer Diseases 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20090030 | 2009-02-02 | ||
| FI20090030A FI20090030A0 (fi) | 2009-02-02 | 2009-02-02 | Onkolyyttiset virukset |
| FI20095751 | 2009-07-02 | ||
| FI20095751A FI121574B (fi) | 2009-02-02 | 2009-07-02 | Ei-Ad5 adenovirusvektoreita ja niihin liittyviä menetelmiä ja käyttöjä |
| PCT/IB2010/050452 WO2010086838A2 (en) | 2009-02-02 | 2010-02-02 | Non-ad5 adenoviral vectors and methods and uses related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012516682A JP2012516682A (ja) | 2012-07-26 |
| JP2012516682A5 true JP2012516682A5 (enExample) | 2013-03-21 |
Family
ID=40404558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011547047A Pending JP2012516682A (ja) | 2009-02-02 | 2010-02-02 | 非Ａｄ５アデノウイルスベクター並びに前記に関連する方法および使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20120063995A1 (enExample) |
| EP (1) | EP2391722B1 (enExample) |
| JP (1) | JP2012516682A (enExample) |
| KR (1) | KR20110110371A (enExample) |
| CN (1) | CN102325887A (enExample) |
| AU (1) | AU2010209334A1 (enExample) |
| BR (1) | BRPI1008159A2 (enExample) |
| CA (1) | CA2750770A1 (enExample) |
| FI (2) | FI20090030A0 (enExample) |
| RU (1) | RU2011136280A (enExample) |
| SG (1) | SG173502A1 (enExample) |
| WO (1) | WO2010086838A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013006669A2 (pt) * | 2010-09-24 | 2019-09-24 | Oncos Therapeutics Oy | vetores adenovirais oncolíticos e métodos e usos relacionados aos mesmos |
| KR20210084651A (ko) * | 2013-04-18 | 2021-07-07 | 틸트 바이오세러퓨틱스 오이 | 향상된 입양 세포 치료 |
| US12421502B2 (en) | 2013-04-18 | 2025-09-23 | Tilt Biotherapeutics Oy | Enhanced adoptive cell therapy |
| CN104946602A (zh) * | 2015-06-11 | 2015-09-30 | 华中科技大学同济医学院附属同济医院 | 具有肿瘤组织靶向性和抑癌基因修复性的重组溶瘤腺病毒Ad5-P16及其应用 |
| EP3783032A1 (en) * | 2016-09-12 | 2021-02-24 | Targovax Oy | Combining adenovirus and checkpoint inhibitors for treating cancer |
| CN108261426B (zh) * | 2017-01-04 | 2019-04-05 | 杭州康万达医药科技有限公司 | 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用 |
| AU2018212017B2 (en) * | 2017-01-30 | 2024-11-28 | Epicentrx, Inc. | Tumor selective TATA -box and CAAT-box mutants |
| WO2019191494A1 (en) * | 2018-03-28 | 2019-10-03 | Epicentrx, Inc. | Personalized cancer vaccines |
| US12239666B2 (en) | 2018-06-19 | 2025-03-04 | H. Lee Moffitt Cancer Center And Research Institute, Inc. Inc. | Oncolytic virus or antigen presenting cell mediated cancer therapy using type I interferon and CD40-ligand |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1934253A (zh) * | 2003-07-18 | 2007-03-21 | 昂尼克斯药物公司 | 用于治疗疾病的b亚组腺病毒载体 |
| WO2005030261A1 (en) * | 2003-08-28 | 2005-04-07 | Cell Genesys, Inc. | Oncolytic adenoviral vectors encoding gm-csf |
| US7473418B2 (en) * | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
-
2009
- 2009-02-02 FI FI20090030A patent/FI20090030A0/fi not_active Application Discontinuation
- 2009-07-02 FI FI20095751A patent/FI121574B/fi not_active IP Right Cessation
-
2010
- 2010-02-02 WO PCT/IB2010/050452 patent/WO2010086838A2/en not_active Ceased
- 2010-02-02 SG SG2011055563A patent/SG173502A1/en unknown
- 2010-02-02 RU RU2011136280/10A patent/RU2011136280A/ru not_active Application Discontinuation
- 2010-02-02 CN CN2010800087768A patent/CN102325887A/zh active Pending
- 2010-02-02 US US13/147,288 patent/US20120063995A1/en not_active Abandoned
- 2010-02-02 BR BRPI1008159A patent/BRPI1008159A2/pt not_active IP Right Cessation
- 2010-02-02 JP JP2011547047A patent/JP2012516682A/ja active Pending
- 2010-02-02 CA CA2750770A patent/CA2750770A1/en not_active Abandoned
- 2010-02-02 AU AU2010209334A patent/AU2010209334A1/en not_active Abandoned
- 2010-02-02 EP EP10704194.9A patent/EP2391722B1/en not_active Not-in-force
- 2010-02-02 KR KR1020117020181A patent/KR20110110371A/ko not_active Withdrawn
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