CN112996909A - 表达pd-1结合蛋白的溶瘤病毒及其应用 - Google Patents
表达pd-1结合蛋白的溶瘤病毒及其应用 Download PDFInfo
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Abstract
提供了一种表达PD‑1结合蛋白的溶瘤病毒，即一种包含表达PD‑1单链抗体的融合蛋白的溶瘤腺病毒。
Description
PCT国内申请，说明书已公开。
Claims (13)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018112597859 | 2018-10-26 | ||
| CN201811259785.9A CN111100846A (zh) | 2018-10-26 | 2018-10-26 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
| PCT/CN2019/112905 WO2020083324A1 (zh) | 2018-10-26 | 2019-10-24 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112996909A true CN112996909A (zh) | 2021-06-18 |
| CN112996909B CN112996909B (zh) | 2023-07-25 |
Family
ID=70331867
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811259785.9A Pending CN111100846A (zh) | 2018-10-26 | 2018-10-26 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
| CN201980069838.7A Active CN112996909B (zh) | 2018-10-26 | 2019-10-24 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811259785.9A Pending CN111100846A (zh) | 2018-10-26 | 2018-10-26 | 表达pd-1结合蛋白的溶瘤病毒及其应用 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20210403564A1 (zh) |
| CN (2) | CN111100846A (zh) |
| WO (1) | WO2020083324A1 (zh) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114438128A (zh) * | 2020-10-30 | 2022-05-06 | 上海市公共卫生临床中心 | 一种增强型溶瘤腺病毒及其应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105111314A (zh) * | 2015-08-13 | 2015-12-02 | 成都百世博生物技术有限公司 | 一种新型融合蛋白、药物组合物及其制备方法和用途 |
| CN106699889A (zh) * | 2015-11-18 | 2017-05-24 | 礼进生物医药科技（上海）有限公司 | 抗pd-1抗体及其治疗用途 |
| CN108064305A (zh) * | 2017-03-24 | 2018-05-22 | 清华大学 | 可编程的溶瘤病毒疫苗系统及其应用 |
| CN108342366A (zh) * | 2017-01-25 | 2018-07-31 | 上海元宋生物技术有限公司 | 靶向癌症的重组溶瘤基因-腺病毒及其构建方法和应用 |
| CN108473977A (zh) * | 2015-08-10 | 2018-08-31 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE045108T2 (hu) * | 2014-07-16 | 2019-12-30 | Transgene Sa | Onkolitikus vírus immunellenõrzõpont-modulátorok expresszálására |
| EP3595715A1 (en) * | 2017-03-17 | 2020-01-22 | CureVac AG | Rna vaccine and immune checkpoint inhibitors for combined anticancer therapy |
-
2018
- 2018-10-26 CN CN201811259785.9A patent/CN111100846A/zh active Pending
-
2019
- 2019-10-24 CN CN201980069838.7A patent/CN112996909B/zh active Active
- 2019-10-24 WO PCT/CN2019/112905 patent/WO2020083324A1/zh active Application Filing
- 2019-10-24 US US17/288,006 patent/US20210403564A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108473977A (zh) * | 2015-08-10 | 2018-08-31 | 信达生物制药(苏州)有限公司 | Pd-1抗体 |
| CN105111314A (zh) * | 2015-08-13 | 2015-12-02 | 成都百世博生物技术有限公司 | 一种新型融合蛋白、药物组合物及其制备方法和用途 |
| CN106699889A (zh) * | 2015-11-18 | 2017-05-24 | 礼进生物医药科技（上海）有限公司 | 抗pd-1抗体及其治疗用途 |
| CN108342366A (zh) * | 2017-01-25 | 2018-07-31 | 上海元宋生物技术有限公司 | 靶向癌症的重组溶瘤基因-腺病毒及其构建方法和应用 |
| CN108064305A (zh) * | 2017-03-24 | 2018-05-22 | 清华大学 | 可编程的溶瘤病毒疫苗系统及其应用 |
Non-Patent Citations (1)
| Title |
|---|
| STACY J KOWALSKY等: "Superagonist IL-15-Armed Oncolytic Virus Elicits Potent Antitumor Immunity and Therapy That Are Enhanced with PD-1 Blockade", 《MOL THER.》 * |
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| Publication number | Publication date |
|---|---|
| WO2020083324A1 (zh) | 2020-04-30 |
| US20210403564A1 (en) | 2021-12-30 |
| CN112996909B (zh) | 2023-07-25 |
| CN111100846A (zh) | 2020-05-05 |
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