JP2012514622A5 - - Google Patents
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- JP2012514622A5 JP2012514622A5 JP2011544864A JP2011544864A JP2012514622A5 JP 2012514622 A5 JP2012514622 A5 JP 2012514622A5 JP 2011544864 A JP2011544864 A JP 2011544864A JP 2011544864 A JP2011544864 A JP 2011544864A JP 2012514622 A5 JP2012514622 A5 JP 2012514622A5
- Authority
- JP
- Japan
- Prior art keywords
- bis
- groups
- group
- conh
- formylazanediyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000000217 alkyl group Chemical group 0.000 claims 19
- 239000000203 mixture Substances 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 13
- -1 2-hydroxypropylene, 2,3-dihydroxybutylene, 2,4-dihydroxypentylene Chemical group 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 239000007983 Tris buffer Substances 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 229960001025 iohexol Drugs 0.000 claims 4
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims 4
- 125000004043 oxo group Chemical group O=* 0.000 claims 4
- YGQILMMZHDXGHE-UHFFFAOYSA-N 1-n,3-n-dimethylbenzene-1,3-dicarboxamide Chemical compound CNC(=O)C1=CC=CC(C(=O)NC)=C1 YGQILMMZHDXGHE-UHFFFAOYSA-N 0.000 claims 3
- QREROTGGGSPKLK-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)C(CO)CO QREROTGGGSPKLK-UHFFFAOYSA-N 0.000 claims 3
- 229960004647 iopamidol Drugs 0.000 claims 3
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 2
- ZBHRREMBEDMDEL-UHFFFAOYSA-N OC(CN(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)CC(CO)O)CO Chemical compound OC(CN(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)CC(CO)O)CO ZBHRREMBEDMDEL-UHFFFAOYSA-N 0.000 claims 2
- SYVULBKLQCIZNC-UHFFFAOYSA-N OC(CN(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)CC(CO)O)CO Chemical compound OC(CN(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)CC(CO)O)CO SYVULBKLQCIZNC-UHFFFAOYSA-N 0.000 claims 2
- CNCNGTBVZPAESI-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)C(CO)CO CNCNGTBVZPAESI-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004437 phosphorous atom Chemical class 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003463 sulfur Chemical class 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- TVCINXHQUODERO-UHFFFAOYSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(NC=O)=C(I)C(C(=O)NCC(O)CO)=C1I TVCINXHQUODERO-UHFFFAOYSA-N 0.000 claims 1
- OSQLMXLGIMLPBY-UHFFFAOYSA-N 3-N,1-bis(2,3-dihydroxypropyl)-2,4,6-triiodocyclohexa-3,5-diene-1,3-dicarboxamide Chemical compound OCC(O)CC1(C(=O)N)C(I)C(C(=O)NCC(O)CO)=C(I)C=C1I OSQLMXLGIMLPBY-UHFFFAOYSA-N 0.000 claims 1
- PCOGFUUOQLBHCL-UHFFFAOYSA-N 3-n-(2,3-dihydroxypropyl)-5-[[5-[3-(2,3-dihydroxypropylcarbamoyl)-n-formyl-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCCO)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCCO)C=2I)I)C=O)=C1I PCOGFUUOQLBHCL-UHFFFAOYSA-N 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims 1
- QRIVGJMYBYCWMT-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)C(CO)CO QRIVGJMYBYCWMT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 229960004108 iobitridol Drugs 0.000 claims 1
- YLPBXIKWXNRACS-UHFFFAOYSA-N iobitridol Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(NC(=O)C(CO)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I YLPBXIKWXNRACS-UHFFFAOYSA-N 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 229960000780 iomeprol Drugs 0.000 claims 1
- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical compound OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 claims 1
- 229960000824 iopentol Drugs 0.000 claims 1
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 claims 1
- 229960002603 iopromide Drugs 0.000 claims 1
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims 1
- 229960004537 ioversol Drugs 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09150292 | 2009-01-09 | ||
| EP09150292.2 | 2009-01-09 | ||
| PCT/EP2010/050118 WO2010079201A1 (en) | 2009-01-09 | 2010-01-08 | Contrast media compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012514622A JP2012514622A (ja) | 2012-06-28 |
| JP2012514622A5 true JP2012514622A5 (https=) | 2013-02-07 |
Family
ID=41650510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011544864A Pending JP2012514622A (ja) | 2009-01-09 | 2010-01-08 | 造影製剤組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110256068A1 (https=) |
| EP (1) | EP2385845A1 (https=) |
| JP (1) | JP2012514622A (https=) |
| CN (1) | CN102271715A (https=) |
| WO (1) | WO2010079201A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2566281C2 (ru) | 2010-07-12 | 2015-10-20 | ДжиИ Хелткер АС | Рентгеновская визуализация при низких концентрациях контрастного агента и/или низкой дозе излучения |
| WO2013041593A1 (en) | 2011-09-21 | 2013-03-28 | Ge Healthcare As | Packaging of contrast media |
| NO333914B1 (no) * | 2011-12-21 | 2013-10-21 | Ge Healthcare As | Stabilisering av diagnostisk røntgensammensetning |
| CN104114190A (zh) * | 2012-01-11 | 2014-10-22 | 通用电气医疗集团股份有限公司 | 具有低碘浓度的x-射线成像造影介质和x-射线成像方法 |
| US9355083B1 (en) * | 2015-02-06 | 2016-05-31 | Atlassian Pty Ltd | Systems and methods for generating an edit script |
| KR102447777B1 (ko) * | 2020-06-05 | 2022-09-28 | 서울대학교산학협력단 | 신규 폴리옥살레이트 유도체, 및 이를 포함하는 조영제 |
| CN113387832A (zh) * | 2021-05-25 | 2021-09-14 | 成都丽璟科技有限公司 | 一种高安全性的泛影酸衍生物造影剂及其制备方法 |
| CN119528755A (zh) * | 2024-11-21 | 2025-02-28 | 江西司太立制药有限公司 | 一种碘佛醇杂质及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (https=) | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| DE2909439A1 (de) | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| IT1193211B (it) | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| US4341756A (en) | 1980-01-31 | 1982-07-27 | The Regents Of The University Of California | Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media |
| DK160868C (da) * | 1982-11-08 | 1991-10-14 | Nyegaard & Co As | Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem |
| JPH0813794B2 (ja) | 1985-08-09 | 1996-02-14 | クツク イマジング，インコ−ポレイテイド | イオン性コントラスト媒体からの非イオン性ポリオ−ルコントラスト媒体 |
| US5035877A (en) | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
| US5043152A (en) | 1988-06-02 | 1991-08-27 | Guerbet S.A. | Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them |
| FR2634571B1 (fr) | 1988-07-19 | 1990-10-19 | Kodak Pathe | Procede d'organisation et de lecture d'un support magnetique et support en faisant application |
| GB9020091D0 (en) | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| IT1256248B (it) | 1992-12-24 | 1995-11-29 | Bracco Spa | Formulazioni iniettabili acquose per radiodiagnostica comprendenti miscele di composti aromatici iodurati utili come agenti opacizzanti ai raggi x |
| DE69524088T2 (de) | 1994-06-21 | 2002-08-29 | Mallinckrodt, Inc. | Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition |
| AU6114396A (en) * | 1995-06-16 | 1997-01-15 | Biophysica Foundation | Formyl derivatives as nonionic contrast media |
| GB9710726D0 (en) | 1997-05-23 | 1997-07-16 | Nycomed Imaging As | Compound |
| IT1319670B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'- |
| ATE529135T1 (de) * | 2004-03-11 | 2011-11-15 | Mallinckrodt Llc | Röntgenkontrastformulierung mit einem gemisch aus einem jodierten monomer und dimer |
| EP2178568B1 (en) * | 2007-07-12 | 2014-07-02 | Ge Healthcare As | Contrast agents |
| JP2011504939A (ja) * | 2007-11-07 | 2011-02-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
-
2010
- 2010-01-08 CN CN2010800044194A patent/CN102271715A/zh active Pending
- 2010-01-08 US US13/142,309 patent/US20110256068A1/en not_active Abandoned
- 2010-01-08 EP EP10700010A patent/EP2385845A1/en not_active Withdrawn
- 2010-01-08 WO PCT/EP2010/050118 patent/WO2010079201A1/en not_active Ceased
- 2010-01-08 JP JP2011544864A patent/JP2012514622A/ja active Pending
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