JP2009536943A5 - - Google Patents

Info

Publication number

JP2009536943A5

JP2009536943A5 JP2009509471A JP2009509471A JP2009536943A5 JP 2009536943 A5 JP2009536943 A5 JP 2009536943A5 JP 2009509471 A JP2009509471 A JP 2009509471A JP 2009509471 A JP2009509471 A JP 2009509471A JP 2009536943 A5 JP2009536943 A5 JP 2009536943A5

Authority

JP

Japan

Prior art keywords

bis

compound

same

different

formula

Prior art date

2007-05-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 24
• 125000000217 alkyl group Chemical group 0.000 claims 10
• 229910052757 nitrogen Inorganic materials 0.000 claims 9
• -1 2,3-dihydroxy-propyl Chemical group 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 239000001257 hydrogen Substances 0.000 claims 6
• 239000007983 Tris buffer Substances 0.000 claims 5
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
• 125000004043 oxo group Chemical group O=* 0.000 claims 4
• 229910052760 oxygen Inorganic materials 0.000 claims 4
• 239000001301 oxygen Substances 0.000 claims 4
• 150000001408 amides Chemical class 0.000 claims 3
• 125000003277 amino group Chemical group 0.000 claims 3
• 150000002148 esters Chemical class 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
• 229910052717 sulfur Inorganic materials 0.000 claims 3
• 239000011593 sulfur Substances 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000004432 carbon atom Chemical group C* 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
• 125000004430 oxygen atom Chemical group O* 0.000 claims 2
• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 125000004437 phosphorous atom Chemical class 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 150000003463 sulfur Chemical class 0.000 claims 2
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
• VPGQGHOERIZXSB-UHFFFAOYSA-N C.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I Chemical compound C.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I.C(C)NC(=O)NC1=C(C(=C(C(=C1I)C(=O)N1CCOCC1)I)C(=O)N1CCOCC1)I VPGQGHOERIZXSB-UHFFFAOYSA-N 0.000 claims 1
• RREKSIMMMBICCP-UHFFFAOYSA-N C.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO Chemical compound C.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO.OC(CN(C(C1=C(C(C(=O)N(C)CC(CO)O)=C(C(=C1I)NC(=O)NCC)I)I)=O)C)CO RREKSIMMMBICCP-UHFFFAOYSA-N 0.000 claims 1
• XLCIWNQXDBEQGS-UHFFFAOYSA-N C.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO Chemical compound C.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO.OC(CN(C(C1=C(C(C(=O)N(CC(CO)O)CC(CO)O)=C(C(=C1I)NC(=O)N(CCC)C)I)I)=O)CC(CO)O)CO XLCIWNQXDBEQGS-UHFFFAOYSA-N 0.000 claims 1
• HIKLBRQTOVWIGW-UHFFFAOYSA-N CC.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I Chemical compound CC.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I.CN(C)C(=O)Nc1c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c(I)c(C(=O)N(CC(O)CO)CC(O)CO)c1I HIKLBRQTOVWIGW-UHFFFAOYSA-N 0.000 claims 1
• MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
• OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
• 239000002872 contrast media Substances 0.000 claims 1
• 239000000032 diagnostic agent Substances 0.000 claims 1
• 229940039227 diagnostic agent Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• VNWKTOKETHGBQD-UHFFFAOYSA-N methane Natural products C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• TVYDQTKEQVEWQU-UHFFFAOYSA-N methyl n-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl]carbamate Chemical compound COC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I TVYDQTKEQVEWQU-UHFFFAOYSA-N 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1