JP5345523B2 - 造影剤 - Google Patents

造影剤 Download PDF

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Publication number
JP5345523B2
JP5345523B2 JP2009509471A JP2009509471A JP5345523B2 JP 5345523 B2 JP5345523 B2 JP 5345523B2 JP 2009509471 A JP2009509471 A JP 2009509471A JP 2009509471 A JP2009509471 A JP 2009509471A JP 5345523 B2 JP5345523 B2 JP 5345523B2
Authority
JP
Japan
Prior art keywords
triiodo
bis
propyl
dihydroxy
tris
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2009509471A
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English (en)
Japanese (ja)
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JP2009536943A (ja
JP2009536943A5 (https=
Inventor
ウィン，ダンカン
ワッズワース，ハリー
ニューウィングトン，イアン・マーティン
Original Assignee
ジーイー・ヘルスケア・アクスイェ・セルスカプ
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Publication of JP2009536943A5 publication Critical patent/JP2009536943A5/ja
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Publication of JP5345523B2 publication Critical patent/JP5345523B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2009509471A 2006-05-11 2007-05-10 造影剤 Expired - Fee Related JP5345523B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20062119 2006-05-11
NO20062119 2006-05-11
PCT/NO2007/000168 WO2007133088A1 (en) 2006-05-11 2007-05-10 Contrast agents

Publications (3)

Publication Number Publication Date
JP2009536943A JP2009536943A (ja) 2009-10-22
JP2009536943A5 JP2009536943A5 (https=) 2011-05-26
JP5345523B2 true JP5345523B2 (ja) 2013-11-20

Family

ID=38421447

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009509471A Expired - Fee Related JP5345523B2 (ja) 2006-05-11 2007-05-10 造影剤

Country Status (5)

Country Link
US (1) US8066974B2 (https=)
EP (1) EP2016046B1 (https=)
JP (1) JP5345523B2 (https=)
ES (1) ES2390494T3 (https=)
WO (1) WO2007133088A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140003687A1 (en) * 2011-01-14 2014-01-02 Baylor College Of Medicine Method and system for evaluating hemodynamics of a blood vessel
CN105017063B (zh) * 2014-04-18 2018-11-20 沈阳中海生物技术开发有限公司 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物
CN108752230B (zh) * 2018-07-12 2020-11-03 浙江海洲制药有限公司 一种造影剂碘克沙醇杂质e的关键中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207465A1 (es) * 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
US4109081A (en) * 1975-05-15 1978-08-22 Mallinckrodt, Inc. 1-(3,5-disubstituted-2,4,6-triiodophenyl)-3-(polyhydroxy-alkyl)urea compounds
FR2703055B1 (fr) * 1993-03-22 1995-07-07 Guerbet Sa Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
IT1264690B1 (it) * 1993-07-08 1996-10-04 Bracco Spa Compositi oligomeri iodurati e composizioni diagnostiche contenenti gli stessi
WO1996009280A1 (fr) * 1994-09-22 1996-03-28 Guerbet S.A. Composes polyiodes, leur preparation et leur application en radiologie x
GB9419203D0 (en) * 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media

Also Published As

Publication number Publication date
US8066974B2 (en) 2011-11-29
WO2007133088A1 (en) 2007-11-22
US20090136425A1 (en) 2009-05-28
ES2390494T3 (es) 2012-11-13
JP2009536943A (ja) 2009-10-22
EP2016046B1 (en) 2012-07-11
EP2016046A1 (en) 2009-01-21

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