JP2011500770A5 - - Google Patents
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- Publication number
- JP2011500770A5 JP2011500770A5 JP2010530487A JP2010530487A JP2011500770A5 JP 2011500770 A5 JP2011500770 A5 JP 2011500770A5 JP 2010530487 A JP2010530487 A JP 2010530487A JP 2010530487 A JP2010530487 A JP 2010530487A JP 2011500770 A5 JP2011500770 A5 JP 2011500770A5
- Authority
- JP
- Japan
- Prior art keywords
- bis
- group
- dihydroxypropyl
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 19
- -1 N-substituted urea group Chemical group 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 10
- KGENISXXKJIIGQ-UHFFFAOYSA-N [3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodophenyl]carbamic acid Chemical compound OCC(O)CNC(=O)C1=C(I)C(NC(O)=O)=C(I)C(C(=O)NCC(O)CO)=C1I KGENISXXKJIIGQ-UHFFFAOYSA-N 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- 238000003384 imaging method Methods 0.000 claims 3
- NARVIWMVBMUEOG-UHFFFAOYSA-N 2-Hydroxy-propylene Natural products CC(O)=C NARVIWMVBMUEOG-UHFFFAOYSA-N 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- JOYRKODLDBILNP-UHFFFAOYSA-N urethane group Chemical group NC(=O)OCC JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims 2
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 1
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 claims 1
- KJFCRDWRVOFQHN-UHFFFAOYSA-N [3-[bis(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodophenyl]carbamic acid Chemical compound OCC(O)CN(CC(O)CO)C(=O)C1=C(I)C=C(I)C(NC(O)=O)=C1I KJFCRDWRVOFQHN-UHFFFAOYSA-N 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 239000004202 carbamide Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- QZUPTXGVPYNUIT-UHFFFAOYSA-N isophthalamide Chemical compound NC(=O)C1=CC=CC(C(N)=O)=C1 QZUPTXGVPYNUIT-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000004437 phosphorous atom Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 150000003463 sulfur Chemical class 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N urea group Chemical group NC(=O)N XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20075474 | 2007-10-30 | ||
| PCT/EP2008/064632 WO2009056555A1 (en) | 2007-10-30 | 2008-10-29 | Contrast agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011500770A JP2011500770A (ja) | 2011-01-06 |
| JP2011500770A5 true JP2011500770A5 (https=) | 2012-12-06 |
Family
ID=40201831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010530487A Pending JP2011500770A (ja) | 2007-10-30 | 2008-10-29 | 造影剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8551449B2 (https=) |
| EP (1) | EP2203190A1 (https=) |
| JP (1) | JP2011500770A (https=) |
| CN (1) | CN101842120A (https=) |
| WO (1) | WO2009056555A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105017063B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 5-氨基-2,4,6-三碘间苯二甲酸衍生物及其盐、水合物或溶剂化物 |
| CN105001114B (zh) * | 2014-04-18 | 2018-11-20 | 沈阳中海生物技术开发有限公司 | 制备碘普罗胺的新方法 |
| EP3548531B1 (en) * | 2016-12-02 | 2023-06-28 | The Texas A&M University System | Chemically modified shape memory polymer embolic foams with increased x-ray visualization |
| CN116813495A (zh) * | 2023-06-16 | 2023-09-29 | 上海慧聚药业有限公司 | 合成碘克沙醇 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2628517C2 (de) * | 1976-06-23 | 1985-02-21 | Schering AG, 1000 Berlin und 4709 Bergkamen | Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel |
| IT1245853B (it) * | 1990-11-16 | 1994-10-25 | Bracco Spa | 1,3-bis(3-(mono o poliidrossi)acilamino-5-(mono o poliidrossi-alchil) aminocarbonil-2,4,6-triiodo-benzoil-amino)-idrossi- o idrossi-alchil- propani, loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono |
| GB9419206D0 (en) * | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| PT1435935E (pt) * | 2001-10-12 | 2009-12-29 | Lasser Family Partnership L P | Meios de contraste de raios-x concentrados podem actuar como antigénios universais e podem inibir ou prevenir reacções alérgicas |
-
2008
- 2008-10-29 EP EP08844863A patent/EP2203190A1/en not_active Withdrawn
- 2008-10-29 WO PCT/EP2008/064632 patent/WO2009056555A1/en not_active Ceased
- 2008-10-29 CN CN200880114820A patent/CN101842120A/zh active Pending
- 2008-10-29 US US12/739,977 patent/US8551449B2/en not_active Expired - Fee Related
- 2008-10-29 JP JP2010530487A patent/JP2011500770A/ja active Pending
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