JP2012514622A - 造影製剤組成物 - Google Patents
造影製剤組成物 Download PDFInfo
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- JP2012514622A JP2012514622A JP2011544864A JP2011544864A JP2012514622A JP 2012514622 A JP2012514622 A JP 2012514622A JP 2011544864 A JP2011544864 A JP 2011544864A JP 2011544864 A JP2011544864 A JP 2011544864A JP 2012514622 A JP2012514622 A JP 2012514622A
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- Prior art keywords
- bis
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- alkyl
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- 239000000203 mixture Substances 0.000 title claims abstract description 105
- 238000002360 preparation method Methods 0.000 title claims abstract description 36
- 150000001875 compounds Chemical class 0.000 claims abstract description 116
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229910052740 iodine Inorganic materials 0.000 claims abstract description 38
- 239000011630 iodine Substances 0.000 claims abstract description 38
- 239000002872 contrast media Substances 0.000 claims abstract description 32
- 230000002708 enhancing effect Effects 0.000 claims abstract description 11
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 52
- 229910052739 hydrogen Inorganic materials 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 26
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 22
- -1 2-hydroxypropylene, 2,3-dihydroxybutylene, 2,4-dihydroxypentylene Chemical group 0.000 claims description 21
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
- XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 claims description 17
- 229960004647 iopamidol Drugs 0.000 claims description 16
- 239000007983 Tris buffer Substances 0.000 claims description 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 13
- 125000002947 alkylene group Chemical group 0.000 claims description 10
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 claims description 10
- 229960001025 iohexol Drugs 0.000 claims description 9
- 150000001408 amides Chemical class 0.000 claims description 8
- 125000004043 oxo group Chemical group O=* 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- 125000003277 amino group Chemical group 0.000 claims description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- ZBHRREMBEDMDEL-UHFFFAOYSA-N OC(CN(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)CC(CO)O)CO Chemical compound OC(CN(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)CC(CO)O)CO ZBHRREMBEDMDEL-UHFFFAOYSA-N 0.000 claims description 5
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 5
- 229960000780 iomeprol Drugs 0.000 claims description 5
- NJKDOADNQSYQEV-UHFFFAOYSA-N iomeprol Chemical compound OCC(=O)N(C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NJKDOADNQSYQEV-UHFFFAOYSA-N 0.000 claims description 5
- 229910052760 oxygen Inorganic materials 0.000 claims description 5
- 239000001301 oxygen Substances 0.000 claims description 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 5
- TVCINXHQUODERO-UHFFFAOYSA-N 1-n,3-n-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(NC=O)=C(I)C(C(=O)NCC(O)CO)=C1I TVCINXHQUODERO-UHFFFAOYSA-N 0.000 claims description 4
- AMDBBAQNWSUWGN-UHFFFAOYSA-N Ioversol Chemical compound OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I AMDBBAQNWSUWGN-UHFFFAOYSA-N 0.000 claims description 4
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- 125000004437 phosphorous atom Chemical class 0.000 claims description 4
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 3
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- YLPBXIKWXNRACS-UHFFFAOYSA-N iobitridol Chemical compound OCC(O)CN(C)C(=O)C1=C(I)C(NC(=O)C(CO)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I YLPBXIKWXNRACS-UHFFFAOYSA-N 0.000 claims description 3
- 229960000824 iopentol Drugs 0.000 claims description 3
- IUNJANQVIJDFTQ-UHFFFAOYSA-N iopentol Chemical compound COCC(O)CN(C(C)=O)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I IUNJANQVIJDFTQ-UHFFFAOYSA-N 0.000 claims description 3
- 229960002603 iopromide Drugs 0.000 claims description 3
- DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000000524 functional group Chemical group 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 claims description 2
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- 125000004434 sulfur atom Chemical group 0.000 claims description 2
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 2
- YGQILMMZHDXGHE-UHFFFAOYSA-N 1-n,3-n-dimethylbenzene-1,3-dicarboxamide Chemical compound CNC(=O)C1=CC=CC(C(=O)NC)=C1 YGQILMMZHDXGHE-UHFFFAOYSA-N 0.000 claims 3
- QREROTGGGSPKLK-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NC(CO)CO)=C(C=C1I)I)I)=O)C(CO)CO QREROTGGGSPKLK-UHFFFAOYSA-N 0.000 claims 3
- SYVULBKLQCIZNC-UHFFFAOYSA-N OC(CN(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)CC(CO)O)CO Chemical compound OC(CN(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)CC(CO)O)CO SYVULBKLQCIZNC-UHFFFAOYSA-N 0.000 claims 2
- CNCNGTBVZPAESI-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCC(CO)O)=C(C=C1I)I)I)=O)C(CO)CO CNCNGTBVZPAESI-UHFFFAOYSA-N 0.000 claims 2
- CIUUPJHGWDRPKJ-UHFFFAOYSA-N 2,4,5-triiodobenzene-1,3-dicarboxamide Chemical compound NC(=O)C1=CC(I)=C(I)C(C(N)=O)=C1I CIUUPJHGWDRPKJ-UHFFFAOYSA-N 0.000 claims 1
- OSQLMXLGIMLPBY-UHFFFAOYSA-N 3-N,1-bis(2,3-dihydroxypropyl)-2,4,6-triiodocyclohexa-3,5-diene-1,3-dicarboxamide Chemical compound OCC(O)CC1(C(=O)N)C(I)C(C(=O)NCC(O)CO)=C(I)C=C1I OSQLMXLGIMLPBY-UHFFFAOYSA-N 0.000 claims 1
- PCOGFUUOQLBHCL-UHFFFAOYSA-N 3-n-(2,3-dihydroxypropyl)-5-[[5-[3-(2,3-dihydroxypropylcarbamoyl)-n-formyl-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodoanilino]-2,4-dihydroxypentyl]-formylamino]-1-n-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)NCCO)=C(I)C(N(CC(O)CC(O)CN(C=O)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(=O)NCCO)C=2I)I)C=O)=C1I PCOGFUUOQLBHCL-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- QRIVGJMYBYCWMT-UHFFFAOYSA-N OCC(CO)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)C(CO)CO Chemical compound OCC(CO)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)N(C=O)N(C(C1=C(C(C(=O)NCCO)=C(C=C1I)I)I)=O)C(CO)CO QRIVGJMYBYCWMT-UHFFFAOYSA-N 0.000 claims 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims 1
- 230000003204 osmotic effect Effects 0.000 abstract description 21
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 5
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- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- DLPPIGPJCKKVBA-UHFFFAOYSA-N Iosimenol Chemical compound OCC(O)CNC(=O)C1=C(I)C(C(=O)N)=C(I)C(N(CC(O)CO)C(=O)CC(=O)N(CC(O)CO)C=2C(=C(C(=O)NCC(O)CO)C(I)=C(C(N)=O)C=2I)I)=C1I DLPPIGPJCKKVBA-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 235000010724 Wisteria floribunda Nutrition 0.000 description 1
- 125000004036 acetal group Chemical group 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000006136 alcoholysis reaction Methods 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 description 1
- YVPYQUNUQOZFHG-UHFFFAOYSA-N amidotrizoic acid Chemical compound CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C(O)=O)=C1I YVPYQUNUQOZFHG-UHFFFAOYSA-N 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 150000001491 aromatic compounds Chemical class 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 125000005279 aryl sulfonyloxy group Chemical group 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 230000007321 biological mechanism Effects 0.000 description 1
- NJMLSGAKXLDYKJ-UHFFFAOYSA-N bis(oxiran-2-yl)methanol Chemical compound C1OC1C(O)C1CO1 NJMLSGAKXLDYKJ-UHFFFAOYSA-N 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229940039231 contrast media Drugs 0.000 description 1
- 238000002586 coronary angiography Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229960005223 diatrizoic acid Drugs 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000022244 formylation Effects 0.000 description 1
- 238000006170 formylation reaction Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000000815 hypotonic solution Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 150000002497 iodine compounds Chemical class 0.000 description 1
- 125000006303 iodophenyl group Chemical group 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000005905 mesyloxy group Chemical group 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 125000004355 nitrogen functional group Chemical group 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004237 preparative chromatography Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000005424 tosyloxy group Chemical group S(=O)(=O)(C1=CC=C(C)C=C1)O* 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09150292 | 2009-01-09 | ||
| EP09150292.2 | 2009-01-09 | ||
| PCT/EP2010/050118 WO2010079201A1 (en) | 2009-01-09 | 2010-01-08 | Contrast media compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012514622A true JP2012514622A (ja) | 2012-06-28 |
| JP2012514622A5 JP2012514622A5 (https=) | 2013-02-07 |
Family
ID=41650510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011544864A Pending JP2012514622A (ja) | 2009-01-09 | 2010-01-08 | 造影製剤組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110256068A1 (https=) |
| EP (1) | EP2385845A1 (https=) |
| JP (1) | JP2012514622A (https=) |
| CN (1) | CN102271715A (https=) |
| WO (1) | WO2010079201A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2566281C2 (ru) | 2010-07-12 | 2015-10-20 | ДжиИ Хелткер АС | Рентгеновская визуализация при низких концентрациях контрастного агента и/или низкой дозе излучения |
| WO2013041593A1 (en) | 2011-09-21 | 2013-03-28 | Ge Healthcare As | Packaging of contrast media |
| NO333914B1 (no) * | 2011-12-21 | 2013-10-21 | Ge Healthcare As | Stabilisering av diagnostisk røntgensammensetning |
| CN104114190A (zh) * | 2012-01-11 | 2014-10-22 | 通用电气医疗集团股份有限公司 | 具有低碘浓度的x-射线成像造影介质和x-射线成像方法 |
| US9355083B1 (en) * | 2015-02-06 | 2016-05-31 | Atlassian Pty Ltd | Systems and methods for generating an edit script |
| KR102447777B1 (ko) * | 2020-06-05 | 2022-09-28 | 서울대학교산학협력단 | 신규 폴리옥살레이트 유도체, 및 이를 포함하는 조영제 |
| CN113387832A (zh) * | 2021-05-25 | 2021-09-14 | 成都丽璟科技有限公司 | 一种高安全性的泛影酸衍生物造影剂及其制备方法 |
| CN119528755A (zh) * | 2024-11-21 | 2025-02-28 | 江西司太立制药有限公司 | 一种碘佛醇杂质及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08505134A (ja) * | 1992-12-24 | 1996-06-04 | ブラッコ エッセ．ピ．ア． | レントゲン撮影造影剤としてヨウ化芳香族化合物を使用する放射線診断用注射剤水溶液 |
| JPH11502231A (ja) * | 1995-06-16 | 1999-02-23 | バイオフィジィカ インコーポレイティド | 非イオン性造影剤としてのホルミル誘導体 |
| JP2007528424A (ja) * | 2004-03-11 | 2007-10-11 | マリンクロッド・インコーポレイテッド | ヨウ化単量体および二量体の混合物を含むｘ線造影剤製剤 |
| JP5340281B2 (ja) * | 2007-07-12 | 2013-11-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH608189A5 (https=) | 1974-12-13 | 1978-12-29 | Savac Ag | |
| GB1548594A (en) | 1976-06-11 | 1979-07-18 | Nyegaard & Co As | Triiodoisophthalic acid amides |
| DE2909439A1 (de) | 1979-03-08 | 1980-09-18 | Schering Ag | Neue nichtionische roentgenkontrastmittel |
| IT1193211B (it) | 1979-08-09 | 1988-06-15 | Bracco Ind Chimica Spa | Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono |
| US4341756A (en) | 1980-01-31 | 1982-07-27 | The Regents Of The University Of California | Novel amino-dioxepane intermediates for the synthesis of new non-ionic contrast media |
| DK160868C (da) * | 1982-11-08 | 1991-10-14 | Nyegaard & Co As | Trijodfenylderivater, fremgangsmaader til fremstilling deraf og radiologisk praeparat indeholdende dem |
| JPH0813794B2 (ja) | 1985-08-09 | 1996-02-14 | クツク イマジング，インコ−ポレイテイド | イオン性コントラスト媒体からの非イオン性ポリオ−ルコントラスト媒体 |
| US5035877A (en) | 1985-08-09 | 1991-07-30 | Cook Imaging Corporation | Non-ionic contrast media from ionic contrast media |
| US5043152A (en) | 1988-06-02 | 1991-08-27 | Guerbet S.A. | Novel iodinated non-ionic triiodobenzene compounds and contrast media containing them |
| FR2634571B1 (fr) | 1988-07-19 | 1990-10-19 | Kodak Pathe | Procede d'organisation et de lecture d'un support magnetique et support en faisant application |
| GB9020091D0 (en) | 1990-09-14 | 1990-10-24 | Nycomed As | Contrast media |
| DE69524088T2 (de) | 1994-06-21 | 2002-08-29 | Mallinckrodt, Inc. | Verbesserte synthese von ioversol unter verwendung einer mit phosphorsäure modifizierten koaddition |
| GB9710726D0 (en) | 1997-05-23 | 1997-07-16 | Nycomed Imaging As | Compound |
| IT1319670B1 (it) | 2000-12-01 | 2003-10-23 | Bracco Spa | Processo per la preparazione di 5-ammino-n,n'-bis(2-idrossi-1-(idrossimetil)etil))-1,3-benzendicarbossammide (i) e 5-ammino-n,n'- |
| JP2011504939A (ja) * | 2007-11-07 | 2011-02-17 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
-
2010
- 2010-01-08 CN CN2010800044194A patent/CN102271715A/zh active Pending
- 2010-01-08 US US13/142,309 patent/US20110256068A1/en not_active Abandoned
- 2010-01-08 EP EP10700010A patent/EP2385845A1/en not_active Withdrawn
- 2010-01-08 WO PCT/EP2010/050118 patent/WO2010079201A1/en not_active Ceased
- 2010-01-08 JP JP2011544864A patent/JP2012514622A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08505134A (ja) * | 1992-12-24 | 1996-06-04 | ブラッコ エッセ．ピ．ア． | レントゲン撮影造影剤としてヨウ化芳香族化合物を使用する放射線診断用注射剤水溶液 |
| JPH11502231A (ja) * | 1995-06-16 | 1999-02-23 | バイオフィジィカ インコーポレイティド | 非イオン性造影剤としてのホルミル誘導体 |
| JP2007528424A (ja) * | 2004-03-11 | 2007-10-11 | マリンクロッド・インコーポレイテッド | ヨウ化単量体および二量体の混合物を含むｘ線造影剤製剤 |
| JP5340281B2 (ja) * | 2007-07-12 | 2013-11-13 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 造影剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010079201A1 (en) | 2010-07-15 |
| US20110256068A1 (en) | 2011-10-20 |
| EP2385845A1 (en) | 2011-11-16 |
| CN102271715A (zh) | 2011-12-07 |
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