JP2012513467A5 - - Google Patents

Info

Publication number

JP2012513467A5

JP2012513467A5 JP2011543601A JP2011543601A JP2012513467A5 JP 2012513467 A5 JP2012513467 A5 JP 2012513467A5 JP 2011543601 A JP2011543601 A JP 2011543601A JP 2011543601 A JP2011543601 A JP 2011543601A JP 2012513467 A5 JP2012513467 A5 JP 2012513467A5

Authority

JP

Japan

Prior art keywords

resistant

bacterium

pharmaceutical composition

clostridium difficile

antibiotic

Prior art date

2009-12-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 241000894006 Bacteria Species 0.000 claims 16
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 241000193163 Clostridioides difficile Species 0.000 claims 10
• 108010013198 Daptomycin Proteins 0.000 claims 8
• 230000003115 biocidal effect Effects 0.000 claims 8
• 229960005484 daptomycin Drugs 0.000 claims 8
• DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical group C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims 8
• 208000035143 Bacterial infection Diseases 0.000 claims 6
• 208000022362 bacterial infectious disease Diseases 0.000 claims 6
• 102100021324 5-azacytidine-induced protein 2 Human genes 0.000 claims 4
• 101710172419 5-azacytidine-induced protein 2 Proteins 0.000 claims 4
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 4
• 241000191967 Staphylococcus aureus Species 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 201000010099 disease Diseases 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 229960003085 meticillin Drugs 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 claims 3
• 208000037384 Clostridium Infections Diseases 0.000 claims 2
• 206010009657 Clostridium difficile colitis Diseases 0.000 claims 2
• 206010054236 Clostridium difficile infection Diseases 0.000 claims 2
• 241001465754 Metazoa Species 0.000 claims 2
• 229930182555 Penicillin Natural products 0.000 claims 2
• JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 2
• 108010059993 Vancomycin Proteins 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 238000004113 cell culture Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 229940049954 penicillin Drugs 0.000 claims 2
• 239000003910 polypeptide antibiotic agent Substances 0.000 claims 2
• 229960003165 vancomycin Drugs 0.000 claims 2
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 2
• 241000282412 Homo Species 0.000 claims 1
• 241000194017 Streptococcus Species 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 0 C*(C)c(cc1)ccc1C(C)=CC(C)=O Chemical compound C*(C)c(cc1)ccc1C(C)=CC(C)=O 0.000 description 1