JP2012512909A5 - - Google Patents
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- JP2012512909A5 JP2012512909A5 JP2011542518A JP2011542518A JP2012512909A5 JP 2012512909 A5 JP2012512909 A5 JP 2012512909A5 JP 2011542518 A JP2011542518 A JP 2011542518A JP 2011542518 A JP2011542518 A JP 2011542518A JP 2012512909 A5 JP2012512909 A5 JP 2012512909A5
- Authority
- JP
- Japan
- Prior art keywords
- umbilical cord
- cell population
- cord tissue
- derived
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims description 41
- 210000001519 tissue Anatomy 0.000 claims description 36
- 210000003954 umbilical cord Anatomy 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 20
- 108010017842 Telomerase Proteins 0.000 claims description 10
- 210000004369 blood Anatomy 0.000 claims description 9
- 239000008280 blood Substances 0.000 claims description 9
- 208000004296 neuralgia Diseases 0.000 claims description 7
- 208000021722 neuropathic pain Diseases 0.000 claims description 7
- 208000002193 Pain Diseases 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 208000028389 Nerve injury Diseases 0.000 claims description 2
- 230000008764 nerve damage Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 16
- 239000003085 diluting agent Substances 0.000 claims 7
- 229940079593 drug Drugs 0.000 claims 7
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- 239000003795 chemical substances by application Substances 0.000 claims 4
- 229950003499 fibrin Drugs 0.000 claims 4
- 208000000094 Chronic Pain Diseases 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 102000008186 Collagen Human genes 0.000 claims 3
- 206010010904 Convulsion Diseases 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 230000036461 convulsion Effects 0.000 claims 3
- 239000000017 hydrogel Substances 0.000 claims 3
- 108010073385 Fibrin Proteins 0.000 claims 2
- 102000009123 Fibrin Human genes 0.000 claims 2
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 239000012062 aqueous buffer Substances 0.000 claims 2
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- 238000003752 polymerase chain reaction Methods 0.000 description 4
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- 210000002950 fibroblast Anatomy 0.000 description 2
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- 102100034608 Angiopoietin-2 Human genes 0.000 description 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 description 1
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- 102000029816 Collagenase Human genes 0.000 description 1
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- 101710115997 Gamma-tubulin complex component 2 Proteins 0.000 description 1
- 102400001369 Heparin-binding EGF-like growth factor Human genes 0.000 description 1
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 description 1
- 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 description 1
- 101001066129 Homo sapiens Glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 1
- 101000669513 Homo sapiens Metalloproteinase inhibitor 1 Proteins 0.000 description 1
- 101000830570 Homo sapiens Tumor necrosis factor alpha-induced protein 3 Proteins 0.000 description 1
- 101000955962 Homo sapiens Vacuolar protein sorting-associated protein 51 homolog Proteins 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 102000001974 Hyaluronidases Human genes 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102100022647 Reticulon-1 Human genes 0.000 description 1
- 101710122684 Reticulon-1 Proteins 0.000 description 1
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 description 1
- 206010043276 Teratoma Diseases 0.000 description 1
- 102000011117 Transforming Growth Factor beta2 Human genes 0.000 description 1
- 101800000304 Transforming growth factor beta-2 Proteins 0.000 description 1
- 102100024596 Tumor necrosis factor alpha-induced protein 3 Human genes 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 210000002798 bone marrow cell Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000005779 cell damage Effects 0.000 description 1
- 208000037887 cell injury Diseases 0.000 description 1
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- 210000000349 chromosome Anatomy 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
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- 102000038379 digestive enzymes Human genes 0.000 description 1
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- 239000001963 growth medium Substances 0.000 description 1
- 102000047486 human GAPDH Human genes 0.000 description 1
- 229960002773 hyaluronidase Drugs 0.000 description 1
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 description 1
- 229940096397 interleukin-8 Drugs 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 230000007433 nerve pathway Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 108010057210 telomerase RNA Proteins 0.000 description 1
- 230000002381 testicular Effects 0.000 description 1
- 238000005382 thermal cycling Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13916908P | 2008-12-19 | 2008-12-19 | |
| US61/139,169 | 2008-12-19 | ||
| PCT/US2009/068879 WO2010071862A1 (en) | 2008-12-19 | 2009-12-19 | Umbilical cord tissue derived cells for treating neuropathic pain and spasticity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512909A JP2012512909A (ja) | 2012-06-07 |
| JP2012512909A5 true JP2012512909A5 (enExample) | 2012-07-19 |
| JP5646502B2 JP5646502B2 (ja) | 2014-12-24 |
Family
ID=41682583
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542518A Expired - Fee Related JP5646502B2 (ja) | 2008-12-19 | 2009-12-19 | 神経因性疼痛を治療するための臍帯組織由来細胞 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20190105351A9 (enExample) |
| EP (1) | EP2379087B1 (enExample) |
| JP (1) | JP5646502B2 (enExample) |
| CN (1) | CN102481321B (enExample) |
| AU (1) | AU2009327382B2 (enExample) |
| BR (1) | BRPI0923177A2 (enExample) |
| CA (1) | CA2747757C (enExample) |
| CY (1) | CY1116344T1 (enExample) |
| DK (1) | DK2379087T3 (enExample) |
| ES (1) | ES2520393T3 (enExample) |
| PT (1) | PT2379087E (enExample) |
| SI (1) | SI2379087T1 (enExample) |
| WO (1) | WO2010071862A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| ES2569780T3 (es) | 2003-06-27 | 2016-05-12 | DePuy Synthes Products, Inc. | Células posparto derivadas de tejido placentario y métodos de preparación y uso de las mismas |
| US8491883B2 (en) * | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| JP5505760B2 (ja) | 2005-09-27 | 2014-05-28 | ティッシュテク・インコーポレーテッド | 羊膜調製物及び精製組成物及びその使用方法 |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| ES2524443T3 (es) | 2006-11-13 | 2014-12-09 | DePuy Synthes Products, LLC | Expansión in vitro de células postparto usando microportadores |
| EP2203186B1 (en) * | 2007-10-05 | 2014-09-24 | DePuy Synthes Products, LLC | Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| US10557116B2 (en) | 2008-12-19 | 2020-02-11 | DePuy Synthes Products, Inc. | Treatment of lung and pulmonary diseases and disorders |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| PL2411504T3 (pl) | 2009-03-26 | 2017-10-31 | Depuy Synthes Products Inc | Komórki ludzkiej tkanki pępowinowej jako terapia choroby Alzheimera |
| US9526770B2 (en) | 2011-04-28 | 2016-12-27 | Tissuetech, Inc. | Methods of modulating bone remodeling |
| DK2714059T3 (en) * | 2011-06-01 | 2019-01-21 | Celularity Inc | TREATMENT OF PAIN WHEN USING PLACENT STAM CELLS |
| RU2576836C2 (ru) * | 2011-08-10 | 2016-03-10 | Депуи Синтез Продактс, Инк. | Лечение заболевания периферических сосудов при помощи клеток, полученных из ткани пуповины |
| JP2015521630A (ja) * | 2012-06-26 | 2015-07-30 | ラスティー プロパティー ホールディングス プロプライエタリー リミテッド | 頭痛の頻度および／または重症度を下げるための組成物および方法 |
| EP2756754B1 (de) | 2013-01-17 | 2017-01-04 | Vita 34 Ag | Verfahren zur Behandlung von Nabelschnurgewebe, insbesondere im Zusammenhang mit der Konservierung des Gewebes |
| US10039792B1 (en) * | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
| TW201603818A (zh) | 2014-06-03 | 2016-02-01 | 組織科技股份有限公司 | 組成物及方法 |
| US20170224736A1 (en) * | 2014-07-29 | 2017-08-10 | Ingeneron, Inc. | Method and apparatus for recovery of umbilical cord tissue derived regenerative cells and uses thereof |
| US20160243288A1 (en) | 2015-02-23 | 2016-08-25 | Tissuetech, Inc. | Apparatuses and methods for treating ophthalmic diseases and disorders |
| US12551509B2 (en) | 2015-11-18 | 2026-02-17 | Lucina Patent Holdco, Llc | Acellular regenerative products and methods of their manufacture |
| CN106906180A (zh) * | 2016-12-28 | 2017-06-30 | 里程 | 一种具有生物活化作用的复合添加剂及其制备方法和用途 |
| WO2019213518A1 (en) * | 2018-05-04 | 2019-11-07 | Figene, Llc | Pain-reducing effects of fibroblasts and treatment of pain |
| CN110772535A (zh) * | 2018-07-12 | 2020-02-11 | 南通大学 | 多系分化持续应激细胞在制备镇痛药物中的应用 |
| EP3873503B1 (en) | 2018-11-04 | 2024-07-24 | Figene, LLC | Treatment of cachexia using fibroblast cells and products thereof |
| US12648968B2 (en) | 2019-09-09 | 2026-06-09 | Spinalcyte Llc | Fibroblast and fibroblast-immunocyte combinations for treatment of subconcussive- and concussive-associated neurological damage |
| WO2021092199A1 (en) * | 2019-11-08 | 2021-05-14 | Kansas State University Research Foundation | Isolation, preservation, and expansion of canine umbilical cord mesenchymal stromal cells |
| CN112190694B (zh) * | 2020-09-17 | 2023-11-10 | 南通大学 | 细胞因子活化素c在治疗神经病理性疼痛方面的应用 |
| WO2022104069A1 (en) | 2020-11-13 | 2022-05-19 | Advanced Therapeutic Lab, Inc. | Therapeutic methods and compositions utilizing stromal vascular fraction derived from adipose tissue |
| WO2022186946A1 (en) * | 2021-03-03 | 2022-09-09 | Axogen Corporation | Human umbilical cord-derived compositions and uses thereof for treating neuropathy |
| US20220280573A1 (en) * | 2021-03-03 | 2022-09-08 | Axogen Corporation | Human umbilical cord-derived compositions and uses thereof for treating neuropathy |
| CN114561355B (zh) * | 2022-01-23 | 2023-04-11 | 四川大学华西医院 | 一种脊髓瘢痕组织细胞急性快速分离方法 |
| JP2025524108A (ja) * | 2022-07-26 | 2025-07-25 | バイオステム テクノロジーズ，インコーポレイテッド | 関節内治療のためのヒト臍帯組成物および方法 |
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-
2009
- 2009-12-19 WO PCT/US2009/068879 patent/WO2010071862A1/en not_active Ceased
- 2009-12-19 CN CN200980156986.9A patent/CN102481321B/zh not_active Expired - Fee Related
- 2009-12-19 SI SI200931065T patent/SI2379087T1/sl unknown
- 2009-12-19 AU AU2009327382A patent/AU2009327382B2/en not_active Ceased
- 2009-12-19 EP EP09795654.4A patent/EP2379087B1/en not_active Not-in-force
- 2009-12-19 BR BRPI0923177-3A patent/BRPI0923177A2/pt not_active Application Discontinuation
- 2009-12-19 JP JP2011542518A patent/JP5646502B2/ja not_active Expired - Fee Related
- 2009-12-19 US US12/642,775 patent/US20190105351A9/en not_active Abandoned
- 2009-12-19 PT PT97956544T patent/PT2379087E/pt unknown
- 2009-12-19 CA CA2747757A patent/CA2747757C/en active Active
- 2009-12-19 ES ES09795654.4T patent/ES2520393T3/es active Active
- 2009-12-19 DK DK09795654.4T patent/DK2379087T3/da active
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2014
- 2014-11-18 CY CY20141100961T patent/CY1116344T1/el unknown
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