JP2012512633A5 - - Google Patents
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- Publication number
- JP2012512633A5 JP2012512633A5 JP2011541228A JP2011541228A JP2012512633A5 JP 2012512633 A5 JP2012512633 A5 JP 2012512633A5 JP 2011541228 A JP2011541228 A JP 2011541228A JP 2011541228 A JP2011541228 A JP 2011541228A JP 2012512633 A5 JP2012512633 A5 JP 2012512633A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- compound
- subunit
- polypeptide fragment
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 239000012634 fragment Substances 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 238000000034 method Methods 0.000 claims 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 10
- 102000004533 Endonucleases Human genes 0.000 claims 8
- 108010042407 Endonucleases Proteins 0.000 claims 8
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241000713297 Influenza C virus Species 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- 241000712464 Orthomyxoviridae Species 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 108020000999 Viral RNA Proteins 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000005094 computer simulation Methods 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 101100338269 Caenorhabditis elegans his-41 gene Proteins 0.000 claims 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 1
- -1 SEQ ID NO: 2 amino acid Chemical class 0.000 claims 1
- 239000007983 Tris buffer Substances 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000004364 calculation method Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- UEGPKNKPLBYCNK-UHFFFAOYSA-L magnesium acetate Chemical compound [Mg+2].CC([O-])=O.CC([O-])=O UEGPKNKPLBYCNK-UHFFFAOYSA-L 0.000 claims 1
- 235000011285 magnesium acetate Nutrition 0.000 claims 1
- 239000011654 magnesium acetate Substances 0.000 claims 1
- 229940069446 magnesium acetate Drugs 0.000 claims 1
- 229910052748 manganese Inorganic materials 0.000 claims 1
- 239000011572 manganese Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 239000012460 protein solution Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 230000006798 recombination Effects 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20325908P | 2008-12-19 | 2008-12-19 | |
| US61/203,259 | 2008-12-19 | ||
| PCT/EP2009/009161 WO2010069600A2 (en) | 2008-12-19 | 2009-12-18 | Polypeptide fragments comprising endonuclease activity and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015127283A Division JP2016013124A (ja) | 2008-12-19 | 2015-06-25 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512633A JP2012512633A (ja) | 2012-06-07 |
| JP2012512633A5 true JP2012512633A5 (https=) | 2013-01-24 |
Family
ID=41668407
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541228A Pending JP2012512633A (ja) | 2008-12-19 | 2009-12-18 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
| JP2015127283A Pending JP2016013124A (ja) | 2008-12-19 | 2015-06-25 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
| JP2017099300A Pending JP2017205107A (ja) | 2008-12-19 | 2017-05-18 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015127283A Pending JP2016013124A (ja) | 2008-12-19 | 2015-06-25 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
| JP2017099300A Pending JP2017205107A (ja) | 2008-12-19 | 2017-05-18 | エンドヌクレアーゼ活性を有するポリペプチド断片、及びそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20120108493A1 (https=) |
| EP (2) | EP2379715B1 (https=) |
| JP (3) | JP2012512633A (https=) |
| KR (5) | KR20160017131A (https=) |
| CN (1) | CN102449144B (https=) |
| AU (1) | AU2009328502B2 (https=) |
| BR (1) | BRPI0923134A2 (https=) |
| CA (1) | CA2745532A1 (https=) |
| ES (1) | ES2604227T3 (https=) |
| IL (1) | IL213360A0 (https=) |
| MX (1) | MX2011006539A (https=) |
| SG (1) | SG172239A1 (https=) |
| WO (1) | WO2010069600A2 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101792745B (zh) | 2009-02-04 | 2014-09-17 | 中国科学院生物物理研究所 | 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构 |
| US8859290B2 (en) * | 2011-07-22 | 2014-10-14 | Rutgers, The State University Of New Jersey | Inhibitors of influenza endonuclease activity and tools for their discovery |
| JP6570448B2 (ja) * | 2013-10-02 | 2019-09-04 | 学校法人 久留米大学 | インフルエンザウイルス阻害薬 |
| CN109477081A (zh) * | 2016-07-07 | 2019-03-15 | 欧洲分子生物学实验室 | 结合细胞Pol Ⅱ C末端结构域（CTD）的病毒多肽片段及其用途 |
| JP6918305B2 (ja) * | 2017-03-10 | 2021-08-11 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスの増殖を阻害するモノクローナル抗体 |
| CN114496063B (zh) * | 2022-01-13 | 2023-05-23 | 北京博康健基因科技有限公司 | 基于天然氨基酸序列的信号肽设计与二级结构从头算建模方法和装置 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482414B1 (en) * | 1998-08-13 | 2002-11-19 | The University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Cold-adapted equine influenza viruses |
| AU2001270033A1 (en) * | 2000-06-23 | 2002-01-08 | Wyeth Holdings Corporation | Nucleotide sequence of influenza A/Udorn/72 (H3N2) genome |
| EP1549318B1 (en) * | 2002-05-01 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Crystal structure of aurora-2 protein and binding pockets thereof |
| WO2004035812A2 (en) * | 2002-10-16 | 2004-04-29 | Isis Innovation Limited | Asparaginyl hydroxylases and modulators thereof |
| JP4739192B2 (ja) * | 2003-05-02 | 2011-08-03 | イーラン ファーマスーティカルズ、インコーポレイテッド | Ｂａｃｅのグリコシル化変異体 |
| US7439327B2 (en) * | 2005-01-18 | 2008-10-21 | Nuvelo, Inc. | Stem cell factor-like proteins and uses thereof |
-
2009
- 2009-12-18 JP JP2011541228A patent/JP2012512633A/ja active Pending
- 2009-12-18 CA CA2745532A patent/CA2745532A1/en not_active Abandoned
- 2009-12-18 WO PCT/EP2009/009161 patent/WO2010069600A2/en not_active Ceased
- 2009-12-18 SG SG2011044617A patent/SG172239A1/en unknown
- 2009-12-18 KR KR1020167002567A patent/KR20160017131A/ko not_active Ceased
- 2009-12-18 KR KR1020167026244A patent/KR20160113335A/ko not_active Ceased
- 2009-12-18 EP EP09798891.9A patent/EP2379715B1/en active Active
- 2009-12-18 KR KR1020177014264A patent/KR20170061193A/ko not_active Abandoned
- 2009-12-18 MX MX2011006539A patent/MX2011006539A/es active IP Right Grant
- 2009-12-18 BR BRPI0923134A patent/BRPI0923134A2/pt not_active IP Right Cessation
- 2009-12-18 CN CN200980157310.1A patent/CN102449144B/zh not_active Expired - Fee Related
- 2009-12-18 KR KR1020167002571A patent/KR20160017132A/ko not_active Abandoned
- 2009-12-18 ES ES09798891.9T patent/ES2604227T3/es active Active
- 2009-12-18 US US13/140,626 patent/US20120108493A1/en not_active Abandoned
- 2009-12-18 EP EP13162372.0A patent/EP2623590A3/en not_active Withdrawn
- 2009-12-18 AU AU2009328502A patent/AU2009328502B2/en not_active Ceased
- 2009-12-18 KR KR1020117013955A patent/KR20110127114A/ko not_active Ceased
-
2011
- 2011-06-05 IL IL213360A patent/IL213360A0/en not_active IP Right Cessation
-
2014
- 2014-10-21 US US14/519,525 patent/US9890368B2/en not_active Expired - Fee Related
-
2015
- 2015-06-25 JP JP2015127283A patent/JP2016013124A/ja active Pending
-
2017
- 2017-05-18 JP JP2017099300A patent/JP2017205107A/ja active Pending
- 2017-07-25 US US15/658,985 patent/US20180010109A1/en not_active Abandoned
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