JP2013521786A5 - - Google Patents
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- Publication number
- JP2013521786A5 JP2013521786A5 JP2012557443A JP2012557443A JP2013521786A5 JP 2013521786 A5 JP2013521786 A5 JP 2013521786A5 JP 2012557443 A JP2012557443 A JP 2012557443A JP 2012557443 A JP2012557443 A JP 2012557443A JP 2013521786 A5 JP2013521786 A5 JP 2013521786A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide fragment
- compound
- amino acid
- seq
- subunit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000012634 fragment Substances 0.000 claims 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims 37
- 229920001184 polypeptide Polymers 0.000 claims 36
- 102000004196 processed proteins & peptides Human genes 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 26
- 150000001413 amino acids Chemical class 0.000 claims 23
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 230000000694 effects Effects 0.000 claims 9
- 102000004533 Endonucleases Human genes 0.000 claims 7
- 108010042407 Endonucleases Proteins 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 206010022000 influenza Diseases 0.000 claims 5
- 101100338269 Caenorhabditis elegans his-41 gene Proteins 0.000 claims 4
- 239000013078 crystal Substances 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
- 108060004795 Methyltransferase Proteins 0.000 claims 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 2
- 208000036142 Viral infection Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 238000004364 calculation method Methods 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000005094 computer simulation Methods 0.000 claims 2
- 238000002156 mixing Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000003384 small molecules Chemical class 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 241000712892 Arenaviridae Species 0.000 claims 1
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 1
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 1
- 241000712464 Orthomyxoviridae Species 0.000 claims 1
- 241000150350 Peribunyaviridae Species 0.000 claims 1
- -1 SEQ ID NO: 2 amino acids Chemical class 0.000 claims 1
- 108020000999 Viral RNA Proteins 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052748 manganese Inorganic materials 0.000 claims 1
- 239000011572 manganese Substances 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34033510P | 2010-03-16 | 2010-03-16 | |
| US61/340,335 | 2010-03-16 | ||
| PCT/EP2011/001274 WO2011113579A2 (en) | 2010-03-16 | 2011-03-15 | Influenza a 2009 pandemic h1n1 polypeptide fragments comprising endonuclease activity and their use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053802A Division JP2016189772A (ja) | 2010-03-16 | 2016-03-17 | エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013521786A JP2013521786A (ja) | 2013-06-13 |
| JP2013521786A5 true JP2013521786A5 (https=) | 2014-04-24 |
Family
ID=43983275
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012557443A Withdrawn JP2013521786A (ja) | 2010-03-16 | 2011-03-15 | エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 |
| JP2016053802A Pending JP2016189772A (ja) | 2010-03-16 | 2016-03-17 | エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016053802A Pending JP2016189772A (ja) | 2010-03-16 | 2016-03-17 | エンドヌクレアーゼ活性を有するインフルエンザａ２００９パンデミックｈ１ｎ１のポリペプチド断片、及びそれらの使用 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US9181307B2 (https=) |
| EP (1) | EP2547696B1 (https=) |
| JP (2) | JP2013521786A (https=) |
| KR (1) | KR20130075726A (https=) |
| CN (2) | CN102803288B (https=) |
| AU (1) | AU2011229469B2 (https=) |
| BR (1) | BR112012023166A2 (https=) |
| CA (1) | CA2790183A1 (https=) |
| IL (1) | IL260192A (https=) |
| MX (1) | MX352906B (https=) |
| SG (3) | SG10201601365RA (https=) |
| WO (1) | WO2011113579A2 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130075726A (ko) | 2010-03-16 | 2013-07-05 | 유럽피안 몰레큘러 바이올로지 래보러토리 | 유행성 인플루엔자 바이러스 ａ 2009 ｈ1ｎ1로부터의 ｒｎａ 의존성 ｒｎａ 폴리머라제의 ｐａ 아단위의 단편 및 이의 용도 |
| US8859290B2 (en) * | 2011-07-22 | 2014-10-14 | Rutgers, The State University Of New Jersey | Inhibitors of influenza endonuclease activity and tools for their discovery |
| JP6918305B2 (ja) * | 2017-03-10 | 2021-08-11 | 地方独立行政法人神奈川県立産業技術総合研究所 | インフルエンザウイルスの増殖を阻害するモノクローナル抗体 |
| CN112837764B (zh) * | 2021-01-21 | 2023-07-07 | 北京晶泰科技有限公司 | 分子杂交方法及平台 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1549318B1 (en) * | 2002-05-01 | 2010-02-17 | Vertex Pharmaceuticals Incorporated | Crystal structure of aurora-2 protein and binding pockets thereof |
| EP2197901B1 (en) * | 2007-10-09 | 2013-12-11 | European Molecular Biology Laboratory (Embl) | Soluble fragments of influenza virus pb2 protein capable of binding rna-cap |
| CN101514335B (zh) * | 2008-02-22 | 2013-04-17 | 中国科学院生物物理研究所 | 流感病毒聚合酶亚基pa的表达纯化及pa氨基端及pa羧基端与pb1氨基端多肽复合体的晶体结构 |
| KR20130075726A (ko) | 2010-03-16 | 2013-07-05 | 유럽피안 몰레큘러 바이올로지 래보러토리 | 유행성 인플루엔자 바이러스 ａ 2009 ｈ1ｎ1로부터의 ｒｎａ 의존성 ｒｎａ 폴리머라제의 ｐａ 아단위의 단편 및 이의 용도 |
-
2011
- 2011-03-15 KR KR1020127026664A patent/KR20130075726A/ko not_active Ceased
- 2011-03-15 SG SG10201601365RA patent/SG10201601365RA/en unknown
- 2011-03-15 JP JP2012557443A patent/JP2013521786A/ja not_active Withdrawn
- 2011-03-15 AU AU2011229469A patent/AU2011229469B2/en not_active Ceased
- 2011-03-15 BR BR112012023166-9A patent/BR112012023166A2/pt not_active IP Right Cessation
- 2011-03-15 CA CA2790183A patent/CA2790183A1/en active Pending
- 2011-03-15 MX MX2012010652A patent/MX352906B/es active IP Right Grant
- 2011-03-15 SG SG2012061081A patent/SG183375A1/en unknown
- 2011-03-15 CN CN201180014380.9A patent/CN102803288B/zh not_active Expired - Fee Related
- 2011-03-15 WO PCT/EP2011/001274 patent/WO2011113579A2/en not_active Ceased
- 2011-03-15 EP EP11709643.8A patent/EP2547696B1/en not_active Not-in-force
- 2011-03-15 US US13/635,064 patent/US9181307B2/en not_active Expired - Fee Related
- 2011-03-15 CN CN201510595018.5A patent/CN105273066A/zh active Pending
- 2011-03-15 SG SG10201703245SA patent/SG10201703245SA/en unknown
-
2015
- 2015-06-26 US US14/751,634 patent/US9783794B2/en not_active Expired - Fee Related
-
2016
- 2016-03-17 JP JP2016053802A patent/JP2016189772A/ja active Pending
-
2017
- 2017-08-08 US US15/672,091 patent/US20180044649A1/en not_active Abandoned
-
2018
- 2018-06-21 IL IL260192A patent/IL260192A/en unknown
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