JP2013527765A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013527765A5 JP2013527765A5 JP2013509041A JP2013509041A JP2013527765A5 JP 2013527765 A5 JP2013527765 A5 JP 2013527765A5 JP 2013509041 A JP2013509041 A JP 2013509041A JP 2013509041 A JP2013509041 A JP 2013509041A JP 2013527765 A5 JP2013527765 A5 JP 2013527765A5
- Authority
- JP
- Japan
- Prior art keywords
- zinc finger
- amino acid
- residue
- terminal
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34372910P | 2010-05-03 | 2010-05-03 | |
| US61/343,729 | 2010-05-03 | ||
| PCT/US2011/000758 WO2011139349A1 (en) | 2010-05-03 | 2011-05-02 | Compositions for linking zinc finger modules |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527765A JP2013527765A (ja) | 2013-07-04 |
| JP2013527765A5 true JP2013527765A5 (https=) | 2015-09-24 |
| JP5898179B2 JP5898179B2 (ja) | 2016-04-06 |
Family
ID=44903931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013509041A Expired - Fee Related JP5898179B2 (ja) | 2010-05-03 | 2011-05-02 | ジンクフィンガーモジュールを連結するための組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8772453B2 (https=) |
| EP (2) | EP2566972B1 (https=) |
| JP (1) | JP5898179B2 (https=) |
| KR (2) | KR101974036B1 (https=) |
| CN (1) | CN102959087B (https=) |
| AU (1) | AU2011249019B2 (https=) |
| CA (1) | CA2797189C (https=) |
| CY (1) | CY1122636T1 (https=) |
| DK (1) | DK2566972T3 (https=) |
| ES (1) | ES2773052T3 (https=) |
| HR (1) | HRP20200254T1 (https=) |
| HU (1) | HUE048072T2 (https=) |
| IL (1) | IL222632B (https=) |
| LT (1) | LT2566972T (https=) |
| PL (1) | PL2566972T3 (https=) |
| PT (1) | PT2566972T (https=) |
| SI (1) | SI2566972T1 (https=) |
| WO (1) | WO2011139349A1 (https=) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120196370A1 (en) | 2010-12-03 | 2012-08-02 | Fyodor Urnov | Methods and compositions for targeted genomic deletion |
| AU2011281062B2 (en) | 2010-07-21 | 2015-01-22 | Board Of Regents, The University Of Texas System | Methods and compositions for modification of a HLA locus |
| WO2012094132A1 (en) | 2011-01-05 | 2012-07-12 | Sangamo Biosciences, Inc. | Methods and compositions for gene correction |
| US9161995B2 (en) | 2011-07-25 | 2015-10-20 | Sangamo Biosciences, Inc. | Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
| CA3099582A1 (en) | 2011-10-27 | 2013-05-02 | Sangamo Biosciences, Inc. | Methods and compositions for modification of the hprt locus |
| WO2013130824A1 (en) | 2012-02-29 | 2013-09-06 | Sangamo Biosciences, Inc. | Methods and compositions for treating huntington's disease |
| US10648001B2 (en) | 2012-07-11 | 2020-05-12 | Sangamo Therapeutics, Inc. | Method of treating mucopolysaccharidosis type I or II |
| JP6329537B2 (ja) | 2012-07-11 | 2018-05-23 | サンガモ セラピューティクス， インコーポレイテッド | 生物学的薬剤の送達のための方法および組成物 |
| SG10201701601WA (en) | 2012-08-29 | 2017-04-27 | Sangamo Biosciences Inc | Methods and compositions for treatment of a genetic condition |
| WO2014071070A1 (en) | 2012-11-01 | 2014-05-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
| US9290800B2 (en) | 2013-03-15 | 2016-03-22 | Pacific Biosciences Of California, Inc. | Targeted rolling circle amplification |
| CN105263312A (zh) | 2013-04-05 | 2016-01-20 | 美国陶氏益农公司 | 用于在植物基因组内整合外源序列的方法和组合物 |
| CA3131284C (en) | 2013-08-28 | 2023-09-19 | David Paschon | Compositions for linking dna-binding domains and cleavage domains |
| EP3441468B1 (en) | 2013-10-17 | 2021-05-19 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| US10117899B2 (en) | 2013-10-17 | 2018-11-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells |
| WO2015070212A1 (en) | 2013-11-11 | 2015-05-14 | Sangamo Biosciences, Inc. | Methods and compositions for treating huntington's disease |
| DK3492593T3 (da) | 2013-11-13 | 2021-11-08 | Childrens Medical Center | Nukleasemedieret regulering af genekspression |
| US10072066B2 (en) | 2014-02-03 | 2018-09-11 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a beta thalessemia |
| CN106459894B (zh) | 2014-03-18 | 2020-02-18 | 桑格摩生物科学股份有限公司 | 用于调控锌指蛋白表达的方法和组合物 |
| US10435685B2 (en) | 2014-08-19 | 2019-10-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for enrichment of nucleic acids |
| AU2016261927B2 (en) | 2015-05-12 | 2022-04-07 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
| US9957501B2 (en) | 2015-06-18 | 2018-05-01 | Sangamo Therapeutics, Inc. | Nuclease-mediated regulation of gene expression |
| AU2016291778B2 (en) | 2015-07-13 | 2021-05-06 | Sangamo Therapeutics, Inc. | Delivery methods and compositions for nuclease-mediated genome engineering |
| BR112018012235A2 (pt) | 2015-12-18 | 2018-12-04 | Sangamo Therapeutics Inc | rompimento alvejado do receptor de células de mhc |
| EP3389677B1 (en) | 2015-12-18 | 2024-06-26 | Sangamo Therapeutics, Inc. | Targeted disruption of the t cell receptor |
| WO2017123757A1 (en) | 2016-01-15 | 2017-07-20 | Sangamo Therapeutics, Inc. | Methods and compositions for the treatment of neurologic disease |
| KR20180101442A (ko) | 2016-02-02 | 2018-09-12 | 상가모 테라퓨틱스, 인코포레이티드 | Dna-결합 도메인 및 절단 도메인을 연결시키기 위한 조성물 |
| KR102455249B1 (ko) | 2016-08-24 | 2022-10-17 | 상가모 테라퓨틱스, 인코포레이티드 | 가공된 표적 특이적 뉴클레아제 |
| EP3995574A1 (en) | 2016-08-24 | 2022-05-11 | Sangamo Therapeutics, Inc. | Regulation of gene expression using engineered nucleases |
| KR102712926B1 (ko) | 2016-10-20 | 2024-10-07 | 상가모 테라퓨틱스, 인코포레이티드 | 파브리병의 치료를 위한 방법 및 조성물 |
| WO2018081775A1 (en) | 2016-10-31 | 2018-05-03 | Sangamo Therapeutics, Inc. | Gene correction of scid-related genes in hematopoietic stem and progenitor cells |
| IL266862B2 (en) | 2016-12-01 | 2024-01-01 | Sangamo Therapeutics Inc | Tau modulators and methods and preparations for their administration |
| MX2019011772A (es) | 2017-04-03 | 2020-01-09 | Encoded Therapeutics Inc | Expresion transgenica selectiva de tejidos. |
| CN110799492B (zh) | 2017-04-28 | 2023-06-27 | 爱康泰生治疗公司 | 用于递送核酸的新型羰基脂质和脂质纳米颗粒制剂 |
| US11655275B2 (en) | 2017-05-03 | 2023-05-23 | Sangamo Therapeutics, Inc. | Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene |
| US11512287B2 (en) | 2017-06-16 | 2022-11-29 | Sangamo Therapeutics, Inc. | Targeted disruption of T cell and/or HLA receptors |
| AU2018313167A1 (en) | 2017-08-08 | 2020-02-27 | Sangamo Therapeutics, Inc. | Chimeric antigen receptor mediated cell targeting |
| BR112020008568A2 (pt) | 2017-11-09 | 2020-10-06 | Sangamo Therapeutics, Inc. | modificação genética de gene de proteína contendo sh2 indutível por citoquina (cish) |
| EP3717505A4 (en) | 2017-12-01 | 2021-12-01 | Encoded Therapeutics, Inc. | GENENICALLY MODIFIED DNA-BINDING PROTEINS |
| CA3089587A1 (en) | 2018-02-08 | 2019-08-15 | Sangamo Therapeutics, Inc. | Engineered target specific nucleases |
| US11421007B2 (en) * | 2018-04-18 | 2022-08-23 | Sangamo Therapeutics, Inc. | Zinc finger protein compositions for modulation of huntingtin (Htt) |
| US11690921B2 (en) | 2018-05-18 | 2023-07-04 | Sangamo Therapeutics, Inc. | Delivery of target specific nucleases |
| AU2019326408A1 (en) | 2018-08-23 | 2021-03-11 | Sangamo Therapeutics, Inc. | Engineered target specific base editors |
| KR20210060533A (ko) | 2018-09-18 | 2021-05-26 | 상가모 테라퓨틱스, 인코포레이티드 | 프로그램화된 세포 사멸 1 (pd1) 특이적 뉴클레아제 |
| IL281615B2 (en) | 2018-09-21 | 2026-01-01 | Acuitas Therapeutics Inc | Systems and methods for producing lipid nanoparticles and liposomes |
| EP3861130A4 (en) * | 2018-10-02 | 2022-08-03 | Sangamo Therapeutics, Inc. | GENETIC MODULATORS |
| WO2020072677A1 (en) | 2018-10-02 | 2020-04-09 | Sangamo Therapeutics, Inc. | Methods and compositions for modulation of tau proteins |
| CA3116576A1 (en) | 2018-10-18 | 2020-04-23 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| PT3908568T (pt) | 2019-01-11 | 2024-09-30 | Acuitas Therapeutics Inc | Lípidos para a administração de agentes ativos por nanopartículas lipídicas |
| AU2019428629A1 (en) | 2019-02-06 | 2021-01-28 | Sangamo Therapeutics, Inc. | Method for the treatment of mucopolysaccharidosis type I |
| CA3132167A1 (en) | 2019-04-02 | 2020-10-08 | Weston P. MILLER IV | Methods for the treatment of beta-thalassemia |
| TW202521561A (zh) | 2019-04-23 | 2025-06-01 | 美商聖加莫治療股份有限公司 | 染色體9開放讀框72基因表現之調節子及其用途 |
| JP2022533713A (ja) | 2019-05-21 | 2022-07-25 | サンガモ セラピューティクス， インコーポレイテッド | 調節性ｔ細胞における制御された導入遺伝子発現 |
| PL3976798T3 (pl) | 2019-05-29 | 2026-04-07 | Encoded Therapeutics, Inc. | Kompozycje i sposoby selektywnej regulacji genów |
| WO2021028359A1 (en) | 2019-08-09 | 2021-02-18 | Sangamo Therapeutics France | Controlled expression of chimeric antigen receptors in t cells |
| JP7824873B2 (ja) | 2019-10-02 | 2026-03-05 | サンガモ セラピューティクス， インコーポレイテッド | プリオン病の治療のためのジンクフィンガータンパク質転写因子 |
| AU2020356962A1 (en) | 2019-10-02 | 2022-04-14 | Sangamo Therapeutics, Inc. | Zinc finger protein transcription factors for repressing alpha-synuclein expression |
| WO2021087361A1 (en) | 2019-11-01 | 2021-05-06 | Sangamo Therapeutics, Inc. | Zinc finger nuclease variants for treating or preventing lysosomal storage diseases |
| TW202134288A (zh) | 2020-01-22 | 2021-09-16 | 美商聖加莫治療股份有限公司 | 用於抑制tau蛋白表現之鋅指蛋白轉錄因子 |
| US20230174612A1 (en) * | 2020-04-09 | 2023-06-08 | The Regents Of The University Of California | Notch receptors with zinc finger-containing transcriptional effector |
| ES3054438T3 (en) | 2020-07-16 | 2026-02-03 | Acuitas Therapeutics Inc | Cationic lipids for use in lipid nanoparticles |
| US12152251B2 (en) | 2020-08-25 | 2024-11-26 | Kite Pharma, Inc. | T cells with improved functionality |
| CN116261594A (zh) | 2020-09-25 | 2023-06-13 | 桑格摩生物治疗股份有限公司 | 用于核碱基编辑的锌指融合蛋白 |
| CN116917335A (zh) | 2020-10-02 | 2023-10-20 | 桑格摩生物治疗股份有限公司 | 用于阻遏α-突触核蛋白(SYNUCLEIN)表达的新颖锌指蛋白转录因子 |
| KR20240011120A (ko) | 2020-12-22 | 2024-01-25 | 크로마 메디슨, 인크. | 후성유전학적 편집을 위한 조성물 및 방법 |
| CA3237482A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
| CA3242402A1 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| JP2025504606A (ja) | 2021-12-22 | 2025-02-13 | サンガモ セラピューティクス， インコーポレイテッド | 核酸塩基編集のための新規ジンクフィンガー融合タンパク質 |
| WO2023141602A2 (en) | 2022-01-21 | 2023-07-27 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| IL316722A (en) | 2022-05-01 | 2024-12-01 | Chroma Medicine Inc | Compositions and methods for epigenetic regulation of PCSK9 expression |
| EP4544058A1 (en) | 2022-06-23 | 2025-04-30 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of ciita expression |
| US20250387518A1 (en) | 2022-06-23 | 2025-12-25 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of b2m expression |
| JP2025524455A (ja) | 2022-06-23 | 2025-07-30 | エヌクロマ・バイオ，インコーポレーテッド | Ｔｒａｃ発現のエピジェネティック調節のための組成物及び方法 |
| WO2024044723A1 (en) | 2022-08-25 | 2024-02-29 | Renagade Therapeutics Management Inc. | Engineered retrons and methods of use |
| IL319704A (en) | 2022-09-23 | 2025-05-01 | Nchroma Bio Inc | Compositions and methods for epigenetic regulation of HBV gene expression |
| WO2024081879A1 (en) | 2022-10-14 | 2024-04-18 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of cd247 expression |
| AU2024270764A1 (en) | 2023-05-15 | 2025-12-04 | Nchroma Bio, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| WO2024238700A1 (en) | 2023-05-15 | 2024-11-21 | Chroma Medicine, Inc. | Compositions and methods for epigenetic regulation of hbv gene expression |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025174765A1 (en) | 2024-02-12 | 2025-08-21 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4512110A (en) | 1981-12-10 | 1985-04-23 | Timesavers, Inc. | Endless abrasive belts |
| US5422251A (en) | 1986-11-26 | 1995-06-06 | Princeton University | Triple-stranded nucleic acids |
| US5176996A (en) | 1988-12-20 | 1993-01-05 | Baylor College Of Medicine | Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use |
| US5420032A (en) | 1991-12-23 | 1995-05-30 | Universitge Laval | Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence |
| US5356802A (en) | 1992-04-03 | 1994-10-18 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease |
| US5487994A (en) | 1992-04-03 | 1996-01-30 | The Johns Hopkins University | Insertion and deletion mutants of FokI restriction endonuclease |
| US5436150A (en) | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5792632A (en) | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US6242568B1 (en) | 1994-01-18 | 2001-06-05 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
| DE69534629D1 (de) | 1994-01-18 | 2005-12-29 | Scripps Research Inst | Derivate von zinkfingerproteinen und methoden |
| US5585245A (en) | 1994-04-22 | 1996-12-17 | California Institute Of Technology | Ubiquitin-based split protein sensor |
| USRE39229E1 (en) | 1994-08-20 | 2006-08-08 | Gendaq Limited | Binding proteins for recognition of DNA |
| US7285416B2 (en) * | 2000-01-24 | 2007-10-23 | Gendaq Limited | Regulated gene expression in plants |
| GB9824544D0 (en) | 1998-11-09 | 1999-01-06 | Medical Res Council | Screening system |
| US5789538A (en) | 1995-02-03 | 1998-08-04 | Massachusetts Institute Of Technology | Zinc finger proteins with high affinity new DNA binding specificities |
| US5925523A (en) | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| GB9703369D0 (en) | 1997-02-18 | 1997-04-09 | Lindqvist Bjorn H | Process |
| GB2338237B (en) | 1997-02-18 | 2001-02-28 | Actinova Ltd | In vitro peptide or protein expression library |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| GB9710807D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| GB9710809D0 (en) | 1997-05-23 | 1997-07-23 | Medical Res Council | Nucleic acid binding proteins |
| US6410248B1 (en) | 1998-01-30 | 2002-06-25 | Massachusetts Institute Of Technology | General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites |
| ES2341926T3 (es) * | 1998-03-02 | 2010-06-29 | Massachusetts Institute Of Technology | Poliproteinas con dedos de cinc que tienen enlazadores mejorados. |
| US6140081A (en) | 1998-10-16 | 2000-10-31 | The Scripps Research Institute | Zinc finger binding domains for GNN |
| US6599692B1 (en) | 1999-09-14 | 2003-07-29 | Sangamo Bioscience, Inc. | Functional genomics using zinc finger proteins |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| US6453242B1 (en) | 1999-01-12 | 2002-09-17 | Sangamo Biosciences, Inc. | Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites |
| US6794136B1 (en) | 2000-11-20 | 2004-09-21 | Sangamo Biosciences, Inc. | Iterative optimization in the design of binding proteins |
| US7151201B2 (en) | 2000-01-21 | 2006-12-19 | The Scripps Research Institute | Methods and compositions to modulate expression in plants |
| ATE355368T1 (de) | 2000-01-24 | 2006-03-15 | Gendaq Ltd | Nucleinsäure bindende polypeptide gekennzeichnet durch flexible linker verbundene nucleinsäuredomäne |
| US6689558B2 (en) | 2000-02-08 | 2004-02-10 | Sangamo Biosciences, Inc. | Cells for drug discovery |
| US20020061512A1 (en) | 2000-02-18 | 2002-05-23 | Kim Jin-Soo | Zinc finger domains and methods of identifying same |
| AU2001263155A1 (en) | 2000-05-16 | 2001-11-26 | Massachusetts Institute Of Technology | Methods and compositions for interaction trap assays |
| US20060268407A1 (en) | 2000-07-07 | 2006-11-30 | Fergason James L | Display system using two displays and polarization direction rotation for showing high-resolution and three-dimensional images and method and use of a DBEF beam splitter |
| JP2002060786A (ja) | 2000-08-23 | 2002-02-26 | Kao Corp | 硬質表面用殺菌防汚剤 |
| US7067317B2 (en) | 2000-12-07 | 2006-06-27 | Sangamo Biosciences, Inc. | Regulation of angiogenesis with zinc finger proteins |
| GB0108491D0 (en) | 2001-04-04 | 2001-05-23 | Gendaq Ltd | Engineering zinc fingers |
| US20040197892A1 (en) * | 2001-04-04 | 2004-10-07 | Michael Moore | Composition binding polypeptides |
| JP2005500061A (ja) | 2001-08-20 | 2005-01-06 | ザ スクリップス リサーチ インスティテュート | Ｃｎｎについての亜鉛フィンガー結合ドメイン |
| US7262054B2 (en) | 2002-01-22 | 2007-08-28 | Sangamo Biosciences, Inc. | Zinc finger proteins for DNA binding and gene regulation in plants |
| JP2006513694A (ja) * | 2002-06-11 | 2006-04-27 | ザ スクリップス リサーチ インスティテュート | 人工転写因子 |
| US8409861B2 (en) | 2003-08-08 | 2013-04-02 | Sangamo Biosciences, Inc. | Targeted deletion of cellular DNA sequences |
| US20070134796A1 (en) | 2005-07-26 | 2007-06-14 | Sangamo Biosciences, Inc. | Targeted integration and expression of exogenous nucleic acid sequences |
| US7888121B2 (en) | 2003-08-08 | 2011-02-15 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| EP1678315B1 (en) | 2003-09-19 | 2011-08-03 | Sangamo BioSciences, Inc. | Engineered zinc finger proteins for regulation of gene expression |
| WO2005061705A1 (en) * | 2003-12-23 | 2005-07-07 | Toolgen, Inc. | Regulation of prokaryotic gene expression with zinc finger proteins |
| US7972854B2 (en) | 2004-02-05 | 2011-07-05 | Sangamo Biosciences, Inc. | Methods and compositions for targeted cleavage and recombination |
| US7253273B2 (en) | 2004-04-08 | 2007-08-07 | Sangamo Biosciences, Inc. | Treatment of neuropathic pain with zinc finger proteins |
| AU2005287278B2 (en) | 2004-09-16 | 2011-08-04 | Sangamo Biosciences, Inc. | Compositions and methods for protein production |
| CA2607104A1 (en) | 2005-05-05 | 2006-11-16 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences |
| ES2582091T3 (es) | 2005-10-18 | 2016-09-09 | Precision Biosciences | Meganucleasas diseñadas racionalmente con especificidad de secuencia y afinidad de unión a ADN alteradas |
| WO2007136685A2 (en) | 2006-05-19 | 2007-11-29 | Sangamo Biosciences, Inc. | Methods and compositions for inactivation of dihydrofolate reductase |
| ES2465996T3 (es) | 2006-05-25 | 2014-06-09 | Sangamo Biosciences, Inc. | Métodos y composiciones para la inactivación genética |
| EP2027262B1 (en) | 2006-05-25 | 2010-03-31 | Sangamo Biosciences Inc. | Variant foki cleavage half-domains |
| WO2008060510A2 (en) | 2006-11-13 | 2008-05-22 | Sangamo Biosciences, Inc. | Zinc finger nuclease for targeting the human glucocorticoid receptor locus |
| DE602008003684D1 (de) | 2007-04-26 | 2011-01-05 | Sangamo Biosciences Inc | Gezielte integration in die ppp1r12c-position |
| EP2188384B1 (en) | 2007-09-27 | 2015-07-15 | Sangamo BioSciences, Inc. | Rapid in vivo identification of biologically active nucleases |
| EP2456877A4 (en) | 2009-07-24 | 2012-05-30 | Sigma Aldrich Co Llc | METHOD OF GENOMIC PROCESSING |
-
2011
- 2011-05-02 HR HRP20200254TT patent/HRP20200254T1/hr unknown
- 2011-05-02 ES ES11777690T patent/ES2773052T3/es active Active
- 2011-05-02 DK DK11777690.6T patent/DK2566972T3/da active
- 2011-05-02 PT PT117776906T patent/PT2566972T/pt unknown
- 2011-05-02 WO PCT/US2011/000758 patent/WO2011139349A1/en not_active Ceased
- 2011-05-02 JP JP2013509041A patent/JP5898179B2/ja not_active Expired - Fee Related
- 2011-05-02 PL PL11777690T patent/PL2566972T3/pl unknown
- 2011-05-02 LT LTEP11777690.6T patent/LT2566972T/lt unknown
- 2011-05-02 KR KR1020187017770A patent/KR101974036B1/ko active Active
- 2011-05-02 CA CA2797189A patent/CA2797189C/en active Active
- 2011-05-02 EP EP11777690.6A patent/EP2566972B1/en active Active
- 2011-05-02 US US13/068,102 patent/US8772453B2/en active Active
- 2011-05-02 SI SI201131844T patent/SI2566972T1/sl unknown
- 2011-05-02 CN CN201180022329.2A patent/CN102959087B/zh active Active
- 2011-05-02 AU AU2011249019A patent/AU2011249019B2/en active Active
- 2011-05-02 HU HUE11777690A patent/HUE048072T2/hu unknown
- 2011-05-02 KR KR1020127028770A patent/KR20130073887A/ko not_active Ceased
- 2011-05-02 EP EP19211724.0A patent/EP3636766A1/en active Pending
-
2012
- 2012-10-23 IL IL222632A patent/IL222632B/en active IP Right Grant
-
2014
- 2014-06-04 US US14/296,159 patent/US9163245B2/en active Active
-
2020
- 2020-02-14 CY CY20201100140T patent/CY1122636T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013527765A5 (https=) | ||
| HRP20200254T1 (hr) | Pripravci za povezivanje modula cink fingera | |
| RU2016146198A (ru) | Терапевтические dll4-связывающие белки | |
| EA201200515A1 (ru) | Полипептиды и их применение | |
| JP2015525217A5 (https=) | ||
| AR072680A1 (es) | Axmi-115 axmi-113 axmi-005 axmi-163 y axmi-184 proteinas insecticidas y metodos de uso de las mismas | |
| MX374682B (es) | Moléculas de unión a 4-1bb. | |
| JP2010529860A5 (https=) | ||
| RU2013128895A (ru) | Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором | |
| HRP20150664T1 (hr) | Antikancerogeni fuzijski protein | |
| AR080229A1 (es) | Proteinas de dominio de armazon de fibronectina que se unen a il -23 (interleucina 23) | |
| JP2009268467A5 (https=) | ||
| CY1112924T1 (el) | Κυτταροδιαπερατοι αναστολεις της jnk-σηματοδοτικης πορειας μεταγωγης | |
| JP2014511698A5 (https=) | ||
| JP2014501510A5 (https=) | ||
| RU2017134456A (ru) | Рекомбинантные связывающие белки и их применение | |
| NZ616761A (en) | Amino acid sequences directed against il-17a, il-17f and/or il17-a/f and polypeptides comprising the same | |
| EA202092589A2 (ru) | Cxcr2-связывающие полипептиды | |
| EP4296673A3 (en) | Peptides and methods for the detection of lyme disease antibodies | |
| EP4450523A3 (en) | Binding fusion proteins, binding fusion protein-drug conjugates, xten-drug conjugates and methods of making and using same | |
| MX357674B (es) | Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. | |
| MX2013013644A (es) | Peptidos de transito al cloroplasto y metodos de uso. | |
| HRP20200007T1 (hr) | Kompleks proteina faktora viii s xten i von willebrandovim faktorom, te njegova uporaba | |
| AU2011353197A8 (en) | A cross linking polypeptide comprising an hexameric single chain antibody binding MHC-MAGE complex that induces apoptosis | |
| CL2011003121A1 (es) | Proteína de fusión que comprende una secuencia de hormona de crecimiento (gh), ligada a un polipéptido recombinante extendido (xten) que comprende al menos 200 aminoácidos, carece de epítopes de células t y los residuos g, a, s, t, e y p suman más del 90%; ácido nucleico, vector y célula; método de producción; composición farmacéutica y uso. |