JP2012512176A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012512176A5 JP2012512176A5 JP2011540971A JP2011540971A JP2012512176A5 JP 2012512176 A5 JP2012512176 A5 JP 2012512176A5 JP 2011540971 A JP2011540971 A JP 2011540971A JP 2011540971 A JP2011540971 A JP 2011540971A JP 2012512176 A5 JP2012512176 A5 JP 2012512176A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- composition
- acid
- galactose
- arabinose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 19
- 229930182830 galactose Natural products 0.000 claims 12
- 239000000284 extract Substances 0.000 claims 11
- 239000002253 acid Substances 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 8
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 claims 7
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 7
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 6
- 239000000287 crude extract Substances 0.000 claims 6
- 239000008103 glucose Substances 0.000 claims 6
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 4
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims 4
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims 4
- AEMOLEFTQBMNLQ-YMDCURPLSA-N D-galactopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-YMDCURPLSA-N 0.000 claims 3
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 claims 3
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 241000209219 Hordeum Species 0.000 claims 2
- 235000007340 Hordeum vulgare Nutrition 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 235000006533 astragalus Nutrition 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241001061264 Astragalus Species 0.000 claims 1
- 241000045403 Astragalus propinquus Species 0.000 claims 1
- 235000018185 Betula X alpestris Nutrition 0.000 claims 1
- 235000018212 Betula X uliginosa Nutrition 0.000 claims 1
- 241000196324 Embryophyta Species 0.000 claims 1
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102000000646 Interleukin-3 Human genes 0.000 claims 1
- 108010002386 Interleukin-3 Proteins 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 230000010437 erythropoiesis Effects 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 230000011132 hemopoiesis Effects 0.000 claims 1
- 229940121364 interleukin derivative Drugs 0.000 claims 1
- 229940076264 interleukin-3 Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 210000004233 talus Anatomy 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12258608P | 2008-12-15 | 2008-12-15 | |
| US61/122,586 | 2008-12-15 | ||
| PCT/US2009/068062 WO2010077867A2 (en) | 2008-12-15 | 2009-12-15 | Treating idiopathic thrombocytopenic purpura with compositions comprising extracts of astragalus membranaceus |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512176A JP2012512176A (ja) | 2012-05-31 |
| JP2012512176A5 true JP2012512176A5 (https=) | 2013-02-14 |
| JP5732604B2 JP5732604B2 (ja) | 2015-06-10 |
Family
ID=42266446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540971A Active JP5732604B2 (ja) | 2008-12-15 | 2009-12-15 | キバナオウギ抽出物を含む組成物による特発性血小板減少性紫斑病の治療 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US8137710B2 (https=) |
| EP (1) | EP2376096B1 (https=) |
| JP (1) | JP5732604B2 (https=) |
| KR (1) | KR101780074B1 (https=) |
| CN (1) | CN102300576B (https=) |
| MY (1) | MY159317A (https=) |
| SG (1) | SG172029A1 (https=) |
| TW (1) | TWI507201B (https=) |
| WO (1) | WO2010077867A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103142726A (zh) * | 2013-02-21 | 2013-06-12 | 上海浦东高星生物技术研究所 | 溃疡止血粉 |
| EP3191110A4 (en) * | 2014-08-18 | 2018-04-18 | Pharmagenesis, Inc. | Polygalacturonan rhamnogalacturonan1 (pgrg1) composition |
| CN104173563A (zh) * | 2014-08-22 | 2014-12-03 | 上海中医药大学附属岳阳中西医结合医院 | 一种治疗免疫性血小板减少症的中药组合物 |
| CN104740405B (zh) * | 2015-04-14 | 2018-09-04 | 日照市中医医院 | 一种治疗过敏性紫癜性肾损害的中药制剂及制备方法 |
| CN104784419A (zh) * | 2015-04-24 | 2015-07-22 | 陕西郝其军制药股份有限公司 | 一种治疗免疫性血小板减少性紫癜的中药组合物及其制备方法 |
| CN108066354A (zh) * | 2016-11-10 | 2018-05-25 | 怀特生技新药股份有限公司 | 黄芪多糖萃取物在制备用于增强癌症免疫疗法功效的药物中的用途 |
| CN109199907A (zh) * | 2017-07-07 | 2019-01-15 | 怀特生技新药股份有限公司 | 黄芪萃取物在制备用于抑制黑色素生成的组合物中的应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708949A (en) * | 1985-09-24 | 1987-11-24 | Yaguang Liu | Therapeutic composition from plant extracts |
| US4795742A (en) * | 1985-09-24 | 1989-01-03 | Yaguang Liu | Therapeutic composition from plant extracts |
| US5336506A (en) * | 1986-07-03 | 1994-08-09 | Advanced Magnetics Inc. | Targeting of therapeutic agents using polysaccharides |
| US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
| US5478576A (en) * | 1986-07-03 | 1995-12-26 | Advanced Magnetics, Inc. | Arabinogalactan derivatives and uses thereof |
| US5589591A (en) * | 1986-07-03 | 1996-12-31 | Advanced Magnetics, Inc. | Endotoxin-free polysaccharides |
| US5679323A (en) * | 1986-07-03 | 1997-10-21 | Advanced Magnetics, Inc. | Hepatocyte-specific receptor-mediated endocytosis-type compositions |
| US4843067A (en) * | 1986-11-19 | 1989-06-27 | Yaguang Liu | Polysaccharide containing pharmaceutical composition for increasing the immune function |
| US4944946A (en) * | 1987-01-27 | 1990-07-31 | Yaguang Liu | Pharmaceutical composition for inhibiting viruses and increasing immune function (PII) |
| US5268467A (en) * | 1988-05-23 | 1993-12-07 | Verbiscar Anthony J | Immunomodulatory polysaccharide fractions from Astragalus plants |
| CN1027168C (zh) | 1989-05-13 | 1994-12-28 | 储大同 | 一种黄芪有效成分的提取方法 |
| US4950751A (en) * | 1989-06-02 | 1990-08-21 | The Nanci Corporation International | Method of isolating arabinogalactan from larch |
| IT1238685B (it) | 1990-02-09 | 1993-09-01 | Indena Spa | Polisaccaridi ad azione immunomodulatrice da astragalus membranaceous e composizioni farmaceutiche che li contengono |
| US5116969B1 (en) * | 1990-04-26 | 1997-04-01 | Larex International Inc | Ultrarefined arabinogalactan product |
| CN1025590C (zh) | 1990-07-20 | 1994-08-10 | 邓恺 | 肛瘘注射液的制备方法 |
| ES2049561B1 (es) | 1991-04-27 | 1994-12-16 | Andromaco Lab | Procedimiento para la obtencion de polimeros con actividad sobre el sistema hematopoyetico. |
| US5547997A (en) | 1991-10-01 | 1996-08-20 | Chemisches Laboratorium Dr. Kurt Richter Gmbh | Plant-derived cosmetic composition and method of treatment of skin |
| US5646029A (en) * | 1993-12-03 | 1997-07-08 | Cooperative Research Centre For Industrial Plant Biopolymers | Plant arabinogalactan protein (AGP) genes |
| US5756098A (en) * | 1995-12-12 | 1998-05-26 | The University Of Montana | Methods for the extraction of phytochemicals from fibrous plants in the absence of solvent |
| KR100195884B1 (ko) | 1996-02-12 | 1999-06-15 | 김박광 | 황기 추출물을 함유하는 혈당강하제 조성물 및 황기 추출물의 제조방법 |
| US5770217A (en) * | 1997-07-02 | 1998-06-23 | Atlatl, Inc. | Dietary supplement for hematological, immune and appetite enhancement |
| HK1046290B (zh) * | 1999-06-30 | 2005-08-12 | 天津赛诺制药有限公司 | 造血的阿拉伯半乳聚糖组合物 |
| KR20030021176A (ko) * | 2000-06-29 | 2003-03-12 | 파마제네시스 인코포레이티드 | 산으로 개질된 아라비노갈락탄 단백질 조성물 |
| KR100440863B1 (ko) | 2001-05-24 | 2004-07-19 | 한국원자력연구소 | 조혈기능 증진 및 방사선 방호용 생약추출물 |
| KR100526404B1 (ko) | 2003-07-31 | 2005-11-08 | 학교법인 한림대학교 | 황기 추출물을 포함하는 뇌허혈성 신경세포손상 방지용조성물 |
| KR100449655B1 (ko) | 2003-11-17 | 2004-09-20 | 한국원자력연구소 | 조혈 및 면역기능 증강 및 방사선 방호용 기능성 식품 |
| JP2006070217A (ja) | 2004-09-03 | 2006-03-16 | Kitasato Inst:The | オウギ属植物地上部由来の多糖および生体防御機能賦活化剤 |
| KR100697212B1 (ko) | 2005-01-29 | 2007-03-22 | 서울향료(주) | 황기 및 당귀의 혼합 생약재 추출물을 유효성분으로 하는,항암제 투여에 의해 유발되는 부작용 치료용 조혈 촉진제 |
| KR100760384B1 (ko) | 2006-02-22 | 2007-09-19 | 경희대학교 산학협력단 | 황기 추출물을 포함하는 혈관형성 촉진 및 골유합 효과를갖는 골절의 예방 및 치료용 조성물 |
-
2009
- 2009-12-15 JP JP2011540971A patent/JP5732604B2/ja active Active
- 2009-12-15 SG SG2011041787A patent/SG172029A1/en unknown
- 2009-12-15 EP EP09836839.2A patent/EP2376096B1/en active Active
- 2009-12-15 CN CN200980155742.9A patent/CN102300576B/zh active Active
- 2009-12-15 US US12/638,845 patent/US8137710B2/en active Active
- 2009-12-15 WO PCT/US2009/068062 patent/WO2010077867A2/en not_active Ceased
- 2009-12-15 KR KR1020117016274A patent/KR101780074B1/ko active Active
- 2009-12-15 MY MYPI2011002701A patent/MY159317A/en unknown
- 2009-12-15 TW TW098143056A patent/TWI507201B/zh active
-
2012
- 2012-02-07 US US13/368,319 patent/US8728543B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012512176A5 (https=) | ||
| Chen et al. | Antiviral activity against porcine epidemic diarrhea virus of Pogostemon cablin polysaccharide | |
| CN101474211A (zh) | 一种桑黄提取物及其制备方法 | |
| CN103073648B (zh) | 一种提高金针菇多糖抗氧化活性的方法 | |
| JP2017525702A5 (https=) | ||
| KR20200038199A (ko) | 발효당을 이용한 저열량의 콤부차 제조방법 | |
| CN120605276B (zh) | 巴戟天-菊糖组合物及其在肾脏纤维化产品中的用途 | |
| AU2018201091A1 (en) | A method for mass production of ginsenoside Rh2-Mix | |
| CN102743333A (zh) | 一种左乙拉西坦口服液及其制备方法 | |
| JP5395733B2 (ja) | ビフィズス菌属の細菌の成長を促進し、顆粒球コロニー刺激因子の放出を促進し、ｔヘルパー細胞タイプｉの分化を促進し、及び／又はｔヘルパー細胞タイプｉｉの分化を抑制するためのキバナシュスラン種・多糖類抽出物及び医薬組成物、及びその調製方法 | |
| CN107412254A (zh) | 金线莲多糖提取物的应用 | |
| CN113549163B (zh) | 具有自然免疫活化作用的多糖类以及含有该多糖类的自然免疫活化剂或饮食品 | |
| CN114085296B (zh) | 一种具有免疫增强作用的血红栓菌均一多糖及其应用 | |
| CN108047349B (zh) | 一种卷边桩菇多糖提取物及其制备方法和医用用途 | |
| CN103342755B (zh) | 枸杞多糖均一级份ⅳ及其制备方法和应用 | |
| CN112811915B (zh) | 一种功能性材料及其制备方法 | |
| TWI744971B (zh) | 毛木耳萃取物用於製備誘導未極化的免疫細胞分化成抗發炎型免疫細胞之組成物的用途 | |
| CN110218262A (zh) | 褐藻来源的富含葡萄糖醛酸的低硫酸化杂聚糖在制备治疗2型糖尿病药物中的应用 | |
| US12552841B2 (en) | CRA4S1 gene, encoded CRA4S1 protein, and application | |
| WO2009022221A2 (en) | Composition and method to stimulate growth and defense against pathogens in plants | |
| WO2004112802A1 (en) | Composition comprising soluble glucan oligomer from saccharomyces cerevisiae is2 inhibiting the swine influenza (siv) and transmissible gastroenteritis coronavirus (tgev) | |
| KR101480150B1 (ko) | 말굽버섯 유래의 보체 활성화 다당체 | |
| CN104911233B (zh) | 一种人参多糖的提取方法及其在制备降血糖药物和食品中的应用 | |
| CN100532395C (zh) | 一种源自灰树花子实体的α-葡聚糖、其制备方法及用途 | |
| CN107827992B (zh) | 一种高纯度条斑紫菜多糖类α-淀粉酶抑制剂的制备方法 |