JP2012511313A - 突然変異ｒｘｘｄモチーフを含むジグアニル酸シクラーゼを用いる環状ジグアノシン一リン酸の酵素的生産方法 - Google Patents
突然変異ｒｘｘｄモチーフを含むジグアニル酸シクラーゼを用いる環状ジグアノシン一リン酸の酵素的生産方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/36—Dinucleotides, e.g. nicotineamide-adenine dinucleotide phosphate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US12092508P | 2008-12-09 | 2008-12-09 | |
| EP08171026 | 2008-12-09 | ||
| EP08171026.1 | 2008-12-09 | ||
| US61/120,925 | 2008-12-09 | ||
| PCT/EP2009/066492 WO2010066666A1 (en) | 2008-12-09 | 2009-12-07 | Process for the enzymatic production of cyclic diguanosine monophosphate employing a diguanylate cyclase comprising a mutated rxxd motif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511313A true JP2012511313A (ja) | 2012-05-24 |
| JP2012511313A5 JP2012511313A5 (https=) | 2013-01-31 |
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| JP2011540039A Pending JP2012511313A (ja) | 2008-12-09 | 2009-12-07 | 突然変異ｒｘｘｄモチーフを含むジグアニル酸シクラーゼを用いる環状ジグアノシン一リン酸の酵素的生産方法 |
Country Status (12)
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| US (1) | US20110288286A1 (https=) |
| EP (1) | EP2376634A1 (https=) |
| JP (1) | JP2012511313A (https=) |
| KR (1) | KR20110099111A (https=) |
| CN (1) | CN102245774A (https=) |
| AR (1) | AR074495A1 (https=) |
| AU (1) | AU2009326306B2 (https=) |
| BR (1) | BRPI0923296A2 (https=) |
| CA (1) | CA2747127A1 (https=) |
| TW (1) | TW201033367A (https=) |
| UY (1) | UY32307A (https=) |
| WO (1) | WO2010066666A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013129427A1 (ja) | 2012-02-29 | 2013-09-06 | ヤマサ醤油株式会社 | cyclic di-GMPの実践的酵素合成法 |
| CN113122593A (zh) * | 2019-12-31 | 2021-07-16 | 安徽古特生物科技有限公司 | 一种利用多聚磷酸盐制备核苷三磷酸和脱氧核苷三磷酸的方法 |
| CN111647611A (zh) * | 2020-07-02 | 2020-09-11 | 杭州美亚药业股份有限公司 | 一种双鸟苷酸环化酶改造基因、编码蛋白、工程菌及其构建方法和应用 |
| CN117701596A (zh) * | 2023-12-08 | 2024-03-15 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种大量合成天然环二鸟苷酸的基因工程菌及其应用 |
Citations (1)
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| JPH08187094A (ja) * | 1994-09-07 | 1996-07-23 | Suntory Ltd | 蛋白の製造方法 |
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| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
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- 2009-12-07 BR BRPI0923296-6A patent/BRPI0923296A2/pt not_active IP Right Cessation
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- 2009-12-07 CA CA2747127A patent/CA2747127A1/en not_active Abandoned
- 2009-12-07 CN CN2009801489188A patent/CN102245774A/zh active Pending
- 2009-12-07 JP JP2011540039A patent/JP2012511313A/ja active Pending
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Patent Citations (1)
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| JPH08187094A (ja) * | 1994-09-07 | 1996-07-23 | Suntory Ltd | 蛋白の製造方法 |
Non-Patent Citations (7)
| Title |
|---|
| JPN5012005026; ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ． ２８１， Ｎｏ． ４２, 2006, Ｐ． ３２０１５-３２０２４ * |
| JPN5012005027; ＪＯＵＲＮＡＬ ＯＦ ＢＡＣＴＥＲＩＯＬＯＧＹ Ｖｏｌ． １８７， Ｎｏ． ５, 2005, Ｐ． １７９２-１７９８ * |
| JPN5012005028; ＢＩＯＴＥＣＨＮＯＬＯＧＹ ＡＮＮＵＡＬ ＲＥＶＩＥＷ Ｖｏｌ． １０, 2004, Ｐ． ３１-５０ * |
| JPN5012005029; ＢＵＬＬＥＴＩＮ ＯＦ ＴＨＥ ＣＨＥＭＩＣＡＬ ＳＯＣＩＥＴＹ ＯＦ ＪＡＰＡＮ Ｖｏｌ． ７７， Ｎｏ． １１, 2004, Ｐ． ２０８９-２０９３ * |
| JPN6014020786; 蛋白質 核酸 酵素 Ｖｏｌ． ４６， Ｎｏ． ９, 2001, Ｐ． １２３８-１２４６ * |
| JPN6014020787; Ｃｕｒｒｅｎｔ Ｏｐｉｎｉｏｎ ｉｎ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．１２， Ｎｏ． ２, 2001, Ｐ． ２０２-２０７ * |
| JPN6014020788; Ｄａｔａｂａｓｅ ＧｅｎＢａｎｋ，［ｏｎｌｉｎｅ］，Ａｃｃｅｓｓｉｏｎ Ｎｏ． ＡＡＫ２５２４７， ＜ｈｔｔｐ：／／ｗｗｗ．ｎｃｂｉ．ｎｌｍ．ｎｉｈ．ｇｏｖ／ｐｒｏｔｅｉｎ／１３４２４９７７？ｓ * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20110288286A1 (en) | 2011-11-24 |
| CA2747127A1 (en) | 2010-06-17 |
| BRPI0923296A2 (pt) | 2015-08-11 |
| EP2376634A1 (en) | 2011-10-19 |
| WO2010066666A1 (en) | 2010-06-17 |
| AU2009326306A1 (en) | 2010-06-17 |
| UY32307A (es) | 2010-02-26 |
| KR20110099111A (ko) | 2011-09-06 |
| CN102245774A (zh) | 2011-11-16 |
| AR074495A1 (es) | 2011-01-19 |
| TW201033367A (en) | 2010-09-16 |
| AU2009326306B2 (en) | 2012-12-13 |
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