JP2012511313A5 - - Google Patents
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- Publication number
- JP2012511313A5 JP2012511313A5 JP2011540039A JP2011540039A JP2012511313A5 JP 2012511313 A5 JP2012511313 A5 JP 2012511313A5 JP 2011540039 A JP2011540039 A JP 2011540039A JP 2011540039 A JP2011540039 A JP 2011540039A JP 2012511313 A5 JP2012511313 A5 JP 2012511313A5
- Authority
- JP
- Japan
- Prior art keywords
- dgc
- mutant
- modified
- motif
- gmp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108010085933 diguanylate cyclase Proteins 0.000 claims 17
- 238000004519 manufacturing process Methods 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- 241000618400 Grapevine geminivirus A Species 0.000 claims 2
- XKMLYUALXHKNFT-UUOKFMHZSA-N Guanosine-5'-triphosphate Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O XKMLYUALXHKNFT-UUOKFMHZSA-N 0.000 claims 2
- 101001071380 Rhizobium sp. (strain MTP-10005) Gamma-resorcylate decarboxylase Proteins 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- UKWAMSAUNRIURK-BWYYQZIESA-N gmgg Chemical compound C1=CC(OC)=CC=C1OC[C@@H]1[C@@H](O[C@H]2[C@@H]([C@@H](OCC=3C=CC=CC=3)[C@H](O[C@H]3[C@H]([C@@H](OCC=C)[C@H](O[C@H]4[C@@H]([C@@H](OCC=5C=CC=CC=5)[C@H](OCC=5C=CC=CC=5)[C@@H](COCC=5C=CC=CC=5)O4)N4C(C5=CC=CC=C5C4=O)=O)[C@@H](COCC=C)O3)OCC=3C=CC=CC=3)[C@@H](COCC=3C=CC=CC=3)O2)N2C(C3=CC=CC=C3C2=O)=O)[C@H](OCC=2C=CC=CC=2)[C@@H](N2C(C3=CC=CC=C3C2=O)=O)[C@H](OCC=C)O1 UKWAMSAUNRIURK-BWYYQZIESA-N 0.000 claims 2
- 150000004712 monophosphates Chemical class 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 230000008856 allosteric binding Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000002255 enzymatic effect Effects 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 210000003000 inclusion body Anatomy 0.000 claims 1
- 230000002018 overexpression Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12092508P | 2008-12-09 | 2008-12-09 | |
| EP08171026.1 | 2008-12-09 | ||
| EP08171026 | 2008-12-09 | ||
| US61/120,925 | 2008-12-09 | ||
| PCT/EP2009/066492 WO2010066666A1 (en) | 2008-12-09 | 2009-12-07 | Process for the enzymatic production of cyclic diguanosine monophosphate employing a diguanylate cyclase comprising a mutated rxxd motif |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012511313A JP2012511313A (ja) | 2012-05-24 |
| JP2012511313A5 true JP2012511313A5 (https=) | 2013-01-31 |
Family
ID=40602165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011540039A Pending JP2012511313A (ja) | 2008-12-09 | 2009-12-07 | 突然変異rxxdモチーフを含むジグアニル酸シクラーゼを用いる環状ジグアノシン一リン酸の酵素的生産方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110288286A1 (https=) |
| EP (1) | EP2376634A1 (https=) |
| JP (1) | JP2012511313A (https=) |
| KR (1) | KR20110099111A (https=) |
| CN (1) | CN102245774A (https=) |
| AR (1) | AR074495A1 (https=) |
| AU (1) | AU2009326306B2 (https=) |
| BR (1) | BRPI0923296A2 (https=) |
| CA (1) | CA2747127A1 (https=) |
| TW (1) | TW201033367A (https=) |
| UY (1) | UY32307A (https=) |
| WO (1) | WO2010066666A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6047143B2 (ja) | 2012-02-29 | 2016-12-21 | ヤマサ醤油株式会社 | cyclicdi−GMPの実践的酵素合成法 |
| CN113122593A (zh) * | 2019-12-31 | 2021-07-16 | 安徽古特生物科技有限公司 | 一种利用多聚磷酸盐制备核苷三磷酸和脱氧核苷三磷酸的方法 |
| CN111647611A (zh) * | 2020-07-02 | 2020-09-11 | 杭州美亚药业股份有限公司 | 一种双鸟苷酸环化酶改造基因、编码蛋白、工程菌及其构建方法和应用 |
| CN117701596A (zh) * | 2023-12-08 | 2024-03-15 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种大量合成天然环二鸟苷酸的基因工程菌及其应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037145A (en) * | 1994-09-07 | 2000-03-14 | Suntory Limited | Process for production of protein |
| JP3995279B2 (ja) * | 1994-09-07 | 2007-10-24 | アスビオファーマ株式会社 | 蛋白の製造方法 |
-
2009
- 2009-12-07 WO PCT/EP2009/066492 patent/WO2010066666A1/en not_active Ceased
- 2009-12-07 JP JP2011540039A patent/JP2012511313A/ja active Pending
- 2009-12-07 BR BRPI0923296-6A patent/BRPI0923296A2/pt not_active IP Right Cessation
- 2009-12-07 TW TW098141714A patent/TW201033367A/zh unknown
- 2009-12-07 CA CA2747127A patent/CA2747127A1/en not_active Abandoned
- 2009-12-07 EP EP09764839A patent/EP2376634A1/en not_active Withdrawn
- 2009-12-07 CN CN2009801489188A patent/CN102245774A/zh active Pending
- 2009-12-07 US US13/133,458 patent/US20110288286A1/en not_active Abandoned
- 2009-12-07 AU AU2009326306A patent/AU2009326306B2/en not_active Ceased
- 2009-12-07 AR ARP090104726A patent/AR074495A1/es not_active Application Discontinuation
- 2009-12-07 KR KR1020117014319A patent/KR20110099111A/ko not_active Withdrawn
- 2009-12-08 UY UY0001032307A patent/UY32307A/es not_active Application Discontinuation
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