JP2012510431A5 - - Google Patents
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- JP2012510431A5 JP2012510431A5 JP2011537796A JP2011537796A JP2012510431A5 JP 2012510431 A5 JP2012510431 A5 JP 2012510431A5 JP 2011537796 A JP2011537796 A JP 2011537796A JP 2011537796 A JP2011537796 A JP 2011537796A JP 2012510431 A5 JP2012510431 A5 JP 2012510431A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- composition
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 45
- 239000012634 fragment Substances 0.000 claims 17
- 125000003275 alpha amino acid group Chemical group 0.000 claims 15
- 102000040430 polynucleotide Human genes 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 14
- 239000002157 polynucleotide Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 13
- 229960005486 vaccine Drugs 0.000 claims 13
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 8
- 208000015943 Coeliac disease Diseases 0.000 claims 6
- 108010068370 Glutens Proteins 0.000 claims 6
- 235000021312 gluten Nutrition 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000028327 secretion Effects 0.000 claims 4
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical group OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 239000002671 adjuvant Substances 0.000 claims 3
- 210000004899 c-terminal region Anatomy 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 230000001939 inductive effect Effects 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000003814 Interleukin-10 Human genes 0.000 claims 2
- 108090000174 Interleukin-10 Proteins 0.000 claims 2
- 102000000588 Interleukin-2 Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 239000004365 Protease Substances 0.000 claims 2
- ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Chemical group OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
- 230000005867 T cell response Effects 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 2
- ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Chemical group OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 230000030741 antigen processing and presentation Effects 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 230000006058 immune tolerance Effects 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 229940076144 interleukin-10 Drugs 0.000 claims 2
- 230000002797 proteolythic effect Effects 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 150000001408 amides Chemical group 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11864308P | 2008-11-30 | 2008-11-30 | |
| US61/118,643 | 2008-11-30 | ||
| PCT/AU2009/001556 WO2010060155A1 (en) | 2008-11-30 | 2009-11-30 | Compositions and methods for treatment of celiac disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015235197A Division JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012510431A JP2012510431A (ja) | 2012-05-10 |
| JP2012510431A5 true JP2012510431A5 (https=) | 2013-03-28 |
| JP5851243B2 JP5851243B2 (ja) | 2016-02-03 |
Family
ID=42225141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011537796A Expired - Fee Related JP5851243B2 (ja) | 2008-11-30 | 2009-11-30 | セリアック病の処置のための組成物および方法 |
| JP2015235197A Expired - Fee Related JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015235197A Expired - Fee Related JP6027215B2 (ja) | 2008-11-30 | 2015-12-01 | セリアック病の処置のための組成物および方法 |
Country Status (16)
| Country | Link |
|---|---|
| US (5) | US8835603B2 (https=) |
| EP (3) | EP2367561B1 (https=) |
| JP (2) | JP5851243B2 (https=) |
| CN (2) | CN102438643B (https=) |
| AU (1) | AU2009321481B2 (https=) |
| BR (1) | BRPI0922122A2 (https=) |
| CA (2) | CA3042826A1 (https=) |
| DK (2) | DK2367561T3 (https=) |
| ES (2) | ES2549481T3 (https=) |
| HK (1) | HK1249446A1 (https=) |
| HR (1) | HRP20150873T1 (https=) |
| HU (1) | HUE027237T2 (https=) |
| MX (1) | MX346450B (https=) |
| NZ (1) | NZ593474A (https=) |
| PT (1) | PT2367561E (https=) |
| WO (1) | WO2010060155A1 (https=) |
Families Citing this family (53)
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| EP2486935B1 (en) | 2004-04-28 | 2021-04-07 | BTG International Limited | Epitopes related to Coeliac Disease |
| US10105437B2 (en) * | 2004-04-28 | 2018-10-23 | Btg International Limited | Epitopes related to coeliac disease |
| CN102438643B (zh) | 2008-11-30 | 2015-07-01 | 免疫桑特公司 | 用于治疗乳糜泻的组合物和方法 |
| US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
| WO2012021512A2 (en) | 2010-08-10 | 2012-02-16 | Ecole Polytechnique Federale De Lausanne | Erythrocyte-binding therapeutics |
| JP5937106B2 (ja) * | 2011-01-20 | 2016-06-22 | サイレックス ラボラトリーズ，エルエルシー | グルテン感受性の検出およびグルテン感受性とセリアック病を鑑別するための方法ならびに装置 |
| ITRM20110487A1 (it) * | 2011-09-19 | 2013-03-20 | Consiglio Per La Ricerca E La Speri Mentazione In | Peptidi aventi effetto protettivo nei confronti della attività infiammatoria del peptide 31-43 della a-gliadina nella malattia celiaca. |
| ES2402286B1 (es) * | 2011-09-29 | 2014-03-04 | Universidad De Valladolid | Péptido inmunogénico del gluten y sus aplicaciones. |
| JP6012767B2 (ja) | 2012-02-07 | 2016-10-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 基板、ペプチドアレイ、および方法 |
| WO2013192532A2 (en) | 2012-06-21 | 2013-12-27 | Northwestern University | Peptide conjugated particles |
| US10006909B2 (en) | 2012-09-28 | 2018-06-26 | Vibrant Holdings, Llc | Methods, systems, and arrays for biomolecular analysis |
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| EP2994480A4 (en) * | 2013-05-08 | 2017-05-17 | JM Biologicals | Compositions and methods for the production of gluten free food products |
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| US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
| US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| KR102717969B1 (ko) | 2014-02-21 | 2024-10-15 | 에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘) | 글리코타겟팅 치료제 |
| US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
| WO2015164714A1 (en) * | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Use of interleukin-2 for diagnosis of celiac disease |
| AU2015314934A1 (en) * | 2014-09-10 | 2017-04-20 | Vibrant Holdings, Llc | Peptide microarrays and novel biomarkers for celiac disease |
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| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| WO2017058074A1 (en) * | 2015-08-30 | 2017-04-06 | Diamyd Medical Ab | Combination therapy using gliadin and gamma aminobutyric acid |
| IL260074B2 (en) | 2015-12-23 | 2026-01-01 | Cour Pharmaceuticals Dev Company Inc | Covalent polymer-antigen particle conjugates |
| EP4309650A3 (en) | 2016-02-18 | 2024-03-27 | Cour Pharmaceuticals Development Company Inc. | Process for the preparation of tolerizing immune-modulating particles |
| EP3464322B1 (en) * | 2016-06-05 | 2023-04-05 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Novel molecules for the treatment of inflammation |
| AU2017290080A1 (en) | 2016-06-28 | 2019-01-24 | Immusant, Inc. | Escalating dosage schedules for treating celiac disease |
| BR112019014418A2 (pt) * | 2017-01-12 | 2020-04-14 | Probi Ab | composições probióticas e usos das mesmas |
| US10538808B2 (en) | 2017-05-26 | 2020-01-21 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| US11253579B2 (en) | 2017-06-16 | 2022-02-22 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
| TW201920249A (zh) | 2017-09-07 | 2019-06-01 | 美商信號生物製藥公司 | 具有結合位點之t細胞調節多聚體多肽及其使用方法 |
| WO2019089572A1 (en) * | 2017-10-30 | 2019-05-09 | Immusant, Inc. | Dosing regimens for celiac disease |
| JP6568193B2 (ja) | 2017-12-19 | 2019-08-28 | ホーユー株式会社 | エピトープ |
| JP2021512905A (ja) * | 2018-02-08 | 2021-05-20 | クール ファーマシューティカルズ ディベロップメント カンパニー インコーポレイテッド | 寛容化粒子によるセリアック病の治療 |
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| US20230001010A1 (en) * | 2019-07-19 | 2023-01-05 | The Regents Of The University Of Michigan | Compositions and methods for treating autoimmune disorders |
| JP7374687B2 (ja) * | 2019-09-26 | 2023-11-07 | 三和酒類株式会社 | ペンタペプチド化合物 |
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| EP3046576A4 (en) | 2013-09-20 | 2017-07-12 | Immusant Inc. | Compositions and methods related to oat sensitivity |
| WO2015164714A1 (en) | 2014-04-24 | 2015-10-29 | Immusant, Inc. | Use of interleukin-2 for diagnosis of celiac disease |
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2009
- 2009-11-30 CN CN200980155615.9A patent/CN102438643B/zh not_active Expired - Fee Related
- 2009-11-30 PT PT98284532T patent/PT2367561E/pt unknown
- 2009-11-30 CA CA3042826A patent/CA3042826A1/en not_active Abandoned
- 2009-11-30 CA CA2744787A patent/CA2744787C/en active Active
- 2009-11-30 ES ES09828453.2T patent/ES2549481T3/es active Active
- 2009-11-30 BR BRPI0922122A patent/BRPI0922122A2/pt not_active IP Right Cessation
- 2009-11-30 MX MX2011005632A patent/MX346450B/es active IP Right Grant
- 2009-11-30 US US13/131,787 patent/US8835603B2/en active Active
- 2009-11-30 EP EP20090828453 patent/EP2367561B1/en not_active Not-in-force
- 2009-11-30 AU AU2009321481A patent/AU2009321481B2/en not_active Ceased
- 2009-11-30 DK DK09828453.2T patent/DK2367561T3/en active
- 2009-11-30 HR HRP20150873TT patent/HRP20150873T1/hr unknown
- 2009-11-30 WO PCT/AU2009/001556 patent/WO2010060155A1/en not_active Ceased
- 2009-11-30 EP EP17175226.4A patent/EP3269379A1/en not_active Withdrawn
- 2009-11-30 NZ NZ593474A patent/NZ593474A/xx not_active IP Right Cessation
- 2009-11-30 EP EP15168279.6A patent/EP2977053B1/en not_active Not-in-force
- 2009-11-30 DK DK15168279.6T patent/DK2977053T3/en active
- 2009-11-30 JP JP2011537796A patent/JP5851243B2/ja not_active Expired - Fee Related
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- 2009-11-30 CN CN201510292861.6A patent/CN105079781B/zh not_active Expired - Fee Related
- 2009-11-30 HU HUE09828453A patent/HUE027237T2/en unknown
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2014
- 2014-08-13 US US14/459,060 patent/US9464120B2/en not_active Expired - Fee Related
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2015
- 2015-12-01 JP JP2015235197A patent/JP6027215B2/ja not_active Expired - Fee Related
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2016
- 2016-09-09 US US15/260,990 patent/US20170158743A1/en not_active Abandoned
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2018
- 2018-06-18 US US16/010,596 patent/US20190048047A1/en not_active Abandoned
- 2018-07-16 HK HK18109154.3A patent/HK1249446A1/en unknown
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2020
- 2020-05-27 US US16/884,533 patent/US20210115096A1/en not_active Abandoned
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