JP2012509273A - 核酸送達系のための放出可能融合性脂質 - Google Patents
核酸送達系のための放出可能融合性脂質 Download PDFInfo
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- JP2012509273A JP2012509273A JP2011536585A JP2011536585A JP2012509273A JP 2012509273 A JP2012509273 A JP 2012509273A JP 2011536585 A JP2011536585 A JP 2011536585A JP 2011536585 A JP2011536585 A JP 2011536585A JP 2012509273 A JP2012509273 A JP 2012509273A
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- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509272A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出性カチオン脂質 |
| JP2019535808A (ja) * | 2016-10-17 | 2019-12-12 | 南京▲緑▼叶制▲薬▼有限公司 | ｂｃｌ−２を抑制するアンチセンスオリゴヌクレオチドの脂質ナノ粒子及びその調製方法 |
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| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| WO2010141566A1 (en) | 2009-06-03 | 2010-12-09 | Immunogen, Inc. | Conjugation methods |
| MX341332B (es) * | 2010-06-03 | 2016-08-16 | Alnylam Pharmaceuticals Inc | Lipidos biodegradables para la administracion de agentes activos. |
| AU2011269041B2 (en) | 2010-06-22 | 2015-05-07 | Centre National De La Recherche Scientifique | Optimized in vivo delivery system with endosomolytic agents for nucleic acid conjugates |
| RS58367B1 (sr) * | 2011-03-29 | 2019-03-29 | Immunogen Inc | Priprema konjugata antitela i majtanzinoida jednostepenim postupkom |
| EP2527440A1 (en) | 2011-05-27 | 2012-11-28 | Institut Curie | Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia |
| US9061063B2 (en) | 2011-12-07 | 2015-06-23 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| US10358680B2 (en) * | 2012-09-11 | 2019-07-23 | Duke University | Nano-plasmonic molecular probes for plasmonics coupling interference |
| IN2015DN03202A (enExample) | 2012-10-04 | 2015-10-02 | Immunogen Inc | |
| CN105611914B (zh) | 2013-06-19 | 2020-09-08 | 加利福尼亚大学董事会 | 局部递送治疗剂的化学构造物 |
| CN105939699B (zh) | 2013-12-03 | 2020-10-02 | 西北大学 | 脂质体颗粒、制备所述脂质体颗粒的方法以及其用途 |
| CN106659796B (zh) * | 2014-03-14 | 2021-04-30 | 加利福尼亚大学董事会 | Tco缀合物和治疗剂递送方法 |
| TWI665192B (zh) | 2014-05-28 | 2019-07-11 | 德商拜耳作物科學股份有限公司 | 製備二氫異唑衍生物之方法 |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| CN106794256B (zh) | 2014-08-19 | 2021-04-30 | 西北大学 | 蛋白质/寡核苷酸核-壳纳米颗粒治疗剂 |
| EP3220895B1 (en) | 2014-11-21 | 2022-08-31 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| CN117567535A (zh) | 2015-09-10 | 2024-02-20 | 坦伯公司 | 生物正交组合物 |
| US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
| CN107951861B (zh) * | 2016-10-17 | 2020-12-01 | 南京绿叶制药有限公司 | 一种脂质纳米粒膜材料组合物 |
| US10383952B2 (en) * | 2016-12-21 | 2019-08-20 | Arcturus Therapeutics, Inc. | Ionizable cationic lipid for RNA delivery |
| ES2983582T3 (es) | 2017-04-07 | 2024-10-23 | Tambo Inc | Composiciones bioortogonales |
| WO2018209270A1 (en) | 2017-05-11 | 2018-11-15 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (snas) |
| KR20200028997A (ko) | 2017-07-13 | 2020-03-17 | 노오쓰웨스턴 유니버시티 | 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법 |
| KR102751412B1 (ko) * | 2017-11-06 | 2025-01-09 | 닛토덴코 가부시키가이샤 | 생물학적 활성 분자의 전달을 위한 융합성 화합물 |
| US12319711B2 (en) | 2019-09-20 | 2025-06-03 | Northwestern University | Spherical nucleic acids with tailored and active protein coronae |
| US12378560B2 (en) | 2019-10-29 | 2025-08-05 | Northwestern University | Sequence multiplicity within spherical nucleic acids |
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- 2009-11-17 EP EP09826954A patent/EP2355799A4/en not_active Withdrawn
- 2009-11-17 CA CA2742846A patent/CA2742846A1/en not_active Abandoned
- 2009-11-17 CN CN2009801459159A patent/CN102215820A/zh active Pending
- 2009-11-17 US US13/129,546 patent/US20110223257A1/en not_active Abandoned
- 2009-11-17 JP JP2011536585A patent/JP2012509273A/ja not_active Ceased
- 2009-11-17 TW TW098138943A patent/TW201021852A/zh unknown
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509272A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出性カチオン脂質 |
| JP2019535808A (ja) * | 2016-10-17 | 2019-12-12 | 南京▲緑▼叶制▲薬▼有限公司 | ｂｃｌ−２を抑制するアンチセンスオリゴヌクレオチドの脂質ナノ粒子及びその調製方法 |
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| WO2010057160A9 (en) | 2011-05-05 |
| CN102215820A (zh) | 2011-10-12 |
| TW201021852A (en) | 2010-06-16 |
| EP2355799A1 (en) | 2011-08-17 |
| CA2742846A1 (en) | 2010-05-20 |
| US20110223257A1 (en) | 2011-09-15 |
| WO2010057160A1 (en) | 2010-05-20 |
| EP2355799A4 (en) | 2012-09-05 |
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