CA2742846A1 - Releasable fusogenic lipids for nucleic acids delivery systems - Google Patents

Releasable fusogenic lipids for nucleic acids delivery systems Download PDF

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Publication number
CA2742846A1
CA2742846A1 CA2742846A CA2742846A CA2742846A1 CA 2742846 A1 CA2742846 A1 CA 2742846A1 CA 2742846 A CA2742846 A CA 2742846A CA 2742846 A CA2742846 A CA 2742846A CA 2742846 A1 CA2742846 A1 CA 2742846A1
Authority
CA
Canada
Prior art keywords
substituted
ch2ch2o
2nhc
ch2ch2
nanoparticle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2742846A
Other languages
English (en)
French (fr)
Inventor
Hong Zhao
Weili Yan
Lianjun Shi
Dechun Wu
Maksim Royzen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Belrose Pharma Inc
Original Assignee
Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of CA2742846A1 publication Critical patent/CA2742846A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
CA2742846A 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems Abandoned CA2742846A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11537808P 2008-11-17 2008-11-17
US61/115,378 2008-11-17
PCT/US2009/064730 WO2010057160A1 (en) 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CA2742846A1 true CA2742846A1 (en) 2010-05-20

Family

ID=42170408

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2742846A Abandoned CA2742846A1 (en) 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems

Country Status (7)

Country Link
US (1) US20110223257A1 (enExample)
EP (1) EP2355799A4 (enExample)
JP (1) JP2012509273A (enExample)
CN (1) CN102215820A (enExample)
CA (1) CA2742846A1 (enExample)
TW (1) TW201021852A (enExample)
WO (1) WO2010057160A1 (enExample)

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EA033468B1 (ru) 2011-03-29 2019-10-31 Immunogen Inc Способы получения конъюгата "антитело-майтансиноид"
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US10358680B2 (en) * 2012-09-11 2019-07-23 Duke University Nano-plasmonic molecular probes for plasmonics coupling interference
EP2904089A4 (en) 2012-10-04 2016-05-25 Immunogen Inc USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES
EP3010486B1 (en) 2013-06-19 2023-11-22 The Regents of The University of California Chemical structures for localized delivery of therapeutic agents
WO2015126502A2 (en) 2013-12-03 2015-08-27 Northwestern University Liposomal particles, methods of making same and uses thereof
AU2015229014B2 (en) * 2014-03-14 2019-07-25 The Regents Of The University Of California TCO conjugates and methods for delivery of therapeutic agents
TWI665192B (zh) 2014-05-28 2019-07-11 Bayer Cropscience Aktiengesellschaft 製備二氫異唑衍生物之方法
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
EP3183007B1 (en) 2014-08-19 2020-06-17 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
WO2016081911A2 (en) * 2014-11-21 2016-05-26 Northwestern University The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
CN108135857A (zh) 2015-09-10 2018-06-08 沙思奇公司 生物正交组合物
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
CN107951861B (zh) * 2016-10-17 2020-12-01 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN107951862B (zh) * 2016-10-17 2021-03-12 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
US10383952B2 (en) * 2016-12-21 2019-08-20 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US10526284B2 (en) 2016-12-21 2020-01-07 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
AU2018250312C1 (en) 2017-04-07 2024-08-22 Tambo, Inc. Bioorthogonal compositions
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
JP2020526558A (ja) 2017-07-13 2020-08-31 ノースウェスタン ユニバーシティ オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法
WO2019090359A1 (en) * 2017-11-06 2019-05-09 Nitto Denko Corporation Fusogenic compounds for delivery of biologically active molecules
US12702719B2 (en) 2019-03-06 2026-08-11 Northwestern University Hairpin-like oligonucleotide-conjugated spherical nucleic acid
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
JP2023537066A (ja) 2020-08-07 2023-08-30 タンボ・インコーポレイテッド トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
EP4304640A1 (en) 2021-03-12 2024-01-17 Northwestern University Antiviral vaccines using spherical nucleic acids
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WO2006007712A1 (en) * 2004-07-19 2006-01-26 Protiva Biotherapeutics, Inc. Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
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Also Published As

Publication number Publication date
WO2010057160A1 (en) 2010-05-20
TW201021852A (en) 2010-06-16
CN102215820A (zh) 2011-10-12
EP2355799A4 (en) 2012-09-05
EP2355799A1 (en) 2011-08-17
WO2010057160A9 (en) 2011-05-05
JP2012509273A (ja) 2012-04-19
US20110223257A1 (en) 2011-09-15

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FZDE Discontinued

Effective date: 20141118