CN102215820A - 用于核酸输送系统的可释放融合脂质 - Google Patents

用于核酸输送系统的可释放融合脂质 Download PDF

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Publication number
CN102215820A
CN102215820A CN2009801459159A CN200980145915A CN102215820A CN 102215820 A CN102215820 A CN 102215820A CN 2009801459159 A CN2009801459159 A CN 2009801459159A CN 200980145915 A CN200980145915 A CN 200980145915A CN 102215820 A CN102215820 A CN 102215820A
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nhc
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nanoparticle
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Chinese (zh)
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赵洪
彦魏丽
史连军
马克西姆·瑞真
乌德春
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2009801459159A 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质 Pending CN102215820A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11537808P 2008-11-17 2008-11-17
US61/115,378 2008-11-17
PCT/US2009/064730 WO2010057160A1 (en) 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems

Publications (1)

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CN102215820A true CN102215820A (zh) 2011-10-12

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CN2009801459159A Pending CN102215820A (zh) 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质

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US (1) US20110223257A1 (enExample)
EP (1) EP2355799A4 (enExample)
JP (1) JP2012509273A (enExample)
CN (1) CN102215820A (enExample)
CA (1) CA2742846A1 (enExample)
TW (1) TW201021852A (enExample)
WO (1) WO2010057160A1 (enExample)

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CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质

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US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
RS58810B1 (sr) 2009-06-03 2019-07-31 Immunogen Inc Metodi konjugacije
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DK3372248T3 (da) 2010-06-22 2020-04-06 Onxeo Optimeret in vivo leveringssystem med endosomolytiske midler til nukleinsyrekonjugater
SMT201900114T1 (it) * 2011-03-29 2019-02-28 Immunogen Inc Preparazione di coniugati maytansinoide-anticorpo mediante un processo a fase unica
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
HK1200089A1 (en) 2011-12-07 2015-07-31 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
SI2791160T1 (sl) 2011-12-16 2022-07-29 Modernatx, Inc. Sestave modificirane MRNA
US10358680B2 (en) * 2012-09-11 2019-07-23 Duke University Nano-plasmonic molecular probes for plasmonics coupling interference
NZ707091A (en) 2012-10-04 2018-12-21 Immunogen Inc Use of a pvdf membrane to purify cell-binding agent cytotoxic agent conjugates
CN105611914B (zh) 2013-06-19 2020-09-08 加利福尼亚大学董事会 局部递送治疗剂的化学构造物
EP3076918A4 (en) 2013-12-03 2017-06-07 Northwestern University Liposomal particles, methods of making same and uses thereof
AU2015229014B2 (en) 2014-03-14 2019-07-25 The Regents Of The University Of California TCO conjugates and methods for delivery of therapeutic agents
TWI665192B (zh) 2014-05-28 2019-07-11 德商拜耳作物科學股份有限公司 製備二氫異唑衍生物之方法
CA2953216C (en) 2014-06-04 2020-12-22 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
US12264344B2 (en) 2014-08-19 2025-04-01 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
CN117567535A (zh) 2015-09-10 2024-02-20 坦伯公司 生物正交组合物
US11364304B2 (en) 2016-08-25 2022-06-21 Northwestern University Crosslinked micellar spherical nucleic acids
WO2018187740A1 (en) 2017-04-07 2018-10-11 Shasqi, Inc. Bioorthogonal compositions
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
KR20200028997A (ko) 2017-07-13 2020-03-17 노오쓰웨스턴 유니버시티 올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
CN111386105B (zh) * 2017-11-06 2023-09-15 日东电工株式会社 用于递送生物活性分子的膜融合化合物
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids

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US20080281044A1 (en) * 2006-08-18 2008-11-13 Monahan Sean D Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers

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US20080281044A1 (en) * 2006-08-18 2008-11-13 Monahan Sean D Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106493A (zh) * 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
WO2018072646A1 (zh) * 2016-10-17 2018-04-26 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861B (zh) * 2016-10-17 2020-12-01 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN112587504A (zh) * 2016-10-17 2021-04-02 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN112587504B (zh) * 2016-10-17 2022-10-18 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质

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US20110223257A1 (en) 2011-09-15
WO2010057160A9 (en) 2011-05-05
WO2010057160A1 (en) 2010-05-20
JP2012509273A (ja) 2012-04-19
EP2355799A4 (en) 2012-09-05
CA2742846A1 (en) 2010-05-20
TW201021852A (en) 2010-06-16
EP2355799A1 (en) 2011-08-17

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Application publication date: 20111012