CN102215820A - 用于核酸输送系统的可释放融合脂质 - Google Patents

用于核酸输送系统的可释放融合脂质 Download PDF

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Publication number
CN102215820A
CN102215820A CN2009801459159A CN200980145915A CN102215820A CN 102215820 A CN102215820 A CN 102215820A CN 2009801459159 A CN2009801459159 A CN 2009801459159A CN 200980145915 A CN200980145915 A CN 200980145915A CN 102215820 A CN102215820 A CN 102215820A
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China
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alkyl
ch2ch2o
nhc
nanoparticle
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Chinese (zh)
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赵洪
彦魏丽
史连军
马克西姆·瑞真
乌德春
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Viskase Holdings Inc
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Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2009801459159A 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质 Pending CN102215820A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11537808P 2008-11-17 2008-11-17
US61/115,378 2008-11-17
PCT/US2009/064730 WO2010057160A1 (en) 2008-11-17 2009-11-17 Releasable fusogenic lipids for nucleic acids delivery systems

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CN102215820A true CN102215820A (zh) 2011-10-12

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CN2009801459159A Pending CN102215820A (zh) 2008-11-17 2009-11-17 用于核酸输送系统的可释放融合脂质

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US (1) US20110223257A1 (enExample)
EP (1) EP2355799A4 (enExample)
JP (1) JP2012509273A (enExample)
CN (1) CN102215820A (enExample)
CA (1) CA2742846A1 (enExample)
TW (1) TW201021852A (enExample)
WO (1) WO2010057160A1 (enExample)

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CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质
US12637422B2 (en) 2017-12-20 2026-05-26 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery

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TW201021853A (en) * 2008-11-17 2010-06-16 Enzon Pharmaceuticals Inc Releasable cationic lipids for nucleic acids delivery systems
US20100233270A1 (en) 2009-01-08 2010-09-16 Northwestern University Delivery of Oligonucleotide-Functionalized Nanoparticles
JP5784592B2 (ja) 2009-06-03 2015-09-24 イミュノジェン・インコーポレーテッド 抱合方法
EP4481047A3 (en) * 2010-06-03 2025-04-16 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
TR201807294T4 (tr) 2010-06-22 2018-06-21 Centre Nat Rech Scient Nükleik asit konjugatları için endosomolitik ajanlar ile optimize edilmiş in vivo aktarım sistemi.
EA033468B1 (ru) 2011-03-29 2019-10-31 Immunogen Inc Способы получения конъюгата "антитело-майтансиноид"
EP2527440A1 (en) 2011-05-27 2012-11-28 Institut Curie Cancer treatment by combining DNA molecules mimicking double strand breaks with hyperthermia
DE21212055T1 (de) 2011-12-07 2022-08-04 Alnylam Pharmaceuticals, Inc. Biologisch abbaubare lipide zur freisetzung von wirkstoffen
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
US10358680B2 (en) * 2012-09-11 2019-07-23 Duke University Nano-plasmonic molecular probes for plasmonics coupling interference
EP2904089A4 (en) 2012-10-04 2016-05-25 Immunogen Inc USE OF A PVDF MEMBRANE FOR PURIFYING CELL BINDING AGENT-CYTOTOXIC AGENT CONJUGATES
EP3010486B1 (en) 2013-06-19 2023-11-22 The Regents of The University of California Chemical structures for localized delivery of therapeutic agents
WO2015126502A2 (en) 2013-12-03 2015-08-27 Northwestern University Liposomal particles, methods of making same and uses thereof
AU2015229014B2 (en) * 2014-03-14 2019-07-25 The Regents Of The University Of California TCO conjugates and methods for delivery of therapeutic agents
TWI665192B (zh) 2014-05-28 2019-07-11 Bayer Cropscience Aktiengesellschaft 製備二氫異唑衍生物之方法
AU2015269412B2 (en) 2014-06-04 2020-03-12 Exicure Operating Company Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
EP3183007B1 (en) 2014-08-19 2020-06-17 Northwestern University Protein/oligonucleotide core-shell nanoparticle therapeutics
CN108135857A (zh) 2015-09-10 2018-06-08 沙思奇公司 生物正交组合物
WO2018039629A2 (en) 2016-08-25 2018-03-01 Northwestern University Micellar spherical nucleic acids from thermoresponsive, traceless templates
AU2018250312C1 (en) 2017-04-07 2024-08-22 Tambo, Inc. Bioorthogonal compositions
WO2018209270A1 (en) 2017-05-11 2018-11-15 Northwestern University Adoptive cell therapy using spherical nucleic acids (snas)
JP2020526558A (ja) 2017-07-13 2020-08-31 ノースウェスタン ユニバーシティ オリゴヌクレオチド官能化金属有機構造体ナノ粒子を調製するための一般的かつ直接的な方法
WO2019090359A1 (en) * 2017-11-06 2019-05-09 Nitto Denko Corporation Fusogenic compounds for delivery of biologically active molecules
US12702719B2 (en) 2019-03-06 2026-08-11 Northwestern University Hairpin-like oligonucleotide-conjugated spherical nucleic acid
US12319711B2 (en) 2019-09-20 2025-06-03 Northwestern University Spherical nucleic acids with tailored and active protein coronae
US12378560B2 (en) 2019-10-29 2025-08-05 Northwestern University Sequence multiplicity within spherical nucleic acids
JP2023537066A (ja) 2020-08-07 2023-08-30 タンボ・インコーポレイテッド トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用
EP4304640A1 (en) 2021-03-12 2024-01-17 Northwestern University Antiviral vaccines using spherical nucleic acids
LU103379B1 (en) * 2024-09-09 2026-03-09 Re3B Therapeutics Ug I G Serum-Protein Coated Fusogenic Lipid Particles For Targeted Drug Delivery

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US20080281044A1 (en) * 2006-08-18 2008-11-13 Monahan Sean D Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

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US20080281044A1 (en) * 2006-08-18 2008-11-13 Monahan Sean D Endosomolytic Modified Poly(Alcohol) and Poly(Amine) Polymers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106493A (zh) * 2014-11-21 2017-08-29 西北大学 球形核酸纳米颗粒缀合物的序列特异性细胞摄取
CN107951862A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861A (zh) * 2016-10-17 2018-04-24 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
WO2018072646A1 (zh) * 2016-10-17 2018-04-26 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN107951861B (zh) * 2016-10-17 2020-12-01 南京绿叶制药有限公司 一种脂质纳米粒膜材料组合物
CN112587504A (zh) * 2016-10-17 2021-04-02 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN112587504B (zh) * 2016-10-17 2022-10-18 南京绿叶制药有限公司 一种抑制bcl-2的反义寡聚核酸的脂质纳米粒及其制备方法
CN110337429A (zh) * 2016-12-21 2019-10-15 阿克丘勒斯治疗公司 用于rna递送的可离子化阳离子脂质
US12527881B2 (en) 2016-12-21 2026-01-20 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US12637422B2 (en) 2017-12-20 2026-05-26 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery

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WO2010057160A1 (en) 2010-05-20
TW201021852A (en) 2010-06-16
EP2355799A4 (en) 2012-09-05
EP2355799A1 (en) 2011-08-17
WO2010057160A9 (en) 2011-05-05
JP2012509273A (ja) 2012-04-19
US20110223257A1 (en) 2011-09-15
CA2742846A1 (en) 2010-05-20

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Application publication date: 20111012