JP2012509272A5 - - Google Patents

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Publication number
JP2012509272A5
JP2012509272A5 JP2011536583A JP2011536583A JP2012509272A5 JP 2012509272 A5 JP2012509272 A5 JP 2012509272A5 JP 2011536583 A JP2011536583 A JP 2011536583A JP 2011536583 A JP2011536583 A JP 2011536583A JP 2012509272 A5 JP2012509272 A5 JP 2012509272A5
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Japan
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JP2011536583A
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Japanese (ja)
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JP2012509272A (ja
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Priority claimed from PCT/US2009/064719 external-priority patent/WO2010057155A1/en
Publication of JP2012509272A publication Critical patent/JP2012509272A/ja
Publication of JP2012509272A5 publication Critical patent/JP2012509272A5/ja
Pending legal-status Critical Current

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JP2011536583A 2008-11-17 2009-11-17 核酸送達系のための放出性カチオン脂質 Pending JP2012509272A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11534808P 2008-11-17 2008-11-17
US11536508P 2008-11-17 2008-11-17
US11528708P 2008-11-17 2008-11-17
US61/115,365 2008-11-17
US61/115,348 2008-11-17
US61/115,287 2008-11-17
PCT/US2009/064719 WO2010057155A1 (en) 2008-11-17 2009-11-17 Releasable cationic lipids for nucleic acids delivery systems

Publications (2)

Publication Number Publication Date
JP2012509272A JP2012509272A (ja) 2012-04-19
JP2012509272A5 true JP2012509272A5 (enExample) 2012-12-27

Family

ID=42170406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536583A Pending JP2012509272A (ja) 2008-11-17 2009-11-17 核酸送達系のための放出性カチオン脂質

Country Status (7)

Country Link
US (1) US20110229581A1 (enExample)
EP (1) EP2364085A4 (enExample)
JP (1) JP2012509272A (enExample)
CN (1) CN102231952A (enExample)
CA (1) CA2742776A1 (enExample)
TW (1) TW201021853A (enExample)
WO (1) WO2010057155A1 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110305769A1 (en) * 2008-11-17 2011-12-15 Enzon Pharmaceuticals, Inc. Branched cationic lipids for nucleic acids delivery system
CN101870719B (zh) * 2010-05-21 2013-09-25 中国科学院上海有机化学研究所 一种同时具有二硫化学键和甾体骨架结构的有机功能化合物、制备方法和用途
CN102161688B (zh) * 2011-02-18 2013-09-04 中国科学院上海有机化学研究所 一种含有胆固醇结构片段的生物相容性合成脂质体、制备方法及其应用
US10184151B2 (en) 2011-10-11 2019-01-22 The Brigham And Women's Hospital, Inc. Micrornas in neurodegenerative disorders
HUE043809T2 (hu) * 2011-11-04 2019-09-30 Nitto Denko Corp Eljárás lipid-nukleinsav részecskék steril elõállítására
US9579338B2 (en) 2011-11-04 2017-02-28 Nitto Denko Corporation Method of producing lipid nanoparticles for drug delivery
KR20140116095A (ko) 2011-12-12 2014-10-01 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 Mrsa pbp2a 및 이의 단편들을 포함하는 단백질, 이를 인코딩한 핵산, 및 mrsa 감염을 예방 및 치료하기 위한 조성물 및 그의 용도
CN102911252B (zh) * 2012-10-25 2014-07-16 四川大学 含肽类树状分子的阳离子脂质、转基因载体及其制备方法和应用
AU2013355258A1 (en) * 2012-12-07 2015-06-11 Alnylam Pharmaceuticals, Inc. Improved nucleic acid lipid particle formulations
WO2014178152A1 (ja) 2013-04-30 2014-11-06 Ｄｅｌｔａ－Ｆｌｙ Ｐｈａｒｍａ株式会社 局所投与用リポソームおよびその用途
JP5914418B2 (ja) * 2013-06-26 2016-05-11 富士フイルム株式会社 脂質粒子、核酸送達キャリア、核酸送達キャリア製造用組成物、脂質粒子の製造方法及び遺伝子導入方法
WO2015021465A2 (en) * 2013-08-09 2015-02-12 New York University Protein engineered systems for delivery of molecules
JPWO2015178438A1 (ja) * 2014-05-20 2017-04-20 アルケア株式会社 皮膚用粘着剤組成物及び皮膚用貼付材
KR101836877B1 (ko) 2014-10-30 2018-03-09 데루타-후라이 화마 가부시키가이샤 국소 투여용 리포플렉스의 신규 제조 방법 및 상기 리포플렉스를 사용하는 항 종양제
EP3252043B1 (en) * 2015-01-30 2020-09-30 NOF Corporation Cationic lipid
EP3315125A1 (en) * 2016-10-31 2018-05-02 Silence Therapeutics (London) Ltd Lipid nanoparticle formulation
WO2018081817A2 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
CN106565763B (zh) * 2016-11-11 2017-12-15 深圳市声光动力生物医药科技有限公司 pH敏感的轴向取代硅酞菁配合物及其制备方法和在医药上的应用
JP7555123B2 (ja) 2018-10-09 2024-09-24 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア 有機溶媒不含かつ劣化剤不含のトランスフェクション・コンピテント・ベシクルを含む組成物及びシステム並びにそれらに関連する方法
MX2021008146A (es) * 2019-01-04 2021-10-13 Oncorus Inc Polinucleotidos de arn encapsulado y metodos de uso.
CN111072504A (zh) * 2019-12-31 2020-04-28 芜湖天道绿色新材料有限公司 一种可降解固化剂的一步制备方法
CN114522252B (zh) * 2022-04-24 2023-08-04 天津外泌体科技有限公司 一步法叠氮化修饰细胞外囊泡的方法及修饰试剂
CN114984236B (zh) * 2022-04-29 2023-03-24 深圳近邻生物科技有限公司 一种响应型核酸递送系统及其制备方法、交联聚合物载体
CN120659770A (zh) * 2023-03-22 2025-09-16 上海环码生物医药有限公司 脂质化合物、脂质纳米颗粒和药物组合物
WO2024201465A1 (en) * 2023-03-27 2024-10-03 Aposense Ltd. Peptide trans-membrane delivery systems and uses thereof
WO2025140618A1 (zh) * 2023-12-29 2025-07-03 康希诺(上海)生物研发有限公司 一种用于递送核酸的脂质纳米颗粒及其制备方法和用途

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071890A (en) * 1994-12-09 2000-06-06 Genzyme Corporation Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
US6383814B1 (en) * 1994-12-09 2002-05-07 Genzyme Corporation Cationic amphiphiles for intracellular delivery of therapeutic molecules
WO1998051278A2 (en) * 1997-05-14 1998-11-19 Inex Pharmaceuticals Corporation High efficiency encapsulation of charged therapeutic agents in lipid vesicles
US6794499B2 (en) * 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6841537B1 (en) * 1998-04-22 2005-01-11 Protiva Biotherapeutics Inc. Combination therapy using nucleic acids and conventional drugs
US6169078B1 (en) * 1998-05-12 2001-01-02 University Of Florida Materials and methods for the intracellular delivery of substances
FR2813794B1 (fr) * 2000-09-08 2003-01-24 Pasteur Institut Procede de couplage, en solution, entre un peptide et un vecteur lipophile et ses applications
US20030077829A1 (en) * 2001-04-30 2003-04-24 Protiva Biotherapeutics Inc.. Lipid-based formulations
US7514099B2 (en) * 2005-02-14 2009-04-07 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
US20070042983A1 (en) * 2001-05-18 2007-02-22 Sirna Therapeutics, Inc. RNA interference mediated inhibition of gene expression using short interfering nucleic acid (siNA)
US20050222064A1 (en) * 2002-02-20 2005-10-06 Sirna Therapeutics, Inc. Polycationic compositions for cellular delivery of polynucleotides
KR101164256B1 (ko) * 2003-09-15 2012-07-10 프로티바 바이오쎄라퓨틱스, 인코포레이티드 폴리에틸렌글리콜 개질된 지질 화합물 및 그의 용도
US20060051405A1 (en) * 2004-07-19 2006-03-09 Protiva Biotherapeutics, Inc. Compositions for the delivery of therapeutic agents and uses thereof
US7404969B2 (en) * 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
CA2638807A1 (en) * 2006-02-01 2007-08-09 The Burnham Institute For Medical Research Lymphatic zip codes in tumors and pre-malignant lesions
US20070293449A1 (en) * 2006-06-20 2007-12-20 Nastech Pharmaceutical Company Inc. Compositions and methods for delivery of double-stranded rna
WO2008043366A2 (en) * 2006-10-13 2008-04-17 Københavns Universitet Three-domain compounds for transmembrane delivery
US20110305769A1 (en) * 2008-11-17 2011-12-15 Enzon Pharmaceuticals, Inc. Branched cationic lipids for nucleic acids delivery system
EP2355799A4 (en) * 2008-11-17 2012-09-05 Enzon Pharmaceuticals Inc CLEANABLE FUSOGENIC LIPIDS FOR NUCLEIC ACID RELIEF SYSTEMS

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