JP2012509366A5 - - Google Patents

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Publication number
JP2012509366A5
JP2012509366A5 JP2011536581A JP2011536581A JP2012509366A5 JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5 JP 2011536581 A JP2011536581 A JP 2011536581A JP 2011536581 A JP2011536581 A JP 2011536581A JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5
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JP
Japan
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nhc
alkyl
compound
group
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JP2011536581A
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English (en)
Japanese (ja)
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JP2012509366A (ja
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Priority claimed from PCT/US2009/064701 external-priority patent/WO2010057150A1/en
Publication of JP2012509366A publication Critical patent/JP2012509366A/ja
Publication of JP2012509366A5 publication Critical patent/JP2012509366A5/ja
Withdrawn legal-status Critical Current

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JP2011536581A 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質 Withdrawn JP2012509366A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11537108P 2008-11-17 2008-11-17
US11537908P 2008-11-17 2008-11-17
US61/115,371 2008-11-17
US61/115,379 2008-11-17
PCT/US2009/064701 WO2010057150A1 (en) 2008-11-17 2009-11-17 Releasable polymeric lipids for nucleic acids delivery systems

Publications (2)

Publication Number Publication Date
JP2012509366A JP2012509366A (ja) 2012-04-19
JP2012509366A5 true JP2012509366A5 (enExample) 2013-01-10

Family

ID=42170403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536581A Withdrawn JP2012509366A (ja) 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質

Country Status (7)

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US (1) US20110305770A1 (enExample)
EP (1) EP2362728A1 (enExample)
JP (1) JP2012509366A (enExample)
CN (1) CN102231950A (enExample)
CA (1) CA2742838A1 (enExample)
TW (1) TW201023914A (enExample)
WO (1) WO2010057150A1 (enExample)

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US8450290B2 (en) * 2007-11-26 2013-05-28 Enzon Pharmaceuticals, Inc. Methods for treating androgen receptor dependent disorders including cancers
EP2350296A4 (en) * 2008-11-17 2013-04-03 Enzon Pharmaceuticals Inc BRANCHED CATIONIC LIPIDS FOR THE SYSTEM FOR INTRODUCING NUCLEIC ACIDS
HK1198628A1 (en) * 2011-08-12 2015-05-22 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
DK2581448T3 (en) * 2011-10-13 2015-04-27 Ass Inst De Myologie Tricyclo-DNA phosphorothioate
DE21212055T1 (de) 2011-12-07 2022-08-04 Alnylam Pharmaceuticals, Inc. Biologisch abbaubare lipide zur freisetzung von wirkstoffen
CA2953341C (en) 2014-06-25 2023-01-24 Acuitas Therapeutics Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2016176330A1 (en) 2015-04-27 2016-11-03 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
US10626217B2 (en) 2015-09-30 2020-04-21 Nof Corporation Lipid derivative in which hydrophilic polymer is bound through cyclic benzylidene acetal linker
US10940201B2 (en) 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
JP6583864B2 (ja) * 2015-09-30 2019-10-09 塩野義製薬株式会社 免疫賦活活性を有する核酸誘導体
CN108368028B (zh) 2015-10-28 2021-09-03 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
US12678515B2 (en) 2015-12-30 2026-07-14 Acuitas Therapeutics, Inc. Lipids and lipid nanoparticle formulations for delivery of nucleic acids
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
EP3568155A4 (en) 2017-01-11 2020-09-23 The Trustees Of The University Of Pennsylvania RNA MODIFIED BY NUCLEOSIDE TO INDUCE AN IMMUNE RESPONSE AGAINST ZIKA VIRUS
US11357856B2 (en) 2017-04-13 2022-06-14 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
US11820728B2 (en) 2017-04-28 2023-11-21 Acuitas Therapeutics, Inc. Carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
JP7355731B2 (ja) 2017-08-16 2023-10-03 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
JP7461872B2 (ja) 2017-08-17 2024-04-04 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
US11524932B2 (en) 2017-08-17 2022-12-13 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP3852911B1 (en) 2018-09-21 2025-01-22 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
TWI724578B (zh) * 2018-10-15 2021-04-11 國立陽明大學 酸鹼敏感型脂質奈米粒子用於包覆抗癌藥物和微小核糖核酸及其用途
CA3116576A1 (en) 2018-10-18 2020-04-23 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
CN109251150B (zh) * 2018-11-02 2021-07-30 宁夏医科大学 一种2，3-二氨基丙酸甲酯的制备方法
PL3908568T3 (pl) 2019-01-11 2024-12-02 Acuitas Therapeutics, Inc. Lipidy do dostarczania środków czynnych w nanocząstkach lipidowych
CA3178344A1 (en) 2020-03-31 2021-10-07 The Trustees Of The University Of Pennsylvania Universal influenza vaccine using nucleoside-modified mrna
EP4178544A4 (en) 2020-07-08 2024-09-25 The Trustees of the University of Pennsylvania NUCLEOSIDE-MODIFIED RNA TO INDUCE AN IMMUNE RESPONSE AGAINST SARS-COV-2 VIRUS
KR20230051172A (ko) 2020-07-16 2023-04-17 아퀴타스 테라퓨틱스 인크. 지질 나노 입자에 사용하기 위한 양이온성 지질
KR102433981B1 (ko) * 2020-12-15 2022-08-19 대구가톨릭대학교산학협력단 HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물
CN114904003B (zh) * 2021-02-09 2023-09-29 广州立得生物医药科技有限公司 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
AU2022281746B2 (en) 2021-05-24 2025-01-16 Suzhou Abogen Biosciences Co., Ltd. Lipid compounds and lipid nanoparticle compositions
CA3233490A1 (en) * 2021-09-28 2023-04-06 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell targeted delivery of therapeutic agents
EP4408437A4 (en) * 2021-10-01 2025-08-27 Univ Pennsylvania LIPID NANOPARTICLE (LNP) COMPOSITIONS AND METHODS OF USE THEREOF
WO2023107920A1 (en) * 2021-12-07 2023-06-15 The Trustees Of The University Of Pennsylvania Anisamide-containing lipids and compositions and methods of use thereof
WO2023114943A2 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN116549659B (zh) * 2022-01-27 2025-11-21 中山大学 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用
CN114699997B (zh) * 2022-03-28 2022-11-25 山东大学 一种具有高抗盐性的碱基@囊泡复合体及其制备方法
CN117126187A (zh) * 2023-08-18 2023-11-28 中国科学技术大学 阳离子脂质、其制备方法、纳米粒子组装体和应用

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MX2009002855A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
EP3434259A1 (en) * 2007-05-04 2019-01-30 Marina Biotech, Inc. Amino acid lipids and uses thereof

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