JP2012509366A5 - - Google Patents

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Publication number
JP2012509366A5
JP2012509366A5 JP2011536581A JP2011536581A JP2012509366A5 JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5 JP 2011536581 A JP2011536581 A JP 2011536581A JP 2011536581 A JP2011536581 A JP 2011536581A JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5
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JP
Japan
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nhc
alkyl
compound
group
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JP2011536581A
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English (en)
Japanese (ja)
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JP2012509366A (ja
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Priority claimed from PCT/US2009/064701 external-priority patent/WO2010057150A1/en
Publication of JP2012509366A publication Critical patent/JP2012509366A/ja
Publication of JP2012509366A5 publication Critical patent/JP2012509366A5/ja
Withdrawn legal-status Critical Current

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JP2011536581A 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質 Withdrawn JP2012509366A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11537908P 2008-11-17 2008-11-17
US11537108P 2008-11-17 2008-11-17
US61/115,379 2008-11-17
US61/115,371 2008-11-17
PCT/US2009/064701 WO2010057150A1 (en) 2008-11-17 2009-11-17 Releasable polymeric lipids for nucleic acids delivery systems

Publications (2)

Publication Number Publication Date
JP2012509366A JP2012509366A (ja) 2012-04-19
JP2012509366A5 true JP2012509366A5 (enExample) 2013-01-10

Family

ID=42170403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536581A Withdrawn JP2012509366A (ja) 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質

Country Status (7)

Country Link
US (1) US20110305770A1 (enExample)
EP (1) EP2362728A1 (enExample)
JP (1) JP2012509366A (enExample)
CN (1) CN102231950A (enExample)
CA (1) CA2742838A1 (enExample)
TW (1) TW201023914A (enExample)
WO (1) WO2010057150A1 (enExample)

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US8450290B2 (en) * 2007-11-26 2013-05-28 Enzon Pharmaceuticals, Inc. Methods for treating androgen receptor dependent disorders including cancers
EP2350296A4 (en) * 2008-11-17 2013-04-03 Enzon Pharmaceuticals Inc BRANCHED CATIONIC LIPIDS FOR THE SYSTEM FOR INTRODUCING NUCLEIC ACIDS
EP2741778A1 (en) * 2011-08-12 2014-06-18 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
EP2581448B1 (en) * 2011-10-13 2015-01-28 Association Institut de Myologie Tricyclo-phosphorothioate DNA
ES3065854T3 (en) 2011-12-07 2026-05-08 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
IL316479A (en) 2014-06-25 2024-12-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle compositions for nucleic acid delivery
JP2018526321A (ja) 2015-04-27 2018-09-13 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア 適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
AU2016332266B2 (en) * 2015-09-30 2020-05-07 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
EP3357514B1 (en) 2015-09-30 2021-04-14 NOF Corporation Lipid derivative in which hydrophilic polymer is bound via cyclic benzylidene acetal linkers
US10940201B2 (en) 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
RS63986B1 (sr) 2015-10-28 2023-03-31 Acuitas Therapeutics Inc Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
BR112019014314A2 (pt) 2017-01-11 2020-02-18 The Trustees Of The University Of Pennsylvania Composição, e, método de indução de uma resposta imune adaptativa contra vírus zika.
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
ES2981244T3 (es) 2017-04-28 2024-10-07 Acuitas Therapeutics Inc Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos
US11639329B2 (en) 2017-08-16 2023-05-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP4501322A3 (en) 2017-08-17 2025-04-16 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
US11542225B2 (en) 2017-08-17 2023-01-03 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036030A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
IL281615B2 (en) 2018-09-21 2026-01-01 Acuitas Therapeutics Inc Systems and methods for producing lipid nanoparticles and liposomes
TWI724578B (zh) * 2018-10-15 2021-04-11 國立陽明大學 酸鹼敏感型脂質奈米粒子用於包覆抗癌藥物和微小核糖核酸及其用途
US12583816B2 (en) 2018-10-18 2026-03-24 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
CN109251150B (zh) * 2018-11-02 2021-07-30 宁夏医科大学 一种2，3-二氨基丙酸甲酯的制备方法
JP7523449B2 (ja) 2019-01-11 2024-07-26 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
JP7798855B2 (ja) 2020-07-16 2026-01-14 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子に使用するためのカチオン性脂質
KR102433981B1 (ko) * 2020-12-15 2022-08-19 대구가톨릭대학교산학협력단 HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물
CN114904003B (zh) * 2021-02-09 2023-09-29 广州立得生物医药科技有限公司 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
WO2022247755A1 (en) 2021-05-24 2022-12-01 Suzhou Abogen Biosciences Co., Ltd. Lipid compounds and lipid nanoparticle compositions
WO2023056282A1 (en) * 2021-09-28 2023-04-06 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell targeted delivery of therapeutic agents
WO2023056418A1 (en) * 2021-10-01 2023-04-06 The Trustees Of The University Of Pennsylvania Lipid nanoparticle (lnp) compositions and methods of use thereof
WO2023107920A1 (en) * 2021-12-07 2023-06-15 The Trustees Of The University Of Pennsylvania Anisamide-containing lipids and compositions and methods of use thereof
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN116549659B (zh) * 2022-01-27 2025-11-21 中山大学 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用
CN114699997B (zh) * 2022-03-28 2022-11-25 山东大学 一种具有高抗盐性的碱基@囊泡复合体及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2073820A4 (en) * 2006-09-15 2014-07-16 Belrose Pharma Inc TARGETED POLYMER PRODRUGS WITH MULTIFUNCTIONAL CONNECTORS
LT2494993T (lt) * 2007-05-04 2018-12-27 Marina Biotech, Inc. Aminorūgščių lipidai ir jų panaudojimas

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