JP2012509366A5 - - Google Patents

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Publication number
JP2012509366A5
JP2012509366A5 JP2011536581A JP2011536581A JP2012509366A5 JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5 JP 2011536581 A JP2011536581 A JP 2011536581A JP 2011536581 A JP2011536581 A JP 2011536581A JP 2012509366 A5 JP2012509366 A5 JP 2012509366A5
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Japan
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nhc
alkyl
compound
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JP2011536581A
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English (en)
Japanese (ja)
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JP2012509366A (ja
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Priority claimed from PCT/US2009/064701 external-priority patent/WO2010057150A1/en
Publication of JP2012509366A publication Critical patent/JP2012509366A/ja
Publication of JP2012509366A5 publication Critical patent/JP2012509366A5/ja
Withdrawn legal-status Critical Current

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JP2011536581A 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質 Withdrawn JP2012509366A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11537108P 2008-11-17 2008-11-17
US11537908P 2008-11-17 2008-11-17
US61/115,379 2008-11-17
US61/115,371 2008-11-17
PCT/US2009/064701 WO2010057150A1 (en) 2008-11-17 2009-11-17 Releasable polymeric lipids for nucleic acids delivery systems

Publications (2)

Publication Number Publication Date
JP2012509366A JP2012509366A (ja) 2012-04-19
JP2012509366A5 true JP2012509366A5 (enExample) 2013-01-10

Family

ID=42170403

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011536581A Withdrawn JP2012509366A (ja) 2008-11-17 2009-11-17 核酸送達系のための放出可能ポリマー脂質

Country Status (7)

Country Link
US (1) US20110305770A1 (enExample)
EP (1) EP2362728A1 (enExample)
JP (1) JP2012509366A (enExample)
CN (1) CN102231950A (enExample)
CA (1) CA2742838A1 (enExample)
TW (1) TW201023914A (enExample)
WO (1) WO2010057150A1 (enExample)

Families Citing this family (34)

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Publication number Priority date Publication date Assignee Title
US8450290B2 (en) * 2007-11-26 2013-05-28 Enzon Pharmaceuticals, Inc. Methods for treating androgen receptor dependent disorders including cancers
US20110305769A1 (en) * 2008-11-17 2011-12-15 Enzon Pharmaceuticals, Inc. Branched cationic lipids for nucleic acids delivery system
WO2013024048A1 (en) * 2011-08-12 2013-02-21 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
ES2535654T3 (es) * 2011-10-13 2015-05-13 Association Institut De Myologie ADN triciclo-fosforotioato
EP3988537A1 (en) 2011-12-07 2022-04-27 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
IL289934B2 (en) 2014-06-25 2023-04-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
EP3289083A4 (en) 2015-04-27 2018-12-19 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
CN114085198A (zh) 2015-06-29 2022-02-25 爱康泰生治疗公司 用于递送核酸的脂质和脂质纳米颗粒制剂
JP6583864B2 (ja) * 2015-09-30 2019-10-09 塩野義製薬株式会社 免疫賦活活性を有する核酸誘導体
US10940201B2 (en) 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
JP6850417B2 (ja) 2015-09-30 2021-03-31 日油株式会社 環状ベンジリデンアセタールリンカーを介して親水性ポリマーが結合した脂質誘導体
RS63986B1 (sr) 2015-10-28 2023-03-31 Acuitas Therapeutics Inc Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
US11241490B2 (en) 2017-01-11 2022-02-08 The Trustees Of The University Of Pennsylvania Nucleoside-modified RNA for inducing an immune response against zika virus
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
WO2018200943A1 (en) 2017-04-28 2018-11-01 Acuitas Therapeutics, Inc. Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
WO2019036008A1 (en) 2017-08-16 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
JP7461872B2 (ja) 2017-08-17 2024-04-04 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子製剤における使用のための脂質
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
WO2019036030A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
EP4613367A1 (en) 2018-09-21 2025-09-10 Acuitas Therapeutics, Inc. Systems and methods for manufacturing lipid nanoparticles and liposomes
US11141491B2 (en) * 2018-10-15 2021-10-12 National Yang Ming Chiao Tung University PH-sensitive lipid nanoparticles for encapsulation of anticancer drugs and microRNA and use thereof
CN109251150B (zh) * 2018-11-02 2021-07-30 宁夏医科大学 一种2,3-二氨基丙酸甲酯的制备方法
CA3125485A1 (en) 2019-01-11 2020-07-16 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
DK4182297T3 (da) 2020-07-16 2025-12-01 Acuitas Therapeutics Inc Kationiske lipider til brug i lipid-nanopartikler
KR102433981B1 (ko) * 2020-12-15 2022-08-19 대구가톨릭대학교산학협력단 HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물
CN114904003B (zh) * 2021-02-09 2023-09-29 广州立得生物医药科技有限公司 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
EP4204390A1 (en) 2021-05-24 2023-07-05 Suzhou Abogen Biosciences Co., Ltd. Lipid compounds and lipid nanoparticle compositions
WO2023056282A1 (en) * 2021-09-28 2023-04-06 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell targeted delivery of therapeutic agents
CA3255883A1 (en) * 2021-10-01 2023-04-06 The Trustees Of The University Of Pennsylvania LIPID NANOPARTICLE (LNP) COMPOSITIONS AND THEIR METHODS OF USE
WO2023107920A1 (en) * 2021-12-07 2023-06-15 The Trustees Of The University Of Pennsylvania Anisamide-containing lipids and compositions and methods of use thereof
WO2023114943A2 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN116549659B (zh) * 2022-01-27 2025-11-21 中山大学 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用
CN114699997B (zh) * 2022-03-28 2022-11-25 山东大学 一种具有高抗盐性的碱基@囊泡复合体及其制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009002855A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
LT2494993T (lt) * 2007-05-04 2018-12-27 Marina Biotech, Inc. Aminorūgščių lipidai ir jų panaudojimas

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