JP2012509366A - 核酸送達系のための放出可能ポリマー脂質 - Google Patents
核酸送達系のための放出可能ポリマー脂質 Download PDFInfo
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- JP2012509366A JP2012509366A JP2011536581A JP2011536581A JP2012509366A JP 2012509366 A JP2012509366 A JP 2012509366A JP 2011536581 A JP2011536581 A JP 2011536581A JP 2011536581 A JP2011536581 A JP 2011536581A JP 2012509366 A JP2012509366 A JP 2012509366A
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Classifications
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyethers (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
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| US11537908P | 2008-11-17 | 2008-11-17 | |
| US11537108P | 2008-11-17 | 2008-11-17 | |
| US61/115,371 | 2008-11-17 | ||
| US61/115,379 | 2008-11-17 | ||
| PCT/US2009/064701 WO2010057150A1 (en) | 2008-11-17 | 2009-11-17 | Releasable polymeric lipids for nucleic acids delivery systems |
Publications (2)
| Publication Number | Publication Date |
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| JP2012509366A true JP2012509366A (ja) | 2012-04-19 |
| JP2012509366A5 JP2012509366A5 (enExample) | 2013-01-10 |
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| EP (1) | EP2362728A1 (enExample) |
| JP (1) | JP2012509366A (enExample) |
| CN (1) | CN102231950A (enExample) |
| CA (1) | CA2742838A1 (enExample) |
| TW (1) | TW201023914A (enExample) |
| WO (1) | WO2010057150A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2012509258A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための分岐カチオン性脂質 |
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| US8450290B2 (en) * | 2007-11-26 | 2013-05-28 | Enzon Pharmaceuticals, Inc. | Methods for treating androgen receptor dependent disorders including cancers |
| CA2843503C (en) * | 2011-08-12 | 2020-12-22 | Ulrich Hersel | Polymeric hyperbranched carrier-linked prodrugs |
| EP2581448B1 (en) * | 2011-10-13 | 2015-01-28 | Association Institut de Myologie | Tricyclo-phosphorothioate DNA |
| US9061063B2 (en) | 2011-12-07 | 2015-06-23 | Alnylam Pharmaceuticals, Inc. | Biodegradable lipids for the delivery of active agents |
| HUE060907T2 (hu) * | 2014-06-25 | 2023-04-28 | Acuitas Therapeutics Inc | Új lipidek és lipid nanorészecske formulációk nukleinsavak bevitelére |
| CA2984125A1 (en) | 2015-04-27 | 2016-11-03 | The Trustees Of The University Of Pennsylvania | Nucleoside-modified rna for inducing an adaptive immune response |
| US10221127B2 (en) | 2015-06-29 | 2019-03-05 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US10940201B2 (en) | 2015-09-30 | 2021-03-09 | Shionogi & Co., Ltd. | Nucleic acid derivative having immunostimulatory activity |
| MX374553B (es) * | 2015-09-30 | 2025-03-06 | Shionogi & Co | Derivado de ácido nucleico que tiene actividad inmunoestimuladora. |
| EP3357514B1 (en) | 2015-09-30 | 2021-04-14 | NOF Corporation | Lipid derivative in which hydrophilic polymer is bound via cyclic benzylidene acetal linkers |
| IL307179A (en) | 2015-10-28 | 2023-11-01 | Acuitas Therapeutics Inc | Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| JP7317715B2 (ja) | 2017-01-11 | 2023-07-31 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | ジカウイルスに対する免疫応答を誘導するためのヌクレオシド改変ｒｎａ |
| US11357856B2 (en) | 2017-04-13 | 2022-06-14 | Acuitas Therapeutics, Inc. | Lipids for delivery of active agents |
| CN116693411A (zh) | 2017-04-28 | 2023-09-05 | 爱康泰生治疗公司 | 用于递送核酸的新型羰基脂质和脂质纳米颗粒制剂 |
| US11639329B2 (en) | 2017-08-16 | 2023-05-02 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US11524932B2 (en) | 2017-08-17 | 2022-12-13 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2019036028A1 (en) | 2017-08-17 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
| US12065396B2 (en) | 2017-08-17 | 2024-08-20 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US12329857B2 (en) | 2018-09-21 | 2025-06-17 | Acuitas Therapeutics, Inc. | Systems and methods for manufacturing lipid nanoparticles and liposomes |
| US11141491B2 (en) * | 2018-10-15 | 2021-10-12 | National Yang Ming Chiao Tung University | PH-sensitive lipid nanoparticles for encapsulation of anticancer drugs and microRNA and use thereof |
| CN109251150B (zh) * | 2018-11-02 | 2021-07-30 | 宁夏医科大学 | 一种2，3-二氨基丙酸甲酯的制备方法 |
| AU2020205717B2 (en) | 2019-01-11 | 2025-09-11 | Acuitas Therapeutics, Inc. | Lipids for lipid nanoparticle delivery of active agents |
| AU2021308681A1 (en) | 2020-07-16 | 2023-03-09 | Acuitas Therapeutics, Inc. | Cationic lipids for use in lipid nanoparticles |
| KR102433981B1 (ko) * | 2020-12-15 | 2022-08-19 | 대구가톨릭대학교산학협력단 | HIF-1α 및 STAT5 전사인자를 억제하는 합성 디코이 올리고핵산 및 이를 유효성분으로 함유하는 아토피 피부염의 예방 또는 치료용 약학적 조성물 |
| CN114904003B (zh) * | 2021-02-09 | 2023-09-29 | 广州立得生物医药科技有限公司 | 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用 |
| AU2022281746B2 (en) | 2021-05-24 | 2025-01-16 | Suzhou Abogen Biosciences Co., Ltd. | Lipid compounds and lipid nanoparticle compositions |
| WO2023056282A1 (en) * | 2021-09-28 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Compositions and methods for t cell targeted delivery of therapeutic agents |
| WO2023056418A1 (en) * | 2021-10-01 | 2023-04-06 | The Trustees Of The University Of Pennsylvania | Lipid nanoparticle (lnp) compositions and methods of use thereof |
| US20250127719A1 (en) * | 2021-12-07 | 2025-04-24 | The Trustees Of The University Of Pennsylvania | Anisamide-containing lipids and compositions and methods of use thereof |
| KR20240123832A (ko) | 2021-12-16 | 2024-08-14 | 아퀴타스 테라퓨틱스 인크. | 지질 나노입자 제형에 사용하기 위한 지질 |
| CN116549659B (zh) * | 2022-01-27 | 2025-11-21 | 中山大学 | 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用 |
| CN114699997B (zh) * | 2022-03-28 | 2022-11-25 | 山东大学 | 一种具有高抗盐性的碱基@囊泡复合体及其制备方法 |
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| JP2010503708A (ja) * | 2006-09-15 | 2010-02-04 | エンゾン ファーマスーティカルズ インコーポレイテッド | 多官能性リンカーを含む標的化ポリマープロドラッグ |
| NZ580707A (en) * | 2007-05-04 | 2011-11-25 | Marina Biotech Inc | Acylated cationic amino acids and uses thereof |
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2009
- 2009-11-17 JP JP2011536581A patent/JP2012509366A/ja not_active Withdrawn
- 2009-11-17 CN CN2009801458902A patent/CN102231950A/zh active Pending
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- 2009-11-17 CA CA2742838A patent/CA2742838A1/en not_active Abandoned
- 2009-11-17 US US13/129,628 patent/US20110305770A1/en not_active Abandoned
- 2009-11-17 WO PCT/US2009/064701 patent/WO2010057150A1/en not_active Ceased
- 2009-11-17 EP EP09826946A patent/EP2362728A1/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509258A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための分岐カチオン性脂質 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102231950A (zh) | 2011-11-02 |
| TW201023914A (en) | 2010-07-01 |
| WO2010057150A8 (en) | 2011-01-06 |
| EP2362728A1 (en) | 2011-09-07 |
| WO2010057150A1 (en) | 2010-05-20 |
| US20110305770A1 (en) | 2011-12-15 |
| CA2742838A1 (en) | 2010-05-20 |
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