JP2012509062A5 - - Google Patents

Download PDF

Info

Publication number
JP2012509062A5
JP2012509062A5 JP2011536388A JP2011536388A JP2012509062A5 JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5 JP 2011536388 A JP2011536388 A JP 2011536388A JP 2011536388 A JP2011536388 A JP 2011536388A JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5
Authority
JP
Japan
Prior art keywords
specific binding
molecule
nucleic acid
target
linking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011536388A
Other languages
English (en)
Japanese (ja)
Other versions
JP5850746B2 (ja
JP2012509062A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/063210 external-priority patent/WO2010056577A1/en
Publication of JP2012509062A publication Critical patent/JP2012509062A/ja
Publication of JP2012509062A5 publication Critical patent/JP2012509062A5/ja
Application granted granted Critical
Publication of JP5850746B2 publication Critical patent/JP5850746B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011536388A 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物 Expired - Fee Related JP5850746B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11539908P 2008-11-17 2008-11-17
US61/115,399 2008-11-17
PCT/US2009/063210 WO2010056577A1 (en) 2008-11-17 2009-11-04 Methods and compositions in particle-based detection of target molecules using linking molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015153520A Division JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Publications (3)

Publication Number Publication Date
JP2012509062A JP2012509062A (ja) 2012-04-19
JP2012509062A5 true JP2012509062A5 (enExample) 2012-12-20
JP5850746B2 JP5850746B2 (ja) 2016-02-03

Family

ID=41510638

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011536388A Expired - Fee Related JP5850746B2 (ja) 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Country Status (4)

Country Link
US (1) US9150910B2 (enExample)
EP (1) EP2358897B1 (enExample)
JP (2) JP5850746B2 (enExample)
WO (1) WO2010056577A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469868B2 (en) 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP6126997B2 (ja) * 2011-02-16 2017-05-10 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 検出可能な標識の標的限局性の係留のための方法及び組成物
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
KR20230169418A (ko) 2013-03-13 2023-12-15 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
CN119709943A (zh) 2014-05-15 2025-03-28 中尺度技术有限责任公司 改进的测定方法
KR102695749B1 (ko) 2016-11-21 2024-08-14 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
JP7525402B2 (ja) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ,インコーポレイティド 化学的組成物とそれを利用する方法
IT201800005685A1 (it) * 2018-05-24 2019-11-24 Kit e procedimento per la rivelazione colorimetrica di un acido nucleico bersaglio in un campione.
CA3135206A1 (en) * 2019-04-29 2020-11-05 Pierre Indermuhle Methods and systems for integrated on-chip single-molecule detection
EP4004208A1 (en) * 2019-07-26 2022-06-01 Ixaka France Aptamer-based multispecific therapeutic agents
CN114574484A (zh) * 2022-03-17 2022-06-03 中国科学院北京基因组研究所(国家生物信息中心) 核酸检测试剂及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4826967A (en) * 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5196306A (en) * 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
DE69007473T2 (de) 1989-03-29 1994-07-21 Du Pont Katalysierte ablagerung von markierungsmittel.
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US7223833B1 (en) * 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
GB9301122D0 (en) * 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US5616464A (en) * 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US6277570B1 (en) * 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
DK0693065T3 (da) * 1993-04-13 2002-03-04 Naxcor Ikke-nucleosidiske cumarinderivater som reagenser til tværbinding af polynucleotider
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
JPH11514525A (ja) * 1995-11-03 1999-12-14 ナックスコー 二本鎖高次構造多型分析
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス,インコーポレイティド 核酸分析法
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
AU5779399A (en) * 1998-08-21 2000-03-27 Naxcor Assays using crosslinkable immobilized nucleic acids
US6303799B1 (en) * 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6743639B1 (en) * 1999-10-13 2004-06-01 Nve Corporation Magnetizable bead detector
US6875621B2 (en) * 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6573048B1 (en) * 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
WO2001094632A2 (en) * 2000-06-02 2001-12-13 Bayer Corporation Highly sensitive gene detection and localization using in situ branched-dna hybridization
AU2002339853A1 (en) * 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20070184436A1 (en) * 2001-06-07 2007-08-09 Joel Myerson Generic capture probe arrays
US7202030B2 (en) * 2001-11-01 2007-04-10 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
US8043868B2 (en) * 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
AU2003222117A1 (en) * 2002-03-29 2003-10-13 Genentech, Inc. Methods and compositions for detection and quantitation of nucleic acid analytes
AUPS159702A0 (en) * 2002-04-09 2002-05-16 Tong, Sun Wing Molecular detection and assay by magneto-thermal biochip micro-assay
US6800768B1 (en) * 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
JP4898119B2 (ja) * 2002-11-22 2012-03-14 エフ.ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
JP2007508020A (ja) * 2003-09-30 2007-04-05 カイロン コーポレイション ヒトdkkl1の新規スプライス改変体
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
WO2006096185A2 (en) * 2004-03-25 2006-09-14 The Government Of The United States Of American, As Represented By The Secretary Of The Navy Reagentless and reusable biosensors with tunable differential binding affinites and methods of making
EP1834181A2 (en) * 2004-12-30 2007-09-19 Perkinelmer Las, Inc. Particle-based multiplex assay system with three or more assay reporters
AU2006244394B2 (en) * 2005-05-06 2010-10-21 Gen-Probe Incorporated Methods of nucleic acid target capture
ATE502120T1 (de) * 2005-05-12 2011-04-15 Affymetrix Inc Multiplex-assays für verzweigtkettige dna
WO2006124711A1 (en) 2005-05-16 2006-11-23 The Board Of Trustees Of The University Of Illinois Composition and method for providing localized delivery of a therapeutic agent
EP2500439B2 (en) * 2005-06-20 2017-08-16 Advanced Cell Diagnostics, Inc. kits and products for detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations.
CA2613101A1 (en) 2005-07-01 2007-01-11 Bioveris Corporation Compositions and methods for detecting, amplifying, and/or isolating nucleic acids
US20100035247A1 (en) 2005-11-04 2010-02-11 U.S. Genomics, Inc. Heterogeneous Assay of Analytes in Solution Using Polymers
JP2007189991A (ja) * 2006-01-20 2007-08-02 Nippon Meat Packers Inc 遺伝子の検出方法
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
US8193335B2 (en) 2006-10-31 2012-06-05 Baseclick Gmbh Click chemistry for the production of reporter molecules
US8709727B2 (en) * 2007-09-17 2014-04-29 Mattias Strömberg Magnetic detection of small entities
US20090111709A1 (en) * 2007-09-18 2009-04-30 Burke Thomas J Affinity Measurements Using Frameless Multiplexed Microarrays
EP2728357B1 (en) * 2007-09-20 2017-02-22 Magarray, Inc. Analyte detection with magnetic sensors
GB0804495D0 (en) 2008-03-11 2008-04-16 Iti Scotland Ltd Surface attachment
US9469868B2 (en) * 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP6126997B2 (ja) * 2011-02-16 2017-05-10 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 検出可能な標識の標的限局性の係留のための方法及び組成物

Similar Documents

Publication Publication Date Title
JP2012509062A5 (enExample)
JP2012509063A5 (enExample)
JP2016512429A5 (enExample)
EP3323896A3 (en) Exonuclease enabled proximity extension assays
WO2007024676A3 (en) Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
JP2018538531A5 (enExample)
JP2019522463A5 (enExample)
JP2014533364A5 (enExample)
JP2011137830A5 (enExample)
EP3009520A1 (en) Site-specific immobilization of DNA origami structures on solid substrates
JP2010529474A5 (enExample)
JP2011524537A5 (enExample)
WO2009012220A3 (en) Analyte detection assays
WO2009109809A3 (en) Atomic force microscope as an analyzing tool for biochip
JP2015529809A5 (enExample)
Chao et al. Hybridization chain reaction amplification for highly sensitive fluorescence detection of DNA with dextran coated microarrays
Jung et al. Highly tunable aptasensing microarrays with graphene oxide multilayers
ATE532066T1 (de) Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen
Jiang et al. Direct microRNA detection with universal tagged probe and time-resolved fluorescence technology
WO2010110929A3 (en) Methods for simultaneous generation of functional ligands
WO2009070640A3 (en) Methods and compositions for amplifying a detectable signal
UA119466C2 (uk) Спосіб виявлення активних форм аналіту та визначення здатності речовин зв'язуватися з активними центрами аналіту
JP2016515827A5 (enExample)
Pinto et al. Real-time apta-PCR for 20000-fold improvement in detection limit
CN102252954B (zh) 单个生物分子反应实时原位表征方法