JP2012509062A5 - - Google Patents

Download PDF

Info

Publication number
JP2012509062A5
JP2012509062A5 JP2011536388A JP2011536388A JP2012509062A5 JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5 JP 2011536388 A JP2011536388 A JP 2011536388A JP 2011536388 A JP2011536388 A JP 2011536388A JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5
Authority
JP
Japan
Prior art keywords
specific binding
molecule
nucleic acid
target
linking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011536388A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012509062A (ja
JP5850746B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/063210 external-priority patent/WO2010056577A1/en
Publication of JP2012509062A publication Critical patent/JP2012509062A/ja
Publication of JP2012509062A5 publication Critical patent/JP2012509062A5/ja
Application granted granted Critical
Publication of JP5850746B2 publication Critical patent/JP5850746B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011536388A 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物 Expired - Fee Related JP5850746B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11539908P 2008-11-17 2008-11-17
US61/115,399 2008-11-17
PCT/US2009/063210 WO2010056577A1 (en) 2008-11-17 2009-11-04 Methods and compositions in particle-based detection of target molecules using linking molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015153520A Division JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Publications (3)

Publication Number Publication Date
JP2012509062A JP2012509062A (ja) 2012-04-19
JP2012509062A5 true JP2012509062A5 (enExample) 2012-12-20
JP5850746B2 JP5850746B2 (ja) 2016-02-03

Family

ID=41510638

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011536388A Expired - Fee Related JP5850746B2 (ja) 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Country Status (4)

Country Link
US (1) US9150910B2 (enExample)
EP (1) EP2358897B1 (enExample)
JP (2) JP5850746B2 (enExample)
WO (1) WO2010056577A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9469868B2 (en) 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP6126997B2 (ja) * 2011-02-16 2017-05-10 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 検出可能な標識の標的限局性の係留のための方法及び組成物
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US9618510B2 (en) * 2013-03-13 2017-04-11 Meso Scale Technologies, Llc. Assay methods
US10408823B2 (en) 2014-05-15 2019-09-10 Meso Scale Technologies, Llc. Assay methods
KR102476709B1 (ko) 2016-11-21 2022-12-09 나노스트링 테크놀로지스, 인크. 화학적 조성물 및 이것을 사용하는 방법
JP7525402B2 (ja) 2018-05-14 2024-07-30 ナノストリング テクノロジーズ，インコーポレイティド 化学的組成物とそれを利用する方法
IT201800005685A1 (it) * 2018-05-24 2019-11-24 Kit e procedimento per la rivelazione colorimetrica di un acido nucleico bersaglio in un campione.
KR20260021093A (ko) 2019-03-01 2026-02-12 메소 스케일 테크놀러지즈, 엘엘시 면역검정 방법에서 사용을 위한 전기화학발광성 표지화된 프로브, 이의 사용 방법 및 이를 포함하는 키트
EP3963091A4 (en) 2019-04-29 2023-07-19 Nautilus Biotechnology, Inc. METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION
CA3148792A1 (en) * 2019-07-26 2021-02-04 Ixaka France Aptamer-based multispecific therapeutic agents
CN114574484A (zh) * 2022-03-17 2022-06-03 中国科学院北京基因组研究所(国家生物信息中心) 核酸检测试剂及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4826967A (en) * 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5124246A (en) * 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5512439A (en) * 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5028594A (en) * 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5196306A (en) * 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
ES2063347T3 (es) 1989-03-29 1995-01-01 Du Pont Deposicion catalizada de indicador.
US5082934A (en) * 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US7223833B1 (en) * 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
GB9301122D0 (en) * 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US6277570B1 (en) * 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) * 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5616464A (en) * 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
US5767259A (en) * 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
CA2159356A1 (en) * 1993-04-13 1994-10-27 Michael L. Wood Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5580731A (en) * 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
EP0863998A4 (en) * 1995-11-03 2002-09-25 Naxcor ANALYSIS OF POLYMORPHISMS IN DOUBLE-STRANDED INFORMATION
JP2002515738A (ja) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド 核酸分析法
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
CA2340361A1 (en) * 1998-08-21 2000-03-16 Peter C. Cheng Assays using crosslinkable immobilized nucleic acids
US6303799B1 (en) * 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20020051971A1 (en) * 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6875621B2 (en) * 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
US6743639B1 (en) * 1999-10-13 2004-06-01 Nve Corporation Magnetizable bead detector
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6573048B1 (en) * 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
JP2003535600A (ja) * 2000-06-02 2003-12-02 バイエル コーポレイション インサイチュ分枝ｄｎａハイブリダイゼーションを用いた高感度遺伝子検出および位置決定
AU2002339853A1 (en) * 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20070184436A1 (en) * 2001-06-07 2007-08-09 Joel Myerson Generic capture probe arrays
AU2002353996A1 (en) * 2001-11-01 2003-05-12 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
US8043868B2 (en) * 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
JP2005521410A (ja) * 2002-03-29 2005-07-21 ジェネンテック・インコーポレーテッド 核酸分析試料の検出と定量化のための方法及び組成物
AUPS159702A0 (en) * 2002-04-09 2002-05-16 Tong, Sun Wing Molecular detection and assay by magneto-thermal biochip micro-assay
US6800768B1 (en) * 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
JP4898119B2 (ja) * 2002-11-22 2012-03-14 エフ．ホフマン−ラ ロシュ アーゲー 検出できるラベルされたヌクレオシド類似体及びその使用方法
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
US20070282015A1 (en) 2003-09-30 2007-12-06 Chiron Corporation Novel Splice Variants of Human Dkkl1
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7332355B2 (en) * 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
WO2006096185A2 (en) * 2004-03-25 2006-09-14 The Government Of The United States Of American, As Represented By The Secretary Of The Navy Reagentless and reusable biosensors with tunable differential binding affinites and methods of making
CA2592851A1 (en) * 2004-12-30 2006-07-06 Mack Schermer Particle-based multiplex assay system with three or more assay reporters
CA2584230C (en) * 2005-05-06 2012-11-27 Gen-Probe Incorporated Methods of nucleic acid target capture
WO2006124771A2 (en) * 2005-05-12 2006-11-23 Panomics, Inc. Multiplex branched-chain dna assays
WO2006124711A1 (en) 2005-05-16 2006-11-23 The Board Of Trustees Of The University Of Illinois Composition and method for providing localized delivery of a therapeutic agent
WO2007001986A2 (en) * 2005-06-20 2007-01-04 Yuling Luo Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
JP2009500020A (ja) 2005-07-01 2009-01-08 バイオヴェリス コーポレイション 核酸を検出、増幅および／また単離するための組成物および方法
WO2007056250A2 (en) 2005-11-04 2007-05-18 U.S. Genomics, Inc. Heterogeneous assay of analytes in solution using polymers
JP2007189991A (ja) * 2006-01-20 2007-08-02 Nippon Meat Packers Inc 遺伝子の検出方法
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
CA2667136A1 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules
US8709727B2 (en) * 2007-09-17 2014-04-29 Mattias Strömberg Magnetic detection of small entities
US20090111709A1 (en) * 2007-09-18 2009-04-30 Burke Thomas J Affinity Measurements Using Frameless Multiplexed Microarrays
EP2200727B1 (en) * 2007-09-20 2014-08-13 Magarray, Inc. Analyte detection with magnetic sensors
GB0804495D0 (en) 2008-03-11 2008-04-16 Iti Scotland Ltd Surface attachment
US9469868B2 (en) * 2008-11-17 2016-10-18 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
JP6126997B2 (ja) * 2011-02-16 2017-05-10 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 検出可能な標識の標的限局性の係留のための方法及び組成物

Similar Documents

Publication Publication Date Title
JP2012509063A5 (enExample)
JP2016512429A5 (enExample)
ES2538038T3 (es) Análisis multiplexado de muestras de ensayo
EP3323896A3 (en) Exonuclease enabled proximity extension assays
WO2007024676A3 (en) Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
JP2018538531A5 (enExample)
JP2019522463A5 (enExample)
JP2014533364A5 (enExample)
US20160102344A1 (en) Site-Specific Immobilization of DNA Origami Structures on Solid Substrates
MX2008014293A (es) Metodos de ensayo sin separacion.
JP2011524537A5 (enExample)
WO2009012220A3 (en) Analyte detection assays
WO2007133703A3 (en) Detection of nucleic acid targets using chemically reactive oligonucleotide probes
WO2009109809A3 (en) Atomic force microscope as an analyzing tool for biochip
JP2015529809A5 (enExample)
JP5850746B2 (ja) 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物
ATE532066T1 (de) Oberflächenimmobilisierter polyelektrolyt mit mehreren, zur kovalenten bindung an biomoleküle fähigen funktionellen gruppen
Jiang et al. Direct microRNA detection with universal tagged probe and time-resolved fluorescence technology
WO2010110929A3 (en) Methods for simultaneous generation of functional ligands
WO2009070640A3 (en) Methods and compositions for amplifying a detectable signal
UA119466C2 (uk) Спосіб виявлення активних форм аналіту та визначення здатності речовин зв'язуватися з активними центрами аналіту
JP2016515827A5 (enExample)
JP2015508500A5 (enExample)
US20170029868A1 (en) Affinity tag nucleic acid and protein compositions, and processes for using same
EP2177909B1 (en) Solid support with enhanced density of signal material and method of detecting target material using the same