JP2012509062A5 - - Google Patents

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Publication number
JP2012509062A5
JP2012509062A5 JP2011536388A JP2011536388A JP2012509062A5 JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5 JP 2011536388 A JP2011536388 A JP 2011536388A JP 2011536388 A JP2011536388 A JP 2011536388A JP 2012509062 A5 JP2012509062 A5 JP 2012509062A5
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JP
Japan
Prior art keywords
specific binding
molecule
nucleic acid
target
linking
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
JP2011536388A
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English (en)
Japanese (ja)
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JP2012509062A (ja
JP5850746B2 (ja
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Priority claimed from PCT/US2009/063210 external-priority patent/WO2010056577A1/en
Publication of JP2012509062A publication Critical patent/JP2012509062A/ja
Publication of JP2012509062A5 publication Critical patent/JP2012509062A5/ja
Application granted granted Critical
Publication of JP5850746B2 publication Critical patent/JP5850746B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2011536388A 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物 Expired - Fee Related JP5850746B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11539908P 2008-11-17 2008-11-17
US61/115,399 2008-11-17
PCT/US2009/063210 WO2010056577A1 (en) 2008-11-17 2009-11-04 Methods and compositions in particle-based detection of target molecules using linking molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015153520A Division JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Publications (3)

Publication Number Publication Date
JP2012509062A JP2012509062A (ja) 2012-04-19
JP2012509062A5 true JP2012509062A5 (enExample) 2012-12-20
JP5850746B2 JP5850746B2 (ja) 2016-02-03

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ID=41510638

Family Applications (2)

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JP2011536388A Expired - Fee Related JP5850746B2 (ja) 2008-11-17 2009-11-04 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物
JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Family Applications After (1)

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JP2015153520A Pending JP2016005472A (ja) 2008-11-17 2015-08-03 連結分子を用いた標的分子の粒子ベースの検出における方法および組成物

Country Status (4)

Country Link
US (1) US9150910B2 (enExample)
EP (1) EP2358897B1 (enExample)
JP (2) JP5850746B2 (enExample)
WO (1) WO2010056577A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5744743B2 (ja) 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
EP3143401A4 (en) 2014-05-15 2017-10-11 Meso Scale Technologies, LLC Improved assay methods
JP6730525B2 (ja) 2016-11-21 2020-07-29 ナノストリング テクノロジーズ,インコーポレイティド 化学組成物とそれを利用する方法
EP3794146B1 (en) 2018-05-14 2025-12-10 Bruker Spatial Biology, Inc. Method for identifying a predetermined nucleotide sequence
IT201800005685A1 (it) * 2018-05-24 2019-11-24 Kit e procedimento per la rivelazione colorimetrica di un acido nucleico bersaglio in un campione.
EP3963091A4 (en) 2019-04-29 2023-07-19 Nautilus Biotechnology, Inc. METHODS AND SYSTEMS FOR ON-CHIP INTEGRATED SINGLE MOLECULE DETECTION
CN119614577A (zh) * 2019-07-26 2025-03-14 艾夏卡法国有限公司 用于细胞靶向和标记的抗cd3核酸适配体
CN114574484A (zh) * 2022-03-17 2022-06-03 中国科学院北京基因组研究所(国家生物信息中心) 核酸检测试剂及其应用

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4599303A (en) * 1983-12-12 1986-07-08 Hri Associates, Inc. Nucleic acid hybridization assay employing probes crosslinkable to target sequences
US4826967A (en) 1987-06-16 1989-05-02 Naxcor Psoralen-nucleoside adducts and method for their preparation
US5124246A (en) 1987-10-15 1992-06-23 Chiron Corporation Nucleic acid multimers and amplified nucleic acid hybridization assays using same
US5512439A (en) 1988-11-21 1996-04-30 Dynal As Oligonucleotide-linked magnetic particles and uses thereof
US5028594A (en) 1988-12-27 1991-07-02 Naxcor Use of photodynamic compositions for cytotoxic effects
US5196306A (en) 1989-03-29 1993-03-23 E. I. Du Pont De Nemours And Company Method for the detection or quantitation of an analyte using an analyte dependent enzyme activation system
JP2948904B2 (ja) 1989-03-29 1999-09-13 エヌ・イー・エヌ・ライフ・サイエンス・プロダクツ・インコーポレイテツド 触媒されたレポーター沈着
US5082934A (en) 1989-04-05 1992-01-21 Naxcor Coumarin derivatives for use as nucleotide crosslinking reagents
US7223833B1 (en) 1991-05-24 2007-05-29 Isis Pharmaceuticals, Inc. Peptide nucleic acid conjugates
GB9301122D0 (en) * 1993-01-21 1993-03-10 Scient Generics Ltd Method of analysis/separation
US6277570B1 (en) 1993-04-13 2001-08-21 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US6495676B1 (en) 1993-04-13 2002-12-17 Naxcor Nucleic acid sequence detection employing probes comprising non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
US5616464A (en) 1994-12-27 1997-04-01 Naxcor Nucleic acid sequence detection employing amplification probes
DK0693065T3 (da) 1993-04-13 2002-03-04 Naxcor Ikke-nucleosidiske cumarinderivater som reagenser til tværbinding af polynucleotider
US5767259A (en) 1994-12-27 1998-06-16 Naxcor Oligonucleotides containing base-free linking groups with photoactivatable side chains
US5681697A (en) * 1993-12-08 1997-10-28 Chiron Corporation Solution phase nucleic acid sandwich assays having reduced background noise and kits therefor
US5580731A (en) 1994-08-25 1996-12-03 Chiron Corporation N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
WO1997027317A1 (en) 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
WO1997016567A1 (en) * 1995-11-03 1997-05-09 Naxcor Double-stranded conformational polymorphism analysis
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US5981297A (en) 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US6696246B1 (en) 1998-08-21 2004-02-24 Naxcor, Inc. Assays using crosslinkable immobilized nucleic acids
US6303799B1 (en) 1998-11-10 2001-10-16 Naxcor Polynucleotide crosslinking agents
US20020051971A1 (en) 1999-05-21 2002-05-02 John R. Stuelpnagel Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6875621B2 (en) 1999-10-13 2005-04-05 Nve Corporation Magnetizable bead detector
US6743639B1 (en) 1999-10-13 2004-06-01 Nve Corporation Magnetizable bead detector
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
US6573048B1 (en) 2000-04-18 2003-06-03 Naxcor Degradable nucleic acid probes and nucleic acid detection methods
ES2287134T3 (es) * 2000-06-02 2007-12-16 Bayer Corporation Procedimiento para la deteccion y localizacion de genes in situ usando hibridacion de adn ramificado.
AU2002339853A1 (en) 2001-05-24 2002-12-03 Genospectra, Inc. Pairs of nucleic acid probes with interactive signaling moieties and nucleic acid probes with enhanced hybridization efficiency and specificity
US20070184436A1 (en) * 2001-06-07 2007-08-09 Joel Myerson Generic capture probe arrays
WO2003037829A2 (en) 2001-11-01 2003-05-08 Rensselaer Polytechnic Institute Solid-phase array-based biocatalytic transformations
US8043868B2 (en) 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
JP2005521410A (ja) 2002-03-29 2005-07-21 ジェネンテック・インコーポレーテッド 核酸分析試料の検出と定量化のための方法及び組成物
AUPS159702A0 (en) 2002-04-09 2002-05-16 Tong, Sun Wing Molecular detection and assay by magneto-thermal biochip micro-assay
US6800768B1 (en) 2002-09-06 2004-10-05 Naxcor, Inc. Non-nucleosidic coumarin derivatives as polynucleotide-crosslinking agents
CA2506797C (en) 2002-11-22 2009-02-10 F.Hoffmann-La Roche Ag Detectable labeled nucleoside analogs and methods of use thereof
CN1580283A (zh) * 2003-08-13 2005-02-16 清华大学 一种检测核酸分子的方法
EP1678325A2 (en) * 2003-09-30 2006-07-12 Chiron Corporation Novel splice variants of human dkkl1
US7906345B2 (en) 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
US7332355B2 (en) 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
US7435386B2 (en) 2004-03-25 2008-10-14 The United States Of America As Represented By The Secretary Of The Navy Reagentless and reusable biosensors with tunable differential binding affinities and methods of making
CA2592851A1 (en) 2004-12-30 2006-07-06 Mack Schermer Particle-based multiplex assay system with three or more assay reporters
ATE551433T1 (de) * 2005-05-06 2012-04-15 Gen Probe Inc Verfahren und produkte zum erfassen von nukleinsäurezielen
EP1880025B1 (en) 2005-05-12 2011-03-16 Affymetrix, Inc. Multiplex branched-chain dna assays
WO2006124711A1 (en) 2005-05-16 2006-11-23 The Board Of Trustees Of The University Of Illinois Composition and method for providing localized delivery of a therapeutic agent
WO2007001986A2 (en) * 2005-06-20 2007-01-04 Yuling Luo Methods of detecting nucleic acids in individual cells and of identifying rare cells from large heterogeneous cell populations
WO2007005626A1 (en) 2005-07-01 2007-01-11 Bioveris Corporation Compositions and methods for detecting, amplifying, and/or isolating nucleic acids
US20100035247A1 (en) 2005-11-04 2010-02-11 U.S. Genomics, Inc. Heterogeneous Assay of Analytes in Solution Using Polymers
JP2007189991A (ja) * 2006-01-20 2007-08-02 Nippon Meat Packers Inc 遺伝子の検出方法
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
WO2008052775A2 (en) 2006-10-31 2008-05-08 Baseclick Gmbh Click chemistry for the production of reporter molecules
EP2195461B1 (en) * 2007-09-17 2015-05-27 Mattias Strömberg Magnetic detection of small entities
US20090111709A1 (en) 2007-09-18 2009-04-30 Burke Thomas J Affinity Measurements Using Frameless Multiplexed Microarrays
CN101868286A (zh) 2007-09-20 2010-10-20 马格雷股份有限公司 采用磁性传感器进行的分析物检测
GB0804495D0 (en) 2008-03-11 2008-04-16 Iti Scotland Ltd Surface attachment
JP5744743B2 (ja) 2008-11-17 2015-07-08 ヘッドウェイ テクノロジーズ, インク.Headway Technologies, Inc. 共有結合形成反応ペアを用いた標的分子の粒子ベースの検出における方法および組成物
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物

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