JP2012508809A5 - - Google Patents
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- Publication number
- JP2012508809A5 JP2012508809A5 JP2011536422A JP2011536422A JP2012508809A5 JP 2012508809 A5 JP2012508809 A5 JP 2012508809A5 JP 2011536422 A JP2011536422 A JP 2011536422A JP 2011536422 A JP2011536422 A JP 2011536422A JP 2012508809 A5 JP2012508809 A5 JP 2012508809A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- vinyl
- alkyl
- independently
- hydrophilic polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001296 polysiloxane Polymers 0.000 claims 55
- -1 polysiloxane Polymers 0.000 claims 38
- 229920001477 hydrophilic polymer Polymers 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 239000000178 monomer Substances 0.000 claims 20
- 229920002554 vinyl polymer Polymers 0.000 claims 19
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 18
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 18
- 125000000524 functional group Chemical group 0.000 claims 14
- 239000000017 hydrogel Substances 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000005647 linker group Chemical group 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 10
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 9
- JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 claims 9
- DPBJAVGHACCNRL-UHFFFAOYSA-N 2-(dimethylamino)ethyl prop-2-enoate Chemical compound CN(C)CCOC(=O)C=C DPBJAVGHACCNRL-UHFFFAOYSA-N 0.000 claims 9
- WHNPOQXWAMXPTA-UHFFFAOYSA-N 3-methylbut-2-enamide Chemical compound CC(C)=CC(N)=O WHNPOQXWAMXPTA-UHFFFAOYSA-N 0.000 claims 9
- 239000002202 Polyethylene glycol Substances 0.000 claims 9
- 229940088644 n,n-dimethylacrylamide Drugs 0.000 claims 9
- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- PNLUGRYDUHRLOF-UHFFFAOYSA-N n-ethenyl-n-methylacetamide Chemical compound C=CN(C)C(C)=O PNLUGRYDUHRLOF-UHFFFAOYSA-N 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 7
- DCBBWYIVFRLKCD-UHFFFAOYSA-N n-[2-(dimethylamino)ethyl]-2-methylprop-2-enamide Chemical compound CN(C)CCNC(=O)C(C)=C DCBBWYIVFRLKCD-UHFFFAOYSA-N 0.000 claims 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 239000000463 material Substances 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 claims 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 4
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 3
- 125000002877 alkyl aryl group Chemical group 0.000 claims 3
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 239000004205 dimethyl polysiloxane Substances 0.000 claims 3
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 3
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims 3
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 3
- 125000000446 sulfanediyl group Chemical group *S* 0.000 claims 3
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 claims 3
- AJQXZWKKWGNGPA-UHFFFAOYSA-N 5-amino-2-methylpent-2-enamide Chemical group NC(=O)C(C)=CCCN AJQXZWKKWGNGPA-UHFFFAOYSA-N 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 230000008878 coupling Effects 0.000 claims 2
- 238000010168 coupling process Methods 0.000 claims 2
- 238000005859 coupling reaction Methods 0.000 claims 2
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000000962 organic group Chemical group 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- OHLUUHNLEMFGTQ-UHFFFAOYSA-N N-methylacetamide Chemical group CNC(C)=O OHLUUHNLEMFGTQ-UHFFFAOYSA-N 0.000 claims 1
- 239000006096 absorbing agent Substances 0.000 claims 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000012867 bioactive agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000003431 cross linking reagent Substances 0.000 claims 1
- 238000009792 diffusion process Methods 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 230000005660 hydrophilic surface Effects 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000003999 initiator Substances 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 239000012633 leachable Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- XHFGWHUWQXTGAT-UHFFFAOYSA-N n-methylpropan-2-amine Chemical group CNC(C)C XHFGWHUWQXTGAT-UHFFFAOYSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000035699 permeability Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 238000004381 surface treatment Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11421608P | 2008-11-13 | 2008-11-13 | |
| US61/114,216 | 2008-11-13 | ||
| PCT/US2009/063944 WO2010056686A1 (en) | 2008-11-13 | 2009-11-11 | Polysiloxane copolymers with terminal hydrophilic polymer chains |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508809A JP2012508809A (ja) | 2012-04-12 |
| JP2012508809A5 true JP2012508809A5 (cg-RX-API-DMAC7.html) | 2012-12-20 |
| JP5460728B2 JP5460728B2 (ja) | 2014-04-02 |
Family
ID=41651368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536422A Expired - Fee Related JP5460728B2 (ja) | 2008-11-13 | 2009-11-11 | 末端親水性ポリマー鎖を有するポリシロキサン共重合体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8048968B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2356170B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5460728B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101536801B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102209745B (cg-RX-API-DMAC7.html) |
| AR (1) | AR074110A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009314169B9 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0921894A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2739810C (cg-RX-API-DMAC7.html) |
| MX (1) | MX2011004959A (cg-RX-API-DMAC7.html) |
| MY (1) | MY150811A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ591769A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2524946C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TWI476218B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010056686A1 (cg-RX-API-DMAC7.html) |
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| EP2513711B1 (en) * | 2009-12-14 | 2017-07-12 | Novartis AG | Methods for making silicone hydrogel lenses from water-based lens formulations |
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| PT2598937T (pt) * | 2010-07-30 | 2016-10-04 | Novartis Ag | Pré-polímeros de polissiloxano anfifílicos e suas utilizações |
| BR112013008221B1 (pt) | 2010-10-06 | 2020-02-11 | Alcon Inc. | Pré-polímero processável em água, lente de contato de hidrogel de silicone e seu método de fabricação |
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| US20130203813A1 (en) | 2011-05-04 | 2013-08-08 | Johnson & Johnson Vision Care, Inc. | Medical devices having homogeneous charge density and methods for making same |
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2009
- 2009-11-11 JP JP2011536422A patent/JP5460728B2/ja not_active Expired - Fee Related
- 2009-11-11 RU RU2011123374/04A patent/RU2524946C2/ru not_active IP Right Cessation
- 2009-11-11 US US12/616,166 patent/US8048968B2/en active Active
- 2009-11-11 WO PCT/US2009/063944 patent/WO2010056686A1/en not_active Ceased
- 2009-11-11 CN CN2009801446322A patent/CN102209745B/zh not_active Expired - Fee Related
- 2009-11-11 CA CA2739810A patent/CA2739810C/en not_active Expired - Fee Related
- 2009-11-11 KR KR1020117010913A patent/KR101536801B1/ko not_active Expired - Fee Related
- 2009-11-11 AU AU2009314169A patent/AU2009314169B9/en not_active Ceased
- 2009-11-11 EP EP09752082A patent/EP2356170B1/en not_active Ceased
- 2009-11-11 MY MYPI20112094 patent/MY150811A/en unknown
- 2009-11-11 AR ARP090104360A patent/AR074110A1/es not_active Application Discontinuation
- 2009-11-11 MX MX2011004959A patent/MX2011004959A/es active IP Right Grant
- 2009-11-11 BR BRPI0921894A patent/BRPI0921894A2/pt not_active IP Right Cessation
- 2009-11-11 NZ NZ591769A patent/NZ591769A/en not_active IP Right Cessation
- 2009-11-13 TW TW098138724A patent/TWI476218B/zh not_active IP Right Cessation
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