JP2012508786A - 活性成分の粒状物質を製造する新規の方法、及びそれにより得られた粒状物質 - Google Patents
活性成分の粒状物質を製造する新規の方法、及びそれにより得られた粒状物質 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- Glanulating (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
- Seasonings (AREA)
Abstract
Description
上述の活性成分の粒子が堆積した固体の粒子支持体に対応するコアからなる粒状物質を得るために、結合剤の水溶液、アルコール溶液又は含水アルコール溶液を噴霧する工程と組み合わせて、前述の支持体上に粉末を付けることにより、活性成分を塗布する工程;
コーティングされた粒状物質を得るために、ラミネーションによるコーティングフィルムの堆積により、前工程で得られた粒状物質をコーティングする1つ又は複数の工程;及び
滑沢剤及び/又は香味料及び/又は甘味料及び/又は着色料と混合する任意の工程。
粒状物質の調製の好ましい実施形態の詳細な説明
構成成分を1つずつ秤量した後、活性成分を(CMS型の)キュービックミキサーに導入する。希釈剤の量を順に秤量し(マンニトール160)、ミキサーに導入する。それからミキサーを動作状態にする。得られる混合物(A)は10分後に満足のいくものになる。
(糖尿病の治療に関して使用される活性成分)
(抗てんかん薬として使用される活性成分)
(高コレステロール血症用)
Claims (11)
- 少なくとも2つの活性成分の粒状物質を製造する方法であって、固体の粒子支持体に粉末を付けることにより、該活性成分を塗布する工程を含み、該活性成分が植物エキスではない、方法。
- 前記粉末を付ける工程が、結合剤の水溶液、アルコール溶液又は含水アルコール溶液を噴霧することを含むことを特徴とする、請求項1に記載の方法。
- 前記粉末を付ける工程の後に、粒状物質のコーティング工程、特にラミネーションにより前記粒状物質上にフィルムの形態でコーティング剤を堆積させることによる該粒状物質のコーティング工程、その後、適切であれば、滑沢剤及び/又は香味料及び/又は甘味料及び/又は着色料と混合する工程を含むことを特徴とする、請求項1又は2に記載の方法。
- 前記支持体がマンニトール、ソルビトール、マルチトール又はキシリトール等のポリオール、ラクトース、リン酸二カルシウム、炭酸カルシウム、炭酸カリウム、炭酸マグネシウム又は炭酸ナトリウム等の炭酸塩、グルコン酸塩、ケイ酸塩、糖結晶、サッカロース、及びシリカ誘導体からなる群の中から選択されることを特徴とする、請求項1〜3のいずれか一項に記載の方法。
- 前記結合剤がデンプン、サッカロース、アラビアゴム、ポリビニルピロリドン、ヒドロキシプロピルメチルセルロース、シェラック、ヒドロキシプロピルセルロース、セルロース、ポリオール、アルギン酸塩、多糖分解グリセリド、又はマクロゴールグリセリド、特にステアロイルマクロゴールグリセリドからなる群から選択される、請求項2〜4のいずれか一項に記載の方法。
- 請求項1〜5のいずれか一項に記載の方法に従って得ることができる粒状物質。
- 少なくとも2つの活性成分の粒状物質であって、該活性成分が植物エキスではなく、該活性成分が支持された固体コアを含み、該コアが好ましくは、マンニトール、ソルビトール、マルチトール又はキシリトール等のポリオール、ラクトース、リン酸二カルシウム、炭酸カルシウム、炭酸カリウム、炭酸マグネシウム又は炭酸ナトリウム等の炭酸塩、グルコン酸塩、ケイ酸塩、糖結晶、サッカロース、及びシリカ誘導体からなる群から選択されることを特徴とする、粒状物質。
- 前記固体コアが中性コアではないことを特徴とする、請求項7に記載の粒状物質。
- 結合剤、特に、デンプン、サッカロース、アラビアゴム、ポリビニルピロリドン、ヒドロキシプロピルメチルセルロース、シェラック、ヒドロキシプロピルセルロース、セルロース、ポリオール、アルギン酸塩、多糖分解グリセリド、又はマクロゴールグリセリド、特にステアロイルマクロゴールグリセリドからなる群から選択される結合剤を含むことを特徴とする、請求項8に記載の粒状物質。
- コーティングされている、特に、シェラック、ポリビニルピロリドン、ポリエチレングリコール、HPMC又はHPC等のセルロース誘導体、サッカロース、アルギン酸塩、脂肪酸のグリセリド及びメタクリル酸ポリマーからなる群の中から選択されるコーティング剤でコーティングされていることを特徴とする、請求項8又は9に記載の粒状物質。
- 前記コアが前記粒状物質の総重量に対して10重量%〜70重量%、及び好ましくは25重量%〜55重量%を示すことを特徴とする、請求項8〜10のいずれか一項に記載の粒状物質。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0857764A FR2938432B1 (fr) | 2008-11-14 | 2008-11-14 | Nouveau procede de preparation de granules de principes actifs, et granules tels qu'obtenus |
FR0857764 | 2008-11-14 | ||
PCT/FR2009/052180 WO2010055268A1 (fr) | 2008-11-14 | 2009-11-13 | Nouveau procédé de préparation de granulés de principes actifs, et granulés tels qu'obtenus |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2012508786A true JP2012508786A (ja) | 2012-04-12 |
JP2012508786A5 JP2012508786A5 (ja) | 2014-05-22 |
JP5608681B2 JP5608681B2 (ja) | 2014-10-15 |
Family
ID=40348849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2011543800A Expired - Fee Related JP5608681B2 (ja) | 2008-11-14 | 2009-11-13 | 活性成分の粒状物質を製造する新規の方法、及びそれにより得られた粒状物質 |
Country Status (25)
Country | Link |
---|---|
US (1) | US20110280945A1 (ja) |
EP (1) | EP2349226A1 (ja) |
JP (1) | JP5608681B2 (ja) |
KR (1) | KR101585705B1 (ja) |
CN (1) | CN102223879A (ja) |
AR (1) | AR074330A1 (ja) |
AU (1) | AU2009315449B2 (ja) |
BR (1) | BRPI0916019A2 (ja) |
CA (1) | CA2743753A1 (ja) |
CL (1) | CL2011001115A1 (ja) |
CO (1) | CO6382108A2 (ja) |
CU (1) | CU20110107A7 (ja) |
EA (1) | EA201100757A1 (ja) |
FR (1) | FR2938432B1 (ja) |
IL (1) | IL212850A0 (ja) |
MA (1) | MA32789B1 (ja) |
MX (1) | MX2011005072A (ja) |
NZ (1) | NZ592857A (ja) |
PE (1) | PE20110945A1 (ja) |
SG (1) | SG195651A1 (ja) |
TN (1) | TN2011000235A1 (ja) |
TW (1) | TWI522113B (ja) |
UA (1) | UA103781C2 (ja) |
WO (1) | WO2010055268A1 (ja) |
ZA (1) | ZA201103543B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2971422B1 (fr) * | 2011-02-11 | 2016-05-20 | Debregeas Et Associes Pharma | Granules d'acide gamma-hydroxybutyrique |
US20140127296A1 (en) * | 2012-11-05 | 2014-05-08 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
US9241956B2 (en) * | 2012-11-05 | 2016-01-26 | Kenneth John Tibbs | Pharmaceutical preparation and method for treatment of diabetes |
US11058635B1 (en) * | 2020-10-15 | 2021-07-13 | King Abdulaziz University | Oral administration of 5-FU in a gelling nanosuspension for targeted delivery to treat colorectal cancers |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0592918A (ja) * | 1991-03-07 | 1993-04-16 | Takeda Chem Ind Ltd | 有核散剤およびその製造方法 |
JPH08310969A (ja) * | 1995-05-22 | 1996-11-26 | Lion Corp | 固形薬品組成物及びその製造方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6327424A (ja) * | 1986-07-17 | 1988-02-05 | Shionogi & Co Ltd | 徐放性製剤およびその製造法 |
FR2790668B1 (fr) * | 1999-03-12 | 2002-07-26 | D B F | Granules contenant une substance vegetale et leur procede de preparation |
AU4764200A (en) * | 1999-05-17 | 2000-12-05 | D.B.F. | Granules containing a plant substance and method for producing the same |
MY148805A (en) * | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
US9247765B2 (en) * | 2004-01-14 | 2016-02-02 | Omniactive Health Technologies Limited | Stable beadlets of lipophilic nutrients |
FR2880541B1 (fr) * | 2005-01-10 | 2008-02-22 | Amalric Veret | Une nouvelle formule de plantes sous forme de micro-granules de xilitol pour renforcer les effets des plantes et leurs proprietes par une meilleure assimilation |
US20060182796A1 (en) * | 2005-02-03 | 2006-08-17 | Abrika Pharmaceuticals, Inc. | Taste masked pharmaceutical compositions |
MX2009002166A (es) * | 2006-08-31 | 2009-03-12 | Eurand Inc | Sistema de distribucion de farmacos, que comprenden soluciones solidas de farmacos debilmente basicos. |
JP5215684B2 (ja) * | 2007-02-14 | 2013-06-19 | 大日精化工業株式会社 | 有機顔料の分散剤およびその使用 |
US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
-
2008
- 2008-11-14 FR FR0857764A patent/FR2938432B1/fr not_active Expired - Fee Related
-
2009
- 2009-11-13 US US13/129,028 patent/US20110280945A1/en not_active Abandoned
- 2009-11-13 AU AU2009315449A patent/AU2009315449B2/en not_active Ceased
- 2009-11-13 PE PE2011001032A patent/PE20110945A1/es not_active Application Discontinuation
- 2009-11-13 AR ARP090104388A patent/AR074330A1/es unknown
- 2009-11-13 BR BRPI0916019A patent/BRPI0916019A2/pt not_active Application Discontinuation
- 2009-11-13 WO PCT/FR2009/052180 patent/WO2010055268A1/fr active Application Filing
- 2009-11-13 SG SG2013082482A patent/SG195651A1/en unknown
- 2009-11-13 NZ NZ592857A patent/NZ592857A/xx not_active IP Right Cessation
- 2009-11-13 EP EP09768187A patent/EP2349226A1/fr not_active Withdrawn
- 2009-11-13 CA CA2743753A patent/CA2743753A1/fr not_active Abandoned
- 2009-11-13 MX MX2011005072A patent/MX2011005072A/es active IP Right Grant
- 2009-11-13 UA UAA201105988A patent/UA103781C2/uk unknown
- 2009-11-13 CN CN2009801457596A patent/CN102223879A/zh active Pending
- 2009-11-13 JP JP2011543800A patent/JP5608681B2/ja not_active Expired - Fee Related
- 2009-11-13 KR KR1020117013588A patent/KR101585705B1/ko active IP Right Grant
- 2009-11-13 EA EA201100757A patent/EA201100757A1/ru unknown
- 2009-11-16 TW TW098138860A patent/TWI522113B/zh not_active IP Right Cessation
-
2011
- 2011-05-12 TN TN2011000235A patent/TN2011000235A1/fr unknown
- 2011-05-12 IL IL212850A patent/IL212850A0/en unknown
- 2011-05-13 CU CU20110107A patent/CU20110107A7/es unknown
- 2011-05-13 MA MA33837A patent/MA32789B1/fr unknown
- 2011-05-13 ZA ZA2011/03543A patent/ZA201103543B/en unknown
- 2011-05-13 CL CL2011001115A patent/CL2011001115A1/es unknown
- 2011-05-13 CO CO11059023A patent/CO6382108A2/es not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0592918A (ja) * | 1991-03-07 | 1993-04-16 | Takeda Chem Ind Ltd | 有核散剤およびその製造方法 |
JPH08310969A (ja) * | 1995-05-22 | 1996-11-26 | Lion Corp | 固形薬品組成物及びその製造方法 |
Also Published As
Publication number | Publication date |
---|---|
JP5608681B2 (ja) | 2014-10-15 |
WO2010055268A1 (fr) | 2010-05-20 |
MX2011005072A (es) | 2011-10-03 |
TN2011000235A1 (fr) | 2012-12-17 |
MA32789B1 (fr) | 2011-11-01 |
FR2938432A1 (fr) | 2010-05-21 |
CO6382108A2 (es) | 2012-02-15 |
UA103781C2 (uk) | 2013-11-25 |
KR101585705B1 (ko) | 2016-01-15 |
CN102223879A (zh) | 2011-10-19 |
EA201100757A1 (ru) | 2011-12-30 |
CA2743753A1 (fr) | 2010-05-20 |
CU20110107A7 (es) | 2012-01-31 |
US20110280945A1 (en) | 2011-11-17 |
AU2009315449B2 (en) | 2015-03-26 |
FR2938432B1 (fr) | 2011-05-20 |
CL2011001115A1 (es) | 2011-11-11 |
AR074330A1 (es) | 2011-01-05 |
TWI522113B (zh) | 2016-02-21 |
BRPI0916019A2 (pt) | 2015-11-10 |
AU2009315449A1 (en) | 2010-05-20 |
EP2349226A1 (fr) | 2011-08-03 |
KR20110095888A (ko) | 2011-08-25 |
PE20110945A1 (es) | 2012-02-01 |
SG195651A1 (en) | 2013-12-30 |
TW201029667A (en) | 2010-08-16 |
ZA201103543B (en) | 2012-01-25 |
NZ592857A (en) | 2013-07-26 |
IL212850A0 (en) | 2011-07-31 |
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