JP2012508274A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2012508274A5 JP2012508274A5 JP2011536383A JP2011536383A JP2012508274A5 JP 2012508274 A5 JP2012508274 A5 JP 2012508274A5 JP 2011536383 A JP2011536383 A JP 2011536383A JP 2011536383 A JP2011536383 A JP 2011536383A JP 2012508274 A5 JP2012508274 A5 JP 2012508274A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- independently
- nitrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- -1 2-thiazolyl Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000003006 2-dimethylaminoethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 1
- 208000005017 glioblastoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327308P | 2008-11-11 | 2008-11-11 | |
| US61/113,273 | 2008-11-11 | ||
| PCT/US2009/063020 WO2010056563A1 (en) | 2008-11-11 | 2009-11-03 | Akt and p70 s6 kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508274A JP2012508274A (ja) | 2012-04-05 |
| JP2012508274A5 true JP2012508274A5 (OSRAM) | 2012-07-12 |
| JP5432275B2 JP5432275B2 (ja) | 2014-03-05 |
Family
ID=41402451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536383A Active JP5432275B2 (ja) | 2008-11-11 | 2009-11-03 | Ａｋｔおよびｐ７０ｓ６キナーゼ阻害剤 |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8148387B2 (OSRAM) |
| EP (1) | EP2358710B1 (OSRAM) |
| JP (1) | JP5432275B2 (OSRAM) |
| KR (1) | KR101334460B1 (OSRAM) |
| CN (1) | CN102216302B (OSRAM) |
| AR (1) | AR074072A1 (OSRAM) |
| AU (1) | AU2009314324B2 (OSRAM) |
| BR (1) | BRPI0921916A2 (OSRAM) |
| CA (1) | CA2743019C (OSRAM) |
| CO (1) | CO6382114A2 (OSRAM) |
| CR (1) | CR20110240A (OSRAM) |
| CY (1) | CY1113409T1 (OSRAM) |
| DK (1) | DK2358710T3 (OSRAM) |
| DO (1) | DOP2011000129A (OSRAM) |
| EA (1) | EA018947B1 (OSRAM) |
| EC (1) | ECSP11011048A (OSRAM) |
| ES (1) | ES2391704T3 (OSRAM) |
| HN (1) | HN2011001247A (OSRAM) |
| HR (1) | HRP20120738T1 (OSRAM) |
| IL (1) | IL211940A (OSRAM) |
| JO (1) | JO2822B1 (OSRAM) |
| MA (1) | MA32776B1 (OSRAM) |
| MX (1) | MX2011005000A (OSRAM) |
| MY (1) | MY161461A (OSRAM) |
| NZ (1) | NZ592062A (OSRAM) |
| PA (1) | PA8846901A1 (OSRAM) |
| PE (1) | PE20110807A1 (OSRAM) |
| PL (1) | PL2358710T3 (OSRAM) |
| PT (1) | PT2358710E (OSRAM) |
| RS (1) | RS52520B (OSRAM) |
| SI (1) | SI2358710T1 (OSRAM) |
| TN (1) | TN2011000207A1 (OSRAM) |
| TW (1) | TWI422587B (OSRAM) |
| UA (1) | UA100190C2 (OSRAM) |
| WO (1) | WO2010056563A1 (OSRAM) |
| ZA (1) | ZA201102549B (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5680638B2 (ja) | 2009-07-02 | 2015-03-04 | サノフイ | 新規な（６−オキソ−１，６−ジヒドロピリミジン−２−イル）アミド誘導体、この調製およびａｋｔ（ｐｋｂ）リン酸化インヒビターとしてのこの医薬的な使用 |
| EP2491032B1 (en) | 2009-10-23 | 2014-04-16 | Eli Lilly and Company | Akt inhibitors |
| JP5906303B2 (ja) | 2011-04-07 | 2016-04-20 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ａｋｔキナーゼ阻害剤としてのイミダゾピリダジン類 |
| EP2730575B1 (en) * | 2011-07-09 | 2015-09-16 | Xuanzhu Pharma Co., Ltd. | Crystal form i of salt of dipeptidyl peptidase-iv inhibitor and preparation method and use thereof |
| US9145392B2 (en) | 2011-09-12 | 2015-09-29 | Merck Patent Gmbh | Imidazole amines as modulators of kinase activity |
| BR112014005468A2 (pt) | 2011-09-12 | 2017-03-21 | Merck Patent Gmbh | derivados de aminopiridina para uso como moduladores de atividade quinase |
| JP6280130B2 (ja) * | 2012-11-16 | 2018-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | キナーゼ活性のモジュレーターとしての新規イミダゾール−ピペリジニル誘導体 |
| ES2620119T3 (es) * | 2012-11-16 | 2017-06-27 | Merck Patent Gmbh | Derivados heterocíclicos novedosos como moduladores de la actividad de quinasa |
| MX370448B (es) * | 2013-03-11 | 2019-12-13 | Merck Patent Gmbh | Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. |
| RU2690679C2 (ru) * | 2014-02-11 | 2019-06-05 | Мерк Патент Гмбх | Новые пиримидинимидазоламины в качестве модуляторов активности киназы |
| TW201718574A (zh) | 2015-08-12 | 2017-06-01 | 美國禮來大藥廠 | Ｃｇｒｐ受體拮抗劑 |
| JP6576553B2 (ja) * | 2016-05-20 | 2019-09-18 | 大鵬薬品工業株式会社 | 新規５Ｈ−ピロロ［２，３−ｄ］ピリミジン−６（７Ｈ）−オン誘導体 |
| AU2021238799A1 (en) * | 2020-03-17 | 2022-09-22 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Fused bicyclic derivative, preparation method therefor, and pharmaceutical use thereof |
| CN113444110B (zh) * | 2020-03-25 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |
| WO2023041061A1 (zh) | 2021-09-17 | 2023-03-23 | 江苏恒瑞医药股份有限公司 | 一种稠合二环类衍生物的可药用盐、晶型及其制备方法 |
| JPWO2024009977A1 (OSRAM) * | 2022-07-05 | 2024-01-11 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1750727A2 (en) | 2004-04-23 | 2007-02-14 | Exelixis, Inc. | Kinase modulators and methods of use |
| MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
| JP5274842B2 (ja) | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| US7423043B2 (en) * | 2005-02-18 | 2008-09-09 | Lexicon Pharmaceuticals, Inc. | 4-Piperidin-1-yl-7H-pyrrolo[2,3-d]pyrimidine compounds |
| US20090325924A1 (en) | 2005-06-30 | 2009-12-31 | Stuart Edward | GPCR Agonists |
| JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
| EP2037931A2 (en) | 2006-04-25 | 2009-03-25 | Astex Therapeutics Limited | Pharmaceutical combinations of pk inhibitors and other active agents |
| WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
-
2009
- 2009-10-28 AR ARP090104158A patent/AR074072A1/es unknown
- 2009-10-29 JO JO2009400A patent/JO2822B1/en active
- 2009-10-29 TW TW098136731A patent/TWI422587B/zh not_active IP Right Cessation
- 2009-10-29 PA PA20098846901A patent/PA8846901A1/es unknown
- 2009-11-03 SI SI200930348T patent/SI2358710T1/sl unknown
- 2009-11-03 RS RS20120443A patent/RS52520B/sr unknown
- 2009-11-03 HR HRP20120738AT patent/HRP20120738T1/hr unknown
- 2009-11-03 US US12/611,139 patent/US8148387B2/en active Active
- 2009-11-03 NZ NZ592062A patent/NZ592062A/xx not_active IP Right Cessation
- 2009-11-03 WO PCT/US2009/063020 patent/WO2010056563A1/en not_active Ceased
- 2009-11-03 DK DK09744896.3T patent/DK2358710T3/da active
- 2009-11-03 BR BRPI0921916A patent/BRPI0921916A2/pt not_active IP Right Cessation
- 2009-11-03 EP EP09744896A patent/EP2358710B1/en active Active
- 2009-11-03 PE PE2011001018A patent/PE20110807A1/es not_active Application Discontinuation
- 2009-11-03 CA CA2743019A patent/CA2743019C/en not_active Expired - Fee Related
- 2009-11-03 CN CN2009801449532A patent/CN102216302B/zh active Active
- 2009-11-03 EA EA201170680A patent/EA018947B1/ru not_active IP Right Cessation
- 2009-11-03 AU AU2009314324A patent/AU2009314324B2/en not_active Ceased
- 2009-11-03 KR KR1020117010569A patent/KR101334460B1/ko not_active Expired - Fee Related
- 2009-11-03 ES ES09744896T patent/ES2391704T3/es active Active
- 2009-11-03 UA UAA201105367A patent/UA100190C2/ru unknown
- 2009-11-03 JP JP2011536383A patent/JP5432275B2/ja active Active
- 2009-11-03 MY MYPI2011002030A patent/MY161461A/en unknown
- 2009-11-03 MX MX2011005000A patent/MX2011005000A/es active IP Right Grant
- 2009-11-03 PT PT09744896T patent/PT2358710E/pt unknown
- 2009-11-03 PL PL09744896T patent/PL2358710T3/pl unknown
-
2011
- 2011-03-24 IL IL211940A patent/IL211940A/en not_active IP Right Cessation
- 2011-04-06 ZA ZA2011/02549A patent/ZA201102549B/en unknown
- 2011-04-25 TN TN2011000207A patent/TN2011000207A1/fr unknown
- 2011-05-03 HN HN2011001247A patent/HN2011001247A/es unknown
- 2011-05-06 CR CR20110240A patent/CR20110240A/es unknown
- 2011-05-09 MA MA33822A patent/MA32776B1/fr unknown
- 2011-05-09 DO DO2011000129A patent/DOP2011000129A/es unknown
- 2011-05-11 EC EC2011011048A patent/ECSP11011048A/es unknown
- 2011-05-12 CO CO11058555A patent/CO6382114A2/es active IP Right Grant
-
2012
- 2012-10-05 CY CY20121100928T patent/CY1113409T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2012508274A5 (OSRAM) | ||
| HRP20120738T1 (hr) | Inhibitori kinaza akt i p70 s6 | |
| JP2007533741A5 (ja) | Ｂａｃｅ阻害剤として有用なピロリジン誘導体 | |
| JP2016516043A5 (OSRAM) | ||
| JP2011507849A5 (OSRAM) | ||
| JP2010526814A5 (OSRAM) | ||
| NZ592297A (en) | 2-Aryl-5-heteroaryl pyridine and pyrimidine derivatives as pharmaceutical active agents | |
| JP2018519323A5 (OSRAM) | ||
| JP2009516697A5 (OSRAM) | ||
| JP2011512412A5 (OSRAM) | ||
| JP2010538076A5 (OSRAM) | ||
| NZ601794A (en) | Di - substituted pyridine derivatives as anticancers | |
| JP2008536825A5 (OSRAM) | ||
| JP2015501799A5 (OSRAM) | ||
| MX2007005189A (es) | Derivados de quinuclidina y su uso como antagonistas del receptor muscarinico m3. | |
| JP2011513305A5 (OSRAM) | ||
| JP2014526549A5 (OSRAM) | ||
| JP2011502958A5 (OSRAM) | ||
| JP2008520742A5 (OSRAM) | ||
| JP2005510473A5 (OSRAM) | ||
| JP2012533546A5 (OSRAM) | ||
| JP2018536653A5 (OSRAM) | ||
| JP2012530765A5 (OSRAM) | ||
| JP2016513681A5 (OSRAM) | ||
| JP2010155827A5 (OSRAM) |