JP2012507562A - 微小球性多孔質生体適合性足場並びにその製造方法及び装置 - Google Patents

微小球性多孔質生体適合性足場並びにその製造方法及び装置 Download PDF

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JP2012507562A
JP2012507562A JP2011534806A JP2011534806A JP2012507562A JP 2012507562 A JP2012507562 A JP 2012507562A JP 2011534806 A JP2011534806 A JP 2011534806A JP 2011534806 A JP2011534806 A JP 2011534806A JP 2012507562 A JP2012507562 A JP 2012507562A
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ダビド リウ
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JP2011534806A 2008-10-30 2009-10-30 微小球性多孔質生体適合性足場並びにその製造方法及び装置 Pending JP2012507562A (ja)

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US19780308P 2008-10-30 2008-10-30
US61/197,803 2008-10-30
PCT/US2009/062744 WO2010062678A2 (en) 2008-10-30 2009-10-30 Micro-spherical porous biocompatible scaffolds and methods and apparatus for fabricating same

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JP2012507562A true JP2012507562A (ja) 2012-03-29
JP2012507562A5 JP2012507562A5 (https=) 2012-12-13

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015112262A (ja) * 2013-12-11 2015-06-22 学校法人藤田学園 組織修復及び/又は再生促進材
JP2018130322A (ja) * 2017-02-15 2018-08-23 ドリームメディカルパートナーズ株式会社 塞栓材及びその製造方法
WO2021206440A1 (ko) * 2020-04-09 2021-10-14 주식회사 피엘마이크로메드 색전 시술용 마이크로 비드 및 증식성 질환 치료용 조성물

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
EP1274472A2 (en) 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
DE01918975T1 (de) 2000-03-24 2006-04-13 Biosphere Medical, Inc., Rockland Mikrokügelchen zur aktiven Embolisierung
KR20140090270A (ko) 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
WO2007090127A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US10919229B2 (en) 2013-08-09 2021-02-16 Kimberly-Clark Worldwide, Inc. Polymeric material for three-dimensional printing
JP2016527374A (ja) 2013-08-09 2016-09-08 キンバリー クラーク ワールドワイド インコーポレイテッド 高分子材料の空隙率を選択的に制御するための技術
MX364107B (es) 2013-08-09 2019-04-11 Kimberly Clark Co Sistema de suministro para agentes activos.
MX364997B (es) * 2013-08-09 2019-05-16 Kimberly Clark Co Material polimerico anisotropico.
BR112016002589B1 (pt) 2013-08-09 2021-08-03 Kimberly-Clark Worldwide, Inc Material polimérico flexível moldado, membro tubular, e, método de moldagem de um material polimérico
KR101831079B1 (ko) * 2013-08-09 2018-02-21 킴벌리-클라크 월드와이드, 인크. 복수모드 포어 분포를 갖는 미세입자
WO2015038988A1 (en) 2013-09-13 2015-03-19 Modern Meadow, Inc. Edible and animal-product-free microcarriers for engineered meat
AU2014321277B2 (en) 2013-09-19 2017-07-20 Terumo Corporation Polymer particles
EP3046956B1 (en) 2013-09-19 2019-08-28 Microvention, Inc. Polymer films
CN103550824B (zh) * 2013-11-01 2016-03-02 南京医科大学附属口腔医院 一种引导骨组织再生的支架的制备方法
EP3065719A4 (en) 2013-11-08 2017-08-09 Terumo Corporation Polymer particles
JP2017505138A (ja) 2014-02-05 2017-02-16 モダン メドー インコーポレイテッド 培養筋細胞から形成される乾燥食品
US20160220498A1 (en) * 2015-01-29 2016-08-04 Aneesh SONI Fully or partially biodegradable device for controlled drug delivery
JP6692834B2 (ja) 2015-02-09 2020-05-13 スリングショット バイオサイエンシーズ, インコーポレイテッド 調整可能な光学特性を有するヒドロゲル粒子およびその使用の方法
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
WO2017026426A1 (ja) * 2015-08-10 2017-02-16 国立大学法人京都大学 有機ポリマー製多孔性粒子、有機ポリマー製多孔性粒子の製造方法およびブロックコポリマー
EP3327070A4 (en) * 2015-08-10 2019-06-26 Kyoto University Porous PARTICLE, METHOD FOR PRODUCING A POROUS PARTICLE AND BLOCK COPOLYMER
EP3337923B2 (en) 2015-09-21 2023-01-04 Modern Meadow, Inc. Fiber reinforced tissue composites
US10258590B2 (en) * 2015-10-14 2019-04-16 Alcresta Therapeutics, Inc. Enteral feeding device and related methods of use
CN105175772A (zh) * 2015-10-22 2015-12-23 山西科瑞迪生物科技有限公司 多肽/核苷酸合成用固相载体材料易官能化活性树脂的制备方法
CN105327405B (zh) * 2015-10-23 2019-01-29 华南理工大学 用于治疗宫颈炎的载药支架及其制备方法
JP7109882B2 (ja) 2016-02-15 2022-08-01 モダン メドウ,インコーポレイテッド コラーゲンフィブリルを含むバイオファブリケーテッド材料を作製するための方法
WO2017152127A1 (en) * 2016-03-03 2017-09-08 Amrita Vishwa Vidyapeetham Mri and ct contrast-enabled composite implants for image-guided tissue regeneration and therapy
MX385370B (es) * 2016-03-31 2025-03-18 Immutrix Therapeutics Inc Metodo para el tratamiento extracorporeo de preeclampsia y trastornos relacionados.
AU2017257274B2 (en) 2016-04-19 2023-07-13 Massachusetts Institute Of Technology Novel CRISPR enzymes and systems
KR20260004568A (ko) 2016-04-19 2026-01-08 더 브로드 인스티튜트, 인코퍼레이티드 신규한 crispr 효소 및 시스템
EP3445853A1 (en) 2016-04-19 2019-02-27 The Broad Institute, Inc. Cpf1 complexes with reduced indel activity
CN107304251A (zh) * 2016-04-22 2017-10-31 中国石油化工股份有限公司 用于选择性激光烧结的聚丙烯粉末及其制备
EP3468704A4 (en) * 2016-06-14 2020-01-29 The Regents of The University of California POROUS POLYMERIC SCAFFOLDS, AND METHODS OF PRODUCING AND USING THE SAME
WO2018035387A1 (en) 2016-08-17 2018-02-22 The Broad Institute, Inc. Novel crispr enzymes and systems
EP4485466A3 (en) 2016-08-17 2025-04-02 The Broad Institute Inc. Novel crispr enzymes and systems
EP3518983B1 (en) 2016-09-28 2024-04-24 Terumo Corporation Polymer particles
GB2573246B (en) 2017-01-31 2022-03-09 Kimberly Clark Co Porous polyester material
WO2018191274A1 (en) * 2017-04-11 2018-10-18 University Of Florida Research Foundation Systems and methods for in-situ, bottom-up tissue generation
WO2018191750A2 (en) 2017-04-14 2018-10-18 The Broad Institute Inc. Novel delivery of large payloads
WO2019135816A2 (en) 2017-10-23 2019-07-11 The Broad Institute, Inc. Novel nucleic acid modifiers
US12221720B2 (en) 2017-11-13 2025-02-11 The Broad Institute, Inc. Methods for determining spatial and temporal gene expression dynamics during adult neurogenesis in single cells
AU2018253595A1 (en) 2017-11-13 2019-05-30 Modern Meadow, Inc. Biofabricated leather articles having zonal properties
EP3710039A4 (en) 2017-11-13 2021-08-04 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER BY TARGETING THE CLEC2D-KLRB1 PATH
CN112004528B (zh) 2017-12-18 2023-01-03 巴德股份有限公司 载药微珠组合物、栓塞组合物和相关方法
US12558308B2 (en) 2017-12-18 2026-02-24 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
CN108126239B (zh) * 2018-01-02 2020-11-10 四川大学 一种孔道结构可控的明胶细胞支架及其制备方法
CN109106986B (zh) * 2018-09-14 2020-12-25 广州润虹医药科技股份有限公司 一种药物控释磷酸钙骨水泥复合微球、其制备方法及应用
AU2020209847B2 (en) 2019-01-17 2024-10-17 Modern Meadow, Inc. Layered collagen materials and methods of making the same
CN109833509B (zh) * 2019-01-18 2021-10-15 太阳雨林(厦门)生物医药有限公司 一种多重缓释血管栓塞载药组合物
US12215382B2 (en) 2019-03-01 2025-02-04 The General Hospital Corporation Liver protective MARC variants and uses thereof
US12534714B2 (en) 2019-03-18 2026-01-27 The Broad Institute, Inc. Type VII CRISPR proteins and systems
WO2020236972A2 (en) 2019-05-20 2020-11-26 The Broad Institute, Inc. Non-class i multi-component nucleic acid targeting systems
US12297426B2 (en) 2019-10-01 2025-05-13 The Broad Institute, Inc. DNA damage response signature guided rational design of CRISPR-based systems and therapies
WO2021163131A1 (en) * 2020-02-10 2021-08-19 Youhealth Biotech, Limited Device, kit, and method for islet transplantation
US20210299309A1 (en) * 2020-03-31 2021-09-30 Parasol Medical, Llc Tent with antimicrobial treatment applied thereto and method of imparting antimicrobial properties to the tent
EP4143258A4 (en) 2020-05-01 2024-05-22 Modern Meadow, Inc. PROTEIN POLYURETHANE ALLOYS AND LAYERING MATERIALS
CN112890882A (zh) * 2021-01-27 2021-06-04 广州跃金科技有限公司 一种注射装置及硅胶填充设备
AU2022376541A1 (en) 2021-10-29 2024-04-18 Slingshot Biosciences, Inc. Hydrogel particles as feeder cells and as synthetic antigen presenting cells
CN114191410A (zh) * 2021-11-15 2022-03-18 深圳北航新兴产业技术研究院 一种诊疗一体化双亲微球缓释微球的制备方法
CN114470308A (zh) * 2022-03-01 2022-05-13 苏州森康微球医疗科技有限公司 一种大孔聚丙烯酸钠栓塞微球的制备工艺
IL316038A (en) 2022-04-04 2024-11-01 Univ California Preparations and methods for genetic complementation
CN119907921A (zh) 2022-05-05 2025-04-29 弹弓生物科学公司 用于血液学的作为红细胞模拟物的工程化颗粒和含有工程化颗粒的组合物
CN114949348B (zh) * 2022-06-30 2023-09-29 成都世联康健生物科技有限公司 藻酸盐-载hDPSCs的GelMA纤维微球及其制备方法
CN120712108A (zh) * 2022-10-26 2025-09-26 弹弓生物科学公司 具有可调整光学性质的大小可调整合成颗粒和用于使用其进行免疫细胞激活的方法
WO2025072383A1 (en) 2023-09-25 2025-04-03 The Broad Institute, Inc. Viral open reading frames, uses thereof, and methods of detecting the same
CN117018298B (zh) * 2023-10-09 2023-12-26 北京华龛生物科技有限公司 一种降解时间可控的可注射多孔微球及其制备方法和应用
WO2025097055A2 (en) 2023-11-02 2025-05-08 The Broad Institute, Inc. Compositions and methods of use of t cells in immunotherapy
WO2025129158A1 (en) 2023-12-15 2025-06-19 The Broad Institute, Inc. Engineered arc delivery vesicles and uses thereof
TW202525349A (zh) * 2023-12-28 2025-07-01 白金科技股份有限公司 微球及其製備方法
CN118406273B (zh) * 2024-05-29 2024-11-19 广东安拓普聚合物科技股份有限公司 一种医用导管用tpu材料及其生产工艺
WO2025250808A1 (en) 2024-05-29 2025-12-04 The Brigham And Women’S Hospital, Inc. Anti-crispr delivery compositions and methods

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001517615A (ja) * 1997-09-24 2001-10-09 アルカームズ コントロールド セラピューティックス,インコーポレイテッド ポリマーを基剤とした制御された放出製剤の製造方法
JP2002541925A (ja) * 1999-04-16 2002-12-10 ラトガーズ,ザ ステイト ユニバーシティ 組織工学用多孔質ポリマー足場
JP2004517699A (ja) * 2001-01-30 2004-06-17 ボード オブ リージェンツ ユニバーシティ オブ テキサス システム 液体中への噴霧凍結によるナノ粒子およびミクロ粒子の製造方法
JP2005533008A (ja) * 2002-03-29 2005-11-04 ボストン サイエンティフィック リミテッド 薬物送達粒子
JP2005535752A (ja) * 2002-08-09 2005-11-24 ボストン サイエンティフィック リミテッド 塞栓術
JP2005537070A (ja) * 2002-08-30 2005-12-08 ボストン サイエンティフィック リミテッド 塞栓術
JP2007506791A (ja) * 2003-09-25 2007-03-22 ラトガース,ザ ステート ユニバーシティ 塞栓治療のための本質的に放射線不透過性であるポリマー生産物

Family Cites Families (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673125A (en) * 1969-05-10 1972-06-27 Kanegafuchi Spinning Co Ltd Method of producing polyvinyl acetal porous articles
GB1381258A (en) * 1970-12-11 1975-01-22 Porvair Ltd Water vapour permeable materials
US3919411A (en) * 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
CA1134977A (en) * 1978-09-07 1982-11-02 Sumitomo Chemical Co., Ltd. Method for preparing highly absorbent polymers
US4314032A (en) * 1978-10-26 1982-02-02 Kureha Kagaku Kogyo Kabushiki Kaisha Crosslinked polyvinyl alcohol gel
US4268495A (en) * 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4306031A (en) * 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
GB2088392B (en) * 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
CA1225585A (en) * 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
GB8418772D0 (en) * 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US5186922A (en) * 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US4680171A (en) * 1985-03-15 1987-07-14 William Shell Visualization of a bloodstream circulation with biodegradable microspheres
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPS6317904A (ja) * 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
CA1329800C (en) * 1987-12-29 1994-05-24 Hiroaki Takayanagi Composite separating agent
JPH064713B2 (ja) * 1988-07-22 1994-01-19 テルモ株式会社 生体適合性材料
JPH0286838A (ja) * 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5258028A (en) * 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5092883A (en) * 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
CA2017570C (en) * 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5007940A (en) * 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
JPH0436328A (ja) * 1990-06-01 1992-02-06 Chuichi Hirayama 大孔径ポリアミノ酸多孔質球状粒子とその製造方法
ATE130517T1 (de) * 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
FR2676927B1 (fr) * 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5554658A (en) * 1991-08-06 1996-09-10 Rosenblatt; Solomon Injection molded PVA Sponge
JP3356447B2 (ja) * 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
AU673160B2 (en) * 1992-02-28 1996-10-31 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JPH05294839A (ja) * 1992-04-20 1993-11-09 Biomaterial Universe Kk シスプラチン含有生体内分解吸収性高分子の微小球お よびその製造法
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ES2113094T3 (es) * 1993-03-09 1998-04-16 Epic Therapeutics Inc Las microparticulas macromoleculares y metodos de obtencion.
US5583162A (en) * 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
UA10911C2 (uk) * 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
US5955108A (en) * 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
JP3625837B2 (ja) * 1995-01-27 2005-03-02 シメッド ライフ システムズ,インコーポレイテッド 塞栓装置
US5752974A (en) * 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19601699A1 (de) * 1996-01-18 1997-07-24 Wacker Chemie Gmbh Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen
US5785977A (en) * 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
EP0889925B1 (en) * 1996-03-27 2004-06-02 Novartis AG Process for manufacture of a porous polymer by use of a porogen
US5823198A (en) * 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
US5925683A (en) * 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US6048908A (en) * 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
US6565885B1 (en) * 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6660301B1 (en) * 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
EP1059943B1 (en) * 1998-03-06 2004-12-01 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US5891470A (en) * 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
US6165193A (en) * 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
FR2784580B1 (fr) * 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6103255A (en) * 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6710126B1 (en) * 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) * 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
EP1263803B1 (en) * 2000-03-13 2007-09-19 BioCure, Inc. Embolic compositions
US6652883B2 (en) * 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
EP1274472A2 (en) * 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
DE01918975T1 (de) * 2000-03-24 2006-04-13 Biosphere Medical, Inc., Rockland Mikrokügelchen zur aktiven Embolisierung
US6537569B2 (en) * 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6911219B2 (en) * 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) * 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US7303575B2 (en) * 2002-08-01 2007-12-04 Lumen Biomedical, Inc. Embolism protection devices
US20040076582A1 (en) * 2002-08-30 2004-04-22 Dimatteo Kristian Agent delivery particle
US7588825B2 (en) * 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) * 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
BR0315194A (pt) * 2002-10-31 2005-08-23 Umd Inc Composições terapêuticas para liberação de droga para a, e através da, cobertura epitelial
US7837733B2 (en) * 2004-06-29 2010-11-23 Spine Wave, Inc. Percutaneous methods for injecting a curable biomaterial into an intervertebral space
KR20140090270A (ko) * 2005-05-09 2014-07-16 바이오스피어 메디칼 에스.에이. 마이크로스피어 및 비이온성 조영제를 사용하는 조성물 및 방법
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
WO2007090127A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US7888410B2 (en) * 2007-04-24 2011-02-15 Eastman Kodak Company Method of making porous particles
EP2351779B1 (en) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001517615A (ja) * 1997-09-24 2001-10-09 アルカームズ コントロールド セラピューティックス,インコーポレイテッド ポリマーを基剤とした制御された放出製剤の製造方法
JP2002541925A (ja) * 1999-04-16 2002-12-10 ラトガーズ,ザ ステイト ユニバーシティ 組織工学用多孔質ポリマー足場
JP2004517699A (ja) * 2001-01-30 2004-06-17 ボード オブ リージェンツ ユニバーシティ オブ テキサス システム 液体中への噴霧凍結によるナノ粒子およびミクロ粒子の製造方法
JP2005533008A (ja) * 2002-03-29 2005-11-04 ボストン サイエンティフィック リミテッド 薬物送達粒子
JP2005535752A (ja) * 2002-08-09 2005-11-24 ボストン サイエンティフィック リミテッド 塞栓術
JP2005537070A (ja) * 2002-08-30 2005-12-08 ボストン サイエンティフィック リミテッド 塞栓術
JP2007506791A (ja) * 2003-09-25 2007-03-22 ラトガース,ザ ステート ユニバーシティ 塞栓治療のための本質的に放射線不透過性であるポリマー生産物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015112262A (ja) * 2013-12-11 2015-06-22 学校法人藤田学園 組織修復及び/又は再生促進材
JP2018130322A (ja) * 2017-02-15 2018-08-23 ドリームメディカルパートナーズ株式会社 塞栓材及びその製造方法
US11253627B2 (en) 2017-02-15 2022-02-22 Dream Medical Partners Corporation Embolic material and method for producing same
WO2021206440A1 (ko) * 2020-04-09 2021-10-14 주식회사 피엘마이크로메드 색전 시술용 마이크로 비드 및 증식성 질환 치료용 조성물

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