JP2012507542A5 - - Google Patents
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- Publication number
- JP2012507542A5 JP2012507542A5 JP2011534668A JP2011534668A JP2012507542A5 JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5 JP 2011534668 A JP2011534668 A JP 2011534668A JP 2011534668 A JP2011534668 A JP 2011534668A JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- benzoic acid
- piperazin
- acid
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10958908P | 2008-10-30 | 2008-10-30 | |
| US61/109,589 | 2008-10-30 | ||
| PCT/US2009/062154 WO2010056506A1 (en) | 2008-10-30 | 2009-10-27 | Diacylglycerol aclytransferase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012507542A JP2012507542A (ja) | 2012-03-29 |
| JP2012507542A5 true JP2012507542A5 (https=) | 2012-12-20 |
Family
ID=42132236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011534668A Withdrawn JP2012507542A (ja) | 2008-10-30 | 2009-10-27 | ジアシルグリセロールアシルトランスフェラーゼ阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8324385B2 (https=) |
| EP (1) | EP2350311B1 (https=) |
| JP (1) | JP2012507542A (https=) |
| CN (1) | CN102203280A (https=) |
| AU (1) | AU2009314358B2 (https=) |
| CA (1) | CA2741601A1 (https=) |
| IL (1) | IL212496A0 (https=) |
| WO (1) | WO2010056506A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| KR101609856B1 (ko) * | 2010-03-17 | 2016-04-07 | 타이벡스 세라피틱스 코포레이션 | Hec1 활성의 조절인자 및 이의 방법 |
| FR2963005B1 (fr) * | 2010-07-23 | 2012-08-17 | Sanofi Aventis | Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique |
| CN101993415B (zh) * | 2010-09-15 | 2013-08-14 | 北京韩美药品有限公司 | 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用 |
| ES2736999T3 (es) | 2011-11-21 | 2020-01-09 | Taivex Therapeutics Corp | Biomarcadores para cánceres que responden a moduladores de la actividad de Hec1 |
| US11071736B2 (en) | 2011-11-21 | 2021-07-27 | Taivex Therapeutics Corporation | Modulators of HEC1 activity and methods therefor |
| TWI640519B (zh) | 2011-11-29 | 2018-11-11 | 泰緯生命科技股份有限公司 | Hec1活性調控因子及其調節方法 |
| JP6129199B2 (ja) * | 2011-12-02 | 2017-05-17 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピペリジン誘導体、その医薬組成物及び使用 |
| US9796729B2 (en) | 2012-11-23 | 2017-10-24 | Glaxosmithkline Llc | Compounds as diacylglycerol acyltransferase inhibitors |
| BR112015011982A8 (pt) * | 2012-11-23 | 2019-10-08 | Glaxosmithkline Llc | compostos inibidores de diacilglicerol aciltransferase, composição farmacêutica compreendendo estes e usos destes |
| WO2014081996A1 (en) * | 2012-11-23 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds as diacylglycerol acyltransferase inhibitors |
| SG11201509070YA (en) * | 2013-05-29 | 2015-12-30 | Bristol Myers Squibb Co | Dihydropyridinone mgat2 inhibitors |
| CA2920815C (en) * | 2013-08-14 | 2021-09-21 | Kalvista Pharmaceuticals Limited | Inhibitors of plasma kallikrein |
| TWI636047B (zh) | 2013-08-14 | 2018-09-21 | 英商卡爾維斯塔製藥有限公司 | 雜環衍生物 |
| LT3119757T (lt) * | 2014-03-17 | 2018-07-10 | Pfizer Inc. | Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme |
| GB201421083D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| GB201421085D0 (en) | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | New enzyme inhibitors |
| EP3227277B1 (en) * | 2014-12-05 | 2020-02-05 | Pulmocide Limited | Antimycotic compound |
| US10865185B2 (en) | 2015-08-21 | 2020-12-15 | Srx Cardio, Llc | Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity |
| US10821106B2 (en) | 2015-08-21 | 2020-11-03 | Srx Cardio, Llc | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity |
| HK1257102A1 (zh) | 2015-08-21 | 2019-10-11 | Portola Pharmaceuticals, Inc. | 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用 |
| US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
| IL263235B (en) | 2016-05-31 | 2022-07-01 | Kalvista Pharmaceuticals Ltd | History of pyrazoles as plasma kallikrein inhibitors |
| GB201609607D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts |
| GB201609603D0 (en) | 2016-06-01 | 2016-07-13 | Kalvista Pharmaceuticals Ltd | Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide |
| GB201719881D0 (en) | 2017-11-29 | 2018-01-10 | Kalvista Pharmaceuticals Ltd | Solid forms of plasma kallikrein inhibitor and salts thereof |
| HUE057912T2 (hu) | 2017-11-29 | 2022-06-28 | Kalvista Pharmaceuticals Ltd | Plazma kallikrein inhibitort tartalmazó dózisformák |
| WO2021028645A1 (en) | 2019-08-09 | 2021-02-18 | Kalvista Pharmaceuticals Limited | Plasma kallikrein inhibitors |
| PH12022551271A1 (en) * | 2019-12-23 | 2023-11-29 | Lg Chemical Ltd | Novel amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof |
| CA3179059A1 (en) * | 2020-06-09 | 2021-12-16 | Anima Biotech Inc. | Collagen 1 translation inhibitors and methods of use thereof |
| US12115154B2 (en) | 2020-12-16 | 2024-10-15 | Srx Cardio, Llc | Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9) |
| AU2022214582C1 (en) * | 2021-01-29 | 2025-02-27 | Korea Research Institute Of Chemical Technology | Benzothiazole and benzimidazole derivatives, pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition comprising same as active ingredient |
| WO2022222890A1 (en) * | 2021-04-19 | 2022-10-27 | Shanghai Yao Yuan Biotechnology Co., Ltd. | Benzothiazole and quinoline derivatives for use in treating kawasaki disease |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3250771A (en) * | 1962-12-17 | 1966-05-10 | Geigy Chem Corp | 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof |
| US3863007A (en) * | 1971-05-21 | 1975-01-28 | Jr Paul L Warner | Sunscreening method containing 4-di (lower)alkylaminobenzamides |
| DE2337461A1 (de) * | 1973-07-24 | 1975-02-06 | Boehringer Mannheim Gmbh | Neue indolderivate und verfahren zu deren herstellung |
| US4066654A (en) * | 1975-04-16 | 1978-01-03 | G. D. Searle & Co. | 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives |
| EP0837052B1 (en) * | 1995-06-21 | 2006-08-23 | Shionogi & Co., Ltd. | Bicyclic amino derivatives and pgd 2 antagonist containing the same |
| US6495558B1 (en) * | 1999-01-22 | 2002-12-17 | Amgen Inc. | Kinase inhibitors |
| CN1230421C (zh) | 1999-02-10 | 2005-12-07 | 三菱制药株式会社 | 酰胺化合物及其药物用途 |
| US6756374B2 (en) * | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| HRP20040199A2 (en) | 2001-08-31 | 2005-04-30 | Aventis Pharma Deutschland Gmbh | Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| AU2003261935A1 (en) | 2002-09-06 | 2004-03-29 | Takeda Pharmaceutical Company Limited | Furan or thiophene derivative and medicinal use thereof |
| KR100772297B1 (ko) * | 2002-11-22 | 2007-11-02 | 니뽄 다바코 산교 가부시키가이샤 | 융합 비시클릭 질소-함유 헤테로사이클 |
| DE10308353A1 (de) * | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7148246B2 (en) * | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
| US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
| AR051596A1 (es) | 2004-10-26 | 2007-01-24 | Irm Llc | Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios |
| US7795283B2 (en) * | 2004-12-14 | 2010-09-14 | Astrazeneca Ab | Oxadiazole derivative as DGAT inhibitors |
| KR100883694B1 (ko) * | 2005-02-07 | 2009-02-12 | 에프. 호프만-라 로슈 아게 | 디아실글리세롤 아실트랜스퍼라제 억제제 |
| EP1884513A4 (en) * | 2005-05-23 | 2010-04-28 | Japan Tobacco Inc | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME |
| KR20080015113A (ko) | 2005-06-11 | 2008-02-18 | 아스트라제네카 아베 | Dgat 억제제로서의 옥사디아졸 유도체 |
| WO2007008541A2 (en) * | 2005-07-08 | 2007-01-18 | Kalypsys, Inc. | Cellular cholesterol absorption modifiers |
| MX2008000966A (es) * | 2005-07-19 | 2008-03-26 | Merck & Co Inc | Nuevos derivados de espirocromanona. |
| CA2630269C (en) * | 2005-11-28 | 2011-07-05 | F. Hoffmann-La Roche Ag | Inhibitors of diacyglycerol acyltransferase (dgat) |
| GB0611507D0 (en) | 2006-06-10 | 2006-07-19 | Astrazeneca Ab | Chemical compounds |
| WO2008098851A1 (en) | 2007-02-14 | 2008-08-21 | Basf Se | Electroluminescent metal complex |
| US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US20090099201A1 (en) * | 2007-05-22 | 2009-04-16 | David Robert Bolin | Diacylglycerol Acyltransferase Inhibitors |
| AU2008253118B2 (en) | 2007-05-22 | 2013-11-21 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8058299B2 (en) * | 2007-05-22 | 2011-11-15 | Via Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| CA2695071A1 (en) * | 2007-08-02 | 2009-02-05 | F. Hoffmann-La Roche Ag | The use of benzamide derivatives for the treatment of cns disorders |
| US8211884B2 (en) | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| WO2010065310A1 (en) | 2008-12-03 | 2010-06-10 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol acyltransferase |
| AU2009333333A1 (en) | 2008-12-17 | 2011-06-30 | Via Pharmaceuticals, Inc | Inhibitors of diacylglycerol aclytransferase |
-
2009
- 2009-10-20 US US12/581,950 patent/US8324385B2/en not_active Expired - Fee Related
- 2009-10-27 WO PCT/US2009/062154 patent/WO2010056506A1/en not_active Ceased
- 2009-10-27 CN CN200980143289XA patent/CN102203280A/zh active Pending
- 2009-10-27 CA CA2741601A patent/CA2741601A1/en not_active Abandoned
- 2009-10-27 JP JP2011534668A patent/JP2012507542A/ja not_active Withdrawn
- 2009-10-27 AU AU2009314358A patent/AU2009314358B2/en not_active Ceased
- 2009-10-27 EP EP09826537.4A patent/EP2350311B1/en not_active Not-in-force
-
2011
- 2011-04-26 IL IL212496A patent/IL212496A0/en unknown
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