JP2012507542A5 - - Google Patents

Download PDF

Info

Publication number
JP2012507542A5
JP2012507542A5 JP2011534668A JP2011534668A JP2012507542A5 JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5 JP 2011534668 A JP2011534668 A JP 2011534668A JP 2011534668 A JP2011534668 A JP 2011534668A JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5
Authority
JP
Japan
Prior art keywords
phenyl
benzoic acid
piperazin
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011534668A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012507542A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/062154 external-priority patent/WO2010056506A1/en
Publication of JP2012507542A publication Critical patent/JP2012507542A/ja
Publication of JP2012507542A5 publication Critical patent/JP2012507542A5/ja
Withdrawn legal-status Critical Current

Links

JP2011534668A 2008-10-30 2009-10-27 ジアシルグリセロールアシルトランスフェラーゼ阻害剤 Withdrawn JP2012507542A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10958908P 2008-10-30 2008-10-30
US61/109,589 2008-10-30
PCT/US2009/062154 WO2010056506A1 (en) 2008-10-30 2009-10-27 Diacylglycerol aclytransferase inhibitors

Publications (2)

Publication Number Publication Date
JP2012507542A JP2012507542A (ja) 2012-03-29
JP2012507542A5 true JP2012507542A5 (https=) 2012-12-20

Family

ID=42132236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011534668A Withdrawn JP2012507542A (ja) 2008-10-30 2009-10-27 ジアシルグリセロールアシルトランスフェラーゼ阻害剤

Country Status (8)

Country Link
US (1) US8324385B2 (https=)
EP (1) EP2350311B1 (https=)
JP (1) JP2012507542A (https=)
CN (1) CN102203280A (https=)
AU (1) AU2009314358B2 (https=)
CA (1) CA2741601A1 (https=)
IL (1) IL212496A0 (https=)
WO (1) WO2010056506A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211884B2 (en) * 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
KR101609856B1 (ko) * 2010-03-17 2016-04-07 타이벡스 세라피틱스 코포레이션 Ｈｅｃ１ 활성의 조절인자 및 이의 방법
FR2963005B1 (fr) * 2010-07-23 2012-08-17 Sanofi Aventis Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique
CN101993415B (zh) * 2010-09-15 2013-08-14 北京韩美药品有限公司 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
US11071736B2 (en) 2011-11-21 2021-07-27 Taivex Therapeutics Corporation Modulators of HEC1 activity and methods therefor
ES2736999T3 (es) 2011-11-21 2020-01-09 Taivex Therapeutics Corp Biomarcadores para cánceres que responden a moduladores de la actividad de Hec1
TWI640519B (zh) 2011-11-29 2018-11-11 泰緯生命科技股份有限公司 Ｈｅｃ１活性調控因子及其調節方法
EP2785690B1 (en) 2011-12-02 2016-07-13 Boehringer Ingelheim International GmbH Piperidine derivatives, pharmaceutical compositions and uses thereof
EA031114B1 (ru) * 2012-11-23 2018-11-30 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи ПРОИЗВОДНЫЕ ДИГИДРОПИРИМИДО[5,4-f]ОКСАЗЕПИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ДИАЦИЛГЛИЦЕРИН АЦИЛТРАНСФЕРАЗЫ
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
KR102291444B1 (ko) * 2013-05-29 2021-08-18 브리스톨-마이어스 스큅 컴퍼니 디히드로피리디논 mgat2 억제제
HUE14755117T2 (hu) * 2013-08-14 2018-12-28 Kalvista Pharmaceuticals Ltd Plazma-kallikrein inhibitorok
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
LT3119757T (lt) 2014-03-17 2018-07-10 Pfizer Inc. Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
ES2790875T3 (es) * 2014-12-05 2020-10-29 Pulmocide Ltd Compuesto antimicótico
EP3337497B1 (en) 2015-08-21 2023-07-12 SRX Cardio, LLC Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity
EP3337564A4 (en) 2015-08-21 2019-01-23 Portola Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR THE USE OF TETRAHYDROISOCHINOLINE SMALL MOLECULES FOR THE BINDING AND MODULATION OF PCSK9 PROTEIN ACTIVITY
HK1257102A1 (zh) 2015-08-21 2019-10-11 Portola Pharmaceuticals, Inc. 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
WO2017147328A1 (en) 2016-02-23 2017-08-31 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
DK3464271T3 (da) 2016-05-31 2020-06-15 Kalvista Pharmaceuticals Ltd Pyrazolderivater som plasma-kallikreininhibitorer
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
PT3716952T (pt) 2017-11-29 2022-04-14 Kalvista Pharmaceuticals Ltd Formas de administração que incluem um inibidor de calicreína plasmática
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
IL294139B2 (en) * 2019-12-23 2025-11-01 Lg Chemical Ltd Novel amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof
CA3179059A1 (en) * 2020-06-09 2021-12-16 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
US20240116897A1 (en) * 2021-01-29 2024-04-11 Korea Research Institute Of Chemical Technology Benzothiazole and benzimidazole derivatives, pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition comprising same as active ingredient
WO2022222890A1 (en) * 2021-04-19 2022-10-27 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
US3863007A (en) * 1971-05-21 1975-01-28 Jr Paul L Warner Sunscreening method containing 4-di (lower)alkylaminobenzamides
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
CN1134411C (zh) * 1995-06-21 2004-01-14 盐野义制药株式会社 双环氨基衍生物及含有此类化合物的前列腺素d2拮抗剂
US6495558B1 (en) * 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
MXPA01008142A (es) 1999-02-10 2003-07-21 Welfide Corp Compuestos de amida, y uso medicinal de los mismos.
US6756374B2 (en) * 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
AU2002333456B2 (en) 2001-08-31 2008-07-17 Sanofi-Aventis Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as PPAR activators
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
RU2342388C2 (ru) * 2002-11-22 2008-12-27 Джапан Тобакко Инк. Конденсированные бициклические азотсодержащие гетероциклы, обладающие dgat ингибирующим действием
US7148246B2 (en) * 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
AR051596A1 (es) 2004-10-26 2007-01-24 Irm Llc Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios
BRPI0519058A2 (pt) * 2004-12-14 2008-12-23 Astrazeneca Ab composto ou um sal prà-droga farmaceuticamente aceitÁvel do mesmo, mÉtodos para produzir uma inibiÇço da atividade de dgat1 e para tratar diabete melito e/ou obesidade em um animal de sangue quente, uso de um composto, composiÇço farmacÊutica, e, processo para preparar um composto
AU2006210056A1 (en) * 2005-02-07 2006-08-10 F. Hoffmann-La Roche Ag Inhibitors of diacylglycerol acyltransferase (DGAT)
AU2006250354A1 (en) * 2005-05-23 2006-11-30 Japan Tobacco Inc. Pyrazole compound and therapeutic agent for diabetes comprising the same
AU2006258917A1 (en) 2005-06-11 2006-12-21 Astrazeneca Ab Oxadiazole derivatives as DGAT inhibitors
WO2007008541A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
WO2007011809A1 (en) * 2005-07-19 2007-01-25 Merck & Co., Inc. Spirochromanone derivatives as acetyl coenzyme a carboxylase (acc) inhibitors
KR20080063865A (ko) 2005-11-28 2008-07-07 에프. 호프만-라 로슈 아게 다이아실글리세롤 아실전이효소(ｄｇａｔ)의 저해제
GB0611507D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
US9284278B2 (en) 2007-02-14 2016-03-15 Basf Se Electroluminescent metal complex
BRPI0811947A2 (pt) 2007-05-22 2014-11-11 Via Pharmaceuticals Inc Composto, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratamento de obesidade, diabetes do tipo ii, dislipidemia ou síndrome metabólica
US8058299B2 (en) * 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8153644B2 (en) * 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US20090099201A1 (en) * 2007-05-22 2009-04-16 David Robert Bolin Diacylglycerol Acyltransferase Inhibitors
US8115011B2 (en) * 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
CN101765425A (zh) * 2007-08-02 2010-06-30 弗·哈夫曼-拉罗切有限公司 苯甲酰胺衍生物用于治疗cns障碍的用途
US8211884B2 (en) 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
AU2009322774A1 (en) * 2008-12-03 2011-06-30 Via Pharmaceuticals, Inc Inhibitors of diacylglycerol acyltransferase
JP2012512252A (ja) 2008-12-17 2012-05-31 ブイアイエイ・ファーマシューティカルズ・インコーポレーテッド ジアシルグリセロールアシルトランスフェラーゼの阻害剤

Similar Documents

Publication Publication Date Title
JP2012507542A5 (https=)
JP5650233B2 (ja) 選択的スフィンゴシン−１−リン酸受容体変調因子および不斉合成方法
EP2350311B1 (en) Diacylglycerol acyltransferase inhibitors
JP2010539152A5 (https=)
JP5922027B2 (ja) 選択的複素環式スフィンゴシン−１−リン酸受容体変調因子
JP2010516742A5 (https=)
JP2010506825A5 (https=)
JP2007520471A5 (https=)
JP2012512252A5 (https=)
JP2005521741A5 (https=)
AU2007263712B2 (en) Piperazinyl derivatives useful in the treatment of GPR38 receptor mediated diseases
JP2012530765A5 (https=)
OA12346A (en) Carboxamide compounds and their use as antagonistsof a human 11 CBY receptor.
NZ627750A (en) Carbamate compounds and of making and using same
RU2012129737A (ru) Замещенные бензамидные производные
CA2515726A1 (en) Isoxazole compounds
NZ592906A (en) Process for the preparation of piperazine compounds and hydrochloride salts thereof
RU2006137272A (ru) Производные 2-фенилпропионовой кислоты и содержащие их фармацевтические композиции
JP2004518702A5 (https=)
NO155805C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
RU2009118281A (ru) Гетероциклические ингибиторы мек и способы их применения
CA2581945A1 (en) Hexafluoroisopropanol substituted ether derivatives
JP2004203871A (ja) 医薬組成物
JP2006510609A5 (https=)
JP2014517836A (ja) 選択的複素環式スフィンゴシン１−リン酸受容体モジュレーター