JP2012507542A5 - - Google Patents

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Publication number
JP2012507542A5
JP2012507542A5 JP2011534668A JP2011534668A JP2012507542A5 JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5 JP 2011534668 A JP2011534668 A JP 2011534668A JP 2011534668 A JP2011534668 A JP 2011534668A JP 2012507542 A5 JP2012507542 A5 JP 2012507542A5
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JP
Japan
Prior art keywords
phenyl
benzoic acid
piperazin
acid
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2011534668A
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English (en)
Japanese (ja)
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JP2012507542A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/062154 external-priority patent/WO2010056506A1/en
Publication of JP2012507542A publication Critical patent/JP2012507542A/ja
Publication of JP2012507542A5 publication Critical patent/JP2012507542A5/ja
Withdrawn legal-status Critical Current

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JP2011534668A 2008-10-30 2009-10-27 ジアシルグリセロールアシルトランスフェラーゼ阻害剤 Withdrawn JP2012507542A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10958908P 2008-10-30 2008-10-30
US61/109,589 2008-10-30
PCT/US2009/062154 WO2010056506A1 (en) 2008-10-30 2009-10-27 Diacylglycerol aclytransferase inhibitors

Publications (2)

Publication Number Publication Date
JP2012507542A JP2012507542A (ja) 2012-03-29
JP2012507542A5 true JP2012507542A5 (https=) 2012-12-20

Family

ID=42132236

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011534668A Withdrawn JP2012507542A (ja) 2008-10-30 2009-10-27 ジアシルグリセロールアシルトランスフェラーゼ阻害剤

Country Status (8)

Country Link
US (1) US8324385B2 (https=)
EP (1) EP2350311B1 (https=)
JP (1) JP2012507542A (https=)
CN (1) CN102203280A (https=)
AU (1) AU2009314358B2 (https=)
CA (1) CA2741601A1 (https=)
IL (1) IL212496A0 (https=)
WO (1) WO2010056506A1 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8211884B2 (en) * 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
JP2011057661A (ja) * 2009-08-14 2011-03-24 Bayer Cropscience Ag 殺虫性カルボキサミド類
KR101609856B1 (ko) * 2010-03-17 2016-04-07 타이벡스 세라피틱스 코포레이션 Hec1 활성의 조절인자 및 이의 방법
FR2963005B1 (fr) * 2010-07-23 2012-08-17 Sanofi Aventis Derives d'oxadiazoles et de pyridazines, leur preparation et leur application en therapeutique
CN101993415B (zh) * 2010-09-15 2013-08-14 北京韩美药品有限公司 作为Hedgehog通路抑制剂的化合物以及包含该化合物的药物组合物及其应用
ES2736999T3 (es) 2011-11-21 2020-01-09 Taivex Therapeutics Corp Biomarcadores para cánceres que responden a moduladores de la actividad de Hec1
US11071736B2 (en) 2011-11-21 2021-07-27 Taivex Therapeutics Corporation Modulators of HEC1 activity and methods therefor
TWI640519B (zh) 2011-11-29 2018-11-11 泰緯生命科技股份有限公司 Hec1活性調控因子及其調節方法
JP6129199B2 (ja) * 2011-12-02 2017-05-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペリジン誘導体、その医薬組成物及び使用
US9796729B2 (en) 2012-11-23 2017-10-24 Glaxosmithkline Llc Compounds as diacylglycerol acyltransferase inhibitors
BR112015011982A8 (pt) * 2012-11-23 2019-10-08 Glaxosmithkline Llc compostos inibidores de diacilglicerol aciltransferase, composição farmacêutica compreendendo estes e usos destes
WO2014081996A1 (en) * 2012-11-23 2014-05-30 Glaxosmithkline Llc Novel compounds as diacylglycerol acyltransferase inhibitors
SG11201509070YA (en) * 2013-05-29 2015-12-30 Bristol Myers Squibb Co Dihydropyridinone mgat2 inhibitors
CA2920815C (en) * 2013-08-14 2021-09-21 Kalvista Pharmaceuticals Limited Inhibitors of plasma kallikrein
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
LT3119757T (lt) * 2014-03-17 2018-07-10 Pfizer Inc. Diacilglicerolio aciltransferazės 2 inhibitoriai, skirti panaudoti metabolinių ir susijusių ligų gydyme
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
EP3227277B1 (en) * 2014-12-05 2020-02-05 Pulmocide Limited Antimycotic compound
US10865185B2 (en) 2015-08-21 2020-12-15 Srx Cardio, Llc Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity
US10821106B2 (en) 2015-08-21 2020-11-03 Srx Cardio, Llc Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity
HK1257102A1 (zh) 2015-08-21 2019-10-11 Portola Pharmaceuticals, Inc. 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
IL263235B (en) 2016-05-31 2022-07-01 Kalvista Pharmaceuticals Ltd History of pyrazoles as plasma kallikrein inhibitors
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
HUE057912T2 (hu) 2017-11-29 2022-06-28 Kalvista Pharmaceuticals Ltd Plazma kallikrein inhibitort tartalmazó dózisformák
WO2021028645A1 (en) 2019-08-09 2021-02-18 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
PH12022551271A1 (en) * 2019-12-23 2023-11-29 Lg Chemical Ltd Novel amino aryl derivative useful as diacylglycerol acyltransferase 2 inhibitor and use thereof
CA3179059A1 (en) * 2020-06-09 2021-12-16 Anima Biotech Inc. Collagen 1 translation inhibitors and methods of use thereof
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
AU2022214582C1 (en) * 2021-01-29 2025-02-27 Korea Research Institute Of Chemical Technology Benzothiazole and benzimidazole derivatives, pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition comprising same as active ingredient
WO2022222890A1 (en) * 2021-04-19 2022-10-27 Shanghai Yao Yuan Biotechnology Co., Ltd. Benzothiazole and quinoline derivatives for use in treating kawasaki disease

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3250771A (en) * 1962-12-17 1966-05-10 Geigy Chem Corp 5-monocarbocyclic aryl-n-lower alkyl-2-pyrrolidine carboxylic acid, esters, amides and derivatives thereof
US3863007A (en) * 1971-05-21 1975-01-28 Jr Paul L Warner Sunscreening method containing 4-di (lower)alkylaminobenzamides
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
US4066654A (en) * 1975-04-16 1978-01-03 G. D. Searle & Co. 1-triarylalkyl-4-phenyl-4-piperidine carboxylic acids and derivatives
EP0837052B1 (en) * 1995-06-21 2006-08-23 Shionogi & Co., Ltd. Bicyclic amino derivatives and pgd 2 antagonist containing the same
US6495558B1 (en) * 1999-01-22 2002-12-17 Amgen Inc. Kinase inhibitors
CN1230421C (zh) 1999-02-10 2005-12-07 三菱制药株式会社 酰胺化合物及其药物用途
US6756374B2 (en) * 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
HRP20040199A2 (en) 2001-08-31 2005-04-30 Aventis Pharma Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar activators
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
AU2003261935A1 (en) 2002-09-06 2004-03-29 Takeda Pharmaceutical Company Limited Furan or thiophene derivative and medicinal use thereof
KR100772297B1 (ko) * 2002-11-22 2007-11-02 니뽄 다바코 산교 가부시키가이샤 융합 비시클릭 질소-함유 헤테로사이클
DE10308353A1 (de) * 2003-02-27 2004-12-02 Aventis Pharma Deutschland Gmbh Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US7148246B2 (en) * 2003-02-27 2006-12-12 Sanofi-Aventis Deutschland Gmbh Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
US6984652B2 (en) * 2003-09-05 2006-01-10 Warner-Lambert Company Llc Gyrase inhibitors
AR051596A1 (es) 2004-10-26 2007-01-24 Irm Llc Compuestos heterociclicos condensados nitrogenados como inhibidores de la actividad del receptor canabinoide 1; composiciones farmaceuticas que los contienen y su empleo en la preparacion de medicamentos para el tratamiento de trastornos alimentarios
US7795283B2 (en) * 2004-12-14 2010-09-14 Astrazeneca Ab Oxadiazole derivative as DGAT inhibitors
KR100883694B1 (ko) * 2005-02-07 2009-02-12 에프. 호프만-라 로슈 아게 디아실글리세롤 아실트랜스퍼라제 억제제
EP1884513A4 (en) * 2005-05-23 2010-04-28 Japan Tobacco Inc PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME
KR20080015113A (ko) 2005-06-11 2008-02-18 아스트라제네카 아베 Dgat 억제제로서의 옥사디아졸 유도체
WO2007008541A2 (en) * 2005-07-08 2007-01-18 Kalypsys, Inc. Cellular cholesterol absorption modifiers
MX2008000966A (es) * 2005-07-19 2008-03-26 Merck & Co Inc Nuevos derivados de espirocromanona.
CA2630269C (en) * 2005-11-28 2011-07-05 F. Hoffmann-La Roche Ag Inhibitors of diacyglycerol acyltransferase (dgat)
GB0611507D0 (en) 2006-06-10 2006-07-19 Astrazeneca Ab Chemical compounds
WO2008098851A1 (en) 2007-02-14 2008-08-21 Basf Se Electroluminescent metal complex
US8115011B2 (en) * 2007-05-22 2012-02-14 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US20090099201A1 (en) * 2007-05-22 2009-04-16 David Robert Bolin Diacylglycerol Acyltransferase Inhibitors
AU2008253118B2 (en) 2007-05-22 2013-11-21 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8153644B2 (en) * 2007-05-22 2012-04-10 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
US8058299B2 (en) * 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
CA2695071A1 (en) * 2007-08-02 2009-02-05 F. Hoffmann-La Roche Ag The use of benzamide derivatives for the treatment of cns disorders
US8211884B2 (en) 2008-08-06 2012-07-03 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
WO2010065310A1 (en) 2008-12-03 2010-06-10 Via Pharmaceuticals, Inc Inhibitors of diacylglycerol acyltransferase
AU2009333333A1 (en) 2008-12-17 2011-06-30 Via Pharmaceuticals, Inc Inhibitors of diacylglycerol aclytransferase

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