JP2012507271A5 - - Google Patents

Info

Publication number

JP2012507271A5

JP2012507271A5 JP2011533752A JP2011533752A JP2012507271A5 JP 2012507271 A5 JP2012507271 A5 JP 2012507271A5 JP 2011533752 A JP2011533752 A JP 2011533752A JP 2011533752 A JP2011533752 A JP 2011533752A JP 2012507271 A5 JP2012507271 A5 JP 2012507271A5

Authority

JP

Japan

Prior art keywords

amino acid

acid residue

group

residue selected

binding protein

Prior art date

2009-11-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000000539 amino acid group Chemical group 0.000 claims 37
• 102000008102 Ankyrins Human genes 0.000 claims 22
• 108010049777 Ankyrins Proteins 0.000 claims 22
• 102000023732 binding proteins Human genes 0.000 claims 18
• 108091008324 binding proteins Proteins 0.000 claims 18
• 229910052739 hydrogen Inorganic materials 0.000 claims 11
• 229910052727 yttrium Inorganic materials 0.000 claims 10
• 229910052757 nitrogen Inorganic materials 0.000 claims 9
• 229910052700 potassium Inorganic materials 0.000 claims 6
• 229910052717 sulfur Inorganic materials 0.000 claims 5
• 229910052740 iodine Inorganic materials 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 2
• 230000003993 interaction Effects 0.000 claims 2
• 102000039446 nucleic acids Human genes 0.000 claims 2
• 108020004707 nucleic acids Proteins 0.000 claims 2
• 150000007523 nucleic acids Chemical class 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 230000003252 repetitive effect Effects 0.000 claims 2
• BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000022873 Ocular disease Diseases 0.000 claims 1
• 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims 1
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229910052698 phosphorus Inorganic materials 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1