JP2012506872A5 - - Google Patents

Download PDF

Info

Publication number
JP2012506872A5
JP2012506872A5 JP2011533399A JP2011533399A JP2012506872A5 JP 2012506872 A5 JP2012506872 A5 JP 2012506872A5 JP 2011533399 A JP2011533399 A JP 2011533399A JP 2011533399 A JP2011533399 A JP 2011533399A JP 2012506872 A5 JP2012506872 A5 JP 2012506872A5
Authority
JP
Japan
Prior art keywords
use according
acyl
heteroaryl
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011533399A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012506872A (ja
JP5602748B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/061978 external-priority patent/WO2010048601A1/en
Publication of JP2012506872A publication Critical patent/JP2012506872A/ja
Publication of JP2012506872A5 publication Critical patent/JP2012506872A5/ja
Application granted granted Critical
Publication of JP5602748B2 publication Critical patent/JP5602748B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011533399A 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた生体防御 Expired - Fee Related JP5602748B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US10813408P 2008-10-24 2008-10-24
US10813708P 2008-10-24 2008-10-24
US10811208P 2008-10-24 2008-10-24
US10811008P 2008-10-24 2008-10-24
US10816808P 2008-10-24 2008-10-24
US61/108,112 2008-10-24
US61/108,137 2008-10-24
US61/108,110 2008-10-24
US61/108,134 2008-10-24
US61/108,168 2008-10-24
US16210909P 2009-03-20 2009-03-20
US61/162,109 2009-03-20
PCT/US2009/061978 WO2010048601A1 (en) 2008-10-24 2009-10-24 Biodefenses using triazole-containing macrolides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014167991A Division JP6002185B2 (ja) 2008-10-24 2014-08-20 トリアゾール含有マクロライドを用いた生体防御

Publications (3)

Publication Number Publication Date
JP2012506872A JP2012506872A (ja) 2012-03-22
JP2012506872A5 true JP2012506872A5 (OSRAM) 2012-12-06
JP5602748B2 JP5602748B2 (ja) 2014-10-08

Family

ID=42119711

Family Applications (10)

Application Number Title Priority Date Filing Date
JP2011533397A Expired - Fee Related JP5711135B2 (ja) 2008-10-24 2009-10-24 胃腸疾患を治療するための方法
JP2011533398A Active JP5715569B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2011533399A Expired - Fee Related JP5602748B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた生体防御
JP2014167991A Expired - Fee Related JP6002185B2 (ja) 2008-10-24 2014-08-20 トリアゾール含有マクロライドを用いた生体防御
JP2014237428A Active JP5922210B2 (ja) 2008-10-24 2014-11-25 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2014237346A Active JP5908569B2 (ja) 2008-10-24 2014-11-25 胃腸疾患を治療するための方法
JP2016080557A Active JP6309995B2 (ja) 2008-10-24 2016-04-13 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2018047869A Pending JP2018115177A (ja) 2008-10-24 2018-03-15 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2019189322A Pending JP2020023544A (ja) 2008-10-24 2019-10-16 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2021146793A Active JP7171860B2 (ja) 2008-10-24 2021-09-09 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2011533397A Expired - Fee Related JP5711135B2 (ja) 2008-10-24 2009-10-24 胃腸疾患を治療するための方法
JP2011533398A Active JP5715569B2 (ja) 2008-10-24 2009-10-24 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Family Applications After (7)

Application Number Title Priority Date Filing Date
JP2014167991A Expired - Fee Related JP6002185B2 (ja) 2008-10-24 2014-08-20 トリアゾール含有マクロライドを用いた生体防御
JP2014237428A Active JP5922210B2 (ja) 2008-10-24 2014-11-25 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2014237346A Active JP5908569B2 (ja) 2008-10-24 2014-11-25 胃腸疾患を治療するための方法
JP2016080557A Active JP6309995B2 (ja) 2008-10-24 2016-04-13 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2018047869A Pending JP2018115177A (ja) 2008-10-24 2018-03-15 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2019189322A Pending JP2020023544A (ja) 2008-10-24 2019-10-16 トリアゾール含有マクロライドを用いた耐性疾患の治療方法
JP2021146793A Active JP7171860B2 (ja) 2008-10-24 2021-09-09 トリアゾール含有マクロライドを用いた耐性疾患の治療方法

Country Status (11)

Country Link
US (7) US9072759B2 (OSRAM)
EP (4) EP2362727B1 (OSRAM)
JP (10) JP5711135B2 (OSRAM)
CN (4) CN105616437A (OSRAM)
AU (4) AU2009308180B2 (OSRAM)
DK (1) DK2358379T3 (OSRAM)
ES (3) ES2565083T3 (OSRAM)
HK (1) HK1252140A1 (OSRAM)
HR (1) HRP20160222T1 (OSRAM)
SI (1) SI2358379T1 (OSRAM)
WO (3) WO2010048601A1 (OSRAM)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
NZ602544A (en) * 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) * 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
JP6042334B2 (ja) * 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ,インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA3130061C (en) * 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
US10633407B2 (en) 2014-10-08 2020-04-28 President And Fellows Of Harvard College 14-membered ketolides and methods of their preparation and use
JP2018509452A (ja) * 2015-03-25 2018-04-05 プレジデント アンド フェローズ オブ ハーバード カレッジ 修飾デソサミン糖をもつマクロライドおよびその使用
CN106554992A (zh) * 2015-09-28 2017-04-05 中国疾病预防控制中心传染病预防控制所 检测耐红霉素弯曲菌的试剂盒
SG11201908454TA (en) * 2017-02-17 2019-10-30 Cempra Pharmaceuticals Inc Triazole-containing macrolides and ophthalmic uses therefor
US10706191B2 (en) * 2017-08-31 2020-07-07 Google Llc Systems and methods for generating a geo-level hierarchical Bayesian model
US11145299B2 (en) 2018-04-19 2021-10-12 X Development Llc Managing voice interface devices

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1354753A (en) 1919-02-11 1920-10-05 E M Lannes Portable building
US2180006A (en) 1936-09-09 1939-11-14 Eastman Kodak Co Process for the separation and refining of amines
GB891817A (en) 1959-04-07 1962-03-21 Upjohn Co Improvements in or relating to injectable tetracyclic preparations
US3843787A (en) 1969-01-15 1974-10-22 Pierrel Spa Water soluble derivative of erythromycin
US3668282A (en) 1970-05-08 1972-06-06 Stauffer Chemical Co Stabilized mixture employing n-(beta-0,0-dialkyldithiophosphoryl) aryl sulfonamides
SE458505B (sv) 1979-07-10 1989-04-10 Lepetit Spa Anvaendningen av rifamycin sv och salter daerav foer framstaellning av en beredning foer behandling av reumatoid artrit samt vissa av salterna och deras framstaellning
US4331803A (en) 1980-06-04 1982-05-25 Taisho Pharmaceutical Co., Ltd. Novel erythromycin compounds
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
JPS59175414A (ja) 1983-03-23 1984-10-04 Toyo Jozo Co Ltd マクロライド抗生物質の安定な経口用製剤および安定化法
US4742049A (en) 1986-06-04 1988-05-03 Abbott Laboratories Semisynthetic erythromycin antibiotics
KR960000434B1 (ko) 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
DE3860503D1 (de) 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
BE1001869A3 (fr) 1988-10-12 1990-04-03 Franz Legros Procede d'encapsulation liposomiale d'antibiotiques aminoglucosidiques, en particulier de la gentamycine.
IL99995A (en) 1990-11-21 1997-11-20 Roussel Uclaf Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5985844A (en) 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5527780A (en) 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
US5834428A (en) * 1995-04-14 1998-11-10 1149336 Ontario Inc. Glucagon-like peptide-2 and its therapeutic use
WO1997001532A1 (en) * 1995-06-28 1997-01-16 Tokuyama Corporation Ketonitrile derivatives and antibacterial agent and drug containing the same
FR2739620B1 (fr) * 1995-10-09 1997-12-19 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-o-methyl erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
US5742049A (en) * 1995-12-21 1998-04-21 Bruker-Franzen Analytik Gmbh Method of improving mass resolution in time-of-flight mass spectrometry
FR2742757B1 (fr) * 1995-12-22 1998-01-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2745290B1 (fr) * 1996-02-28 1998-04-03 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
US5719272A (en) 1996-04-02 1998-02-17 Abbott Laboratories 2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
CA2263972C (en) * 1996-09-04 2008-01-29 Abbott Laboratories 6-o-substituted ketolides having antibacterial activity
CA2274958A1 (en) 1996-12-13 1998-06-18 Gerald Wayne Becker Inhibitors of the enzymatic activity of psa
HN1998000074A (es) 1997-06-11 1999-01-08 Pfizer Prod Inc Derivados de macrolidos c-4 sustituidos
US6407074B1 (en) 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
WO1998056800A1 (en) 1997-06-11 1998-12-17 Pfizer Products Inc. 9-oxime erythromycin derivatives
HN1998000086A (es) * 1997-06-11 1999-03-08 Pfizer Prod Inc Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos.
HN1998000159A (es) 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
IL135792A0 (en) 1997-12-01 2001-05-20 Abbott Lab 6-o-alkyl derivatives of erythronolide b
TR200002771T2 (tr) * 1998-03-26 2001-02-21 Fujisawa Pharmaceutical Co.,Ltd. Devamlı salımı olan preparatlar
FR2777282B1 (fr) 1998-04-08 2001-04-20 Hoechst Marion Roussel Inc Nouveaux derives de la 2-fluoro 3-de((2,6-dideoxy 3-c-methyl 3-0-methyl-alpha-l-ribohexopyranosyl) oxyl) 6-o-methyl 3-oxo erythromycine, leur procede de preparation et leur application a la synthese de principes actifs de medicaments
US6020521A (en) 1998-08-26 2000-02-01 Abbott Laboratories Macrolide LHRH antagonists
US6387885B1 (en) 1998-08-26 2002-05-14 Abbott Laboratories 3′,3′-N-bis-desmethyl-3′-N-cycloalkyl erythromycin derivatives as LHRH antagonists
FR2785612A1 (fr) 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
KR100317907B1 (ko) 1998-11-24 2001-12-24 김 완 주 신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
ES2273964T3 (es) 1998-12-10 2007-05-16 Pfizer Products Inc. Antibioticos de carbamato y carbazato cetolida.
CZ20012675A3 (cs) 1999-01-27 2002-04-17 Pfizer Products Inc. Ketolidová antibiotika
CA2292359C (en) 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
FR2789392B1 (fr) 1999-02-04 2001-10-05 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AR023264A1 (es) 1999-04-08 2002-09-04 Hokuriku Pharmaceutical Derivados de eritromicina
JP2000351794A (ja) 1999-04-08 2000-12-19 Hokuriku Seiyaku Co Ltd エリスロマイシン誘導体
WO2000063224A2 (en) 1999-04-16 2000-10-26 Kosan Biosciences, Inc. Macrolide antiinfective agents
MXPA01010521A (es) 1999-04-16 2003-08-19 Johnson & Johnson Antibacteriales de cetolidos.
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
WO2001010878A1 (fr) 1999-08-06 2001-02-15 Taisho Pharmaceutical Co., Ltd. Derives d'erythromycine a
WO2001010787A1 (en) 1999-08-09 2001-02-15 Eric Au An apparatus for treating wastewater
US6096922A (en) 1999-11-01 2000-08-01 Air Products And Chemicals, Inc. Process for the synthesis of dialkyl, diaryl, and arylalkyl aminosulfur trifluorides
KR100336447B1 (ko) 1999-11-24 2002-05-15 민경윤 클라리스로마이신의 개선된 제조방법
JP2001261694A (ja) 2000-03-06 2001-09-26 Pfizer Prod Inc ケトライド抗生物質
ES2242668T3 (es) * 2000-03-15 2005-11-16 Hanmi Pharm. Co., Ltd. Metodo para obtener claritromicina en cristales de forma ii.
NZ523693A (en) 2000-07-10 2004-08-27 Chiron Corp Macrolide formulations for inhalation and methods of treatment of endobronchial infections
US20020115621A1 (en) * 2000-08-07 2002-08-22 Wei-Gu Su Macrolide antibiotics
GB0031312D0 (en) 2000-12-21 2001-02-07 Glaxo Group Ltd Macrolides
DK1320355T3 (da) * 2001-05-18 2006-07-31 Chiron Corp System til administration af en tobramycinformulering
WO2003004509A2 (en) 2001-07-03 2003-01-16 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
US20030176327A1 (en) * 2001-10-25 2003-09-18 Cassell Gail Houston Antibiotics for treating biohazardous bacterial agents
BR0307898A (pt) 2002-02-22 2004-12-07 Pharmacia Corp Formulações de droga antibiótica oftálmica contendo um composto de ciclodextrina e cloreto de cetil piridìnio
EP2226316B1 (en) 2002-05-30 2016-01-13 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
BR0311883A (pt) 2002-06-17 2005-04-05 Epigenesis Pharmaceuticals Llc Recipiente selado, kit, e, métodos para a profilaxia ou tratamento da asma, para a profilaxia ou tratamento da doença pulmonar obstrutiva crÈnica, para a redução ou exaustão da adenosina em um tecido do paciente e para profilaxia ou tratamento de um distúrbio ou condição associada com nìveis altos de adenosina ou sensibilidade à adenosina em um tecido do paciente
BR0312634A (pt) 2002-07-08 2005-05-10 Pliva Istrazivacki Inst D O O Novos compostos, composições e métodos para tratamento de doenças e condições inflamatórias
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
ITMI20022292A1 (it) 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
CA2523541A1 (en) 2003-04-25 2004-11-11 Chiron Corporation Novel ketolide derivatives
WO2004096822A2 (en) 2003-04-25 2004-11-11 Chiron Corporation Pyridyl substituted ketolide antibiotics
ATE348837T1 (de) 2003-05-13 2007-01-15 Glaxo Group Ltd Neue 14- und 15-gliedrige ringverbindungen
WO2005007143A2 (en) * 2003-07-14 2005-01-27 The Board Of Trustees Of The University Of Illinois Use of makrolides and ketolides for the treatment of tuberculosis
US7457520B2 (en) * 2003-07-24 2008-11-25 Time Warner Cable, Inc. Technique for providing a virtual digital video recorder service through a communications network
GB0402578D0 (en) 2004-02-05 2004-03-10 Cambridge Theranostics Ltd Methods of treatment of atherosclerosis
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
WO2005105821A2 (en) 2004-04-28 2005-11-10 Alembic Limited Process for the preparation of telithromycin
WO2005108412A1 (en) 2004-05-06 2005-11-17 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. Ester linked macrolides useful for the treatment of microbial infections
WO2006080954A1 (en) * 2004-07-28 2006-08-03 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
GB0424958D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
GB0424959D0 (en) 2004-11-11 2004-12-15 Glaxo Group Ltd Novel compounds
JP2008526947A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する9a−カルバモイル−γ−アミノプロピル−および9a−チオカルバモイル−γ−アミノプロピル−アザリド
DE602006006546D1 (de) 2005-01-14 2009-06-10 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
ATE523519T1 (de) 2005-01-14 2011-09-15 Glaxo Group Ltd Makrolidverbindungen mit biotin und fotoaffinitätsgruppe zur identifizierung eines makrolid-targets
US9597314B2 (en) 2005-03-22 2017-03-21 Azevan Pharmaceuticals, Inc. Beta-lactamylalkanoic acids for treating premenstrual disorders
JP2009500356A (ja) 2005-07-07 2009-01-08 エラン ファーマ インターナショナル リミテッド ナノ粒子クラリスロマイシン製剤
US8048874B2 (en) 2005-07-19 2011-11-01 Azevan Pharmaceuticals, Inc. Beta-lactamyl phenylalanine, cysteine, and serine vasopressin antagonists
JP5405114B2 (ja) 2005-10-31 2014-02-05 レオ ファーマ アクティーゼルスカブ 抗生物質である結晶フシジン酸の調製
GB0522715D0 (en) 2005-11-08 2005-12-14 Helperby Therapeutics Ltd New use
WO2007059307A2 (en) 2005-11-15 2007-05-24 Teva Pharmaceutical Industries Ltd. Crystalline and amorphous forms of telithromycin
EP1954294A2 (en) 2005-11-23 2008-08-13 Ranbaxy Laboratories Limited Use of macrolide derivatives for treating acne
WO2007060518A2 (en) * 2005-11-23 2007-05-31 Ranbaxy Laboratories Limited Ketolide derivatives as antibacterial agents
DOP2006000268A (es) 2005-12-22 2007-07-31 Pfizer Prod Inc Agentes antibacterianos
CN101045063B (zh) 2006-03-28 2011-01-26 广州朗圣药业有限公司 注射用克拉霉素水溶性制剂
RU2455308C2 (ru) 2006-05-01 2012-07-10 Тайсо Фармасьютикал Ко., Лтд. Макролидные производные
WO2007143507A2 (en) 2006-06-05 2007-12-13 Auspex Pharmaceuticals, Inc. Preparation and utility of substituted erythromycin analogs
DE102006036199B4 (de) * 2006-08-03 2016-01-07 Deere & Company Förderzusammenbau und Presse
CN101129383B (zh) 2006-08-25 2014-04-02 天津和美生物技术有限公司 含氨基糖苷类抗生素的抗生素复方
WO2009055557A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
US20090209547A1 (en) * 2008-02-15 2009-08-20 In Jong Kim C-8 halogenated macrolides
HRP20160222T1 (hr) 2008-10-24 2016-04-08 Cempra Pharmaceuticals, Inc. Biozaštite uporabom makrolida koji sadrže triazol
US9814657B2 (en) 2009-04-27 2017-11-14 Premier Dental Products Company Buffered microencapsulated compositions and methods
CA2767614C (en) 2009-07-13 2019-01-15 Cempra Pharmaceuticals Inc. Fusidic acid dosing regimens for treatment of bacterial infections
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
US20110119604A1 (en) 2009-11-19 2011-05-19 Clevest Solutions Inc. System and method for a configurable and extensible allocation and scheduling tool
SI2544537T1 (sl) 2010-03-10 2017-12-29 Cempra Pharmaceuticals, Inc. Formulacije makrolidnih antibiotikov za parenteralni vnos
NZ602544A (en) 2010-03-22 2014-11-28 Cempra Pharmaceuticals Inc Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
US8247394B2 (en) 2010-06-02 2012-08-21 Cempra Pharmaceuticals Inc. Methods of treating urethritis and related infections using fusidic acid
WO2012012257A2 (en) 2010-07-19 2012-01-26 Virginia Commonwealth University BIVALENT MULTIFUNCTIONAL LIGANDS TARGETING Aβ OLIGOMERS AS TREATMENT FOR ALZHEIMER'S DISEASE
WO2012030513A2 (en) 2010-08-30 2012-03-08 Cempra Pharmaceuticals Inc. Methods of treating bacterial infections through pulmonary delivery of fusidic acid
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ,インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
WO2012042534A2 (en) 2010-09-28 2012-04-05 Glenmark Generics Limited Processes for the preparation of r-sitagliptin and intermediates thereof
WO2012162439A2 (en) 2011-05-23 2012-11-29 Cem-102 Pharmaceuticals, Inc. Compositions comprising fusidic acid and packages therefor
AU2012303691B2 (en) 2011-08-27 2014-06-19 Wockhardt Limited 1,6- diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
WO2013032591A1 (en) 2011-08-29 2013-03-07 Infinity Pharmaceuticals Inc. Heterocyclic compounds and uses thereof
US8461188B2 (en) 2011-10-20 2013-06-11 Trius Therapeutics, Inc. Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use
HK1205939A1 (en) 2012-03-27 2015-12-31 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
CA3130061C (en) 2013-04-04 2024-05-28 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
AU2015217293A1 (en) 2014-02-14 2016-09-01 Cempra Pharmaceuticals, Inc. Compositions and methods for treating diabetes and liver diseases
CN106660945A (zh) 2014-05-27 2017-05-10 迪法玛弗朗西斯有限公司 叠氮基烷基胺盐及其作为中间体的用途
JP2017523975A (ja) 2014-08-05 2017-08-24 センプラ ファーマシューティカルズ,インコーポレイテッド 経口抗菌薬粉末懸濁製剤
PE20180219A1 (es) 2015-03-06 2018-01-31 Cempra Pharmaceuticals Inc Procesos para preparar fluorocetolidos

Similar Documents

Publication Publication Date Title
JP2012506872A5 (OSRAM)
JP2012506870A5 (OSRAM)
JP2006182786A5 (OSRAM)
JP2010524932A5 (OSRAM)
JP2020097577A5 (OSRAM)
JP2009502743A5 (OSRAM)
JP2006143751A5 (OSRAM)
JP2011528713A5 (OSRAM)
EA201692214A1 (ru) Вещества, связывающие ядерные рецепторы
JP2016506916A5 (OSRAM)
JP2009507909A5 (OSRAM)
JP2006523216A5 (OSRAM)
JP2013518107A5 (OSRAM)
JP2011006480A5 (OSRAM)
MX2010007374A (es) Nuevos derivados de c-21-ceto lupano, preparacion y uso de los mismos.
TW200833663A (en) Therapeutic agents
JP2014500861A5 (OSRAM)
NZ593712A (en) Intermediates for synthesising nucleoside aryl phosphoramidates
JP2008528671A5 (OSRAM)
MXPA01006474A (es) Derivados colquinol como agentes perjudiciales vasculares.
JP2013522229A5 (OSRAM)
JP2017505785A5 (OSRAM)
JP2009500423A5 (OSRAM)
RU2015149527A (ru) Производные доластатина 10 и ауристатинов
JP2019535723A5 (OSRAM)