JP2012505922A5 - - Google Patents
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- Publication number
- JP2012505922A5 JP2012505922A5 JP2011532295A JP2011532295A JP2012505922A5 JP 2012505922 A5 JP2012505922 A5 JP 2012505922A5 JP 2011532295 A JP2011532295 A JP 2011532295A JP 2011532295 A JP2011532295 A JP 2011532295A JP 2012505922 A5 JP2012505922 A5 JP 2012505922A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- peptide
- muc1
- residues
- consecutive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 70
- 102100034256 Mucin-1 Human genes 0.000 claims description 66
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims description 62
- 239000000203 mixture Substances 0.000 claims description 56
- 210000004027 cell Anatomy 0.000 claims description 44
- 210000004881 tumor cell Anatomy 0.000 claims description 20
- 206010028980 Neoplasm Diseases 0.000 claims description 10
- 125000000539 amino acid group Chemical group 0.000 claims description 10
- 238000011394 anticancer treatment Methods 0.000 claims description 8
- 201000011510 cancer Diseases 0.000 claims description 8
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 8
- 235000018417 cysteine Nutrition 0.000 claims description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 7
- 150000008574 D-amino acids Chemical class 0.000 claims description 6
- 230000002401 inhibitory effect Effects 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 150000008575 L-amino acids Chemical class 0.000 claims description 4
- 108010008707 Mucin-1 Proteins 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 206010060862 Prostate cancer Diseases 0.000 claims description 4
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 4
- 208000032839 leukemia Diseases 0.000 claims description 4
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 4
- 239000000816 peptidomimetic Substances 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 4
- 230000026683 transduction Effects 0.000 claims description 4
- 238000010361 transduction Methods 0.000 claims description 4
- 230000003442 weekly effect Effects 0.000 claims description 4
- 239000000872 buffer Substances 0.000 claims description 3
- 230000006907 apoptotic process Effects 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 238000000315 cryotherapy Methods 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 238000001794 hormone therapy Methods 0.000 claims description 2
- 238000009169 immunotherapy Methods 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- 238000001361 intraarterial administration Methods 0.000 claims description 2
- 238000007912 intraperitoneal administration Methods 0.000 claims description 2
- 230000002601 intratumoral effect Effects 0.000 claims description 2
- 238000001990 intravenous administration Methods 0.000 claims description 2
- 230000017074 necrotic cell death Effects 0.000 claims description 2
- 230000025308 nuclear transport Effects 0.000 claims description 2
- 238000006384 oligomerization reaction Methods 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 238000007920 subcutaneous administration Methods 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000007910 systemic administration Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 238000000034 method Methods 0.000 description 37
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- 238000011319 anticancer therapy Methods 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 108010070875 Human Immunodeficiency Virus tat Gene Products Proteins 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10638008P | 2008-10-17 | 2008-10-17 | |
| US61/106,380 | 2008-10-17 | ||
| US17710909P | 2009-05-11 | 2009-05-11 | |
| US61/177,109 | 2009-05-11 | ||
| PCT/US2009/061051 WO2010045586A2 (en) | 2008-10-17 | 2009-10-16 | Muc-1 cytoplasmic domain peptides as inhibitors of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238315A Division JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505922A JP2012505922A (ja) | 2012-03-08 |
| JP2012505922A5 true JP2012505922A5 (https=) | 2012-06-21 |
| JP5657549B2 JP5657549B2 (ja) | 2015-01-21 |
Family
ID=42046194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532295A Active JP5657549B2 (ja) | 2008-10-17 | 2009-10-16 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
| JP2014238315A Active JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014238315A Active JP6030622B2 (ja) | 2008-10-17 | 2014-11-26 | 癌の阻害剤としてのｍｕｃ−１細胞質ドメインペプチド |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8524669B2 (https=) |
| EP (2) | EP2727601B1 (https=) |
| JP (2) | JP5657549B2 (https=) |
| KR (1) | KR101689408B1 (https=) |
| CN (1) | CN102245632B (https=) |
| AU (1) | AU2009305550B2 (https=) |
| BR (1) | BRPI0920360A2 (https=) |
| CA (1) | CA2741065C (https=) |
| DE (1) | DE09740811T9 (https=) |
| DK (1) | DK2352508T3 (https=) |
| ES (1) | ES2395028T3 (https=) |
| IL (1) | IL212383A (https=) |
| MX (1) | MX2011004082A (https=) |
| NZ (1) | NZ592537A (https=) |
| PL (1) | PL2352508T3 (https=) |
| PT (1) | PT2352508E (https=) |
| RU (1) | RU2539832C2 (https=) |
| WO (1) | WO2010045586A2 (https=) |
| ZA (1) | ZA201103150B (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101689408B1 (ko) | 2008-10-17 | 2016-12-23 | 다나-파버 캔서 인스티튜트 인크. | 암의 저해제로서 ｍｕｃ-1 세포질 도메인 펩티드 |
| JP5702371B2 (ja) | 2009-05-27 | 2015-04-15 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｕｃ１のアンタゴニストを使用した、炎症の阻害 |
| WO2011100688A1 (en) * | 2010-02-12 | 2011-08-18 | Dana-Farber Cancer Institute, Inc. | Improved antagonists of muc1 |
| US8952054B2 (en) | 2010-03-15 | 2015-02-10 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of MUC1 and methods of identifying the same |
| WO2011150360A1 (en) | 2010-05-28 | 2011-12-01 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds and their use |
| US8907054B2 (en) * | 2011-08-08 | 2014-12-09 | Marquette University | Dpy-30 binding peptides |
| KR102049928B1 (ko) * | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
| JP6153526B2 (ja) | 2011-09-06 | 2017-06-28 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | ポリペプチドワクチン |
| US8754124B2 (en) | 2011-11-23 | 2014-06-17 | Board Of Regents, The University Of Texas System | Oligo-benzamide compounds and their use in treating cancers |
| WO2013078288A1 (en) * | 2011-11-23 | 2013-05-30 | The Board Of Regents Of The University Of Texas System | Oligo-benzamide compounds for use in treating cancers |
| US9044421B2 (en) | 2012-03-28 | 2015-06-02 | Genus Oncology, Llc | Treating MUC1-expressing cancers with combination therapies |
| US9789156B2 (en) | 2013-03-11 | 2017-10-17 | Dana-Farber Cancer Institute, Inc. | Combination anti-human epidermal growth factor receptor 2 (anti-HER2) cancer therapy using mucin 1 (MUC1) peptides and hemotherapeutics |
| WO2014164395A1 (en) * | 2013-03-11 | 2014-10-09 | Dana-Farber Cancer Institute, Inc. | Combination anti-estrogen receptor cancer therapy using muc1 peptides and chemotherapeutics |
| US10059775B2 (en) | 2014-01-29 | 2018-08-28 | Dana-Farber Cancer Institute, Inc. | Antibodies against the MUC1-C/extracellular domain (MUC1-C/ECD) |
| US10507227B2 (en) | 2014-04-15 | 2019-12-17 | The Hospital For Sick Children | Cationic antimicrobial peptides |
| EP3542814B1 (en) | 2018-03-21 | 2022-08-24 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Novel peptide-based compounds for use in the prevention, treatment and/or detection of cancer |
| WO2025217515A2 (en) * | 2024-04-12 | 2025-10-16 | Dana-Farber Cancer Institute, Inc. | Identification of muc1-c as a target for the treatment of squamous cell carcinomas |
| CN119236051B (zh) * | 2024-09-29 | 2025-12-19 | 北京大学 | Muc1抑制剂在制备预防、治疗细菌感染药物中的应用 |
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| US5475085A (en) | 1991-02-07 | 1995-12-12 | Molecumetics, Ltd. | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| WO1992013878A2 (en) | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
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| CN1091138A (zh) | 1992-08-27 | 1994-08-24 | 迪金研究有限公司 | 疫苗 |
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| US5446128A (en) | 1993-06-18 | 1995-08-29 | The Board Of Trustees Of The University Of Illinois | Alpha-helix mimetics and methods relating thereto |
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| AU706443B2 (en) * | 1994-04-22 | 1999-06-17 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Melanoma antigens |
| US5912232A (en) | 1994-09-23 | 1999-06-15 | Board Of Regents Of The University Of Nebraska | Anti-inflammatory polypeptide antagonists of human I1-8 |
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| US5840833A (en) | 1995-10-27 | 1998-11-24 | Molecumetics, Ltd | Alpha-helix mimetics and methods relating thereto |
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| NO961031D0 (no) * | 1996-03-13 | 1996-03-13 | Det Norske Radiumshospital Tum | Fremgangsmåte til å drepe uönskede målceller |
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| US20020044943A1 (en) | 1997-09-10 | 2002-04-18 | Longenecker B. Michael | MUC-1 as an immunosuppressive therapeutic agent for the treatment of inflammatory and autoimmune conditions |
| AU767185B2 (en) | 1998-03-23 | 2003-11-06 | President And Fellows Of Harvard College | Synthesis of compounds and libraries of compounds |
| US6459996B1 (en) | 1998-08-13 | 2002-10-01 | American Home Products Corporation | Crystal structure of E. coli GDP-fucose synthetase (and complexes thereof) and methods of identifying agonists and antagonists using same |
| NZ510230A (en) | 1998-08-25 | 2004-01-30 | Scripps Research Inst | Predicting protein function by electronic comparison of functional site descriptors |
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| AU2006249801A1 (en) * | 2005-05-26 | 2006-11-30 | Dana-Farber Cancer Institute, Inc. | Modulation of MUC1-dependent anti-estrogen resistance |
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| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| KR101689408B1 (ko) | 2008-10-17 | 2016-12-23 | 다나-파버 캔서 인스티튜트 인크. | 암의 저해제로서 ｍｕｃ-1 세포질 도메인 펩티드 |
| JP5702371B2 (ja) | 2009-05-27 | 2015-04-15 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｍｕｃ１のアンタゴニストを使用した、炎症の阻害 |
| WO2011100688A1 (en) | 2010-02-12 | 2011-08-18 | Dana-Farber Cancer Institute, Inc. | Improved antagonists of muc1 |
| US8952054B2 (en) | 2010-03-15 | 2015-02-10 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of MUC1 and methods of identifying the same |
-
2009
- 2009-10-16 KR KR1020117011149A patent/KR101689408B1/ko active Active
- 2009-10-16 JP JP2011532295A patent/JP5657549B2/ja active Active
- 2009-10-16 EP EP13194715.2A patent/EP2727601B1/en active Active
- 2009-10-16 DE DE09740811T patent/DE09740811T9/de active Active
- 2009-10-16 CN CN200980149998.9A patent/CN102245632B/zh active Active
- 2009-10-16 MX MX2011004082A patent/MX2011004082A/es active IP Right Grant
- 2009-10-16 PL PL09740811T patent/PL2352508T3/pl unknown
- 2009-10-16 DK DK09740811.6T patent/DK2352508T3/da active
- 2009-10-16 NZ NZ592537A patent/NZ592537A/en not_active IP Right Cessation
- 2009-10-16 BR BRPI0920360-5A patent/BRPI0920360A2/pt not_active IP Right Cessation
- 2009-10-16 RU RU2011119606/10A patent/RU2539832C2/ru not_active IP Right Cessation
- 2009-10-16 PT PT97408116T patent/PT2352508E/pt unknown
- 2009-10-16 US US12/580,865 patent/US8524669B2/en active Active
- 2009-10-16 AU AU2009305550A patent/AU2009305550B2/en active Active
- 2009-10-16 WO PCT/US2009/061051 patent/WO2010045586A2/en not_active Ceased
- 2009-10-16 EP EP09740811.6A patent/EP2352508B1/en active Active
- 2009-10-16 ES ES09740811.6T patent/ES2395028T3/es active Active
- 2009-10-16 CA CA2741065A patent/CA2741065C/en active Active
-
2011
- 2011-04-14 IL IL212383A patent/IL212383A/en active IP Right Grant
- 2011-04-29 ZA ZA2011/03150A patent/ZA201103150B/en unknown
-
2012
- 2012-02-24 US US13/404,689 patent/US8957185B2/en active Active
-
2014
- 2014-11-26 JP JP2014238315A patent/JP6030622B2/ja active Active
-
2015
- 2015-02-12 US US14/620,349 patent/US9546201B2/en active Active
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