JP2012504129A - Ｃ型肝炎ウイルス阻害剤 - Google Patents

Ｃ型肝炎ウイルス阻害剤 Download PDF

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Publication number
JP2012504129A
JP2012504129A JP2011529247A JP2011529247A JP2012504129A JP 2012504129 A JP2012504129 A JP 2012504129A JP 2011529247 A JP2011529247 A JP 2011529247A JP 2011529247 A JP2011529247 A JP 2011529247A JP 2012504129 A JP2012504129 A JP 2012504129A
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Prior art keywords
mmol
hcv
solvent
compound
alkyl
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Japanese (ja)
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JP2012504129A5 (enExample
Inventor
シェルドン・ヒーバート
ラムクマール・ラジャマニ
ポール・マイケル・スコラ
マイケル・エス・ボーシャー
ロングティ・リ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2012504129A publication Critical patent/JP2012504129A/ja
Publication of JP2012504129A5 publication Critical patent/JP2012504129A5/ja
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011529247A 2008-09-29 2009-09-25 Ｃ型肝炎ウイルス阻害剤 Ceased JP2012504129A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US10090108P 2008-09-29 2008-09-29
US61/100,901 2008-09-29
US12/566,441 2009-09-24
US12/566,441 US8563505B2 (en) 2008-09-29 2009-09-24 Hepatitis C virus inhibitors
PCT/US2009/058342 WO2010036871A1 (en) 2008-09-29 2009-09-25 Macrocyclic compounds as hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
JP2012504129A true JP2012504129A (ja) 2012-02-16
JP2012504129A5 JP2012504129A5 (enExample) 2012-10-18

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011529247A Ceased JP2012504129A (ja) 2008-09-29 2009-09-25 Ｃ型肝炎ウイルス阻害剤

Country Status (6)

Country Link
US (1) US8563505B2 (enExample)
EP (1) EP2337784B1 (enExample)
JP (1) JP2012504129A (enExample)
CN (1) CN102227436A (enExample)
ES (1) ES2401731T3 (enExample)
WO (1) WO2010036871A1 (enExample)

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UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
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