ES2401731T3 - Compuestos macrocíclicos como inhibidores del virus de la hepatitis C - Google Patents
Compuestos macrocíclicos como inhibidores del virus de la hepatitis C Download PDFInfo
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- ES2401731T3 ES2401731T3 ES09792995T ES09792995T ES2401731T3 ES 2401731 T3 ES2401731 T3 ES 2401731T3 ES 09792995 T ES09792995 T ES 09792995T ES 09792995 T ES09792995 T ES 09792995T ES 2401731 T3 ES2401731 T3 ES 2401731T3
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- 241000711549 Hepacivirus C Species 0.000 title description 4
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- 125000001188 haloalkyl group Chemical group 0.000 claims abstract description 21
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 18
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- 125000003118 aryl group Chemical group 0.000 claims abstract description 16
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- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10090108P | 2008-09-29 | 2008-09-29 | |
| US100901P | 2008-09-29 | ||
| US12/566,441 US8563505B2 (en) | 2008-09-29 | 2009-09-24 | Hepatitis C virus inhibitors |
| US566441 | 2009-09-24 | ||
| PCT/US2009/058342 WO2010036871A1 (en) | 2008-09-29 | 2009-09-25 | Macrocyclic compounds as hepatitis c virus inhibitors |
Publications (1)
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|---|---|
| ES2401731T3 true ES2401731T3 (es) | 2013-04-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09792995T Active ES2401731T3 (es) | 2008-09-29 | 2009-09-25 | Compuestos macrocíclicos como inhibidores del virus de la hepatitis C |
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| Country | Link |
|---|---|
| US (1) | US8563505B2 (enExample) |
| EP (1) | EP2337784B1 (enExample) |
| JP (1) | JP2012504129A (enExample) |
| CN (1) | CN102227436A (enExample) |
| ES (1) | ES2401731T3 (enExample) |
| WO (1) | WO2010036871A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0911260A2 (pt) * | 2008-04-15 | 2015-09-29 | Intermune Inc | composto, composição farmacêutica, método de inibição de atividade da protease de ns3/ns4 in, vitro e usos de compostos |
| US8207341B2 (en) | 2008-09-04 | 2012-06-26 | Bristol-Myers Squibb Company | Process or synthesizing substituted isoquinolines |
| UY32099A (es) * | 2008-09-11 | 2010-04-30 | Enanta Pharm Inc | Inhibidores macrocíclicos de serina proteasas de hepatitis c |
| EA201170441A1 (ru) * | 2008-10-15 | 2012-05-30 | Интермьюн, Инк. | Терапевтические противовирусные пептиды |
| AR075584A1 (es) | 2009-02-27 | 2011-04-20 | Intermune Inc | COMPOSICIONES TERAPEUTICAS QUE COMPRENDEN beta-D-2'-DESOXI-2'-FLUORO-2'-C-METILCITIDINA Y UN DERIVADO DE ACIDO ISOINDOL CARBOXILICO Y SUS USOS. COMPUESTO. |
| MX2011012155A (es) | 2009-05-13 | 2012-02-28 | Enanta Pharm Inc | Compuestos macrociclicos como inhibidores del virus de hepatitis c. |
| JP2013505952A (ja) * | 2009-09-28 | 2013-02-21 | インターミューン・インコーポレーテッド | Ｃ型肝炎ウイルス複製の新しい大環状阻害剤 |
| TW201119667A (en) * | 2009-10-19 | 2011-06-16 | Enanta Pharm Inc | Bismacrocyclic compounds as hepatitis C virus inhibitors |
| WO2012087833A1 (en) | 2010-12-22 | 2012-06-28 | Abbott Laboratories | Hepatitis c inhibitors and uses thereof |
| JP2014502620A (ja) | 2010-12-30 | 2014-02-03 | エナンタ ファーマシューティカルズ インコーポレイテッド | 大環状ｃ型肝炎セリンプロテアーゼ阻害剤 |
| US8951964B2 (en) | 2010-12-30 | 2015-02-10 | Abbvie Inc. | Phenanthridine macrocyclic hepatitis C serine protease inhibitors |
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| WO2010036871A1 (en) | 2010-04-01 |
| CN102227436A (zh) | 2011-10-26 |
| EP2337784A1 (en) | 2011-06-29 |
| JP2012504129A (ja) | 2012-02-16 |
| EP2337784B1 (en) | 2013-01-16 |
| US8563505B2 (en) | 2013-10-22 |
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