JP2012503665A5 - - Google Patents
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- Publication number
- JP2012503665A5 JP2012503665A5 JP2011529177A JP2011529177A JP2012503665A5 JP 2012503665 A5 JP2012503665 A5 JP 2012503665A5 JP 2011529177 A JP2011529177 A JP 2011529177A JP 2011529177 A JP2011529177 A JP 2011529177A JP 2012503665 A5 JP2012503665 A5 JP 2012503665A5
- Authority
- JP
- Japan
- Prior art keywords
- oral dosage
- dosage form
- solid oral
- pharmaceutically acceptable
- aliskiren
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006186 oral dosage form Substances 0.000 claims 13
- 239000007787 solid Substances 0.000 claims 13
- 150000003839 salts Chemical class 0.000 claims 12
- UXOWGYHJODZGMF-QORCZRPOSA-N Aliskiren Chemical compound COCCCOC1=CC(C[C@@H](C[C@H](N)[C@@H](O)C[C@@H](C(C)C)C(=O)NCC(C)(C)C(N)=O)C(C)C)=CC=C1OC UXOWGYHJODZGMF-QORCZRPOSA-N 0.000 claims 11
- 229960004601 aliskiren Drugs 0.000 claims 11
- 239000000463 material Substances 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 5
- 239000008187 granular material Substances 0.000 claims 5
- 238000002844 melting Methods 0.000 claims 5
- 230000008018 melting Effects 0.000 claims 5
- 238000002156 mixing Methods 0.000 claims 5
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 5
- 229960004699 valsartan Drugs 0.000 claims 5
- 206010019280 Heart failures Diseases 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 4
- 239000003826 tablet Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000007909 melt granulation Methods 0.000 claims 3
- 206010002383 Angina Pectoris Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 2
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 2
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 claims 2
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 208000033679 diabetic kidney disease Diseases 0.000 claims 2
- 238000001125 extrusion Methods 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007941 film coated tablet Substances 0.000 claims 1
- 239000007888 film coating Substances 0.000 claims 1
- 238000009501 film coating Methods 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 238000007873 sieving Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9959508P | 2008-09-24 | 2008-09-24 | |
| US61/099,595 | 2008-09-24 | ||
| US16179909P | 2009-03-20 | 2009-03-20 | |
| US61/161,799 | 2009-03-20 | ||
| PCT/US2009/057993 WO2010036686A1 (en) | 2008-09-24 | 2009-09-23 | Galenical formulation comprising aliskiren and process for its preparation by melt extrusion granulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503665A JP2012503665A (ja) | 2012-02-09 |
| JP2012503665A5 true JP2012503665A5 (enExample) | 2012-11-08 |
Family
ID=41323516
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529177A Pending JP2012503665A (ja) | 2008-09-24 | 2009-09-23 | アリスキレンを含むガレヌス製剤および溶融押出し造粒によるその調製方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20110177166A1 (enExample) |
| EP (1) | EP2328562A1 (enExample) |
| JP (1) | JP2012503665A (enExample) |
| KR (1) | KR20110063684A (enExample) |
| CN (1) | CN102164584A (enExample) |
| AR (1) | AR073651A1 (enExample) |
| AU (1) | AU2009296718A1 (enExample) |
| BR (1) | BRPI0919077A2 (enExample) |
| CA (1) | CA2736259A1 (enExample) |
| CL (1) | CL2011000614A1 (enExample) |
| CO (1) | CO6351712A2 (enExample) |
| EC (1) | ECSP11010998A (enExample) |
| MA (1) | MA32722B1 (enExample) |
| MX (1) | MX2011003077A (enExample) |
| PE (1) | PE20110925A1 (enExample) |
| RU (1) | RU2011116122A (enExample) |
| TW (1) | TW201016210A (enExample) |
| WO (1) | WO2010036686A1 (enExample) |
| ZA (1) | ZA201101686B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102348452A (zh) * | 2009-03-20 | 2012-02-08 | 诺瓦提斯公司 | 缬沙坦和阿利吉仑的固定剂量组合的盖仑制剂 |
| EP2382967A1 (de) * | 2010-04-21 | 2011-11-02 | ratiopharm GmbH | Aliskiren in Form einer festen Dispersion |
| TWI841376B (zh) * | 2013-03-01 | 2024-05-01 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| FR3055800B1 (fr) * | 2016-09-15 | 2020-06-26 | Unither Pharmaceuticals | Composition solide a ingestion rapide et deglutition facilitee, sous forme de particules solides non agglomerees, comprenant deux differents types de particules |
| CN114129569B (zh) * | 2020-09-04 | 2026-01-23 | 上海医药集团股份有限公司 | 一种含氮的饱和杂环化合物的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR048431A1 (es) * | 2004-03-17 | 2006-04-26 | Novartis Ag | Formulaciones galenicas de compuestos organicos |
| AR050615A1 (es) * | 2004-08-27 | 2006-11-08 | Novartis Ag | Composiciones farmaceuticas para la administracion oral |
| US20080075772A1 (en) * | 2006-04-13 | 2008-03-27 | Lawrence Solomon | Pharmaceutical compositions having novel scoring patterns and methods of using those compositions |
| US8119841B2 (en) * | 2006-11-07 | 2012-02-21 | Novartis Ag | Crystalline forms of aliskiren hemifumarate |
| EP1972335A1 (en) * | 2007-03-23 | 2008-09-24 | Krka | Solid dosage forms comprising aliskiren and pharmaceutically acceptable salts thereof |
| WO2009040427A1 (en) * | 2007-09-28 | 2009-04-02 | Novartis Ag | Galenical formulations of organic compounds |
| WO2009045795A2 (en) * | 2007-09-28 | 2009-04-09 | Novartis Ag | Galenical formulations of aliskiren and valsartan |
| EP2062874B1 (en) * | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
-
2009
- 2009-09-22 AR ARP090103629A patent/AR073651A1/es unknown
- 2009-09-23 EP EP09792885A patent/EP2328562A1/en not_active Withdrawn
- 2009-09-23 PE PE2011000667A patent/PE20110925A1/es not_active Application Discontinuation
- 2009-09-23 CN CN2009801373641A patent/CN102164584A/zh active Pending
- 2009-09-23 CA CA2736259A patent/CA2736259A1/en not_active Abandoned
- 2009-09-23 US US13/120,182 patent/US20110177166A1/en not_active Abandoned
- 2009-09-23 TW TW098132133A patent/TW201016210A/zh unknown
- 2009-09-23 MX MX2011003077A patent/MX2011003077A/es not_active Application Discontinuation
- 2009-09-23 WO PCT/US2009/057993 patent/WO2010036686A1/en not_active Ceased
- 2009-09-23 BR BRPI0919077A patent/BRPI0919077A2/pt not_active IP Right Cessation
- 2009-09-23 RU RU2011116122/15A patent/RU2011116122A/ru not_active Application Discontinuation
- 2009-09-23 KR KR1020117009209A patent/KR20110063684A/ko not_active Withdrawn
- 2009-09-23 AU AU2009296718A patent/AU2009296718A1/en not_active Abandoned
- 2009-09-23 JP JP2011529177A patent/JP2012503665A/ja active Pending
-
2011
- 2011-03-04 ZA ZA2011/01686A patent/ZA201101686B/en unknown
- 2011-03-23 CL CL2011000614A patent/CL2011000614A1/es unknown
- 2011-03-25 CO CO11036970A patent/CO6351712A2/es not_active Application Discontinuation
- 2011-04-20 MA MA33785A patent/MA32722B1/fr unknown
- 2011-04-21 EC EC2011010998A patent/ECSP11010998A/es unknown
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