JP2012502067A5 - - Google Patents
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- Publication number
- JP2012502067A5 JP2012502067A5 JP2011526310A JP2011526310A JP2012502067A5 JP 2012502067 A5 JP2012502067 A5 JP 2012502067A5 JP 2011526310 A JP2011526310 A JP 2011526310A JP 2011526310 A JP2011526310 A JP 2011526310A JP 2012502067 A5 JP2012502067 A5 JP 2012502067A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydrogen
- halogen
- alkyl
- perhaloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9582608P | 2008-09-10 | 2008-09-10 | |
| US61/095,826 | 2008-09-10 | ||
| US23174909P | 2009-08-06 | 2009-08-06 | |
| US61/231,749 | 2009-08-06 | ||
| PCT/US2009/056519 WO2010030785A2 (en) | 2008-09-10 | 2009-09-10 | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012502067A JP2012502067A (ja) | 2012-01-26 |
| JP2012502067A5 true JP2012502067A5 (OSRAM) | 2012-11-01 |
Family
ID=42005738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011526310A Pending JP2012502067A (ja) | 2008-09-10 | 2009-09-10 | 疾患の治療のためのヒスタミン受容体の複素環阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20100120741A1 (OSRAM) |
| EP (1) | EP2324029A4 (OSRAM) |
| JP (1) | JP2012502067A (OSRAM) |
| KR (1) | KR20110095857A (OSRAM) |
| CN (1) | CN102388044A (OSRAM) |
| AR (1) | AR073574A1 (OSRAM) |
| AU (1) | AU2009291719A1 (OSRAM) |
| CA (1) | CA2735369A1 (OSRAM) |
| CL (1) | CL2011000431A1 (OSRAM) |
| MX (1) | MX2011002264A (OSRAM) |
| RU (1) | RU2011113419A (OSRAM) |
| TW (1) | TW201024297A (OSRAM) |
| UY (1) | UY32111A (OSRAM) |
| WO (1) | WO2010030785A2 (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004031656A1 (de) * | 2004-06-30 | 2006-01-19 | Merck Patent Gmbh | Tetrahydrochinoline |
| KR101208778B1 (ko) | 2008-03-03 | 2012-12-05 | 노파르티스 아게 | Ｔｌｒ 활성 조정제로서의 화합물 및 조성물 |
| TWI547522B (zh) | 2009-07-07 | 2016-09-01 | 愛爾康研究有限公司 | 環氧乙烷環氧丁烷嵌段共聚物組成物 |
| EP2470544A1 (en) * | 2009-08-26 | 2012-07-04 | Cylene Pharmaceuticals, Inc. | Condensed quinolines as protein kinase modulators |
| JP2013053070A (ja) * | 2009-11-06 | 2013-03-21 | Takeda Chem Ind Ltd | ジヒドロピロロキノリン誘導体 |
| TW201200518A (en) | 2010-03-10 | 2012-01-01 | Kalypsys Inc | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| DE102010025786A1 (de) * | 2010-07-01 | 2012-01-05 | Merck Patent Gmbh | Pyrazolochinoline |
| TW201206936A (en) | 2010-07-19 | 2012-02-16 | Alcon Res Ltd | Methods and compositions for the treatment of allergy |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
| KR101649610B1 (ko) * | 2011-04-21 | 2016-08-19 | 오리제니스 게엠베하 | 키나아제 억제제로서의 헤테로사이클릭 화합물 |
| WO2013039785A2 (en) | 2011-09-12 | 2013-03-21 | Kalypsys, Inc. | Heterocyclic inhibitors of histamine receptors for the treatment of disease |
| CN103889986B (zh) * | 2011-09-30 | 2017-07-21 | C&C新药研究所 | 新杂环衍生物及其应用 |
| US9873694B2 (en) | 2011-10-04 | 2018-01-23 | Janus Biotherapeutics, Inc. | Imidazole quinoline-based immune system modulators |
| US20140045856A1 (en) | 2012-07-31 | 2014-02-13 | Boehringer Ingelheim International Gmbh | 4-Methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes |
| US10000482B2 (en) * | 2012-10-19 | 2018-06-19 | Origenis Gmbh | Kinase inhibitors |
| US9255105B2 (en) * | 2012-12-06 | 2016-02-09 | Enaltec Labs Private Limited | Process of preparing alcaftadine |
| ES2790675T3 (es) | 2013-02-01 | 2020-10-28 | Wellstat Therapeutics Corp | Compuestos de amina que tienen actividad anti-inflamatoria, antifúngica, antiparasitaria y anticáncer |
| WO2014152029A2 (en) * | 2013-03-15 | 2014-09-25 | Epigenetix, Inc. | Oxazolo[5,4-c]quinolin-2-one compounds as bromodomain inhibitors |
| WO2015012704A1 (en) * | 2013-07-25 | 2015-01-29 | Uniwersytet Jagielloński | Pyrroloquinoline derivatives as 5-ht6 antagonists, preparation method and use thereof |
| US10688082B2 (en) | 2015-06-11 | 2020-06-23 | Merck Sharp & Dohme Corp. | Aminopyrazine compounds with A2A antagonist properties |
| US11028090B2 (en) | 2017-01-26 | 2021-06-08 | Dong Wha Pharm. Co., Ltd. | [1,2,4]Triazolo[4,3-a]quinoxaline derivative, method for preparing same, and pharmaceutical composition for preventing or treating BET protein-related diseases, containing same as active ingredient |
| WO2019177971A1 (en) * | 2018-03-12 | 2019-09-19 | Mavupharma, Inc. | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof |
| WO2019200500A1 (zh) * | 2018-04-15 | 2019-10-24 | 苏州大学张家港工业技术研究院 | 1,2,4-三氮唑及其制备方法 |
| WO2019206242A1 (zh) * | 2018-04-27 | 2019-10-31 | 北京鼎材科技有限公司 | 有机电致发光材料及器件 |
| TW202021969A (zh) * | 2018-05-31 | 2020-06-16 | 南韓商Ｃ＆Ｃ新藥研究所 | 雜環衍生物及其用途 |
| CN109705141B (zh) * | 2019-02-20 | 2020-05-29 | 苏州大学 | 一种恶唑并喹啉类化合物及其制备方法与应用 |
| CN114746421A (zh) * | 2019-11-19 | 2022-07-12 | 南京明德新药研发有限公司 | 作为atm抑制剂的有取代的喹啉吡咯酮类合物及其应用 |
| US11530218B2 (en) | 2020-01-20 | 2022-12-20 | Incyte Corporation | Spiro compounds as inhibitors of KRAS |
| US11739102B2 (en) | 2020-05-13 | 2023-08-29 | Incyte Corporation | Fused pyrimidine compounds as KRAS inhibitors |
| WO2022047093A1 (en) | 2020-08-28 | 2022-03-03 | Incyte Corporation | Vinyl imidazole compounds as inhibitors of kras |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
| WO2022204112A1 (en) | 2021-03-22 | 2022-09-29 | Incyte Corporation | Imidazole and triazole kras inhibitors |
| EP4067357A1 (en) * | 2021-03-30 | 2022-10-05 | JW Pharmaceutical Corporation | Novel crystalline form of 1-(8-bromopyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazin-4-yl)-n-methylazetidin-3-amine hydrogen sulfate monohydrate |
| WO2023283213A1 (en) | 2021-07-07 | 2023-01-12 | Incyte Corporation | Tricyclic compounds as inhibitors of kras |
| US12441742B2 (en) | 2021-08-31 | 2025-10-14 | Incyte Corporation | Naphthyridine compounds as inhibitors of KRAS |
| US12030883B2 (en) | 2021-09-21 | 2024-07-09 | Incyte Corporation | Hetero-tricyclic compounds as inhibitors of KRAS |
| JP2024537824A (ja) | 2021-10-01 | 2024-10-16 | インサイト・コーポレイション | ピラゾロキノリンｋｒａｓ阻害剤 |
| MX2024004444A (es) | 2021-10-14 | 2024-05-08 | Incyte Corp | Compuestos de quinolina como inhibidores de la proteina del virus de sarcoma de rata kirsten (kras). |
| CN116969943A (zh) * | 2022-04-28 | 2023-10-31 | 轩竹生物科技股份有限公司 | 三并环类二酰甘油激酶抑制剂及其用途 |
| JP2025516926A (ja) * | 2022-08-03 | 2025-05-30 | アビスコ セラピューティクス カンパニー リミテッド | 窒素含有三縮合環ｐｒｍｔ５阻害剤、その製造方法および薬学上の用途 |
| JP2025533677A (ja) * | 2022-09-26 | 2025-10-07 | 上海湃隆生物科技有限公司 | 新型ｐｒｍｔ５阻害剤およびその使用 |
| EP4594520A2 (en) | 2022-09-30 | 2025-08-06 | Sixfold Bioscience Ltd. | Compositions containing oligonucleotides with theranostic applications |
| CN116332789A (zh) * | 2023-03-10 | 2023-06-27 | 上海康鹏科技股份有限公司 | 一种4-氨基-2-氟苯甲酰胺的制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053600A (en) * | 1973-03-08 | 1977-10-11 | Sandoz, Inc. | Tricyclic 1,2,4-triazolo-quinazolines |
| US4495187A (en) * | 1982-10-18 | 1985-01-22 | Pfizer Inc. | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents |
| IN160956B (OSRAM) * | 1982-10-18 | 1987-08-22 | Pfizer | |
| CN1285834A (zh) * | 1997-11-11 | 2001-02-28 | 小野药品工业株式会社 | 稠合吡嗪化合物 |
| CA2471087A1 (en) * | 2001-12-21 | 2003-07-03 | Jsw-Research Forschungslabor Gmbh | Pyrazolyl-substituted triazoloquinoxalines |
| US20100035863A1 (en) * | 2006-09-12 | 2010-02-11 | Ucb Pharma, S.A. | 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions |
| EP1972629A1 (en) * | 2007-03-23 | 2008-09-24 | Mutabilis SA | New imidazolo-heteroaryl derivatives with antibacterial properties |
| FR2921927B1 (fr) * | 2007-10-03 | 2012-10-12 | Univ De Montpellier 1 | Imidazo°1,2-a!quinoxalines et derives pour le traitement des cancers |
-
2009
- 2009-09-10 TW TW098130500A patent/TW201024297A/zh unknown
- 2009-09-10 MX MX2011002264A patent/MX2011002264A/es not_active Application Discontinuation
- 2009-09-10 EP EP09813607A patent/EP2324029A4/en not_active Withdrawn
- 2009-09-10 US US12/556,866 patent/US20100120741A1/en not_active Abandoned
- 2009-09-10 AR ARP090103487A patent/AR073574A1/es not_active Application Discontinuation
- 2009-09-10 CN CN2009801427590A patent/CN102388044A/zh active Pending
- 2009-09-10 JP JP2011526310A patent/JP2012502067A/ja active Pending
- 2009-09-10 KR KR1020117008096A patent/KR20110095857A/ko not_active Withdrawn
- 2009-09-10 AU AU2009291719A patent/AU2009291719A1/en not_active Abandoned
- 2009-09-10 RU RU2011113419/04A patent/RU2011113419A/ru not_active Application Discontinuation
- 2009-09-10 CA CA2735369A patent/CA2735369A1/en not_active Abandoned
- 2009-09-10 WO PCT/US2009/056519 patent/WO2010030785A2/en not_active Ceased
- 2009-09-10 UY UY0001032111A patent/UY32111A/es not_active Application Discontinuation
-
2011
- 2011-02-28 CL CL2011000431A patent/CL2011000431A1/es unknown
- 2011-11-21 US US13/301,131 patent/US20120065187A1/en not_active Abandoned
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