JP2012210156A5 - - Google Patents
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- Publication number
- JP2012210156A5 JP2012210156A5 JP2011076235A JP2011076235A JP2012210156A5 JP 2012210156 A5 JP2012210156 A5 JP 2012210156A5 JP 2011076235 A JP2011076235 A JP 2011076235A JP 2011076235 A JP2011076235 A JP 2011076235A JP 2012210156 A5 JP2012210156 A5 JP 2012210156A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- mixed
- flk
- cardiomyocytes
- kdr positive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 17
- 238000000034 method Methods 0.000 claims 13
- 210000004413 cardiac myocyte Anatomy 0.000 claims 6
- 238000012258 culturing Methods 0.000 claims 4
- 210000002889 endothelial cell Anatomy 0.000 claims 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- 229930105110 Cyclosporin A Natural products 0.000 claims 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 238000010030 laminating Methods 0.000 claims 1
- 238000003475 lamination Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- DMRMZQATXPQOTP-GWTDSMLYSA-M sodium;(4ar,6r,7r,7as)-6-(6-amino-8-bromopurin-9-yl)-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4h-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol Chemical compound [Na+].C([C@H]1O2)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1Br DMRMZQATXPQOTP-GWTDSMLYSA-M 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 229920000208 temperature-responsive polymer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011076235A JP5840855B2 (ja) | 2011-03-30 | 2011-03-30 | 胚性幹細胞から心筋シートを製造する方法 |
| EP12763936.7A EP2692859B1 (en) | 2011-03-30 | 2012-03-30 | Method for producing cardiomyocyte sheet from embryonic stem cells |
| US14/009,018 US9623052B2 (en) | 2011-03-30 | 2012-03-30 | Method for producing myocardial sheet from embryonic stem cell |
| PCT/JP2012/059427 WO2012133945A1 (ja) | 2011-03-30 | 2012-03-30 | 胚性幹細胞から心筋シートを製造する方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011076235A JP5840855B2 (ja) | 2011-03-30 | 2011-03-30 | 胚性幹細胞から心筋シートを製造する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012210156A JP2012210156A (ja) | 2012-11-01 |
| JP2012210156A5 true JP2012210156A5 (enExample) | 2014-05-15 |
| JP5840855B2 JP5840855B2 (ja) | 2016-01-06 |
Family
ID=46931617
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011076235A Expired - Fee Related JP5840855B2 (ja) | 2011-03-30 | 2011-03-30 | 胚性幹細胞から心筋シートを製造する方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9623052B2 (enExample) |
| EP (1) | EP2692859B1 (enExample) |
| JP (1) | JP5840855B2 (enExample) |
| WO (1) | WO2012133945A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9598668B2 (en) | 2008-10-14 | 2017-03-21 | Cellseed Inc. | Temperature-responsive cell culture substrate and method for producing the same |
| JP5920741B2 (ja) | 2012-03-15 | 2016-05-18 | ｉＨｅａｒｔ Ｊａｐａｎ株式会社 | 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法 |
| EP3006559B1 (en) * | 2013-05-31 | 2019-11-06 | iHeart Japan Corporation | Layered cell sheet incorporating hydrogel |
| JP6248617B2 (ja) * | 2013-12-25 | 2017-12-20 | 大日本印刷株式会社 | 細胞シートの製造方法 |
| KR101987395B1 (ko) * | 2014-05-01 | 2019-06-10 | 아이하트 재팬 가부시키가이샤 | Cd82 양성 심근 전구세포 |
| JP7180965B2 (ja) | 2014-11-12 | 2022-11-30 | テルモ株式会社 | 心筋細胞シート |
| US10711247B2 (en) | 2015-08-31 | 2020-07-14 | Tokyo Women's Medical University | Method for reducing pluripotent stem cells, method for producing cell population having reduced pluripotent stem cells |
| KR102049211B1 (ko) | 2016-12-02 | 2019-11-26 | 다카라 바이오 가부시키가이샤 | 내피세포의 제조 방법 |
| EP3778869A4 (en) | 2018-03-30 | 2021-12-08 | Kyoto University | CARDIOMYOCYTE MATURATION PROMOTER |
| MX2020010184A (es) | 2018-03-30 | 2020-10-28 | Orizuru Therapeutics Inc | Compuesto heterociclico. |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US20040009566A1 (en) | 2000-07-21 | 2004-01-15 | Teruo Okano | Heart muscle-like cell sheet, three-dimensional construct, heart muscle-like tissue and process for producing the same |
| DK2266499T3 (en) | 2003-08-01 | 2015-06-29 | Cellseed Inc | Three-dimensional tissue structure. |
| EP1674562A4 (en) | 2003-10-03 | 2007-04-11 | Keiichi Fukuda | METHOD OF INDUCING DIFFERENTIATION OF STEM CELLS INTO MYOCARDIAL CELLS |
| WO2006022377A1 (ja) | 2004-08-27 | 2006-03-02 | Daiichi Asubio Pharma Co., Ltd. | 細胞内ミトコンドリアを指標とした心筋細胞の選択方法 |
| KR20130099253A (ko) | 2005-06-22 | 2013-09-05 | 제론 코포레이션 | 영장류 다능성 줄기 세포의 심근세포 계통 세포로의 분화 |
| SG169359A1 (en) | 2006-01-31 | 2011-03-30 | Univ Keio | A method for purifying cardiomyocytes or programmed cardiomyocytes derived from stem cells or fetuses |
| JP5149791B2 (ja) | 2006-04-28 | 2013-02-20 | 第一三共株式会社 | 多能性幹細胞から心筋細胞を分化誘導する方法 |
| WO2009118928A1 (en) * | 2008-03-26 | 2009-10-01 | Kyoto University | Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells |
| JP5387294B2 (ja) | 2009-09-29 | 2014-01-15 | ブラザー工業株式会社 | サーバに接続されるプリンタ及びサーバ |
| JP5654786B2 (ja) | 2010-06-28 | 2015-01-14 | 株式会社セルシード | アクリルアミド誘導体および該誘導体を含む重合体 |
-
2011
- 2011-03-30 JP JP2011076235A patent/JP5840855B2/ja not_active Expired - Fee Related
-
2012
- 2012-03-30 US US14/009,018 patent/US9623052B2/en not_active Expired - Fee Related
- 2012-03-30 WO PCT/JP2012/059427 patent/WO2012133945A1/ja not_active Ceased
- 2012-03-30 EP EP12763936.7A patent/EP2692859B1/en not_active Not-in-force
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