JP2012184234A5 - - Google Patents
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- JP2012184234A5 JP2012184234A5 JP2012095094A JP2012095094A JP2012184234A5 JP 2012184234 A5 JP2012184234 A5 JP 2012184234A5 JP 2012095094 A JP2012095094 A JP 2012095094A JP 2012095094 A JP2012095094 A JP 2012095094A JP 2012184234 A5 JP2012184234 A5 JP 2012184234A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- pharmaceutical composition
- acceptable salt
- use according
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims 11
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 5
- 159000000000 sodium salts Chemical class 0.000 claims 3
- 201000005569 Gout Diseases 0.000 claims 2
- 102000005773 Xanthine dehydrogenase Human genes 0.000 claims 2
- 108010091383 Xanthine dehydrogenase Proteins 0.000 claims 2
- 108010093894 Xanthine oxidase Proteins 0.000 claims 2
- 229960003459 allopurinol Drugs 0.000 claims 2
- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960005101 febuxostat Drugs 0.000 claims 2
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 2
- ASUMVAPLXCRBMA-UHFFFAOYSA-N (3,5-dichloro-4-hydroxyphenyl)-(2,3-dihydro-1,4-benzoxazin-4-yl)methanone Chemical compound C1=C(Cl)C(O)=C(Cl)C=C1C(=O)N1C2=CC=CC=C2OCC1 ASUMVAPLXCRBMA-UHFFFAOYSA-N 0.000 claims 1
- UBVZQGOVTLIHLH-UHFFFAOYSA-N 4-[5-pyridin-4-yl-1h-[1,2,4]triazol-3-yl]-pyridine-2-carbonitrile Chemical compound C1=NC(C#N)=CC(C=2N=C(NN=2)C=2C=CN=CC=2)=C1 UBVZQGOVTLIHLH-UHFFFAOYSA-N 0.000 claims 1
- 201000001431 Hyperuricemia Diseases 0.000 claims 1
- 229940122272 Oxidoreductase inhibitor Drugs 0.000 claims 1
- 229940083914 URAT1 inhibitor Drugs 0.000 claims 1
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
- TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
- 229940123769 Xanthine oxidase inhibitor Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000002457 oxidoreductase inhibitor Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 229950004176 topiroxostat Drugs 0.000 claims 1
- 229940116269 uric acid Drugs 0.000 claims 1
- 239000003064 xanthine oxidase inhibitor Substances 0.000 claims 1
- FGQFOYHRJSUHMR-UHFFFAOYSA-N OC(CSc([n]1-c2ccc(C3CC3)c3c2cccc3)nnc1Br)=O Chemical compound OC(CSc([n]1-c2ccc(C3CC3)c3c2cccc3)nnc1Br)=O FGQFOYHRJSUHMR-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99057407P | 2007-11-27 | 2007-11-27 | |
| US60/990,574 | 2007-11-27 | ||
| US9438808P | 2008-09-04 | 2008-09-04 | |
| US61/094,388 | 2008-09-04 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536189A Division JP5099794B2 (ja) | 2007-11-27 | 2008-11-26 | 新規化合物、組成物、及び使用方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150149A Division JP5905934B2 (ja) | 2007-11-27 | 2014-07-23 | 新規化合物、組成物、及び使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012184234A JP2012184234A (ja) | 2012-09-27 |
| JP2012184234A5 true JP2012184234A5 (OSRAM) | 2013-07-04 |
Family
ID=40679222
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536189A Active JP5099794B2 (ja) | 2007-11-27 | 2008-11-26 | 新規化合物、組成物、及び使用方法 |
| JP2012095094A Pending JP2012184234A (ja) | 2007-11-27 | 2012-04-18 | 新規化合物、組成物、及び使用方法 |
| JP2014150149A Active JP5905934B2 (ja) | 2007-11-27 | 2014-07-23 | 新規化合物、組成物、及び使用方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536189A Active JP5099794B2 (ja) | 2007-11-27 | 2008-11-26 | 新規化合物、組成物、及び使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014150149A Active JP5905934B2 (ja) | 2007-11-27 | 2014-07-23 | 新規化合物、組成物、及び使用方法 |
Country Status (35)
| Country | Link |
|---|---|
| US (8) | US8084483B2 (OSRAM) |
| EP (2) | EP2217577B1 (OSRAM) |
| JP (3) | JP5099794B2 (OSRAM) |
| KR (2) | KR101411806B1 (OSRAM) |
| CN (3) | CN102643241B (OSRAM) |
| AR (1) | AR069753A1 (OSRAM) |
| AU (2) | AU2008329673C1 (OSRAM) |
| BR (1) | BRPI0819847B1 (OSRAM) |
| CA (1) | CA2706858C (OSRAM) |
| CL (1) | CL2008003529A1 (OSRAM) |
| CY (1) | CY2019010I2 (OSRAM) |
| DK (1) | DK2217577T3 (OSRAM) |
| EA (2) | EA018193B3 (OSRAM) |
| EC (1) | ECSP10010310A (OSRAM) |
| ES (1) | ES2513390T3 (OSRAM) |
| HR (1) | HRP20140950T1 (OSRAM) |
| HU (1) | HUS1900009I1 (OSRAM) |
| IL (1) | IL205974A (OSRAM) |
| LT (1) | LTPA2019003I1 (OSRAM) |
| LU (1) | LUC00103I2 (OSRAM) |
| MA (1) | MA31936B1 (OSRAM) |
| ME (2) | ME01294B (OSRAM) |
| MX (1) | MX2010005776A (OSRAM) |
| MY (1) | MY147370A (OSRAM) |
| NO (1) | NO2016016I2 (OSRAM) |
| NZ (4) | NZ585583A (OSRAM) |
| PL (1) | PL2217577T3 (OSRAM) |
| PT (1) | PT2217577E (OSRAM) |
| RS (1) | RS53569B1 (OSRAM) |
| SG (1) | SG183721A1 (OSRAM) |
| SI (1) | SI2217577T1 (OSRAM) |
| TN (1) | TN2010000237A1 (OSRAM) |
| TW (1) | TWI415840B (OSRAM) |
| WO (1) | WO2009070740A2 (OSRAM) |
| ZA (1) | ZA201003769B (OSRAM) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007050087A1 (en) | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| EP2135608B8 (en) * | 2004-08-25 | 2012-03-21 | Ardea Biosciences, Inc. | S-triazolyl alpha -mercaptoacetanilides as inhibitors of HIV reverse transcriptase |
| JP5099794B2 (ja) * | 2007-11-27 | 2012-12-19 | アルデア バイオサイエンシーズ インク. | 新規化合物、組成物、及び使用方法 |
| AU2009289646B2 (en) * | 2008-09-04 | 2012-07-05 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8242154B2 (en) | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| WO2010048592A1 (en) * | 2008-10-24 | 2010-04-29 | Ardea Biosciences, Inc. | Compositions comprising 4- (2- ( 5-br0m0-4- ( 1-cyclopropylnaphthalen-4-yl) -4h-1, 2, 4-triaz0l-3-ylthi0) acetamido -3-chlorobenzoic acid and pharmaceutically acceptable salts thereof |
| WO2010048593A1 (en) * | 2008-10-24 | 2010-04-29 | Ardea Biosciences, Inc. | Compositions comprising 4- (2- ( 5-br0m0-4- ( l-cyclopropylnaphthalen-4-yl) -4h-1, 2, 4-triazol-3-ylthio) acetamido -3-chlorobenzoic acid and pharmaceutically acceptable salts thereof |
| US20100160351A1 (en) * | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| WO2010135530A2 (en) * | 2009-05-20 | 2010-11-25 | Ardea Biosciences, Inc. | Compounds, compositions and methods for modulating uric acid levels |
| EP2432468A2 (en) | 2009-05-20 | 2012-03-28 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| MX2012007925A (es) * | 2010-01-08 | 2012-08-03 | Ardea Biosciences Inc | Formas polimorficas, cristalinas y de mesofase de 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-ilti o)acetato de sodio, y usos de las mismas. |
| CA2794798C (en) | 2010-03-30 | 2017-05-30 | Ardea Biosciences, Inc. | Treatment of gout |
| TR201806828T4 (tr) * | 2010-06-15 | 2018-06-21 | Ardea Biosciences Inc | Gut ve hiperürisemi tedavisi. |
| CA2802692C (en) | 2010-06-16 | 2016-01-05 | Ardea Biosciences, Inc. | Phenylthioacetate compounds useful as uricosuric agents |
| AR081930A1 (es) * | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
| CN106176736A (zh) * | 2010-10-15 | 2016-12-07 | 阿迪亚生命科学公司 | 用于治疗高尿酸血症及相关疾病的方法 |
| EP2632270A1 (en) * | 2010-10-28 | 2013-09-04 | Mapi Pharma Limited | Polymorphs of febuxostat |
| BR112013016982A2 (pt) | 2010-12-30 | 2016-10-25 | Ardea Biosciences Inc | formas polimórficas de ácido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acético e usos destes |
| WO2012122532A2 (en) * | 2011-03-09 | 2012-09-13 | Biocryst Pharmaceuticals, Inc. | Compositions and methods for treatment of hyperuricemia |
| PH12013502427A1 (en) * | 2011-05-24 | 2020-10-19 | Ardea Biosciences Inc | Hypertension and hyperuricemia |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN106963761A (zh) | 2011-11-03 | 2017-07-21 | 阿迪亚生命科学公司 | 3,4‑二取代的吡啶化合物、其使用方法以及包含该化合物的组合物 |
| US9060987B2 (en) | 2011-11-04 | 2015-06-23 | Cymabay Therapeutics, Inc. | Methods for treating gout flares |
| US9023856B2 (en) | 2011-11-04 | 2015-05-05 | Cymabay Therapeutics, Inc. | Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent |
| CA2859689C (en) * | 2011-11-04 | 2018-05-22 | Cymabay Therapeutics, Inc. | Methods for treating gout in patient subpopulations |
| KR101848121B1 (ko) * | 2011-11-04 | 2018-04-11 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 통풍 발열의 치료법 |
| CN104066430A (zh) * | 2012-01-27 | 2014-09-24 | 帝人制药株式会社 | 糖尿病的治疗药 |
| AR091651A1 (es) * | 2012-07-03 | 2015-02-18 | Ardea Biosciences Inc | Elaboracion de acido 2-(5-bromo-4-(4-ciclopropilnaftalen-1-il)-4h-1,2,4-triazol-3-iltio)acetico |
| AR093468A1 (es) * | 2012-11-14 | 2015-06-10 | Teijin Pharma Ltd | Derivados de piridina |
| CN102973530B (zh) * | 2012-12-14 | 2016-08-03 | 贵州信邦制药股份有限公司 | 一种非布索坦双层肠溶片剂及其制备方法 |
| PL2998296T3 (pl) | 2013-05-13 | 2018-12-31 | Shanghai Hengrui Pharmaceutical Co. Ltd. | Pochodna kwasu cykloalkilowego, sposób jej otrzymywania i jej zastosowanie farmaceutyczne |
| CN105263913B (zh) * | 2013-06-14 | 2017-12-15 | 广东东阳光药业有限公司 | 硫代1,2,4‑三唑衍生物及其制备方法 |
| CN103524440B (zh) * | 2013-10-15 | 2015-09-09 | 苏州鹏旭医药科技有限公司 | 痛风治疗药Lesinurad的制备方法及Lesinurad中间体 |
| CN104447589B (zh) * | 2013-11-20 | 2017-01-11 | 广东东阳光药业有限公司 | 一种尿酸调节剂的制备方法及其中间体 |
| CN103588716A (zh) * | 2013-11-22 | 2014-02-19 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的新晶型及其制备方法 |
| JP6470761B2 (ja) * | 2013-11-22 | 2019-02-13 | クリスタル ファーマテック カンパニー、リミテッドCrystal Pharmatech Co., Ltd. | レシヌラドおよびそのナトリウム塩の結晶形態 |
| CN103613552A (zh) * | 2013-12-02 | 2014-03-05 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸钠的新晶型及其制备方法 |
| CN103626710A (zh) * | 2013-12-20 | 2014-03-12 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的共晶及其制备方法 |
| WO2015095703A1 (en) * | 2013-12-20 | 2015-06-25 | Crystal Pharmatech, Inc. | Novel salts and co-crystals of lesinurad |
| CN103755651A (zh) * | 2013-12-23 | 2014-04-30 | 苏州晶云药物科技有限公司 | 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基)乙酸的盐的新晶型及其制备方法 |
| CN105294585B (zh) * | 2014-07-02 | 2019-02-12 | 成都海创药业有限公司 | 一种治疗痛风的化合物 |
| CN106036135A (zh) * | 2014-07-25 | 2016-10-26 | 许伟琦 | 一种防止结石、快速排结石的药物、组合物、兽药 |
| CN104326994A (zh) * | 2014-10-27 | 2015-02-04 | 张远强 | 一种腈基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
| CN104341365A (zh) * | 2014-10-27 | 2015-02-11 | 张远强 | 卤代三氮唑丙二酸类化合物、其制备方法及用途 |
| CN104341363B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 一种硝基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
| CN104370841B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
| CN104327000B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 苯基取代的三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
| CN104370842B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 苯基取代的三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
| CN104326993B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 一种硝基取代三氮唑亚磺酰丙二酸类化合物、其制备方法及用途 |
| CN104326998B (zh) * | 2014-10-27 | 2016-08-17 | 张远强 | 苯基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
| CN104326996A (zh) * | 2014-10-27 | 2015-02-04 | 张远强 | 一种硝基取代三氮唑丙二酸类化合物、其制备方法及用途 |
| CN104341362B (zh) * | 2014-10-27 | 2016-07-13 | 张远强 | 三氮唑磺酰丙二酸类化合物、其制备方法及用途 |
| CN104341364A (zh) * | 2014-10-27 | 2015-02-11 | 张远强 | 三氮唑丙二酸类化合物、其制备方法及用途 |
| CN104326995A (zh) * | 2014-10-27 | 2015-02-04 | 张远强 | 一种腈基取代的三氮唑丙二酸类化合物、其制备方法及用途 |
| CN104529848A (zh) * | 2014-11-10 | 2015-04-22 | 安徽万邦医药科技有限公司 | 一种1-环丙基-4-异硫氰酰基萘的合成方法 |
| AU2015371308A1 (en) | 2014-12-23 | 2017-08-03 | Intellectual Property Associates, Llc | Methods and formulations for transdermal administration |
| CA2971125C (en) | 2014-12-29 | 2024-05-21 | Nippon Chemiphar Co., Ltd. | Urat1 inhibitor |
| CN105985295B (zh) * | 2015-02-17 | 2018-11-20 | 华润赛科药业有限责任公司 | 一种旋光纯的硫代乙酸类化合物 |
| CN105622531A (zh) * | 2015-04-03 | 2016-06-01 | 南京明德新药研发股份有限公司 | 轴手性异构体及其制备方法和制药用途 |
| CN104710374A (zh) * | 2015-04-14 | 2015-06-17 | 安徽省逸欣铭医药科技有限公司 | 一种痛风新化合物及制备方法、用途及其药物制剂 |
| CN106187926B (zh) | 2015-04-30 | 2018-11-27 | 天津药物研究院有限公司 | 含二芳基甲烷结构的羧酸类urat1抑制剂、制备方法及其在高尿酸血症和痛风治疗上的用途 |
| WO2016203436A1 (en) * | 2015-06-19 | 2016-12-22 | Dr. Reddy's Laboratories Limited | Amorphous and amorphous solid dispersion of lesinurad and their preparation |
| EP3112334A1 (en) | 2015-06-29 | 2017-01-04 | DPx Fine Chemicals Austria GmbH & CoKG | Process for manufacturing 1-cyclopropyl-naphthalenes |
| CN104987311A (zh) * | 2015-06-30 | 2015-10-21 | 安徽万邦医药科技有限公司 | 一种[4-(4-环丙基萘-1-基)-5-硝基- 4h-[1,2,4]三唑-3-基硫烷基]-乙酸乙酯的制备方法及其中间体(5-硝基-4h-[1,2,4]三唑-3-基硫基)-乙酸乙酯 |
| CN105017168A (zh) * | 2015-07-01 | 2015-11-04 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
| CN105153056A (zh) * | 2015-07-01 | 2015-12-16 | 安徽万邦医药科技有限公司 | 一种[5-溴-4-(4-环丙基萘-1-基)-4h-[1,2,4]三唑-3-基硫烷基]-乙酸甲酯的新制备方法 |
| EP3342414B1 (en) * | 2015-08-26 | 2022-04-06 | Stagen Co., Ltd. | Agent for enhancing atp in cells |
| WO2017036884A1 (en) | 2015-08-28 | 2017-03-09 | Sandoz Ag | A lesinurad, free form / lesinurad ethyl ester co-crystal |
| CN105301126B (zh) * | 2015-10-10 | 2021-02-12 | 大道隆达(北京)医药科技发展有限公司 | 一种托匹司他有关物质的分析方法 |
| US10626096B2 (en) | 2015-11-24 | 2020-04-21 | Sanford Burnham Prebys Medical Discovery Institute | Azole derivatives as apelin receptor agonist |
| CN108699027B (zh) * | 2015-12-28 | 2021-08-06 | 重庆复创医药研究有限公司 | 吲嗪类衍生物、组合物及使用方法 |
| US20170319552A1 (en) * | 2016-02-24 | 2017-11-09 | Ardea Biosciences, Inc. | Atropisomers of triazole derivative |
| CN107176930B (zh) * | 2016-03-11 | 2020-12-01 | 广东赛烽医药科技有限公司 | 2-[5-溴-4-(4-氟代环丙基萘-1-基)-4h-1,2,4-三唑-3-基硫基]乙酸化合物及其应用 |
| CN107337649B (zh) * | 2016-04-29 | 2020-10-16 | 四川科伦药物研究院有限公司 | 一种乙酸钠水合物无定型及其制备方法和用途 |
| JP6724246B2 (ja) * | 2016-05-23 | 2020-07-15 | シーストーン ファーマシューティカル (スージョウ) カンパニー リミテッド | チオフェン化合物、その合成方法及び医療における応用 |
| CN106074540B (zh) * | 2016-06-10 | 2018-10-16 | 江西博屾医疗器械有限公司 | 一种用于高尿酸血症治疗的药物组合物及其应用 |
| US10633351B2 (en) | 2016-06-17 | 2020-04-28 | Medshine Discovery Inc. | Halogenated compound and axially chiral isomer thereof |
| CN105943552A (zh) * | 2016-06-17 | 2016-09-21 | 王枝宝 | 一种氢氧化钾的医药用途 |
| CN106083847B (zh) * | 2016-08-03 | 2018-10-30 | 山东大学 | 一种咪唑并吡啶巯乙酸类衍生物及其制备方法与应用 |
| CZ307277B6 (cs) * | 2016-09-30 | 2018-05-09 | Zentiva, K.S. | Způsob výroby 2-(5-brom-4-(1-cyklopropylnaftalen-4-yl)-4H-1,2,4-triazol-3-ylthio)octové kyseliny - lesinuradu |
| EP3281941B1 (en) | 2016-08-11 | 2019-07-24 | Zentiva K.S. | Process for preparing 2-(5-bromo-4-(1-cyclopropylnaphthalen-4-yl)-4h-1,2,4-triazol-3-ylthio)acetic acid |
| CN108014108A (zh) * | 2016-11-03 | 2018-05-11 | 江苏万邦生化医药股份有限公司 | lesinurad或其医药上可接受的盐在制备治疗或预防库欣综合征的药物中的应用 |
| US10513500B2 (en) | 2016-11-10 | 2019-12-24 | Apotex Inc. | Crystalline forms of Lesinurad |
| JP7406990B2 (ja) | 2016-11-11 | 2023-12-28 | ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ | ヒト血漿様培地 |
| CN108164471B (zh) * | 2016-12-07 | 2019-09-13 | 浙江京新药业股份有限公司 | Lesinurad衍生物及其制备方法和用途 |
| US10351537B2 (en) | 2017-03-10 | 2019-07-16 | Apotex Inc. | Processes for the preparation of lesinurad and intermediates thereof |
| EP3315494A1 (en) | 2017-04-19 | 2018-05-02 | Química Sintética, S.A. | Amorphous form of lesinurad and processes for its preparation |
| CN108947919B (zh) * | 2017-05-17 | 2023-05-02 | 上海奥博生物医药股份有限公司 | 一种抗痛风药Lesinurad的新型制备方法及其关键中间体 |
| WO2018218250A2 (en) | 2017-05-26 | 2018-11-29 | Vibrant Holdings, Llc | Photoactive compounds and methods for biomolecule detection and sequencing |
| JP2020534285A (ja) | 2017-09-15 | 2020-11-26 | アンパサンド バイオファーマシューティカルズ インコーポレイテッドAmpersand Biopharmaceuticals Inc. | 投与および処置の方法 |
| AU2018370811B2 (en) | 2017-11-23 | 2021-01-21 | Dongbao Purple Star (Hangzhou) Biopharmaceutical Co., Ltd. | Crystal form of URAT1 inhibitor, and preparation method therefor |
| EP3498697A1 (en) | 2017-12-12 | 2019-06-19 | Química Sintética, S.A. | Novel salts and polymorphs of lesinurad |
| DK3725781T3 (da) * | 2017-12-15 | 2022-12-19 | Medshine Discovery Inc | Krystal og salt af 4-(naphthalen-1-yl)-4H-1,2,4-triazol-forbindelse og fremgangsmåde til fremstilling deraf |
| JP7422087B2 (ja) | 2018-05-09 | 2024-01-25 | ヴィブラント ホールディングス リミテッド ライアビリティ カンパニー | 光活性化された作用物質を使用してポリヌクレオチドアレイを合成する方法 |
| IL280880B2 (en) | 2018-08-27 | 2025-04-01 | Regeneron Pharma | Using Raman Spectroscopy in Downstream Purification |
| CN109369783B (zh) * | 2018-11-30 | 2021-09-10 | 昆明医科大学 | 一种多肽rdp1及其提纯方法与应用 |
| CN111320588B (zh) * | 2018-12-14 | 2024-02-09 | 上海奥博生物医药股份有限公司 | 一种纯化Lesinurad的方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2006101A (en) | 1932-07-05 | 1935-06-25 | Meaf Mach En Apparaten Fab Nv | Reversing mechanism for dry gas meters |
| US4198513A (en) * | 1970-09-25 | 1980-04-15 | Merck & Co., Inc. | 1,2,4-Triazoles |
| NL7112373A (OSRAM) * | 1970-09-25 | 1972-03-28 | ||
| JPS5641637B2 (OSRAM) | 1973-11-26 | 1981-09-29 | ||
| US4889868A (en) | 1984-12-20 | 1989-12-26 | Rorer Pharmaceutical Corporation | Bis-imidazolinoamino derivatives as antiallergy compounds |
| US5260322A (en) * | 1990-10-08 | 1993-11-09 | Merck & Co., Inc. | Angiotension II antagonists in the treatment of hyperuricemia |
| US6832996B2 (en) | 1995-06-07 | 2004-12-21 | Arthrocare Corporation | Electrosurgical systems and methods for treating tissue |
| JPH07215940A (ja) | 1994-01-27 | 1995-08-15 | Torii Yakuhin Kk | 抗ウイルス活性を有する化合物 |
| WO1995029897A1 (en) | 1994-04-29 | 1995-11-09 | G.D. Searle & Co. | METHOD OF USING (H+/K+) ATPase INHIBITORS AS ANTIVIRAL AGENTS |
| JP3964478B2 (ja) | 1995-06-30 | 2007-08-22 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ヘテロ環含有カルボン酸誘導体及びそれを含有する医薬 |
| US6017925A (en) | 1997-01-17 | 2000-01-25 | Merck & Co., Inc. | Integrin antagonists |
| EP0910565A1 (en) | 1997-02-14 | 1999-04-28 | Bayer Corporation | Amide derivatives as selective neuropeptide y receptor antagonists |
| US6245817B1 (en) | 1997-02-14 | 2001-06-12 | Bayer Corporation | NPY5 receptor antagonists and methods for using same |
| BRPI9909191B8 (pt) | 1998-03-27 | 2021-07-06 | Janssen Pharmaceutica Nv | derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende |
| ATE240958T1 (de) | 1998-11-12 | 2003-06-15 | Neurocrine Biosciences Inc | Crf rezeptor-antagonisten und darauf bezogene methoden |
| WO2000037471A1 (en) | 1998-12-23 | 2000-06-29 | Neurogen Corporation | 2-amino-9-alkylpurines: gaba brain receptor ligands |
| US6593077B2 (en) | 1999-03-22 | 2003-07-15 | Special Materials Research And Technology, Inc. | Method of making thin films dielectrics using a process for room temperature wet chemical growth of SiO based oxides on a substrate |
| US6624194B1 (en) * | 1999-06-04 | 2003-09-23 | Metabolex, Inc. | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| JP2004525914A (ja) | 2001-03-02 | 2004-08-26 | スミスクライン ビーチャム コーポレーション | 逆転写酵素阻害剤としてのベンゾフェノン類 |
| JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
| BRPI0212775B8 (pt) | 2002-01-28 | 2021-05-25 | Fuji Yakuhin Co Ltd | composto de 1,2,4-triazol e medicamento |
| CA2484233A1 (en) | 2002-05-13 | 2003-11-27 | Eli Lilly And Company | Multicyclic compounds for use as melanin concentrating hormone antagonists in the treatment of obesity and diabetes |
| EA009478B1 (ru) | 2002-08-23 | 2008-02-28 | Ардеа Байосайенсиз, Инк. | Ненуклеозидные ингибиторы обратной транскриптазы |
| US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
| EA011164B1 (ru) | 2003-02-07 | 2009-02-27 | Янссен Фармацевтика Н. В. | Производные пиримидина для профилактики вич-инфекции |
| KR20060121878A (ko) | 2003-09-25 | 2006-11-29 | 얀센 파마슈티카 엔.브이. | Hiv를 저해하는 퓨린 유도체 |
| US20080031901A1 (en) * | 2004-09-24 | 2008-02-07 | Abbott Laboratories | Sustained release monoeximic formulations of opioid and nonopioid analgesics |
| US8236488B2 (en) | 2003-11-14 | 2012-08-07 | Human Cell Systems, Inc. | Method of screening for therapeutic compounds for vascular disorders and hypertension based on URAT1 activity modulation |
| US20050250794A1 (en) | 2003-12-19 | 2005-11-10 | Andrew Napper | Methods of treating a disorder |
| EP1723123A4 (en) * | 2004-03-08 | 2009-12-02 | Wyeth Corp | ION CHANNEL MODULATORS |
| CN1934095A (zh) * | 2004-03-08 | 2007-03-21 | 惠氏公司 | 离子通道调节剂 |
| US7323480B2 (en) | 2004-05-25 | 2008-01-29 | Metabolex, Inc. | Substituted triazoles as modulators of PPAR and methods of their preparation |
| US20060013556A1 (en) | 2004-07-01 | 2006-01-19 | Thomas Poslinski | Commercial information and guide |
| WO2007050087A1 (en) * | 2004-08-25 | 2007-05-03 | Ardea Biosciences, Inc. | N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS |
| EP2135608B8 (en) | 2004-08-25 | 2012-03-21 | Ardea Biosciences, Inc. | S-triazolyl alpha -mercaptoacetanilides as inhibitors of HIV reverse transcriptase |
| GB0422057D0 (en) | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
| EP1932833B1 (en) * | 2005-10-07 | 2012-08-01 | Kissei Pharmaceutical Co., Ltd. | Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same |
| WO2007077042A1 (en) | 2006-01-06 | 2007-07-12 | Topotarget Switzerland Sa | New method for the treatment of gout or pseudogout |
| AU2007230991A1 (en) | 2006-03-22 | 2007-10-04 | Syndexa Pharmaceuticals Corporation | Compounds and methods for treatment of disorders associated with ER stress |
| US8034834B2 (en) | 2006-05-25 | 2011-10-11 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders with HSP90 inhibitors |
| WO2007140002A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for treating non-hodgkin's lymphoma |
| US7687526B2 (en) | 2006-09-07 | 2010-03-30 | Amgen Inc. | Benzo-fused compounds for use in treating metabolic disorders |
| EP1939181A1 (en) | 2006-12-27 | 2008-07-02 | sanofi-aventis | Heteroaryl-substituted carboxamides and use thereof for the stimulation of the expression of NO synthase |
| AU2008206231A1 (en) | 2007-01-19 | 2008-07-24 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents |
| JP5099794B2 (ja) * | 2007-11-27 | 2012-12-19 | アルデア バイオサイエンシーズ インク. | 新規化合物、組成物、及び使用方法 |
| US8242154B2 (en) * | 2008-09-04 | 2012-08-14 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| US8173690B2 (en) * | 2008-09-04 | 2012-05-08 | Ardea Biosciences, Inc. | Compounds, compositions and methods of using same for modulating uric acid levels |
| WO2010048592A1 (en) | 2008-10-24 | 2010-04-29 | Ardea Biosciences, Inc. | Compositions comprising 4- (2- ( 5-br0m0-4- ( 1-cyclopropylnaphthalen-4-yl) -4h-1, 2, 4-triaz0l-3-ylthi0) acetamido -3-chlorobenzoic acid and pharmaceutically acceptable salts thereof |
| WO2010071865A1 (en) | 2008-12-19 | 2010-06-24 | Nuon Therapeutics, Inc. | Pharmaceutical compositions and methods for treating hyperuricemia and related disorders |
| PH12013502427A1 (en) | 2011-05-24 | 2020-10-19 | Ardea Biosciences Inc | Hypertension and hyperuricemia |
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