JP2012072065A - リポソーム含有組成物、並びに、該組成物を配合してなる皮膚用水溶性化粧料 - Google Patents
リポソーム含有組成物、並びに、該組成物を配合してなる皮膚用水溶性化粧料 Download PDFInfo
- Publication number
- JP2012072065A JP2012072065A JP2010216050A JP2010216050A JP2012072065A JP 2012072065 A JP2012072065 A JP 2012072065A JP 2010216050 A JP2010216050 A JP 2010216050A JP 2010216050 A JP2010216050 A JP 2010216050A JP 2012072065 A JP2012072065 A JP 2012072065A
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- JP
- Japan
- Prior art keywords
- water
- liposome
- composition
- soluble
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Landscapes
- Cosmetics (AREA)
Abstract
【解決手段】皮膚用水溶性化粧料に配合される組成物であって、(A)リン脂質、(B)水溶性の生理活性物質、並びに(C)1,2−アルカンジールからなるリポソームを含有してなる組成物とする。また、該組成物を配合してなる皮膚用水溶性化粧料とする。
【選択図】なし
Description
〔1〕皮膚用水溶性化粧料に配合される組成物であって、(A)リン脂質、(B)水溶性の生理活性物質、並びに(C)1,2−アルカンジールからなるリポソームを含有してなる組成物、
〔2〕(A)成分が、水素添加リン脂質である前記〔1〕に記載の組成物、
〔3〕(C)成分が、炭素数8〜12の1,2−アルカンジールである前記〔1〕又は〔2〕に記載の組成物、並びに
〔4〕前記〔1〕〜〔3〕の何れかに記載の組成物を配合してなる皮膚用水溶性化粧料
に関する。
(C)成分/((A)成分+(B)成分)=0.01〜0.7
の範囲を満たすことが好ましく、0.02〜0.5の範囲を満たすことがより好ましい。含有質量比が0.01未満の場合、水溶性の生理活性物質の効果が十分に発揮されないために好ましくない。また、0.7よりも大きい場合、リポソームの凝集、沈殿が生じるために好ましくない。
表1および表2に記した組成に従い、処方例1〜8の各リポソームを薄膜法にて調製し、下記試験に供した。結果を表1および表2に併記する。
処方例1〜8で調製した各リポソームを、40℃の恒温槽に1時間保管(インキュベート)後、分光蛍光光度計(励起波長:490nm、蛍光波長:530nm)を用いて、内包物(5,6−カルボキシフルオレセイン)の漏れ出しを測定した蛍光強度の値から漏出率(%)を算出し、下記基準に従って評価した。
F1:インキュベート前の蛍光強度
F2:40℃にてインキュベート後の蛍光強度
F3:Triton−X100を加え、加熱処理した後の蛍光強度(100%漏出)
○:漏出率(%)が、0%以上20%未満
△:漏出率(%)が、20%以上30%未満
×:漏出率(%)が、30%以上
表3に記した組成に従い、実施例1〜4の漏れ出し抑制効果に優れるリポソーム含有組成物を常法に準じて調製した。
表4に記した組成に従い、実施例1〜4の各リポソーム含有組成物を配合した実施例5〜8の皮膚用水溶性化粧料を常法に準じて調製し、下記評価に供した。尚、実施例5は液状の皮膚用水溶性化粧料、実施例6はジェル状の皮膚用水溶性化粧料、実施例7は乳液状の皮膚用水溶性化粧料、実施例8はクリーム状の皮膚用水溶性化粧料として調製した。
実施例5〜8で得られた試料の製造直後のリポソームの形態を透過型電子顕微鏡により観察した。次いで、各試料を50mL容の透明ガラス容器にそれぞれ封入し、40℃の恒温槽に夫々6週間保存した後のリポソームの形態を透過型電子顕微鏡により再度観察し、以下の評価基準に従って評価した。
尚、透過型電子顕微鏡での観察は、ネガティブ染色法で行った。
○:製造直後と全く変化が認められない(リポソームの形態が崩壊していない)
△:リポソームの形態が一部崩壊している
×:リポソームの形態が全崩壊している
Claims (4)
- 皮膚用水溶性化粧料に配合される組成物であって、(A)リン脂質、(B)水溶性の生理活性物質、並びに(C)1,2−アルカンジールからなるリポソームを含有してなる組成物。
- (A)成分が、水素添加リン脂質である請求項1に記載の組成物。
- (C)成分が、炭素数8〜12の1,2−アルカンジールである請求項1又は2に記載の組成物。
- 請求項1〜3の何れかに記載の組成物を配合してなる皮膚用水溶性化粧料。
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US10426715B2 (en) | 2015-03-27 | 2019-10-01 | Kose Corporation | Liposome composition |
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JP2004244350A (ja) * | 2003-02-13 | 2004-09-02 | Mibelle Ag Cosmetics | スキンケアおよびヘアケア用化粧品 |
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JP2007291035A (ja) * | 2006-04-27 | 2007-11-08 | Fancl Corp | リポソーム及びリポソーム含有化粧料 |
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JP2008184431A (ja) * | 2007-01-30 | 2008-08-14 | Kuraray Co Ltd | 皮膚外用剤 |
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JP2004244350A (ja) * | 2003-02-13 | 2004-09-02 | Mibelle Ag Cosmetics | スキンケアおよびヘアケア用化粧品 |
JP2006176471A (ja) * | 2004-12-24 | 2006-07-06 | Japan Natural Laboratory Co Ltd | ユビキノン類を有効成分とする遅効性又は持続性化粧料又はパック用貼付剤。 |
JP2006298840A (ja) * | 2005-04-21 | 2006-11-02 | Konica Minolta Medical & Graphic Inc | リポソーム含有製剤の製造方法およびリポソーム含有製剤 |
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JP2007332088A (ja) * | 2006-06-16 | 2007-12-27 | Pola Chem Ind Inc | ベシクル系に好適な皮膚外用剤 |
JP2008184431A (ja) * | 2007-01-30 | 2008-08-14 | Kuraray Co Ltd | 皮膚外用剤 |
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US10426715B2 (en) | 2015-03-27 | 2019-10-01 | Kose Corporation | Liposome composition |
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