JP2012012320A - 固体脂質エマルション及び皮膚外用剤 - Google Patents
固体脂質エマルション及び皮膚外用剤 Download PDFInfo
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- JP2012012320A JP2012012320A JP2010148980A JP2010148980A JP2012012320A JP 2012012320 A JP2012012320 A JP 2012012320A JP 2010148980 A JP2010148980 A JP 2010148980A JP 2010148980 A JP2010148980 A JP 2010148980A JP 2012012320 A JP2012012320 A JP 2012012320A
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Abstract
【解決手段】油相100質量部中、下記(A)〜(D)を60質量部以上含有する油相と、
(A)特定のビフェニル化合物から選ばれる1種以上、
(B)室温で固体又はペースト状であるトリグリセライド及び/又はワックスエステルから選ばれる1種以上、
(C)炭素数12以上の直鎖で飽和のアルコールから選ばれる1種以上、
(D)ホスファチジルコリン含量が60質量%以上であるリン脂質から選ばれる1種以上
水相とを含有し、
(A)〜(D)成分の組成比が下記(a)〜(c)
(a)(C)成分、(D)成分の質量比(C)/(D)が1/3〜50/1、
(b)(C)成分及び(D)成分と、(B)成分の質量比〔(C)+(D)〕/(B)が1/10〜3/1、
(c)(A)成分と、(B)成分、(C)成分及び(D)成分の質量比(A)/[(B)+(C)+(D)]が1/10以下
である固体脂質エマルション及びこれを含有する皮膚外用剤。
【選択図】なし
Description
従って、本発明の課題は、ビフェニル化合物を十分に効果を奏する量安定に保持し、かつ、優れた使用感を有する皮膚外用剤を提供することにある。
(A)下記一般式(1)及び(2)で示されるビフェニル化合物から選ばれる1種以上、
(B)室温で固体又はペースト状であるトリグリセライド及びワックスエステルから選ばれる1種以上、
(C)炭素数12以上の直鎖で飽和のアルコールから選ばれる1種以上、及び
(D)ホスファチジルコリン含量が60質量%以上であるリン脂質から選ばれる1種以上
水相とを含有し、
(A)〜(D)成分の組成比が下記(a)〜(c)
(a)(C)成分、(D)成分の質量比(C)/(D)が1/3〜50/1、
(b)(C)成分及び(D)成分と、(B)成分の質量比〔(C)+(D)〕/(B)が1/10〜3/1、
(c)(A)成分と、(B)成分、(C)成分及び(D)成分の質量比(A)/[(B)+(C)+(D)]が1/10以下
であることを特徴とする固体脂質エマルションを提供するものである。
(A)成分の固体脂質エマルション又は皮膚外用剤中における含有量は、エマルションの安定性向上、皮膚に塗布した際の使用感またメラニン生成抑制作用向上の点から、0.01〜8質量%が好ましく、より好ましくは0.05〜5質量%、さらに好ましくは0.1〜3質量%である。
(a)(C)成分と(D)成分の質量比(C)/(D)が、1/3〜50/1の範囲内であることが必要であり、好ましくは1/2〜20/1、より好ましくは1/2〜10/1である。
(固体脂質粒子の確認方法)
偏光顕微鏡(OPTIPHOT2−POL、ニコン社製)により組成物の観察を行い、固体脂質粒子の形成有無及びその形状、また、ビフェニル化合物の析出について観察を行った。
(B)パルミチン酸セチルを5g、(C)ヘキサデカノールを1g、(D)ジパルミトイルホスファチジルコリンを1g、(A)ビフェニル化合物1を0.3gの油相を加温して均一に溶解した。次いで、予め80℃に加温した精製水92.7gをマグネチックスターラーにて400回転/分で攪拌しながら、油相を徐々に加え乳化を行った。この乳化液を室温まで冷却し、本発明の固体脂質粒子エマルションを得た。得られた固体脂質粒子エマルションを偏光顕微鏡で観察し、粒子径約100〜500μm(平均粒子径:320μm)の球状で結晶質の固体脂質粒子の生成を確認した。この固体脂質粒子エマルションを25℃、1ヶ月の条件にて保存し、経時安定性を外観観察、偏光顕微鏡により確認したところ、固体脂質粒子相のクリーミングは認められたものの、固体脂質粒子の崩壊や合一は認められず、また、ビフェニル化合物の析出も認められず安定であった。
実施例1で得た固体脂質粒子エマルションから水を濾別し、凍結乾燥を行い、本発明の固体脂質粒子の粉末を得た。得られた固体脂質粒子を偏光顕微鏡で観察し、粒子径が約100〜500μmである球状で結晶質の固体脂質粒子を確認した。この固体脂質粒子の粉末を、実施例1と同様に25℃、1ヶ月の条件にて保存し、その安定性を偏光顕微鏡で確認したところ、固体脂質粒子の崩壊や合一は認められず、また、結晶状態を保っており安定であった。
下記表1の組成からなる実施例3及び比較例1〜3を,実施例1と同様の方法にて製造し、得られた組成物の外観観察及び偏光顕微鏡観察にて、固体脂質粒子の形成及びビフェニル化合物の析出を評価した。
下記表2の組成からなる実施例4及び比較例4〜6を,実施例1と同様の方法にて製造し、得られた組成物の外観観察及び偏光顕微鏡観察にて、固体脂質粒子の形成及びビフェニル化合物の析出を評価した。
下記表3の組成からなる実施例5〜6及び比較例7〜8を,実施例1と同様の方法にて製造し、得られた組成物の外観観察及び偏光顕微鏡観察にて、固体脂質粒子の形成及びビフェニル化合物の析出を評価した。尚、実施例6及び比較例7〜8に用いたトリ2−エチルヘキサン酸グリセリルは、室温で液状である。
しかしながら、本発明の要件を満たさない成分(E)を高濃度に含有する比較例7〜8では、凝集塊の形成や、ビフェニル化合物の析出が認められるなどの問題が生じた。尚、比較例7においては、固体脂質粒子が一部形成されていたが、粒子の軟化及び液状化が生じ、均一な固体脂質粒子が形成できておらず、ビフェニル化合物の析出も見られた。
下記表4の組成からなる本発明の固体脂質粒子エマルションを製造した。製造方法は、油相成分を均一に混合溶解した後に、予め混合し80℃に加温した水相を攪拌下で油相に加え、ホモミキサーを用いて5000回転/分にて乳化を行い、攪拌下で室温まで冷却した。
下記表5の組成からなる本発明の固体脂質粒子エマルションを製造した。製造方法は、油相成分を均一に混合溶解した後に、予め混合し80℃に加温した水相に攪拌下で加え、ホモミキサーを用いて5000回転/分にて乳化を行い、攪拌下で室温まで冷却した。
Claims (6)
- 油相100質量部に対して、下記(A)〜(D)を60質量部以上含有する油相と、
(A)下記一般式(1)及び(2)で示されるビフェニル化合物から選ばれる1種以上、
(B)室温で固体又はペースト状であるトリグリセライド及びワックスエステルから選ばれる1種以上、
(C)炭素数12以上の直鎖で飽和のアルコールから選ばれる1種以上、及び
(D)ホスファチジルコリン含量が60質量%以上であるリン脂質から選ばれる1種以上
水相とを含有し、
(A)〜(D)成分の組成比が下記(a)〜(c)
(a)(C)成分、(D)成分の質量比(C)/(D)が1/3〜50/1、
(b)(C)成分及び(D)成分と、(B)成分の質量比〔(C)+(D)〕/(B)が1/10〜3/1、
(c)(A)成分と、(B)成分、(C)成分及び(D)成分の質量比(A)/[(B)+(C)+(D)]が1/10以下
であることを特徴とする固体脂質エマルション。
- さらに油相中に(E)室温で液状の油成分を油相に含有し、(A)から(D)成分の総量)に対して、室温で液状の油成分(E)の質量比〔(E)/(A+B+C+D)〕が、2/5以下である請求項1記載の固体脂質エマルション。
- 請求項1又は2に記載の固体脂質エマルションから、水相を除去することにより得られる固体脂質粒子。
- 請求項1又は2に記載の固体脂質エマルションを含有する皮膚外用剤。
- 請求項3に記載の固体脂質粒子を含有する皮膚外用剤。
- 美白化粧料である請求項4又は5記載の皮膚外用剤。
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JP2015063468A (ja) * | 2013-09-24 | 2015-04-09 | 花王株式会社 | ハイドロゲル粒子 |
CN106999411A (zh) * | 2014-12-23 | 2017-08-01 | 莱雅公司 | 脂肪酸酯用于皮肤去油光的用途和包含这种酯的组合物 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06145040A (ja) * | 1992-11-05 | 1994-05-24 | Kanebo Ltd | メラニン生成抑制剤 |
JP2001348310A (ja) * | 2000-06-06 | 2001-12-18 | Kanebo Ltd | 油中水型固形メイクアップ化粧料 |
JP2004075540A (ja) * | 2002-08-09 | 2004-03-11 | Rohto Pharmaceut Co Ltd | 外用ゲル状組成物 |
JP2004269502A (ja) * | 2003-02-19 | 2004-09-30 | Kose Corp | 水中油型乳化化粧料 |
JP2006232731A (ja) * | 2005-02-24 | 2006-09-07 | Kanebo Cosmetics Inc | 固体脂質粒子製剤 |
JP2008007433A (ja) * | 2006-06-27 | 2008-01-17 | Kao Corp | 美白化粧料 |
-
2010
- 2010-06-30 JP JP2010148980A patent/JP5555074B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06145040A (ja) * | 1992-11-05 | 1994-05-24 | Kanebo Ltd | メラニン生成抑制剤 |
JP2001348310A (ja) * | 2000-06-06 | 2001-12-18 | Kanebo Ltd | 油中水型固形メイクアップ化粧料 |
JP2004075540A (ja) * | 2002-08-09 | 2004-03-11 | Rohto Pharmaceut Co Ltd | 外用ゲル状組成物 |
JP2004269502A (ja) * | 2003-02-19 | 2004-09-30 | Kose Corp | 水中油型乳化化粧料 |
JP2006232731A (ja) * | 2005-02-24 | 2006-09-07 | Kanebo Cosmetics Inc | 固体脂質粒子製剤 |
JP2008007433A (ja) * | 2006-06-27 | 2008-01-17 | Kao Corp | 美白化粧料 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015063468A (ja) * | 2013-09-24 | 2015-04-09 | 花王株式会社 | ハイドロゲル粒子 |
CN106999411A (zh) * | 2014-12-23 | 2017-08-01 | 莱雅公司 | 脂肪酸酯用于皮肤去油光的用途和包含这种酯的组合物 |
JP2018500345A (ja) * | 2014-12-23 | 2018-01-11 | ロレアル | 皮膚にマット感を付与するための脂肪酸エステル及びこのエステルを含む組成物の使用 |
JP2020203912A (ja) * | 2014-12-23 | 2020-12-24 | ロレアル | 皮膚にマット感を付与するための脂肪酸エステル及びこのエステルを含む組成物の使用 |
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