JP2012008144A - 表面増強ラマン分光法(sers)活性複合体ナノ粒子、前記の製造の方法及び前記の使用の方法 - Google Patents
表面増強ラマン分光法(sers)活性複合体ナノ粒子、前記の製造の方法及び前記の使用の方法 Download PDFInfo
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- JP2012008144A JP2012008144A JP2011207595A JP2011207595A JP2012008144A JP 2012008144 A JP2012008144 A JP 2012008144A JP 2011207595 A JP2011207595 A JP 2011207595A JP 2011207595 A JP2011207595 A JP 2011207595A JP 2012008144 A JP2012008144 A JP 2012008144A
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
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- 229920001059 synthetic polymer Polymers 0.000 description 1
- NBOMNTLFRHMDEZ-UHFFFAOYSA-N thiosalicylic acid Chemical compound OC(=O)C1=CC=CC=C1S NBOMNTLFRHMDEZ-UHFFFAOYSA-N 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 150000003624 transition metals Chemical class 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
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- 238000001845 vibrational spectrum Methods 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
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Abstract
【解決手段】
ナノ粒子、これを準備する方法及びナノ粒子の実施形態を使用してターゲット分子を検出する方法が開示される。例示するナノ粒子の一つの実施形態は、とりわけ、表面増強ラマン分光法活性複合体ナノ構造を含む。表面増強ラマン分光法活性複合体ナノ構造は、コアと、少なくとも一つのレポーター分子と、カプセル化物質を含む。レポーター分子は、コアに結合されている。レポーター分子は、イソチオシアン酸塩染料、多硫化有機染料、多ヘテロ硫化有機染料、ベンゾトリアゾール染料及びこれらの組み合わせから選択される。カプセル化物質はコア及びレポーター分子の上に配置される。カプセル化物質によるカプセル化の後に、レポーター分子は測定可能な表面増強ラマン分光法シグナルを有する。
【選択図】図1
Description
従って、少なくとも添付の特許請求の範囲について権利が請求される。
Claims (23)
- コアと、
前記コアに結合されたレポーター分子であって、イソチオシアン酸塩染料、多硫化有機染料、多ヘテロ硫化有機染料、ベンゾトリアゾール染料及びこれらの組み合わせから選択されるレポーター分子と、
前記コア及び前記レポーター分子の上に配置されるカプセル化物質であって、カプセル化された前記レポーター分子が測定可能な表面増強ラマン分光法シグナルを有するカプセル化物質
を備えた表面増強ラマン分光法活性複合体ナノ構造を備えたナノ構造。 - 前記レポーター分子がチアシアニン染料、ジチアシアニン染料、チアカルボシアニン染料及びジチアカルボシアニン染料から選択される、請求項1に記載のナノ構造。
- 前記レポーター分子がマラカイトグリーンイソチオシアン酸塩、テトラメチルローダミン−5−イソチオシアン酸塩、X−ローダミン−5−イソチオシアン酸塩、X−ローダミン−6−イソチオシアン酸塩及び3,3’−ジエチルシアジカルボシアニンヨウジドから選択される、請求項1に記載のナノ構造。
- 前記コアが金である、請求項3に記載のナノ構造。
- 前記コアが金、銀、銅、ナトリウム、アルミニウム、クロム及びこれらの組み合わせから選択される、請求項1に記載のナノ構造。
- 前記コアが約200ナノメートルより小さい直径を有する、請求項1に記載のナノ構造。
- 前記カプセル化物質がシリカ、ポリマー、金属酸化物、金属硫化物、蛋白質、ペプチド及びこれらの組み合わせから選択される、請求項1に記載のナノ構造。
- 前記カプセル化物質がシリカである、請求項1に記載のナノ構造。
- 前記カプセル化物質が約50ナノメートルより小さい直径を有する、請求項1に記載のナノ構造。
- 前記レポーター分子がコアの表面の1〜75パーセントを覆う、請求項1に記載のナノ構造。
- 表面増強ラマン分光法活性複合体ナノ構造がサイトメトリーシステム、化学配列システム、生物分子配列システム、バイオセンシングシステム、バイオラベリングシステム、高速スクリーニングシステム、遺伝子発現システム、蛋白質発現システム、医療診断システム、診断ライブラリ及びマイクロ流体システムから選択されるシステムに組み込まれる、請求項1に記載のナノ構造。
- コアと、
前記コア上に配置されたレポーター分子であって、前記コアの表面の約15〜50パーセントを覆うレポーター分子と、
前記コア及び前記レポーター分子を覆うカプセル化物質であって、カプセル化された前記レポーター分子が測定可能な表面増強ラマン分光法シグナルを有するカプセル化物質
を備えた表面増強ラマン分光法活性複合体ナノ構造。 - 前記レポーター分子がイソチオシアン酸塩染料、多硫化有機染料、多ヘテロ硫化有機染料、ベンゾトリアゾール染料及びこれらの組み合わせから選択される、請求項12に記載のナノ構造。
- 前記コアが金であって、前記レポーター分子がマラカイトグリーンイソチオシアン酸塩、テトラメチルローダミン−5−イソチオシアン酸塩、X−ローダミン−5−イソチオシアン酸塩、X−ローダミン−6−イソチオシアン酸塩及び3,3’−ジエチルシアジカルボシアニンヨウジドから選択され、前記カプセル化物質がシリカである、請求項12に記載のナノ構造。
- 前記コアに結合された結合剤をさらに備えた、請求項12に記載のナノ構造。
- 前記結合剤が前記コアの表面の40〜60パーセントを覆う、請求項15に記載のナノ構造。
- 前記レポーター分子がマラカイトグリーンイソチオシアン酸塩、テトラメチルローダミン−5−イソチオシアン酸塩、X−ローダミン−5−イソチオシアン酸塩、X−ローダミン−6−イソチオシアン酸塩、3,3’−ジエチルシアジカルボシアニンヨウジド及びこれらの組み合わせから選択される共鳴ラマンレポーターである、請求項12に記載のナノ構造。
- コアをレポーター分子に導入することであって、前記レポーター分子が前記コアに結合され、前記レポーター分子がイソチオシアン酸塩染料、多硫化有機染料、多ヘテロ硫化有機染料、ベンゾトリアゾール染料及びこれらの組み合わせから選択されることと、
カプセル化物質を前記コア及び前記レポーター分子の上に配置することであって、前記カプセル化物質を配置した後に前記レポーター分子が測定可能な表面増強ラマン分光法シグナルを有すること、
を含む、ナノ構造を準備する方法。 - 前記レポーター分子が、前記コアの表面の約1〜75パーセントを覆うように、前記レポーター分子を総量に導入すること
をさらに含む、請求項18に記載の方法。 - 結合された少なくとも一つのレポーター分子を有する前記コアに結合剤を導入することであって、前記結合剤がコアの覆われていない部分に結合すること
をさらに含む、請求項19に記載の方法。 - ターゲット分子を請求項1に記載のナノ構造に付加することと、
放射線源によりレポーター分子を励起することと、
前記ターゲット分子の存在を決定するために、前記レポーター分子に対応するナノ構造の表面増強ラマン分光法スペクトルを測定すること
を含む、少なくとも一つのターゲット分子を検出する方法。 - 前記分子が生体分子を含む、請求項21に記載の方法。
- 前記レポーター分子が共鳴ラマンレポーター分子であって、
前記ターゲット分子の存在を決定するために、前記レポーター分子に対応するナノ構造の表面増強共鳴ラマン分光法スペクトルを測定すること
をさらに含む、請求項21に記載の方法。
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CA2536266A1 (en) | 2005-07-14 |
JP5244312B2 (ja) | 2013-07-24 |
CA2536266C (en) | 2013-10-15 |
EP1660320A2 (en) | 2006-05-31 |
EP1660320B1 (en) | 2013-05-29 |
AU2004308238B2 (en) | 2009-12-10 |
WO2005062741A2 (en) | 2005-07-14 |
EP1660320A4 (en) | 2010-03-10 |
AU2004308238A1 (en) | 2005-07-14 |
US7588827B2 (en) | 2009-09-15 |
JP2007502716A (ja) | 2007-02-15 |
WO2005062741A3 (en) | 2006-03-02 |
US20090140206A1 (en) | 2009-06-04 |
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