JP2011529329A5 - - Google Patents
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- Publication number
- JP2011529329A5 JP2011529329A5 JP2010506476A JP2010506476A JP2011529329A5 JP 2011529329 A5 JP2011529329 A5 JP 2011529329A5 JP 2010506476 A JP2010506476 A JP 2010506476A JP 2010506476 A JP2010506476 A JP 2010506476A JP 2011529329 A5 JP2011529329 A5 JP 2011529329A5
- Authority
- JP
- Japan
- Prior art keywords
- oct3
- nucleic acids
- acids encoding
- klf4
- nuclear reprogramming
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101150086694 SLC22A3 gene Proteins 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 12
- 150000007523 nucleic acids Chemical class 0.000 claims 12
- 102000039446 nucleic acids Human genes 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 8
- 230000008672 reprogramming Effects 0.000 claims 8
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 6
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 6
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 6
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 6
- 210000001082 somatic cell Anatomy 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 206010021143 Hypoxia Diseases 0.000 claims 4
- 230000001146 hypoxic effect Effects 0.000 claims 4
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 claims 1
- 229940102566 valproate Drugs 0.000 claims 1
- 229960000604 valproic acid Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8484208P | 2008-07-30 | 2008-07-30 | |
| US61/084,842 | 2008-07-30 | ||
| US14117708P | 2008-12-29 | 2008-12-29 | |
| US61/141,177 | 2008-12-29 | ||
| US20393108P | 2008-12-30 | 2008-12-30 | |
| US61/203,931 | 2008-12-30 | ||
| PCT/JP2009/063906 WO2010013845A1 (en) | 2008-07-30 | 2009-07-30 | Method of efficiently establishing induced pluripotent stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529329A JP2011529329A (ja) | 2011-12-08 |
| JP2011529329A5 true JP2011529329A5 (cg-RX-API-DMAC7.html) | 2012-08-23 |
| JP5562231B2 JP5562231B2 (ja) | 2014-07-30 |
Family
ID=41610532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010506476A Active JP5562231B2 (ja) | 2008-07-30 | 2009-07-30 | 効率的な人工多能性幹細胞の樹立方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9528092B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2307539B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5562231B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101685209B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN107012123A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2697621C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2010013845A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010042490A1 (en) * | 2008-10-06 | 2010-04-15 | Boston Medical Center Corporation | A single lentiviral vector system for induced pluripotent (ips) stem cells derivation |
| US10328103B2 (en) | 2009-01-03 | 2019-06-25 | Ray C. Wasielewski | Medical treatment composition comprising mammalian dental pulp stem cells |
| US8470308B2 (en) * | 2009-01-03 | 2013-06-25 | Ray C. Wasielewski | Enhanced medical implant comprising disrupted tooth pulp and tooth particles |
| JP5637354B2 (ja) * | 2009-03-30 | 2014-12-10 | 独立行政法人産業技術総合研究所 | 精製転写因子の調製法と細胞導入技術 |
| KR101774206B1 (ko) | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| KR20120061053A (ko) | 2009-08-27 | 2012-06-12 | 시냅틱 리서치, 엘엘씨 | 유도 만능 줄기(ｉＰＳ) 세포 또는 조직 특이적 세포를 생성하기 위한 신규한 단백질 전달 시스템 |
| US20120301438A1 (en) * | 2009-09-14 | 2012-11-29 | The Johns Hopkins University | Reprogramming Blood Cells to Pluripotent and Multipotent Stem Cells |
| US20120276070A1 (en) * | 2009-11-17 | 2012-11-01 | Vitro Diagnositics, Inc. | Induced Pluripotent Stem Cells and Related Methods |
| US8691574B2 (en) | 2010-06-15 | 2014-04-08 | Cellular Dynamics International, Inc. | Generation of induced pluripotent stem cells from small volumes of peripheral blood |
| KR101861171B1 (ko) * | 2010-06-18 | 2018-05-31 | 후지필름 셀룰러 다이내믹스, 인코포레이티드 | 투석된 혈청이 있는 심근세포 배지 |
| JP6029137B2 (ja) | 2010-12-03 | 2016-11-24 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| KR20140063501A (ko) | 2010-12-22 | 2014-05-27 | 페이트 세러퓨틱스, 인코포레이티드 | 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼 |
| WO2013014929A1 (en) | 2011-07-25 | 2013-01-31 | Kyoto University | Method for screening induced pluripotent stem cells |
| RU2014117642A (ru) * | 2011-10-03 | 2015-11-10 | Ниссан Кемикал Индастриз, Лтд. | Способ получения мегакариоцитов и/или тромбоцитов из плюрипотентных стволовых клеток |
| WO2013058403A1 (ja) | 2011-10-21 | 2013-04-25 | 国立大学法人京都大学 | 層流による多能性維持単一分散細胞培養法 |
| JP5999658B2 (ja) | 2011-11-25 | 2016-09-28 | 国立大学法人京都大学 | 多能性幹細胞の培養方法 |
| WO2013147082A1 (ja) * | 2012-03-28 | 2013-10-03 | 株式会社クオリーメン | 不死化幹細胞及びその産生物を有効成分とする医薬組成物並びに医薬製剤 |
| WO2013176233A1 (ja) | 2012-05-23 | 2013-11-28 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
| US20150133467A1 (en) * | 2012-06-06 | 2015-05-14 | Kyoto University | Screening method, protein instability and/or stability inducers, and protein activity assessment |
| CA2895791A1 (en) | 2013-01-25 | 2014-07-31 | Xcell Biosciences, Inc. | Methods, compositions, kits, and systems for selective enrichment of target cells |
| US20160002599A1 (en) | 2013-02-08 | 2016-01-07 | Kyoto University | Production methods for megakaryocytes and platelets |
| EP2966163B1 (en) | 2013-03-06 | 2018-01-17 | Kyoto University | Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells |
| US9790468B2 (en) | 2013-03-15 | 2017-10-17 | Avita Iinternational Ltd. | Multifunctional immature dental pulp stem cells and therapeutic applications |
| US10519421B2 (en) | 2013-03-21 | 2019-12-31 | Kyoto University | Induction of motor neurons from pluripotent stem cells |
| EP2980207B1 (en) | 2013-03-25 | 2018-12-05 | Foundation for Biomedical Research and Innovation at Kobe | Cell sorting method |
| US10961508B2 (en) | 2013-04-12 | 2021-03-30 | Kyoto University | Method for inducing alveolar epithelial progenitor cells |
| JP6429280B2 (ja) | 2013-05-14 | 2018-11-28 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
| JP6378183B2 (ja) | 2013-08-07 | 2018-08-22 | 国立大学法人京都大学 | 膵ホルモン産生細胞の製造法 |
| EP3042951B1 (en) | 2013-09-05 | 2019-02-20 | Kyoto University | New method for inducing dopamine-producing neural precursor cells |
| WO2015064754A1 (ja) | 2013-11-01 | 2015-05-07 | 国立大学法人京都大学 | 新規軟骨細胞誘導方法 |
| FR3016372B1 (fr) * | 2014-01-13 | 2018-01-19 | Centre Leon Berard | Procede de preparation de cellules pluripotentes induites |
| CA2937522C (en) * | 2014-01-24 | 2022-08-23 | Quarrymen Corporation | Pharmaceutical composition for cancer treatment and pharmaceutical preparation for cancer treatment containing same composition as active ingredient |
| CN104894060B (zh) * | 2014-03-03 | 2018-11-06 | 中国科学院上海生命科学研究院 | 诱导体细胞转分化为神经干细胞的方法及其应用 |
| ES2966757T3 (es) * | 2014-03-04 | 2024-04-24 | Fate Therapeutics Inc | Métodos de reprogramación mejorados y plataformas de cultivo celular |
| SG11201701191WA (en) | 2014-07-18 | 2017-03-30 | Univ Kyoto | Method for inducing t cells for cell-based immunotherapy from pluripotent stem cells |
| EP3328995B1 (en) | 2015-07-29 | 2021-03-31 | Hadasit Medical Research Services And Development | Large scale production of retinal pigment epithelial cells |
| SG10202111851YA (en) | 2015-10-16 | 2021-12-30 | Fate Therapeutics Inc | Platform for the Induction & Maintenance of Ground State Pluripotency |
| EP3447130A4 (en) | 2016-04-22 | 2019-11-13 | Kyoto University | METHOD FOR PRODUCING DOPAMINE-PROPERING NEURAL PRESERVATOR CELLS |
| WO2017223199A1 (en) * | 2016-06-22 | 2017-12-28 | Xcell Biosciences, Inc. | Methods for increasing cell culture transfection efficiency and cellular reprogramming |
| WO2018089011A1 (en) | 2016-11-10 | 2018-05-17 | Viacyte, Inc | Pdx1 pancreatic endoderm cells in cell delivery devices and methods thereof |
| EP3824912A4 (en) | 2018-07-19 | 2022-04-20 | Kyoto University | PLATEFORM CARTILAGE DERIVED FROM PLURIPOTENTS STEM CELLS AND METHODS FOR PRODUCTION OF PLATEFORM CARTILAGE |
| JP7357369B2 (ja) | 2018-07-23 | 2023-10-06 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| EP3900787A4 (en) | 2018-12-21 | 2022-02-23 | Kyoto University | LUBRICIN-LOCALIZED CARTILE-LIKE TISSUE, METHOD OF MANUFACTURE THEREOF AND COMPOSITION THEREOF FOR TREATMENT OF ARTICULATE-CARTILAGE DEFECTS |
| WO2020227677A1 (en) * | 2019-05-09 | 2020-11-12 | Figene, Llc | Fibroblast generated patient-specific vaccines |
| WO2020230138A1 (en) | 2019-05-14 | 2020-11-19 | Aleph Farms Ltd. | Pluripotent cell aggregates and use thereof |
| US20230030814A1 (en) | 2019-12-12 | 2023-02-02 | National University Corporation Chiba University | Freeze-Dried Preparations Comprising Megakaryocytes and Platelets |
| JP7429294B2 (ja) | 2020-07-13 | 2024-02-07 | 国立大学法人京都大学 | 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法 |
| WO2022019152A1 (ja) | 2020-07-20 | 2022-01-27 | 学校法人 愛知医科大学 | 多能性細胞の未分化維持培養用組成物、多能性細胞の未分化維持培養用培地、多能性細胞の未分化状態での維持培養方法、および多能性細胞の製造方法 |
| US20250145948A1 (en) | 2022-02-09 | 2025-05-08 | Sumitomo Pharma Co., Ltd. | Method for assessing differentiation potential of cells in culture broth in differentiation of pluripotent stem cells into neural cells of midbrain floor plate region |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999020741A1 (en) | 1997-10-23 | 1999-04-29 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells |
| AU6842001A (en) * | 2000-06-15 | 2001-12-24 | Tanja Dominko | Pluripotent mammalian cells |
| PT2457999T (pt) | 2002-12-16 | 2019-01-28 | Technion Res & Dev Foundation | Sistema de cultura para células estaminais pluripotentes |
| WO2006019366A1 (en) | 2003-03-28 | 2006-02-23 | Wisconsin Alumni Research Foundation | Physiochemical culture conditions for embryonic stem cells |
| CA2579652A1 (en) | 2004-09-08 | 2006-03-16 | Wisconsin Alumni Research Foundation | Culturing human embryonic stem cells |
| WO2006073911A1 (en) | 2004-12-30 | 2006-07-13 | Stemlifeline, Inc. | Methods and compositions relating to embryonic stem cell lines |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| AU2006325975B2 (en) | 2005-12-13 | 2011-12-08 | Kyoto University | Nuclear reprogramming factor |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| KR101188527B1 (ko) | 2007-01-04 | 2012-10-05 | 칼 트리그베이슨 | 다능성 줄기세포를 증식할 수 있는 조성물 및 방법 |
| DK3399025T3 (da) | 2007-03-23 | 2025-06-16 | Wisconsin Alumni Res Found | Omprogrammering af somatiske celler |
| WO2009032456A2 (en) | 2007-08-01 | 2009-03-12 | Primegen Biotech Llc | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| EP2227540A4 (en) | 2007-11-29 | 2011-11-02 | Children S Hospital Of Orange County | DIFFERENTIATION OF HUMAN CELLS |
| US9290740B2 (en) | 2008-03-07 | 2016-03-22 | Worcester Polytechnic Institute | Use of basic fibroblast growth factor in the de-differentiation of animal connective tissue cells |
| US20100279404A1 (en) | 2008-05-02 | 2010-11-04 | Shinya Yamanaka | Method of nuclear reprogramming |
| WO2009142717A2 (en) | 2008-05-19 | 2009-11-26 | President And Fellows Of Harvard College | Methods and products for dedifferentiation of cells |
| CA2695590C (en) | 2008-06-27 | 2018-01-09 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| EP2333050A4 (en) | 2008-09-04 | 2013-07-03 | Riken | IPS CELLS FROM B-CELLS AND ITS APPLICATION |
| EP2336303B1 (en) | 2008-09-08 | 2015-07-15 | Riken | NKT CELL-DERIVED iPS CELLS AND NKT CELLS DERIVED THEREFROM |
| CN101492676B (zh) * | 2008-09-16 | 2011-02-16 | 中国科学院广州生物医药与健康研究院 | 用脑膜细胞生成诱导的多能性干细胞的方法及其用途 |
| KR101774206B1 (ko) | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
-
2009
- 2009-07-30 EP EP09803075.2A patent/EP2307539B1/en active Active
- 2009-07-30 US US12/672,222 patent/US9528092B2/en active Active
- 2009-07-30 CN CN201611216942.9A patent/CN107012123A/zh active Pending
- 2009-07-30 CN CN200980100065A patent/CN101848994A/zh active Pending
- 2009-07-30 JP JP2010506476A patent/JP5562231B2/ja active Active
- 2009-07-30 KR KR1020107002641A patent/KR101685209B1/ko active Active
- 2009-07-30 CA CA2697621A patent/CA2697621C/en active Active
- 2009-07-30 WO PCT/JP2009/063906 patent/WO2010013845A1/en not_active Ceased
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